Abstract:
Gentisic acid sodium salt is shown to be useful as a treatment to improve systemic hemodynamics, hepatic mitochondrial function and lactic acidemia in patients with septic shock.
Abstract:
The use of a uni-pressure and dual-pressure augmented mouse permits users to simultaneously control cursor positions as well as multiple levels of discrete action modes for common desktop application tasks. One, two or more independent pressure sensors can be mounted onto several locations on the body of the mouse. Various selection techniques are described to control many discrete levels and to simultaneously control different variable functions with pressure sensors on an input device for an electronic device.
Abstract:
The present invention relates to replication-competent Arteriviruses having a decreased DUB/deISGylating activity due to a mutation in the PLP2 domain of the non-structural protein nsp2, to their use as a medicament, their use as a vaccine and in prophylaxis, to vaccines comprising such Arteriviruses and to Arteriviral PLP2-ubiquitin complexes.
Abstract:
A solid state sensor may be used to down-convert microwave signal into a low-frequency voltage or current signal, where its phase still carries the information of a measured continuous wave (CW) microwave phase. Two CW microwaves may be mixed and a solid state sensor used to rectify the mixed microwave into a direct voltage or current signal. The measurement system may include an input node for receiving a microwave signal from a source from which the output microwave is coherently split into two parts by a microwave power divider. Each part may travel in a separate path and couple at the solid state sensor. A lock-in amplifier coupled to the solid state sensor may be used to determine simultaneously a magnitude and phase of the microwave signals received from the microwave source.
Abstract:
Systems, devices and methods of reconstructing an image from a positron emission tomography scan that may include detecting a plurality of photons selected from scattered photons and unscattered photons by a plurality of detectors, identifying a time interval for each of the plurality of photons by a processing device, matching each of the plurality of photons into a plurality of pairs of coincident photons based upon a substantially simultaneous time interval identified by the processing device, measuring an energy produced by each of the plurality of photons by the plurality of detectors, determining a scattering angle for each pair of coincident photons from an annihilation point relative to the position of the plurality of detectors by the processing device based on the energy produced and reconstructing an image using a reconstruction algorithm, wherein the reconstruction algorithm uses the scattering angle of each pair of coincident photons.
Abstract:
A novel ligated reagent complex is provided. The ligated reagent includes at least one zero-valent atom, whether metal, metalloid, or non-metal, in complex with at least one hydride molecule and at least one nitrile compound. The ligated reagent complex can be useful in the synthesis of nanoparticles. Also provided is a method for preparing a ligated reagent complex. The method includes a step of ball-milling a mixture that includes a preparation containing a zero-valent element, a hydride molecule, and a nitrile compound.
Abstract:
Embodiments of an improved sensor for dielectrophoretic cytometry are presented. In one embodiment, the sensor includes a plurality of sensor electrodes as well as an actuation electrode. Embodiments of microfluidic systems incorporating such sensor are also described. Additionally, embodiments of methods or performing cytometry analysis are also presented.
Abstract:
Reductively degradable micelles comprising poly(-βamino ester)s-g-poly(ethylene glycol) amphiphilic copolymers provided with aromatic phenylbutylamine side groups, suitable for sequestering therein anthrocyclines. The anthrocycline-loaded reductively degradable micelles are useful for therapeutic treatment of cancers.
Abstract:
A new seeder for laser-based velocity measurements in gaseous combusting and non-combusting flows is described herein. The performance of the seeder was tested under a variety of flow rate conditions. The testing revealed that control over the concentration of seeding particles, stability of particles supply, extended range of flow rate, and breakup of the agglomerates makes the newly designed seeder advantageous over its counterparts, especially for weak flow rates applications.
Abstract:
Described herein is a method for mixing unequal amounts of two reagents to produce a detectable reaction in a microfluidic chip. In one example, there is a fluorescent microfluidic urinary albumin chip (UAL-Chip) that exploits the nonimmunological fluorescent assay. In this chip, we constructed a passive and continuous mixing module, in which the loading process requires only an inexpensive dropper, and the signal is stable over time, as discussed below. We applied a pressure-balancing strategy based on the immiscible oil coverage which highly improves the precision in controlling the mixing ratio of sample and dye. The UAL-Chip has achieved an estimated limit of detection (LOD) of 8.4 μg/ml using albumin standards, which is below the 30 μg albumin per ml urine level considered to be indicative of kidney damage.