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    METHOD AND COMPUTER PROGRAM FOR PREDICTING BILIRUBIN LEVELS IN NEONATES
    82.
    发明申请
    METHOD AND COMPUTER PROGRAM FOR PREDICTING BILIRUBIN LEVELS IN NEONATES 审中-公开

    公开(公告)号：US20200300872A1

    公开(公告)日：2020-09-24

    申请号：US16651992

    申请日：2018-09-27

    Applicant: UNIVERSITÄT BASEL

    Inventor： Gilbert KOCH ,  Sven WELLMANN ,  Marc PFISTER ,  Severin KASSER ,  Melanie WILBAUX

    IPC: G01N33/72 ,  G16H50/20 ,  G16H10/00 ,  G06F17/18

    Abstract: The invention relates to methods for estimating a bilirubin level of a neonate, comprising the steps of acquiring a series of bilirubin levels estimated at different time points from a sample obtained from a neonate; acquiring a plurality of covariates from the neonate, each comprising an information about a neonatal property; providing a pre-defined bilirubin model function; determining a plurality of model parameters of the bilirubin model function; and determining from the series of acquired bilirubin levels and the bilirubin model function with the determined model parameters an expected bilirubin level of the neonate for a time particularly later than a lastly acquired bilirubin level of the series of bilirubin levels.

    CORE BIOPSY NEEDLE
    83.
    发明申请
    CORE BIOPSY NEEDLE 审中-公开

    公开(公告)号：US20200253590A1

    公开(公告)日：2020-08-13

    申请号：US16753784

    申请日：2018-10-05

    Applicant: UNIVERSITÄT BASEL ,  ARTIDIS AG

    Inventor： Marija PLODINEC ,  Ludovit Pavel ZWEIFEL ,  Philipp Maximillian OERTLE ,  Armin STUMPP ,  Marko LOPARIC

    IPC: A61B10/02 ,  A61L24/10

    Abstract: The invention relates to a core biopsy needle (1) for obtaining a tissue sample comprising a hollow outer needle (10) extending along a longitudinal axis (L), and an inner needle (20), which is at least partially arranged or arrangeable within said outer needle along said longitudinal axis (L), wherein said inner needle (20) comprises at least one tissue-holding surface (21), wherein said tissue-holding surface (21) is adapted such that a tissue (3) adheres to the at least one tissue-holding surface (21), when the core biopsy needle (1) is inserted into the tissue (3).

    TREATMENT OF NEUROLOGICAL DISORDERS
    86.
    发明申请
    TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开

    公开(公告)号：US20190284178A1

    公开(公告)日：2019-09-19

    申请号：US16301729

    申请日：2017-05-17

    Applicant: PIQUR THERAPEUTICS AG ,  UNIVERSITÄT BASEL

    Inventor： Denise RAGEOT ,  Paul HEBEISEN ,  Florent BEAUFILS ,  Doriano FABBRO ,  Petra HILLMANN-WÜLLNER ,  Hoa Huu Phuc NGUYEN ,  Wolfgang LÖSCHER ,  Claudia BRANDT ,  Alexander Markus SELE

    IPC: C07D413/14 ,  C07D451/02 ,  C07D417/14 ,  C07D451/14 ,  C07D498/08 ,  C07D519/00 ,  A61P25/08 ,  A61P25/28

    Abstract: The present invention is relates to a compound of formula (I), wherein X1, X2 and X3 are, independently of each other, N or CH; with the proviso that at least two of X1, X2 and X3 are N; Y is N or CH; R1 and R2 are independently of each other (iii) a morpholinyl of formula (II) wherein the arrow denotes the bond in formula (I); and wherein R3 and R4 are independently of each other H, C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1-C2alkoxy, C1-C2alkoxyC1-C3alkyl, CN, or C(O)O—C1-C2alkyl; or R3 and R4 form together a bivalent residue —R5R6— selected from C1-C3alkylene optionally substituted with 1 to 4 F, —CH2—O—CH2—, —CH2—NH—CH2—, or any of the structures wherein the arrows denote the bonds in formula (II); or (iv) a saturated 6-membered heterocyclic ring Z selected from thiomorpholinyl and piperazinyl, optionally substituted by 1 to 3 R7; wherein R7 is independently at each occurrence C1-C3alkyl optionally substituted with one or two OH, C1-C2fluoroalkyl, C1-C2alkoxyC1-C3alkyl, C3-C6cycloalkyl; or two R7 substituents form together a bivalent residue —R8R9— selected from C1-C3alkylene optionally substituted with 1 to 4 F, —CH2—O—CH2— or —O—CH2CH2—O—; with the proviso that at least one of R1 and R2 is a morpholinyl of formula II; and prodrugs, metabolites, tautomers, solvates and pharmaceutically acceptable salts thereof, for use in the prevention or treatment of a neurological disorder in a subject.

    Method and computer program for predicting bilirubin levels in neonates
    90.
    发明授权
    Method and computer program for predicting bilirubin levels in neonates 有权

    公开(公告)号：US11656234B2

    公开(公告)日：2023-05-23

    申请号：US16651992

    申请日：2018-09-27

    Applicant: UNIVERSITÄT BASEL

    Inventor： Gilbert Koch ,  Sven Wellmann ,  Marc Pfister ,  Severin Kasser ,  Melanie Wilbaux

    IPC: G01N33/72 ,  G06F17/18 ,  G16H10/00 ,  G16H50/20

    CPC classification number: G01N33/728 ,  G06F17/18 ,  G16H10/00 ,  G16H50/20 ,  Y10T436/146666

    Abstract: The invention relates to a method and a computer program for estimating a bilirubin level of a neonate, composed of the steps of:



    Acquiring a series of bilirubin levels estimated at different time points from a sample obtained from a neonate,
    Acquiring a plurality of covariates from the neonate, each composed of an information about a neonatal property,
    Providing a pre-defined bilirubin model function, wherein the bilirubin model function is configured to describe a time course of a bilirubin level of a neonate,
    Determining a plurality of model parameters of the bilirubin model function, wherein each model parameter is estimated from at least one covariate of the plurality of covariates and an associated population model parameter,
    Determining from the series of acquired bilirubin levels and the bilirubin model function with the determined model parameters an expected bilirubin level of the neonate for a time particularly later than a lastly acquired bilirubin level of the series of bilirubin levels.

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