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94 条记录 (耗时 0.034 秒)

    Potent and Selective Mediators of Cholesterol Efflux
    81.
    发明申请
    Potent and Selective Mediators of Cholesterol Efflux 有权
    胆固醇流出的有效和选择性调解者

    公开(公告)号：US20120329703A1

    公开(公告)日：2012-12-27

    申请号：US12519116

    申请日：2007-12-13

    申请人： John K. Bielicki ,  Jan Johansson

    发明人： John K. Bielicki ,  Jan Johansson

    IPC分类号： A61K38/16 ,  A61P9/10 ,  A61P3/06 ,  C07K14/00 ,  A61P9/00

    CPC分类号： C07K14/775 ,  A61K38/00 ,  A61K38/16 ,  C07K14/4703

    摘要： The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., Apo AI and Apo E), and having high selectivity for ABAC1 that parallels that of full-length apolipoproteins. The invention also provides compositions comprising such polypeptides, methods of identifying, screening and synthesizing such polypeptides, and methods of treating, preventing or diagnosing diseases and disorders associated with dyslipidemia, hypercholesterolemia and inflammation.

    摘要翻译： 本发明提供了具有与全长载脂蛋白（例如Apo AI和Apo E）平行的胆固醇流出活性的非天然存在的多肽的家族，并且对于与全长载脂蛋白的ABAC1平行的ABAC1具有高选择性。 本发明还提供包含这些多肽的组合物，鉴定，筛选和合成这些多肽的方法，以及治疗，预防或诊断与血脂异常，高胆固醇血症和炎症相关的疾病和病症的方法。

    BEARING FOR A SHAFT OF A GYRATORY CRUSHER AND METHOD OF ADJUSTING THE GAP WIDTH OF THE CRUSHER
    83.
    发明申请
    BEARING FOR A SHAFT OF A GYRATORY CRUSHER AND METHOD OF ADJUSTING THE GAP WIDTH OF THE CRUSHER 失效
    轴承用于摇摆式破碎机和调整破碎机的宽度的方法

    公开(公告)号：US20100116915A1

    公开(公告)日：2010-05-13

    申请号：US12493591

    申请日：2009-06-29

    申请人： Percy NORRMAN ,  Jan Johansson ,  Torbjörn Nilsson-Wulff ,  Niklas Bennstedt

    发明人： Percy NORRMAN ,  Jan Johansson ,  Torbjörn Nilsson-Wulff ,  Niklas Bennstedt

    IPC分类号： B02C2/04 ,  B02C25/00

    CPC分类号： B02C2/04 ,  B02C2/047 ,  B02C2/06 ,  B02C2210/02

    摘要： A gyratory crusher has a crushing head fixedly attached to an upper portion of a substantially vertical shaft, on which crushing head a first crushing shell is mounted, and a frame on which a second crushing shell is mounted. The second crushing shell defines, together with the first crushing shell, a crushing gap. The gyratory crusher has a space adapted to contain liquid. The space is defined by a piston, which is formed at least partly of the lower end of the shaft, a cylinder, which is formed at least partly in an eccentric assembly, and a bottom element. The space is adapted to form a cushion with the aid of the liquid, so that the cushion can serve as a thrust bearing transmitting vertical forces from the crushing head to the bottom element.

    摘要翻译： 旋转式破碎机具有固定地连接到基本垂直的轴的上部的破碎头，在其上安装有破碎头，第一破碎壳和其上安装有第二破碎壳的框架。 第二破碎壳与第一破碎壳一起限定了破碎间隙。 回转破碎机具有适于容纳液体的空间。 空间由至少部分地由轴的下端形成的活塞，至少部分地形成在偏心组件中的圆柱体和底部元件限定。 该空间适于借助于液体形成缓冲垫，使得该衬垫可以用作传递从破碎头到底部元件的垂直力的止推轴承。

    SYSTEMS, DEVICES, AND METHODS FOR CONTROLLABLY COUPLING QUBITS
    84.
    发明申请
    SYSTEMS, DEVICES, AND METHODS FOR CONTROLLABLY COUPLING QUBITS 有权
    用于控制QUBITS的系统，设备和方法

    公开(公告)号：US20090192041A1

    公开(公告)日：2009-07-30

    申请号：US12242133

    申请日：2008-09-30

    申请人： Jan Johansson ,  Andrew J. Berkley

    发明人： Jan Johansson ,  Andrew J. Berkley

    IPC分类号： H03K19/195 ,  H01L39/02

    CPC分类号： G06N99/002 ,  B82Y10/00

    摘要： A transverse coupling system may include a first qubit, a second qubit, a first conductive path capacitively connecting the first qubit and the second qubit, a second conductive path connecting the first qubit and the second qubit, and a dc SQUID connecting the first and the second conductive paths wherein the compound junction loop is threaded by an amount of magnetic flux.

    摘要翻译： 横向耦合系统可以包括第一量子比特，第二量子比特，电容性地连接第一量子位和第二量子位的第一导电路径，连接第一量子位和第二量子位的第二导电路径，以及连接第一和第二量子位的直流SQUID 第二导电路径，其中复合连接环被一定量的磁通量穿过。

    Synthetic lipid mixtures for the preparation of a reconstituted surfactant
    85.
    发明授权
    Synthetic lipid mixtures for the preparation of a reconstituted surfactant 有权
    用于制备重构表面活性剂的合成脂质混合物

    公开(公告)号：US07511011B2

    公开(公告)日：2009-03-31

    申请号：US10512869

    申请日：2003-05-12

    申请人： Tore Curstedt ,  Jan Johansson ,  Bengt Robertson

    发明人： Tore Curstedt ,  Jan Johansson ,  Bengt Robertson

    IPC分类号： A61K38/16

    CPC分类号： C07K14/785 ,  A61K38/00

    摘要： The invention relates to reconstituted surfactants consisting of artificial phospholipids and peptides able to lower the air-liquid surface tension, more particularly to reconstituted surfactants, comprising special phospholipid mixtures and artificial peptides which are analogues of the natural surfactant SP-C protein for the treatment of respiratory distress syndrome (RDS) and other diseases relates to pulmonary surfactant dysfunctions.

    摘要翻译： 本发明涉及由人造磷脂和能够降低空气 - 液体表面张力的肽组成的重构表面活性剂，更具体地说，涉及包含特殊磷脂混合物和人造肽的重构表面活性剂，其是天然表面活性剂SP-C蛋白的类似物，用于治疗 呼吸窘迫综合征（RDS）等疾病涉及肺表面活性物质功能障碍。

    RF power LDMOS transistor with multiple gate fingers
    88.
    发明授权
    RF power LDMOS transistor with multiple gate fingers 有权
    RF功率LDMOS晶体管具有多个栅极指

    公开(公告)号：US07095080B2

    公开(公告)日：2006-08-22

    申请号：US10658137

    申请日：2003-09-09

    申请人： Jan Johansson ,  Nils Af Ekenstam

    发明人： Jan Johansson ,  Nils Af Ekenstam

    IPC分类号： H01L29/76 ,  H01L29/94

    CPC分类号： H01L29/7835 ,  H01L23/4824 ,  H01L29/4175 ,  H01L29/41758 ,  H01L29/41775 ,  H01L29/42372 ,  H01L29/4238 ,  H01L2924/0002 ,  H01L2924/00

    摘要： In an RF power LDMOS transistor comprising multiple pairs of parallel gate fingers (11) located on opposite side of an associated p+ sinker (23), and metal clamps (14) for short-circuiting the p+ sinkers (23), each gate finger (11) of a pair is associated with separate metal clamps (14) that short-circuit the n+ source region (20) and the p+ sinker (23) associated with particular gate finger (11). The separate metal clamps (14) associated with each gate finger pairs are separated by a slot (15) that extends between the parallel gate fingers (11), and a metal runner (13) extends in the slot (15) between the separate metal clamps (14) associated with each finger pair from a gate pad. Both gate fingers (11) of a gate finger pair are connected to the associated metal runner (13) at both ends and at predetermined positions along their lengths.

    摘要翻译： 在包括位于相关联的沉淀片（23）的相对侧的多对平行栅极指（11）的RF功率LDMOS晶体管中，以及金属夹（14），用于短路p < （23），一对的每个栅极指（11）与分离的金属夹​​具（14）相关联，使得N +源极区（20）和 与特定门指（11）相关联的p + SUPER沉降片（23）。 与每个门指对相关联的单独的金属夹具（14）由在平行门指（11）之间延伸的槽（15）分开，并且金属流道（13）在槽（15）之间延伸在分开的金属 夹子（14），其与每个手指对相关联。 门指对的两个门指（11）在其两端和沿其长度的预定位置处连接到相关联的金属流道（13）。

    Discordant helix stabilization for prevention of amyloid formation
    89.
    发明申请
    Discordant helix stabilization for prevention of amyloid formation 审中-公开
    用于预防淀粉样蛋白形成的不协调的螺旋稳定

    公开(公告)号：US20050059084A1

    公开(公告)日：2005-03-17

    申请号：US10772230

    申请日：2004-02-04

    申请人： Jan Johansson

    发明人： Jan Johansson

    IPC分类号： A61P25/28 ,  G01N33/68 ,  G01N33/53

    CPC分类号： C07K1/1136 ,  G01N33/6896 ,  G01N2500/04 ,  G01N2800/2821 ,  G01N2800/2828

    摘要： The invention is based on the discovery that the presence of a discordant helix in a protein or peptide is predictive of that protein or peptide's ability to form amyloid. The invention includes methods for detecting discordant helices and methods of screening for compounds that stabilize the α-helix of a discordant helix-containing polypeptide. Compounds discovered using these methods are useful for treating or preventing disorders in which amyloid is produced. Such disorders include Alzheimer's disease and prion-associated disorders.

    摘要翻译： 本发明基于以下发现：蛋白质或肽中不一致螺旋的存在预示该蛋白或肽形成淀粉样蛋白的能力。 本发明包括用于检测不一致螺旋的方法和筛选稳定不一致的含螺旋的多肽的α-螺旋的化合物的方法。 使用这些方法发现的化合物可用于治疗或预防产生淀粉样蛋白的疾病。 这些疾病包括阿尔茨海默病和朊病毒相关疾病。