Novel therapeutic targets in cancer

    公开(公告)号:US20050090434A1

    公开(公告)日:2005-04-28

    申请号:US10461862

    申请日:2003-06-13

    摘要: The present invention relates to novel sequences for use in detection, diagnosis and treatment of cancers, especially lymphomas. The invention provides cancer-associated (CA) polynucleotide sequences whose expression is associated with cancer. The present invention provides CA polypeptides associated with cancer that are present on the cell surface and present novel therapeutic targets against cancer. The present invention further provides diagnostic compositions and methods for the detection of cancer. The present invention provides monoclonal and polyclonal antibodies specific for the CA polypeptides. The present invention also provides diagnostic tools and therapeutic compositions and methods for screening, prevention and treatment of cancer.

    Multi-port flow control valves
    85.
    发明申请
    Multi-port flow control valves 失效
    多端口流量控制阀

    公开(公告)号:US20050002831A1

    公开(公告)日:2005-01-06

    申请号:US10488146

    申请日:2002-08-30

    摘要: Multi-port flow control valves are provided wherein the outlet ports may be opened in cascade fashion to allow fluid to flow through the outlet ports into at least two conduits in which the opening of the outlet ports is controlled by a signal indicating the need for fluid in the conduits. The valves are particularly useful for controller the supply of heating/cooling fluid to multiple heating/cooling coils employed to control reactions. In a preferred embodiment the opening of the ports is controlled according to the heat measured in the reaction

    摘要翻译: 提供了多端口流量控制阀,其中出口端口可以以级联的方式打开,以允许流体通过出口端口流动到至少两个管道中,其中出口端口的开口由表示需要流体的信号控制 在管道中。 这些阀对于控制器提供加热/冷却流体到用于控制反应的多个加热/冷却盘管特别有用。 在优选实施例中,端口的开口根据反应中测量的热量来控制

    Golfer's putting practice device
    87.
    发明授权
    Golfer's putting practice device 失效
    高尔夫球手的投球练习装置

    公开(公告)号:US4966370A

    公开(公告)日:1990-10-30

    申请号:US468139

    申请日:1990-01-22

    申请人: David Morris

    发明人: David Morris

    IPC分类号: A63B47/02 A63B63/00 A63B69/36

    摘要: A golf ball retainer is disclosed for use with a practice putting carpet, the two forming a golf practice putting device. The putting carpet is conventional and includes a raised end that contains an orifice which serves as a golf cup or target. The ball retainer in a presently preferred embodiment is molded from a vinyl plastic in one integral piece that has a substantially E-shape in cross section. The ball retainer is comprised of a first, grasping section that includes a pair of hooks on the ends of spaced apart arms. The hooks can removeably grasp an edge of the carpet. A second, catcher section of the ball retainer is also comprised of two spaced apart arms, one of which is used by the first section. The catcher section can retainably receive a ball rolling into contact between its arms.

    摘要翻译: 公开了一种用于练习放置地毯的高尔夫球保持器,两者形成高尔夫练习放置装置。 放置地毯是常规的,并且包括具有用作高尔夫球杯或目标的孔的凸起端。 目前优选的实施例中的球保持器由一个整体件中的乙烯基塑料模制而成,其横截面具有基本E形。 球保持器包括第一抓握部分,其包括在间隔开的臂的端部上的一对钩。 钩子可以移除地抓住地毯的边缘。 球保持器的第二捕获器部分还包括两个间隔开的臂,其中之一由第一部分使用。 捕获器部分可以保持接收滚动到其臂之间的接触的球。

    Latch circuit
    88.
    发明授权
    Latch circuit 失效
    锁存电路

    公开(公告)号:US3988643A

    公开(公告)日:1976-10-26

    申请号:US518103

    申请日:1974-10-25

    申请人: David Morris

    发明人: David Morris

    IPC分类号: H02M3/156 H02H7/20 H02H3/08

    CPC分类号: H02M3/1563

    摘要: A Schmidt trigger voltage regulator having a latching circuit at its input to disable the regulator during an overload condition and automatically resets the latching circuit when the overload condition is removed thereby allowing the regulator to function in its normal voltage regulating mode.

    摘要翻译: 施密特触发电压调节器在其输入端具有锁存电路,以在过载状态下禁止调节器,并且在过载条件被去除时自动复位锁存电路,从而允许调节器在其正常电压调节模式下工作。

    Chokeless Schmitt-trigger regulator
    89.
    发明授权
    Chokeless Schmitt-trigger regulator 失效
    施密特触发调节器

    公开(公告)号:US3983472A

    公开(公告)日:1976-09-28

    申请号:US449688

    申请日:1974-03-11

    申请人: David Morris

    发明人: David Morris

    IPC分类号: H02M3/338 H02M3/335

    CPC分类号: H02M3/3385

    摘要: A switching regulator is series connected to an oscillator. A schmitt trigger responds to load voltage variations to control the on-off conditions of the switching regulator. When the switching regulator is on the oscillator is on to provide through transformer coupling an output to a capacitor connected across the load. When the voltage across the capacitor increases to a predetermined value the schmitt trigger turns the switching regulator off and thereby the oscillator too, the capacitor continuing to discharge into the load.

    摘要翻译: 开关稳压器串联连接到振荡器。 施密特触发器响应负载电压变化来控制开关稳压器的开 - 关状态。 当开关稳压器在振荡器上时,通过变压器将输出耦合到跨过负载连接的电容器。 当电容器两端的电压增加到预定值时,施密特触发器关闭开关稳压器,从而使振荡器也断开,电容器继续放电进入负载。