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    Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers
    81.
    发明申请
    Detection of biochemical interactions on a biosensor using tunable filters and tunable lasers 审中-公开
    使用可调谐滤波器和可调谐激光器检测生物传感器上的生物化学相互作用

    公开(公告)号：US20090269244A1

    公开(公告)日：2009-10-29

    申请号：US12321715

    申请日：2009-01-22

    Applicant: Brian T. Cunningham ,  Peter Y. Li ,  Constance Chang-Hasnain ,  Carlos Mateus

    Inventor： Brian T. Cunningham ,  Peter Y. Li ,  Constance Chang-Hasnain ,  Carlos Mateus

    IPC: G01N21/31

    CPC classification number: G01N21/45 ,  G01N21/39 ,  G01N21/75 ,  G01N21/7743 ,  G01N33/54373

    Abstract: An apparatus and method for detection of peak wavelength values of colorimetric resonant optical biosensors using tunable filters and tunable lasers is provided. Biomolecular interactions may be detected on a biosensor by directing collimated white light towards a surface of the biosensor. Molecular binding on the surface of the biosensor is indicated in a shift in the peak wavelength value of the reflected or transmitted light from the biosensor, while an increase in the wavelength corresponds to an increase in molecular absorption. A tunable laser light source may generate the collimated white light and a tunable filter may receive the reflected or transmitted light and pass the light to a photodiode sensor. The photodiode sensor then quantifies an amount of the light reflected or transmitted through the tunable filter as a function of the tuning voltage of the tunable filter.

    Abstract translation: 提供了使用可调滤波器和可调谐激光器检测比色共振光学生物传感器的峰值波长值的装置和方法。 可以在生物传感器上通过将准直的白光指向生物传感器的表面来检测生物分子相互作用。 生物传感器的表面上的分子结合以来自生物传感器的反射或透射光的峰值波长值的偏移来表示，而波长的增加对应于分子吸收的增加。 可调激光光源可以产生准直的白光，并且可调滤光器可以接收反射或透射的光并将光传递到光电二极管传感器。 然后光电二极管传感器根据可调谐滤波器的调谐电压量化反射或透过可调谐滤波器的光量。

    Label-free biosensors based upon distributed feedback laser
    83.
    发明申请
    Label-free biosensors based upon distributed feedback laser 有权
    基于分布式反馈激光器的无标签生物传感器

    公开(公告)号：US20090179637A1

    公开(公告)日：2009-07-16

    申请号：US12317826

    申请日：2008-12-29

    Applicant: Brian T. Cunningham ,  Meng Lu

    Inventor： Brian T. Cunningham ,  Meng Lu

    IPC: G01J3/30 ,  G01R33/20

    CPC classification number: G01N21/7743 ,  G01N2021/7709

    Abstract: A biosensor based upon a vertically emitting, distributed feedback (DFB) laser is disclosed. In one configuration, the DFB laser comprises a replica-molded, one- or two-dimensional dielectric grating coated with a laser dye-doped-polymer as the gain medium. A sensor is also described in which the grating layer and the active layer are combined into a single layer. DFB lasers using an inorganic or organic thin film with alternating regions of high and low index of refraction as the active layer are also disclosed. The sensor actively generates its own narrowband high intensity light output without stringent requirements for coupling alignment, thereby resulting in a simple, robust illumination and detection configuration.

    Abstract translation: 公开了一种基于垂直发射分布反馈（DFB）激光器的生物传感器。 在一种配置中，DFB激光器包括涂覆有激光染料掺杂聚合物作为增益介质的复制模制的一维或二维介质光栅。 还描述了传感器，其中光栅层和有源层被组合成单层。 还公开了使用具有高折射率和低折射率的交替区域的无机或有机薄膜作为活性层的DFB激光器。 传感器主动产生自己的窄带高强度光输出，无需对耦合对准的严格要求，从而产生简单，鲁棒的照明和检测配置。

    Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis
    84.
    发明申请
    Photonic crystal sensors with integrated fluid containment structure, sample handling devices incorporating same, and uses thereof for biomolecular interaction analysis 有权
    具有集成流体容纳结构的光子晶体传感器，结合其的样品处理装置及其用于生物分子相互作用分析的用途

    公开(公告)号：US20090079976A1

    公开(公告)日：2009-03-26

    申请号：US12011093

    申请日：2008-01-23

    Applicant: Brian T. Cunningham ,  Charles Choi

    Inventor： Brian T. Cunningham ,  Charles Choi

    IPC: G01N21/03

    CPC classification number: G01N21/4133 ,  B01L3/5025 ,  B01L3/5027 ,  B01L3/5085 ,  B01L2300/0636 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/0867 ,  B01L2400/0406 ,  B01L2400/0487 ,  B82Y20/00 ,  G01N21/253 ,  G01N21/7743 ,  G02B2006/1213

    Abstract: Photonic crystal (PC) sensors, and sensor arrays and sensing systems incorporating PC sensors are described which have integrated fluid containment and/or fluid handling structures. The PC sensors are further integrated into a sample handling device such as a microwell plate. Sensors and sensing systems of the present disclosure are capable of high throughput sensing of analytes in fluid samples, bulk refractive index detection, and label-free detection of a range of molecules, including biomolecules and therapeutic candidates. The present disclosure also provides a commercially attractive fabrication platform for making photonic crystal sensors and systems wherein an integrated fluid containment structure and a photonic crystal structure are fabricated in a single molding or imprinting processing step amendable to high throughput processing.

    Abstract translation: 描述了具有集成流体容纳和/或流体处理结构的光子晶体（PC）传感器以及包含PC传感器的传感器阵列和感测系统。 PC传感器进一步集成到诸如微孔板之类的样品处理装置中。 本公开的传感器和感测系统能够高流量感测流体样品中的分析物，体积折射率检测和一系列分子（包括生物分子和治疗候选物）的无标记检测。 本公开还提供了用于制造光子晶体传感器和系统的商业上有吸引力的制造平台，其中集成流体容纳结构和光子晶体结构在可修改为高通量处理的单个模制或压印处理步骤中制造。

    Photonic crystal defect cavity biosensor
    90.
    发明授权
    Photonic crystal defect cavity biosensor 失效
    光子晶体缺陷腔生物传感器

    公开(公告)号：US06990259B2

    公开(公告)日：2006-01-24

    申请号：US10812635

    申请日：2004-03-29

    Applicant: Brian T. Cunningham

    Inventor： Brian T. Cunningham

    IPC: G02B6/00

    CPC classification number: G01N21/03 ,  B82Y20/00 ,  G01J3/2803 ,  G01J3/2823 ,  G01N21/253 ,  G01N21/552 ,  G01N2021/0346 ,  G02B6/1225

    Abstract: A biosensor is described having the form of a photonic crystal having defect cavities formed in a periodic pattern in the device. The invention provides a higher sensitivity and a greater degree of spatial localization of incoupled photons than previously reported photonic crystal biosensor devices.

    Abstract translation: 描述了具有在装置中以周期性图案形成的缺陷腔的光子晶体的形式的生物传感器。 本发明提供了比先前报道的光子晶体生物传感器装置更高的灵敏度和更大程度的离子化光子的空间定位。

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