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    Label-free biosensors based upon distributed feedback laser
    1.
    发明授权
    Label-free biosensors based upon distributed feedback laser 有权
    基于分布式反馈激光器的无标签生物传感器

    公开(公告)号：US08268637B2

    公开(公告)日：2012-09-18

    申请号：US12317826

    申请日：2008-12-29

    Applicant: Brian T. Cunningham ,  Meng Lu

    Inventor： Brian T. Cunningham ,  Meng Lu

    IPC: G01N33/551

    CPC classification number: G01N21/7743 ,  G01N2021/7709

    Abstract: A biosensor based upon a vertically emitting, distributed feedback (DFB) laser is disclosed. In one configuration, the DFB laser comprises a replica-molded, one- or two-dimensional dielectric grating coated with a laser dye-doped-polymer as the gain medium. A sensor is also described in which the grating layer and the active layer are combined into a single layer. DFB lasers using an inorganic or organic thin film with alternating regions of high and low index of refraction as the active layer are also disclosed. The sensor actively generates its own narrowband high intensity light output without stringent requirements for coupling alignment, thereby resulting in a simple, robust illumination and detection configuration.

    Abstract translation: 公开了一种基于垂直发射分布反馈（DFB）激光器的生物传感器。 在一种配置中，DFB激光器包括涂覆有激光染料掺杂聚合物作为增益介质的复制模制的一维或二维介质光栅。 还描述了传感器，其中光栅层和有源层被组合成单层。 还公开了使用具有高折射率和低折射率的交替区域的无机或有机薄膜作为活性层的DFB激光器。 传感器主动产生自己的窄带高强度光输出，无需对耦合对准的严格要求，从而产生简单，鲁棒的照明和检测配置。

    Biosensors with porous dielectric surface for fluorescence enhancement and methods of manufacture
    3.
    发明授权
    Biosensors with porous dielectric surface for fluorescence enhancement and methods of manufacture 有权
    具有多孔电介质表面的荧光增强生物传感器和制造方法

    公开(公告)号：US07869032B2

    公开(公告)日：2011-01-11

    申请号：US12079171

    申请日：2008-03-24

    Applicant: Wei Zhang ,  Brian T. Cunningham

    Inventor： Wei Zhang ,  Brian T. Cunningham

    IPC: G01J3/30

    CPC classification number: G01N21/648 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/7743 ,  G01N2021/7726 ,  G02B6/1226

    Abstract: Biosensors are disclosed which include a surface for binding to sample molecule to the biosensor in the form of a porous, thin film of dielectric material, e.g., TiO2. In one example the porous, thin film is in the form of a multitude of sub-micron sized rod-like structures (“nanorods”) projecting therefrom. In one embodiment, the biosensor is in the form of a photonic crystal biosensor. The approach of depositing a thin film of dielectric nanorods may be applied to any enhanced fluorescence biosensor surface structure, including 1-dimensional photonic crystals, 2-dimensional photonic crystals, 3-dimensional photonic crystals, surface plasmon resonance surfaces, planar waveguides, and grating-coupled waveguides. The dielectric nanorod structures can be fabricated on the surface of a biosensor by the glancing angle deposition technique (GLAD).

    Abstract translation: 公开了生物传感器，其包括以多孔的介电材料薄膜（例如TiO 2）的形式将样品分子结合到生物传感器的表面。 在一个实例中，多孔薄膜是从其突出的多个亚微米尺寸的棒状结构（“纳米棒”）的形式。 在一个实施例中，生物传感器是光子晶体生物传感器的形式。 沉积介电纳米棒薄膜的方法可以应用于任何增强的荧光生物传感器表面结构，包括一维光子晶体，二维光子晶体，三维光子晶体，表面等离子体共振表面，平面波导和光栅 耦合波导。 介电纳米棒结构可以通过扫视角沉积技术（GLAD）在生物传感器的表面上制造。

    Photonic crystal sensors with intergrated fluid containment structure
    4.
    发明授权
    Photonic crystal sensors with intergrated fluid containment structure 有权
    光子晶体传感器具有集成的流体封闭结构

    公开(公告)号：US07742662B2

    公开(公告)日：2010-06-22

    申请号：US11983109

    申请日：2007-11-06

    Applicant: Brian T. Cunningham

    Inventor： Brian T. Cunningham

    IPC: G02B6/00

    CPC classification number: B01L3/5085 ,  B01L3/5027 ,  B01L2300/0636 ,  B01L2300/0654 ,  B82Y20/00 ,  G01N21/253 ,  G02B2006/1213

    Abstract: Photonic crystal (PC) sensors, and sensor arrays and sensing systems incorporating PC sensors are described which have integrated fluid containment and/or fluid handling structures. Sensors and sensing systems of the present disclosure are capable of high throughput sensing of analytes in fluid samples, bulk refractive index detection, and label-free detection of a range of molecules, including biomolecules and therapeutic candidates. The present disclosure also provides a commercially attractive fabrication platform for making photonic crystal sensors and systems wherein an integrated fluid containment structure and a photonic crystal structure are fabricated in a single molding or imprinting processing step amendable to high throughput processing.

    Abstract translation: 描述了具有集成流体容纳和/或流体处理结构的光子晶体（PC）传感器以及包含PC传感器的传感器阵列和感测系统。 本公开的传感器和感测系统能够高流量感测流体样品中的分析物，体积折射率检测和一系列分子（包括生物分子和治疗候选物）的无标记检测。 本公开还提供了用于制造光子晶体传感器和系统的商业上有吸引力的制造平台，其中集成流体容纳结构和光子晶体结构在可修改为高通量处理的单个模制或压印处理步骤中制造。

    Fluorescence detection enhancement using photonic crystal extraction
    8.
    发明申请
    Fluorescence detection enhancement using photonic crystal extraction 有权
    使用光子晶体提取的荧光检测增强

    公开(公告)号：US20080278722A1

    公开(公告)日：2008-11-13

    申请号：US11986156

    申请日：2007-11-19

    Applicant: Brian T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

    Inventor： Brian T. Cunningham ,  Nikhil Ganesh ,  Patrick C. Mathias ,  Ian D. Block

    IPC: G01J3/30

    CPC classification number: G01N21/648 ,  B82Y15/00 ,  B82Y20/00 ,  G01N21/6428 ,  G01N33/54373 ,  G01N33/582 ,  G01N2021/7786 ,  G02B2006/1213

    Abstract: Enhancement of fluorescence emission from fluorophores bound to a sample and present on the surface of two-dimensional photonic crystals is described. The enhancement of fluorescence is achieved by the combination of high intensity near-fields and strong coherent scattering effects, attributed to leaky photonic crystal eigenmodes (resonance modes). The photonic crystal simultaneously exhibits resonance modes which overlap both the absorption and emission wavelengths of the fluorophore. A significant enhancement in fluorescence intensity from the fluorophores on the photonic crystal surface is demonstrated.

    Abstract translation: 描述了结合到样品并存在于二维光子晶体表面上的荧光团的荧光发射的增强。 归因于泄漏的光子晶体本征模式（共振模式），通过高强度近场和强相干散射效应的组合来实现荧光的增强。 光子晶体同时呈现与荧光团的吸收和发射波长重叠的共振模式。 证明了来自荧光团在光子晶体表面上的荧光强度的显着增强。

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