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155 条记录 (耗时 0.04 秒)

    Methods for the Preparation of a Fine Chemical by Fermentation
    83.
    发明申请
    Methods for the Preparation of a Fine Chemical by Fermentation 审中-公开
    通过发酵制备精细化学品的方法

    公开(公告)号：US20080038787A1

    公开(公告)日：2008-02-14

    申请号：US10579693

    申请日：2004-12-17

    申请人： Oskar Zelder ,  Corinna Klopprogge ,  Hartwig Schroder ,  Stefan Hafner ,  Burkhard Kroger ,  Patrick Kiefer ,  Elmar Heinzle ,  Christoph Wittmann

    发明人： Oskar Zelder ,  Corinna Klopprogge ,  Hartwig Schroder ,  Stefan Hafner ,  Burkhard Kroger ,  Patrick Kiefer ,  Elmar Heinzle ,  Christoph Wittmann

    IPC分类号： C12P13/08 ,  C12N1/21

    CPC分类号： C12P13/08

    摘要： The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

    摘要翻译： 本发明的特征在于通过使酶编码基因失调来增加精细化学品例如来自微生物例如棒状杆菌的赖氨酸的生产的方法， 即甘油激酶。 在优选的实施方案中，本发明提供了通过增加甘油激酶活性的表达来增加谷氨酸棒杆菌中赖氨酸的产生的方法。 本发明还提供了通过调节向草酰乙酸（OAA）的碳通量来生产赖氨酸的新方法。 在优选的实施方案中，本发明提供了通过使用果糖或蔗糖作为碳源来生产赖氨酸的方法。

    Psod expression units
    87.
    发明授权
    Psod expression units 有权
    Psod表达单位

    公开(公告)号：US08071365B2

    公开(公告)日：2011-12-06

    申请号：US12030575

    申请日：2008-02-13

    申请人： Burkhard Kroger ,  Oskar Zelder ,  Corinna Klopprogge ,  Hartwig Schroder ,  Stefan Haefner

    发明人： Burkhard Kroger ,  Oskar Zelder ,  Corinna Klopprogge ,  Hartwig Schroder ,  Stefan Haefner

    IPC分类号： C12N15/00 ,  C12N1/20

    CPC分类号： C12N15/77

    摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

    摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。

    PROCESS FOR THE PRODUCTION OF BETA-LYSINE
    88.
    发明申请
    PROCESS FOR THE PRODUCTION OF BETA-LYSINE 审中-公开
    生产β-木质素的方法

    公开(公告)号：US20090029425A1

    公开(公告)日：2009-01-29

    申请号：US12281789

    申请日：2007-03-07

    申请人： Oskar Zelder ,  Weo Kyu Jeong ,  Corinna Klopprogge ,  Andrea Herold ,  Hartwig Schroder

    发明人： Oskar Zelder ,  Weo Kyu Jeong ,  Corinna Klopprogge ,  Andrea Herold ,  Hartwig Schroder

    IPC分类号： C12P13/08 ,  C12P13/00 ,  C12P17/10

    CPC分类号： C12P13/08 ,  C12P13/005 ,  C12P13/02

    摘要： Process for the production of -lysine by constructing a recombinant microorganism which has a deregulated lysine 2,3-aminomutase gene and at least one deregulated gene selected from the group (i) which consists of aspartokinase, aspartatesemialdehyde dehydrogenase, dihydrodipicolinate synthase, dihydrodipicolinate reductase, tetrahydrodipicolinate succinylase, succinyl-amino-ketopimelate transaminase, succinyl-diamino-pimelate desuccinylase, diaminopimelate epimerase, diamino-pimelate dehydrogenase, arginyl-tRNA synthetase, diaminopimelate decarboxylase, pyruvate carboxylase, phosphoenolpyruvate carboxylase, glucose-6-phosphate dehydrogenase, transketolase, transaldolase, 6-phosphogluconolactonase, fructose 1,6-biphosphatase, homoserine dehydrogenase, phophoenolpyruvate carboxykinase, succinyl-CoA synthetase, methylmalonyl-CoA mutase, provided that if aspartokinase is deregulated as gene (i) at least a second gene (i) other than aspartokinase has to be deregulated, and cultivating said microorganism.

    摘要翻译： 通过构建具有失调的赖氨酸2,3-氨基变位酶基因的重组微生物和选自由天冬氨酸激酶，天冬氨酸二甲二醇脱氢酶，二氢吡啶二羧酸合酶，二氢吡啶二羧酸还原酶，二氢吡啶二羧酸还原酶组成的组中的至少一种去调节基因的生产赖氨酸的方法， 四氢吡啶二羧酸琥珀酰基酶，琥珀酰 - 氨基 - 酮基庚酸酯转氨酶，琥珀酰 - 二氨基 - 庚二酸二琥珀酰化酶，二氨基庚酸酯差向异构酶，二氨基庚二酸脱氢酶，精氨酰-tRNA合成酶，二氨基庚二酸脱羧酶，丙酮酸羧化酶，磷酸烯醇丙酮酸羧化酶，葡萄糖-6-磷酸脱氢酶，转酮酶，转醛醇酶， 6-磷酸葡糖淀粉酶，果糖1,6-二磷酸酶，高丝氨酸脱氢酶，磷酸烯醇丙酮酸羧激酶，琥珀酰辅酶A合成酶，甲基丙二酰-CoA变位酶，条件是如果天冬氨酸激酶被解调为基因（i）至少第二种基因（i）除了天冬氨酸激酶 放松管制，培养说 微生物。

    PGRO EXPRESSION UNITS
    89.
    发明申请
    PGRO EXPRESSION UNITS 有权
    PGRO表达单位

    公开(公告)号：US20080286841A1

    公开(公告)日：2008-11-20

    申请号：US12038642

    申请日：2008-02-27

    申请人： Burkhard Kroger ,  Oskar Zelder ,  Corinna Klopprogge ,  Hartwig Schroder ,  Stefan Haefner

    发明人： Burkhard Kroger ,  Oskar Zelder ,  Corinna Klopprogge ,  Hartwig Schroder ,  Stefan Haefner

    IPC分类号： C12P13/12 ,  C12N15/87 ,  C12N15/11 ,  C12N15/00 ,  C12N1/00 ,  C12P1/00 ,  C12P13/08

    CPC分类号： C12N15/77 ,  C12P13/08

    摘要： The present invention relates to the use of nucleic acid sequences for regulating the transcription and expression of genes, the novel promoters and expression units themselves, methods for altering or causing the transcription rate and/or expression rate of genes, expression cassettes comprising the expression units, genetically modified microorganisms with altered or caused transcription rate and/or expression rate, and methods for preparing biosynthetic products by cultivating the genetically modified microorganisms.

    摘要翻译： 本发明涉及核酸序列用于调节基因的转录和表达，新型启动子和表达单元本身的用途，用于改变或引起基因的转录速率和/或表达速率的方法，包含表达单位的表达盒 具有改变或引起的转录速率和/或表达速率的转基因微生物，以及通过培养转基因微生物来制备生物合成产物的方法。