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公开(公告)号:US20120190814A1
公开(公告)日:2012-07-26
申请号:US13389616
申请日:2010-08-10
申请人: Mark Smith , Stephen Caddick , James Baker
发明人: Mark Smith , Stephen Caddick , James Baker
IPC分类号: C07K1/06 , C07K5/065 , C07K14/00 , C07K14/655 , C07D207/456 , C07C323/60
CPC分类号: A61K47/545 , A61K47/551 , A61K47/60 , A61K47/62 , A61K49/0017 , C07D207/416 , C07D207/456 , C07D209/52 , C07K14/435 , C07K14/655 , G01N33/58 , Y02P20/55
摘要: The present invention relates to the use of a compound comprising a moiety of formula (I) as a reagent for protecting a thiol group in a thiol compound wherein X, X′ and Y are as defined herein. The protecting group methodology of the present invention allows straightforward and selective protection of thiol groups. Cleaving of the thiol group to regenerate the thiol functional group is also facile and controllable. The present invention further provides an analogous protecting group methodology directed to protection of disulfide groups.
摘要翻译: 本发明涉及包含式(I)部分的化合物作为保护硫醇化合物中硫醇基的试剂的用途,其中X,X'和Y如本文所定义。 本发明的保护基团方法允许硫醇基团的直接和选择性保护。 硫醇基团的裂解再生硫醇官能团也是容易和可控的。 本发明还提供了用于保护二硫化物基团的类似的保护基方法。
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公开(公告)号:US20120084369A1
公开(公告)日:2012-04-05
申请号:US12963528
申请日:2010-12-08
申请人: Alberto Henriquez , Kevin London , Raymond M. Reskusich , Kashif Mehmood , James Baker , Debaprajna Bhattacharyya
发明人: Alberto Henriquez , Kevin London , Raymond M. Reskusich , Kashif Mehmood , James Baker , Debaprajna Bhattacharyya
IPC分类号: G06F15/16
CPC分类号: H04L67/08 , H04L67/1014 , H04L67/2809 , H04L67/40
摘要: Techniques are disclosed for connecting a user to all of his resources (e.g. remote desktop or remote application) in a deployment of server farm(s). The user's client sends a message to the deployment requesting any disconnected resources for the user and/or any active resources communicating with a different client. The deployment determines what those resources are, then strips out redundant information (e.g. two resources are remote applications executing within the same session) and sends a stripped list to the client, which reconnects. The client first reconnects to a resource that is not a VM and stores any user input (e.g. credentials) prompted for during that log in. Then, it reconnects to the other resources in parallel, using in these later reconnections any input received from the client during the first reconnection.
摘要翻译: 公开了用于将用户连接到服务器场的部署中的他的所有资源(例如远程桌面或远程应用程序)的技术。 用户的客户端向部署发送消息,请求用户和/或与不同客户端通信的任何活动资源的任何断开的资源。 部署确定这些资源是什么,然后删除冗余信息(例如两个资源是在同一会话内执行的远程应用程序),并将一个已删除的列表发送给重新连接的客户端。 客户端首先重新连接到不是VM的资源,并存储在该登录期间提示的任何用户输入(例如凭据)。然后,并行重新连接到其他资源,在这些后续重新连接中使用从客户端接收的任何输入 在第一次重新连接期间。
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公开(公告)号:US20080167649A1
公开(公告)日:2008-07-10
申请号:US12051361
申请日:2008-03-19
申请人: Stuart D. Edwards , James Baker , Hugh Sharkey , Ronald G. Lax
发明人: Stuart D. Edwards , James Baker , Hugh Sharkey , Ronald G. Lax
IPC分类号: A61B18/18
CPC分类号: A61B18/1477 , A61B8/13 , A61B18/1206 , A61B18/18 , A61B18/20 , A61B2018/00577 , A61B2018/00702 , A61B2018/00726 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00821 , A61B2018/00875 , A61B2218/002
摘要: A delivery device is disclosed, which may include a needle and at least one deployable electrode retractable into the needle in a retracted geometry that may be substantially straight. The at least one deployable electrode may be operatively connectable to a radiofrequency energy source for delivery of radiofrequency energy. At least a distal portion of the at least one electrode may be deployable, from the needle in a lateral direction relative to a longitudinal axis of the needle, to a deployed geometry that may include at least one radius of curvature in three planes. The deployed geometry may include a helical portion.
摘要翻译: 公开了一种输送装置,其可以包括针和至少可伸缩的电极,其可缩回的几何形状可以是基本上直的。 所述至少一个可部署电极可以可操作地连接到用于传送射频能量的射频能量源。 所述至少一个电极的至少远端部分可以相对于所述针的纵向轴线在横向方向上从所述针可展开到可在三个平面中包括至少一个曲率半径的展开几何形状。 展开的几何形状可以包括螺旋部分。
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公开(公告)号:US20080038295A1
公开(公告)日:2008-02-14
申请号:US11786860
申请日:2007-04-13
申请人: James Baker , Anna Bielinska , Andrzej Myc
发明人: James Baker , Anna Bielinska , Andrzej Myc
IPC分类号: A61K39/275 , A61P31/00
CPC分类号: A61K39/285 , A61K39/12 , A61K2039/5252 , A61K2039/55566 , C12N2710/24134
摘要: The present invention relates to methods and compositions for stimulating an immune response. Specifically, the present invention provides methods of inducing an immune response to an orthopox virus (e.g., vaccinia virus) in a subject (e.g., a human subject) and compositions useful in such methods (e.g., a nanoemulsion comprising vaccinia virus). Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine (e.g., vaccination) and research applications.
摘要翻译: 本发明涉及用于刺激免疫应答的方法和组合物。 具体而言,本发明提供了在受试者(例如,人类受试者)中诱导针对正痘病毒(例如痘苗病毒)的免疫应答的方法和用于此类方法(例如,包含痘苗病毒的纳米乳剂)的组合物。 本发明的组合物和方法尤其可用于临床(例如治疗和预防性药物(例如,疫苗接种)和研究应用)。
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公开(公告)号:US20060219846A1
公开(公告)日:2006-10-05
申请号:US11097923
申请日:2005-04-01
申请人: Michael Johnson , James Baker , Frank Eichstadt , Michael Bain
发明人: Michael Johnson , James Baker , Frank Eichstadt , Michael Bain
IPC分类号: B64G1/12
CPC分类号: B64G1/62 , B64G1/12 , B64G1/24 , B64G1/646 , B64G2001/1092
摘要: A reentry vehicle includes a nose section, a modular section comprised of two or more connected modules, a flared section. The nose section is connected to a first end of the modular section, and the flared section is positioned proximate a second end of the modular cylindrical section.
摘要翻译: 再入式车辆包括鼻部,由两个或多个连接的模块组成的模块部分,一个扩口部分。 鼻部部分连接到模块化部分的第一端,并且扩口部分位于模块化圆柱形部分的第二端附近。
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86.
公开(公告)号:US20060187448A1
公开(公告)日:2006-08-24
申请号:US11355387
申请日:2006-02-16
申请人: Jing Ye , Theodore Norris , James Baker
发明人: Jing Ye , Theodore Norris , James Baker
IPC分类号: G01J3/30
CPC分类号: G01J3/4406 , G01J3/10 , G01J3/2889 , G01N21/6408 , G01N21/6458
摘要: A fluorescence detection system for testing a sample having at least one fluorophore. The fluorescence detection system comprises a white light generation system outputting a white light pulse. The white light pulse has a first frequency range and a first time duration. The white light pulse excites the at least one fluorophore of the sample to emit a fluorescence. The fluorescence has a second frequency range and a second time duration, wherein the first time duration is less than the second time duration. A time-resolving detector receives the fluorescence and at least a portion of the white light pulse and separates the fluorescence from the portion of the white light pulse.
摘要翻译: 一种用于测试具有至少一个荧光团的样品的荧光检测系统。 荧光检测系统包括输出白光脉冲的白光发生系统。 白光脉冲具有第一频率范围和第一持续时间。 白光脉冲激发样品的至少一个荧光团以发射荧光。 荧光具有第二频率范围和第二持续时间,其中第一持续时间小于第二持续时间。 时间分辨检测器接收荧光和白光脉冲的至少一部分,并将荧光与白光脉冲的该部分分离。
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公开(公告)号:US20060093938A1
公开(公告)日:2006-05-04
申请号:US10978688
申请日:2004-10-31
申请人: Leonard Stulc , Ronald Moudry , Zbigniew Tokarski , Charles Simpson , Gay Herman , A. Fordahl , James Baker
发明人: Leonard Stulc , Ronald Moudry , Zbigniew Tokarski , Charles Simpson , Gay Herman , A. Fordahl , James Baker
IPC分类号: G03G9/087
CPC分类号: G03G9/0825 , G03G9/08782 , G03G9/08788 , G03G9/08797
摘要: Dry electrographic toner compositions are provided comprising a plurality of dry toner particles, wherein the toner particles comprise polymeric binder comprising at least one amphipathic copolymer comprising one or more S material portions and one or more D material portions. The dry electrographic toner composition comprises a wax associated with the dry toner particles, wherein substantially all of the wax is associated with the toner particle at the surface thereof. Methods of making electrographic toner compositions are also provided comprising preparing polymeric binder particles comprising at least one amphipathic copolymer comprising one or more S material portions and one or more D material portions, preparing toner particles, drying the toner particles, and milling the dry toner particles in the presence of a wax component to provide a dry toner particle composition having the wax associated with the toner particles. These toner compositions provide images having excellent durability and erasure resistance properties at low fusion temperatures and with little undesired offset.
摘要翻译: 提供包含多个干调色剂颗粒的干燥电摄影调色剂组合物,其中调色剂颗粒包含包含至少一种包含一个或多个S材料部分和一个或多个D材料部分的两亲共聚物的聚合物粘合剂。 干电摄影调色剂组合物包含与干调色剂颗粒相关联的蜡,其中基本上所有的蜡在其表面与调色剂颗粒相关联。 还提供了制备电子照相色调剂组合物的方法,包括制备包含至少一种包含一种或多种S材料部分和一种或多种D材料部分的两亲共聚物的聚合物粘合剂颗粒,制备调色剂颗粒,干燥调色剂颗粒和研磨干调色剂颗粒 在蜡组分的存在下,提供具有与调色剂颗粒相关的蜡的干调色剂颗粒组合物。 这些调色剂组合物在低熔融温度下提供具有优异的耐久性和耐擦性能的图像,并且几乎没有不希望的偏移。
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88.
公开(公告)号:US20060093392A1
公开(公告)日:2006-05-04
申请号:US10977978
申请日:2004-10-29
申请人: James Baker , Truman Kellie , Robert Brenner
发明人: James Baker , Truman Kellie , Robert Brenner
IPC分类号: G03G21/00
CPC分类号: G03G21/206
摘要: An apparatus for oxidizing volatile organic compounds from an electrographic printer may comprising a) a printer system that vents a gas stream containing volatile organic compounds to a first inlet; b) a first mast transfer element transmitting the gas stream to a catalytic treatment system, c) The catalytic treatment system comprising separate contact sections for an unsupported catalyst and a supported catalyst; a diverter system that can direct the gas stream along paths selected from the group consisting of to the unsupported catalyst only, to the supported catalyst only, first the unsupported catalyst and then the supported catalyst, and the supported catalyst and then the unsupported catalyst.
摘要翻译: 用于从电印机中氧化挥发性有机化合物的设备可以包括:a)将含有挥发性有机化合物的气流排放到第一入口的打印机系统; b)将气流传送到催化处理系统的第一桅杆转移元件,c)催化处理系统包括用于未负载的催化剂和负载催化剂的分开的接触部分; 一种分流器系统,其可以将气流沿着从仅由无载体催化剂组成的组中选择的路径引导到仅负载的催化剂,首先将未负载的催化剂,然后负载的催化剂以及负载的催化剂,然后是未负载的催化剂引导。
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公开(公告)号:US20060088332A1
公开(公告)日:2006-04-27
申请号:US10971536
申请日:2004-10-22
申请人: Robert Brenner , James Baker
发明人: Robert Brenner , James Baker
IPC分类号: G03G15/00
CPC分类号: G03G21/206 , G03G21/203
摘要: A system is provided within an electrophotographic imaging environment that removes or decomposes airborne hydrocarbons (as vapor and/or droplets), at least some of which are provided from evaporation or airborne dispersal of hydrocarbon carrier from electrophotographic toners or inks during and imaging process. The system comprises a catalyst that assists in the oxidation or decomposition of hydrocarbons and a (catalyst and vapor phase) heating and oxygen-providing components comprising an chemical oxygen-generator. The chemical reaction that occurs in the oxygen generation provides both a) immediate and significant amounts of heat that heats both the catalyst and the gas phase containing the hydrocarbon and the oxygen and b) oxygen to assist in the decomposition and/or oxidation of the hydrocarbon and other airborne materials.
摘要翻译: 在电子照相成像环境中提供一种系统,其去除或分解空气中的碳氢化合物(作为蒸气和/或液滴),其中至少一些由在载体和成像过程中的电子照相调色剂或油墨的烃载体的蒸发或空气传播中提供。 该系统包括有助于烃的氧化或分解的催化剂和包含化学发生氧的(催化剂和气相)加热和供氧组分。 在氧气发生中发生的化学反应提供a)立即和显着量的热量,其加热催化剂和含有烃和氧气的气相,以及b)氧气以帮助烃的分解和/或氧化 和其他机载材料。
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公开(公告)号:US20060052232A1
公开(公告)日:2006-03-09
申请号:US11248781
申请日:2005-11-16
申请人: Kathyrn Bretscher , Richard Rusin , Bradley Craig , Sumita Mitra , Joel Oxmann , Janis Gust , Cheryl Hayne , James Westberg , Matthew Trom , Brant Kolb , Dwight Jacobs , David Kaisaki , James Baker
发明人: Kathyrn Bretscher , Richard Rusin , Bradley Craig , Sumita Mitra , Joel Oxmann , Janis Gust , Cheryl Hayne , James Westberg , Matthew Trom , Brant Kolb , Dwight Jacobs , David Kaisaki , James Baker
IPC分类号: C04B35/14
CPC分类号: A61K6/083 , A61K6/0073 , A61K6/087 , C01P2006/12 , C08K3/013 , C09C1/00 , C09C1/3045 , C09C1/40 , Y10S522/908 , Y10T428/2993 , C08L33/00 , C08L63/00
摘要: Polymerizable compositions that include: (a) a cationically active functional group; (b) an initiation system capable of initiating cationic polymerization of the cationically active functional group; and (c) a filler composition that includes various radiopacifying fillers in an amount sufficient to render the polymerizable composition radiopaque. Components (a), (b), and (c) are selected such that the polymerizable composition polymerizes to form a polymerized composition having a Barcol hardness, measured using a GYZJ-935 meter, of at least 10 within 30 minutes following initiation of the cationically active functional group at a reaction temperature of 25° C.
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