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    Modified nucleotides
    82.
    发明申请
    Modified nucleotides 有权
    修饰的核苷酸

    公开(公告)号：US20090325172A1

    公开(公告)日：2009-12-31

    申请号：US12455397

    申请日：2009-06-01

    申请人： John Milton ,  Xiaolin Wu ,  Mark Smith ,  Joseph Brennan ,  Colin Barnes ,  Xiaohai Liu ,  Silke Ruediger

    发明人： John Milton ,  Xiaolin Wu ,  Mark Smith ,  Joseph Brennan ,  Colin Barnes ,  Xiaohai Liu ,  Silke Ruediger

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6869 ,  C07H1/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/14 ,  C07H19/16 ,  C07H19/20 ,  C07H21/00 ,  C12Q2525/186 ,  C12Q2535/113 ,  Y02P20/55 ,  C12Q2525/197

    摘要： The invention provides modified nucleotide or nucleoside molecule comprising a purine or pyrimidine base and a ribose or deoxyribose sugar moiety having a removable 3′-OH blocking group covalently attached thereto, such that the 3′ carbon atom has attached a group of the structure —O-Z wherein Z is any of —C(R′)2-O—R″, —C(R′)2-N(R″)2, —C(R′)2-N(H)R″, —C(R′)2-S—R″ and —C(R′)2-F, wherein each R″ is or is part of a removable protecting group; each R′ is independently a hydrogen atom, an alkyl, substituted alkyl, arylalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclic, acyl, cyano, alkoxy, aryloxy, heteroaryloxy or amido group, or a detectable label attached through a linking group; or (R′)2 represents an alkylidene group of formula ═C(R′″)2 wherein each R′″ may be the same or different and is selected from the group comprising hydrogen and halogen atoms and alkyl groups; and wherein said molecule may be reacted to yield an intermediate in which each R″ is exchanged for H or, where Z is —C(R′)2-F, the F is exchanged for OH, SH or NH2, preferably OH, which intermediate dissociates under aqueous conditions to afford a molecule with a free 3′OH; with the proviso that where Z is —C(R′)2-S—R″, both R′ groups are not H.

    摘要翻译： 本发明提供了修饰的核苷酸或核苷分子，其包含嘌呤或嘧啶碱基和核糖或脱氧核糖糖部分，其具有共价连接到其上的可移除的3'-OH封闭基团，使得3'碳原子连接有一组结构-OZ 其中Z是-C（R'）2 -O-R“，-C（R'）2 -N（R”）2，-C（R'）2 -N（H）R“ ，-C（R'）2 -S-R“和-C（R'）2 -F，其中每个R”或是可除去的保护基团的一部分; 每个R'独立地是氢原子，烷基，取代的烷基，芳基烷基，烯基，炔基，芳基，杂芳基，杂环，酰基，氰基，烷氧基，芳氧基，杂芳氧基或酰氨基，或通过连接基团连接的可检测标记; 或（R'）2表示式-C（R“'）2的亚烷基，其中每个R”可以相同或不同，并且选自氢和卤素原子和烷基; 并且其中所述分子可以反应以产生其中每个R“被交换为H的中间体，或者其中Z是-C（R'）2-F，F被交换成OH，SH或NH 2，优选OH， 该中间体在水性条件下解离以得到具有游离3'OH的分子; 条件是其中Z是-C（R'）2 -S-R“，两个R'基团都不是H.

    METHOD AND APPARATUS FOR CONTROLLING OPERATION OF A SYRINGE
    83.
    发明申请
    METHOD AND APPARATUS FOR CONTROLLING OPERATION OF A SYRINGE 审中-公开
    一种用于控制SYRINGE操作的方法和装置

    公开(公告)号：US20080287873A1

    公开(公告)日：2008-11-20

    申请号：US12102234

    申请日：2008-04-14

    申请人： Aldo LIBERATORE ,  Mark Smith

    发明人： Aldo LIBERATORE ,  Mark Smith

    IPC分类号： A61M5/20

    CPC分类号： A61M5/1456 ,  A61M5/16827 ,  A61M5/172

    摘要： A system is provided for controlling operation of a syringe. The system comprises a controller having an interface and at least one input mechanism; and a syringe gun communicably connected to the controller. The syringe gun comprises an elongated body with an open faced barrel cradle and open faced plunger bay for holding a syringe in the body, a plunger cradle moveable within the plunger bay for operating on a plunger of the syringe, and an actuating device for moving the plunger cradle according to a control signal. The controller generates the control signal for controlling the syringe gun.

    摘要翻译： 提供一种用于控制注射器的操作的系统。 该系统包括具有接口和至少一个输入机构的控制器; 以及可连接到控制器的注射器枪。 注射器枪包括具有敞开的桶支架的细长主体和用于将注射器保持在主体中的开口的柱塞间隔;活塞支架，其可在柱塞间隔中移动，用于在注射器的柱塞上操作;以及致动装置， 活塞支架根据控制信号。 控制器产生用于控制注射枪的控制信号。

    Noise suppressor
    85.
    发明申请
    Noise suppressor 有权
    噪声抑制器

    公开(公告)号：US20080219472A1

    公开(公告)日：2008-09-11

    申请号：US11714746

    申请日：2007-03-07

    申请人： Harprit Singh Chhatwal ,  Hui Ll ,  Andrew Linkens ,  Mark Smith

    发明人： Harprit Singh Chhatwal ,  Hui Ll ,  Andrew Linkens ,  Mark Smith

    IPC分类号： H04B15/00

    CPC分类号： G10L21/0208 ,  G10L2021/02168

    摘要： A method of determining noise in an audio stream, the method comprising: acquiring a plurality of consecutive time frames of the audio stream each comprising samples of the audio stream; generating a discrete frequency spectrum for each frame responsive to the frame samples; partitioning the frequency spectrum of each frame into a plurality of same frequency bands; determining an audio energy for each frequency band in each frame; and determining an estimate of noise energy for each frequency band in a temporally last time frame responsive to a relatively small number of smallest values for the audio energy in the frequency band of the plurality of time frames.

    摘要翻译： 一种确定音频流中的噪声的方法，所述方法包括：获取音频流的多个连续时间帧，每个音频流包括音频流的采样; 响应于帧样本为每个帧生成离散频谱; 将每个帧的频谱划分成多个相同的频带; 确定每帧中每个频带的音频能量; 以及响应于所述多个时间帧中的频带中的音频能量的相对较小数量的最小值，在时间上最后一帧中确定每个频带的噪声能量的估计。

    Anti-viral nucleosides
    86.
    发明授权
    Anti-viral nucleosides 失效
    抗病毒核苷

    公开(公告)号：US07378402B2

    公开(公告)日：2008-05-27

    申请号：US11208510

    申请日：2005-08-22

    申请人： Joseph Armstrong Martin ,  Keshab Sarma ,  David Bernard Smith ,  Mark Smith

    发明人： Joseph Armstrong Martin ,  Keshab Sarma ,  David Bernard Smith ,  Mark Smith

    IPC分类号： C07H19/00 ,  C07H19/06 ,  A01N43/04 ,  A61K31/70

    CPC分类号： C07H19/06 ,  C07H19/067 ,  C07H19/12

    摘要： 4-Amino-1-((2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one (I:R1=R2=R3=R4=H) and prodrugs thereof are hepatitis C(HCV) polymerase inhibitors. Also disclosed are compositions and methods for inhibiting HCV and treating HCV-mediated diseases, processes for making the compounds and synthetic intermediates employed in the process.

    摘要翻译： 4-氨基-1 - （（2R，3S，4S，5R）-5-叠氮基-3,4-二羟基-5-羟基甲基 - 四氢 - 呋喃-2-基）-1H-嘧啶-2-酮（I： R 1 = R 2 = R 3 = R 4 = H），其前药是丙型肝炎（HCV） ）聚合酶抑制剂。 还公开了用于抑制HCV和治疗HCV介导的疾病的组合物和方法，用于制备该方法中使用的化合物和合成中间体的方法。

    INTRAVASCULAR FILTER MONITORING
    87.
    发明申请
    INTRAVASCULAR FILTER MONITORING 审中-公开
    血管内滤器监测

    公开(公告)号：US20080051671A1

    公开(公告)日：2008-02-28

    申请号：US11929007

    申请日：2007-10-30

    申请人： Thomas Broome ,  Anthony Vrba ,  Narin Anderson ,  Justin Crank ,  James Hansen ,  Horng-Ban Lin ,  Mark Smith

    发明人： Thomas Broome ,  Anthony Vrba ,  Narin Anderson ,  Justin Crank ,  James Hansen ,  Horng-Ban Lin ,  Mark Smith

    IPC分类号： A61B5/026

    CPC分类号： A61B5/02158 ,  A61B5/02156 ,  A61F2/013

    摘要： Devices and methods for monitoring the flow of blood through an intravascular device are disclosed. An apparatus for monitoring blood flow in accordance with an exemplary embodiment of the present invention includes an intravascular device coupled to an elongated member, a first sensor adapted to measure fluidic pressure proximal the intravascular device, a second sensor adapted to measure fluidic pressure distal the intravascular device, and a control unit for comparing the signals received from the first and second sensors to determine the pressure drop across the intravascular device.

    摘要翻译： 公开了通过血管内装置监测血流的装置和方法。 根据本发明的示例性实施例的用于监测血流的装置包括联接到细长构件的血管内装置，适于测量血管内装置近侧的流体压力的第一传感器，适于测量血管内远端的流体压力的第二传感器 装置和控制单元，用于比较从第一和第二传感器接收的信号，以确定穿过血管内装置的压降。

    HIGH TEMPERATURE REFRIGERATION CYCLE METHOD AND APPARATUS
    89.
    发明申请
    HIGH TEMPERATURE REFRIGERATION CYCLE METHOD AND APPARATUS 审中-公开
    高温制冷循环方法和装置

    公开(公告)号：US20070251668A1

    公开(公告)日：2007-11-01

    申请号：US11691359

    申请日：2007-03-26

    申请人： Mark Smith

    发明人： Mark Smith

    IPC分类号： F25B13/00

    CPC分类号： F25B30/00

    摘要： A refrigeration apparatus for removing heat from a high temperature region. The refrigeration apparatus wherein the high temperature region is a stream of fluid having a temperature above 160 degrees Fahrenheit. The heat from the high temperature region is used to evaporate the refrigerant in a refrigeration cycle.

    摘要翻译： 一种用于从高温区域除去热量的制冷装置。 其中高温区域是温度高于160华氏度的流体流的制冷装置。 来自高温区域的热量用于在制冷循环中蒸发制冷剂。

    Automated glass entrance door assembly for walk-in coolers
    90.
    发明授权
    Automated glass entrance door assembly for walk-in coolers 有权
    自动玻璃入口门组件，用于步入式冷却器

    公开(公告)号：US07259359B2

    公开(公告)日：2007-08-21

    申请号：US11153159

    申请日：2005-06-15

    申请人： Jerry Davey ,  Mark Smith

    发明人： Jerry Davey ,  Mark Smith

    IPC分类号： H05B3/06

    CPC分类号： H05B3/84 ,  A47F3/0404 ,  E06B3/4618

    摘要： An automated glass cooler entrance door assembly for an opening in a walk-in cooler comprising at least one fixed, stationary side door that defines a walkway about the opening for ingress and egress into the cooler, at least one opposing sliding door operatively suspended from a concealed drive mechanism above the opening to slide sideways from a closed position across the opening to close-off the cooler to and from an opened position overlapping the fixed stationary side door to allow customer ingress and egress to the cooler via the walkway through the opening and each of the doors comprising heated glass that is electrically connected to electrical power to heat the same.

    摘要翻译： 一种用于步入式冷却器中的开口的自动玻璃冷却器入口门组件，包括至少一个固定的侧门，所述至少一个固定侧门限定了围绕所述开口的入口进入所述冷却器，至少一个相对的滑动门，其可操作地从 在开口上方的隐藏的驱动机构从关闭位置横过开口侧向滑动以将冷却器关闭到与固定的固定侧门重叠的打开位置，以允许客户通过人行道通过开口进入和排出冷却器，并且 每个门包括电连接到电力以加热玻璃的加热玻璃。