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81.Novel tricyclic azepine derivatives, method for production thereof and pharmaceutical compositions comprising the same 审中-公开
标题翻译: 新型三环吖庚因衍生物,其制备方法和包含其的药物组合物公开(公告)号:US20060079677A1
公开(公告)日:2006-04-13
申请号:US10543729
申请日:2004-02-03
申请人: Sebastien Gallet , Pascal Berthelot , Nicolas Lebegue , Nathalie Flouquet , Pascal Carato , John Hickman , Alain Pierre , Bruno Pfeiffer , Pierre Renard
发明人: Sebastien Gallet , Pascal Berthelot , Nicolas Lebegue , Nathalie Flouquet , Pascal Carato , John Hickman , Alain Pierre , Bruno Pfeiffer , Pierre Renard
IPC分类号: C07D498/02 , C07D487/02
CPC分类号: C07D513/04 , C07D515/04
摘要: A compound of formula (I): wherein: represents benzo or pyrido, optionally fused in the 2-3, 3-4 or 4-5 position to a phenyl, (C4-C8)cycloalkyl or heterocyclic group, which may be optionally substituted, W represents X—Y or Y—X, wherein: X represents and Y represents oxygen or N—R3, n represents zero or an integer from 1 to 6, G, R1, R2 and R3 are as defined in the description, its enantiomers and diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful for the treatment of cancerous diseases.
摘要翻译: 式(I)的化合物:其中:代表苯并或吡啶并任选地在2-3,3-4或4-5位融合成苯基,(C 1-4 - 8个)环烷基或杂环基,其可以是任选取代的,W表示XY或YX,其中:X表示且Y表示氧或NR 3,n表示0或1的整数 至6,G,R 1,R 2和R 3 3如说明书中所定义,其对映异构体和非对映异构体及其加成盐 与药学上可接受的酸或碱,以及含有该酸或碱的药物,可用于治疗癌性疾病。
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公开(公告)号:US5721276A
公开(公告)日:1998-02-24
申请号:US657972
申请日:1996-05-30
申请人: Isabelle Lesieur , Patrick Depreux , Veronique Leclerc , Philippe Delagrange , Pierre Renard , Beatrice Guardiola Lemaitre
发明人: Isabelle Lesieur , Patrick Depreux , Veronique Leclerc , Philippe Delagrange , Pierre Renard , Beatrice Guardiola Lemaitre
IPC分类号: C07D333/60 , A61K31/165 , A61K31/34 , A61K31/343 , A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/403 , A61K31/404 , A61K31/405 , A61P3/04 , A61P9/08 , A61P9/10 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , A61P43/00 , C07C231/02 , C07C235/34 , C07C235/36 , C07D209/18 , C07D307/79 , C07D307/80 , C07D307/92 , C07D311/92 , C07D333/24 , C07C233/05
CPC分类号: C07D307/79 , C07C235/34 , C07C235/36 , C07D209/18 , C07D307/92 , C07D311/92 , C07D333/24 , C07C2101/02 , C07C2101/04 , C07C2101/14
摘要: The invention relates to a compound selected from those of formula (I): ##STR1## in which A, B, X and R.sub.1 are as defined in the description, and medicinal product containing the same useful for treating a disorder of the melatoninergic system.
摘要翻译: 本发明涉及一种选自式(I)的化合物:其中A,B,X和R 1如说明书中所定义,其中含有相同用途的药物产品可用于治疗 褪黑激素系统。
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公开(公告)号:US5196434A
公开(公告)日:1993-03-23
申请号:US765959
申请日:1991-09-26
申请人: Thierry Taverne , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人: Thierry Taverne , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号: A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/44 , A61K31/495 , A61K31/496 , A61K31/505 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K31/5415 , A61P9/12 , A61P25/04 , A61P25/18 , A61P25/20 , C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D491/056
CPC分类号: C07D277/68 , C07D265/36 , C07D279/16 , C07D417/12
摘要: Compound of general formula (I): ##STR1## where R.sub.1, R.sub.2, R.sub.3, n, X and A are defined in the description.Medicinal products.
摘要翻译: 通式(I)的化合物:其中R 1,R 2,R 3,n,X和A在说明书中定义。 药用产品。
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公开(公告)号:US06310074B1
公开(公告)日:2001-10-30
申请号:US09573704
申请日:2000-05-18
申请人: Patrick Depreux , Said Yous , Gwenael Cheve , Gérald Guillaumet , Marie-Claude Viaud , Carlos Larraya , Caroline Bennejean , Philippe Delagrange , Pierre Renard , Carole Descamps-Francois
发明人: Patrick Depreux , Said Yous , Gwenael Cheve , Gérald Guillaumet , Marie-Claude Viaud , Carlos Larraya , Caroline Bennejean , Philippe Delagrange , Pierre Renard , Carole Descamps-Francois
IPC分类号: A61K3138
CPC分类号: C07D307/79 , C07D333/60 , C07D471/04
摘要: The invention relates to compound of formula (I): A—G1—Cy—G2—Cy′—G3—B (I) wherein: A represents a grouping NR1C(Q)R2, C(Q)NR2R3 or NR1C(Q)NR2R3, B represents a grouping NR1C(Q)R2, NR1C(Q)NR2R3, C(Q)NR2R3, C(Q)OR1, NR1C(Q)OR2 or NR2R3, G1 and G3 represent an optionally substituted alkylene chain, Cy and Cy′, which are different, represent a ring structure or G2 represents a chain and medicinal products containing the same are useful in treating or in preventing melatoninergic disorders.
摘要翻译: 本发明涉及式(I)化合物:其中:A表示NR1C(Q)R2,C(Q)NR2R3或NR1C(Q)NR2R3基团,B表示分组NR1C(Q)R2,NR1C(Q)NR2R3 ,C(Q)NR2R3,C(Q)OR1,NR1C(Q)OR2或NR2R3,G1和G3表示任选取代的亚烷基链,Cy和Cy'不同,表示环结构.G2表示含有 这同样可用于治疗或预防褪黑激素障碍。
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85.
公开(公告)号:US5322843A
公开(公告)日:1994-06-21
申请号:US54720
申请日:1993-04-28
申请人: Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人: Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号: A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K31/5415 , A61P1/14 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16 , C07D413/12 , C07D417/12
CPC分类号: C07D263/58 , C07D277/68 , C07D413/10 , C07D413/12
摘要: Compounds of general formula (I): ##STR1## wherein R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
摘要翻译: 通式(I)的化合物:其中R,X,A,B和p在说明书中定义。 可用于治疗包含其的睡眠障碍的药用产品。
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公开(公告)号:US5240919A
公开(公告)日:1993-08-31
申请号:US848373
申请日:1992-03-09
申请人: Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人: Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号: A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K31/5415 , A61P1/14 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16 , C07D413/12 , C07D417/12
CPC分类号: C07D263/58 , C07D277/68 , C07D413/10 , C07D413/12
摘要: Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
摘要翻译: 通式(I)的化合物:其中R,X,A,B和p在说明书中定义。 可用于治疗包含其的睡眠障碍的药用产品。
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公开(公告)号:US5386034A
公开(公告)日:1995-01-31
申请号:US78001
申请日:1993-06-15
申请人: Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人: Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号: A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K31/5415 , A61P1/14 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16 , C07D413/12 , C07D417/12
CPC分类号: C07D263/58 , C07D277/68 , C07D413/10 , C07D413/12
摘要: Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products. Useful for treating sleep disorders comprising the same.
摘要翻译: 通式(I)的化合物:其中R,X,A,B和p在说明书中定义。 药用产品。 用于治疗包含其的睡眠障碍。
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公开(公告)号:US5300507A
公开(公告)日:1994-04-05
申请号:US55665
申请日:1993-04-28
申请人: Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人: Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号: A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K31/5415 , A61P1/14 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16 , C07D413/12 , C07D417/12 , C07D413/06 , C07D417/06
CPC分类号: C07D263/58 , C07D277/68 , C07D413/10 , C07D413/12
摘要: Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleeping disorders comprising the same.
摘要翻译: 通式(I)的化合物:其中R,X,A,B和p在说明书中定义。 用于治疗包含其的睡眠障碍的药用产品。
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89.Aminoalkyl-benzothiazolinone and -benzoxazolinone compounds having a high 5-HT1A affinity 失效
标题翻译: 具有高5-HT1A亲和力的氨基烷基 - 苯并噻唑啉酮和 - 苯并恶唑啉酮化合物公开(公告)号:US5268381A
公开(公告)日:1993-12-07
申请号:US945492
申请日:1992-09-16
申请人: Thierry Taverne , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人: Thierry Taverne , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号: C07D265/36 , C07D277/68 , C07D279/16 , C07D417/12 , A61K31/42 , A61K31/425
CPC分类号: C07D277/68 , C07D265/36 , C07D279/16 , C07D417/12
摘要: Compounds of general formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, n, X and A are defined in the description. Medicinal products containing the same are useful as antidepressives or anxiolytics due to their 5-HT1A receptor agonist activity.
摘要翻译: 通式(I)的化合物:其中R 1,R 2,R 3,n,X和A在说明书中定义。 含有它们的药物由于其5-HT1A受体激动剂活性而可用作抗抑郁药或抗焦虑药。
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公开(公告)号:US5436348A
公开(公告)日:1995-07-25
申请号:US223176
申请日:1994-04-05
申请人: Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
发明人: Said Yous , Isabelle Lesieur , Patrick Depreux , Daniel H. Caignard , Beatrice Guardiola , Gerard Adam , Pierre Renard
IPC分类号: A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/445 , A61K31/495 , A61K31/496 , A61K31/535 , A61K31/536 , A61K31/5377 , A61K31/538 , A61K31/54 , A61K31/5415 , A61P1/14 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D263/58 , C07D265/36 , C07D277/68 , C07D279/16 , C07D413/12 , C07D417/12
CPC分类号: C07D263/58 , C07D277/68 , C07D413/10 , C07D413/12
摘要: Compounds of general formula (I): ##STR1## where R, X, A, B and p are defined in the description. Medicinal products useful for treating sleep disorders comprising the same.
摘要翻译: 通式(I)的化合物:其中R,X,A,B和p在说明书中定义。 可用于治疗包含其的睡眠障碍的药用产品。
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