公开(公告)号：US20100298670A1

公开(公告)日：2010-11-25

申请号：US12469564

申请日：2009-05-20

申请人： Rupinder Bharmi ,  Gene A. Bornzin

发明人： Rupinder Bharmi ,  Gene A. Bornzin

IPC分类号： A61B5/145

CPC分类号： A61B5/0452 ,  A61B5/0031 ,  A61B5/042 ,  A61B5/14546 ,  A61N1/36557 ,  A61N1/368 ,  A61N1/37211

摘要： A method for diagnosing an electrolyte level with a cardiac rhythm management device includes recording intra-cardiac electrograms from multiple sites. The method determines the electrolyte level based upon a comparative analysis of intra-cardiac electrograms recorded from at least two of the sites. The electrolyte level can be quantified based upon a general model, or a patient specific model.

摘要翻译： 用心律管理装置诊断电解质水平的方法包括记录多个部位的心脏内电图。 该方法基于从至少两个位点记录的心脏内电图的比较分析来确定电解质水平。 可以基于一般模型或患者特异性模型量化电解质水平。

公开(公告)号：US07801607B1

公开(公告)日：2010-09-21

申请号：US11735872

申请日：2007-04-16

申请人： Gene A. Bornzin ,  Peter Boileau

发明人： Gene A. Bornzin ,  Peter Boileau

IPC分类号： A61N1/37

CPC分类号： A61N1/3627 ,  A61N1/3624 ,  A61N1/3712 ,  A61N1/3714

摘要： An implantable cardiac device is programmed to detect and classify premature atrial contractions (PACs) and administer responsive pacing therapy. The responsive pacing therapy is in the form of an atrial extrastimulus, which is intended to preempt initiation of a reentrant tachycardia. The atrial extrastimulus is timed to occur late enough after a PAC to ensure atrial capture, but early enough that the resulting atrial depolarization does not conduct through the AV node to the ventricles if the PAC has already done so. If both of these criteria cannot be met, the device may be configured to inhibit the atrial extrastimulus.

摘要翻译： 可植入心脏装置被编程以检测和分类早产性心房收缩（PAC）并进行响应性起搏治疗。 响应性起搏治疗是以心房超激发的形式，其旨在抢先引发折返性心动过速。 房间超激发定时发生在PAC后足够晚，以确保心房捕获，但足够早，如果PAC已经这样做，所产生的心房去极化不会通过AV节点进入心室。 如果这两个标准都不能满足，则可以将该装置配置成抑制心房再刺激。

公开(公告)号：US20100121395A1

公开(公告)日：2010-05-13

申请号：US12267483

申请日：2008-11-07

申请人： Jong Gill ,  Gene A. Bornzin

发明人： Jong Gill ,  Gene A. Bornzin

IPC分类号： A61N1/368

CPC分类号： A61N1/368 ,  A61B5/0452 ,  A61N1/3704

摘要： An intrinsic inter-atrial conduction delay is determined by a pacemaker or implantable cardioverter-defibrillator based, at least in part, on far-field atrial events sensed using ventricular pacing/sensing leads. An atrioventricular pacing delay is then set based on the inter-atrial conduction delay. By detecting atrial events using ventricular leads, rather than using atrial leads, a more useful measurement of the intrinsic inter-atrial conduction delay can be obtained. In this regard, since atrial electrodes detect atrial activity locally around the electrodes, a near-field atrial event sensed using an atrial electrode might not properly represent the actual timing of the atrial event across both the right and left atria. Far-field atrial events sensed using ventricular leads thus allow for a more useful measurement of inter-atrial conduction delays for use in setting atrioventricular pacing delays. The delivery of individual V-pulses to the heart of the patient may be timed relative to the ends of individual far-field atrial events.

摘要翻译： 至少部分地基于使用心室起搏/感测引线感测的远场心房事件，起搏器或植入式心律转复除颤器确定内在的心房间传导延迟。 然后基于心房间传导延迟来设置房室起搏延迟。 通过使用心室导联检测心房事件，而不是使用心房线，可以获得更有用的内在心房传导延迟的测量。 在这方面，由于心房电极在电极周围局部地检测心房活动，使用心房电极感测到的近场心房事件可能不能正确地表示在右心房和左心房两侧的心房事件的实际时间。 使用心室引线检测的远场心房事件因此允许更有用的测量心房间传导延迟，用于设置房室起搏延迟。 单个V脉冲到患者心脏的传送可以相对于单个远场心房事件的结束而定时。

公开(公告)号：US20100114236A1

公开(公告)日：2010-05-06

申请号：US12263348

申请日：2008-10-31

申请人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore

发明人： Naixiong Jiang ,  Gene A. Bornzin ,  John W. Poore

IPC分类号： A61N1/362 ,  H01M10/36

CPC分类号： A61N1/378 ,  A61N1/3956 ,  A61N1/3981 ,  H01M8/16 ,  H01M10/0525 ,  H01M10/425 ,  H01M10/44 ,  H01M16/006 ,  H02J7/0054 ,  H02J7/0063 ,  Y02E60/527

摘要： A system and method for powering an implantable cardiac therapy device (ICTD) via a hybrid battery system. The hybrid battery is comprised of a low voltage and low current bioelectric cell, a high voltage and high current rechargeable cell, and a charging means. Via the charging means, the bioelectric cell maintains the rechargeable cell at or near full power. The rechargeable cell is configured to power some or all operations of the ICTD. Some ICTD operations may be powered directly by the bioelectric cell. The rechargeable cell is further configured to be charged via a continuous charging process, reducing the complexity of the charging circuitry. In an embodiment, at least the bioelectric cell is external to the ICTD, enabling easy replacement of this power source. In an embodiment, a consumable anode of the bioelectric cell is external to the ICTD, enabling replacement of the power source by replacing only the anode.

摘要翻译： 通过混合电池系统为植入式心脏治疗装置（ICTD）供电的系统和方法。 混合电池包括低电压和低电流生物电池，高电压和高电流可再充电电池以及充电装置。 通过充电装置，生物电池将可再充电电池维持在或接近全功率。 可充电电池被配置为为ICTD的一些或所有操作供电。 一些ICTD操作可以由生物电池直接供电。 可再充电电池还被配置为经由连续充电过程进行充电，从而降低充电电路的复杂性。 在一个实施例中，至少生物电池在ICTD的外部，使得能够容易地更换该电源。 在一个实施例中，生物电池的消耗性阳极在ICTD的外部，能够通过仅替换阳极来替换电源。

公开(公告)号：US07648464B1

公开(公告)日：2010-01-19

申请号：US11458617

申请日：2006-07-19

申请人： Jong Gill ,  Peter Boileau ,  Gene A. Bornzin ,  Joseph J. Florio ,  Xiaoyi Min

发明人： Jong Gill ,  Peter Boileau ,  Gene A. Bornzin ,  Joseph J. Florio ,  Xiaoyi Min

IPC分类号： A61B5/021

CPC分类号： A61B5/0215 ,  A61B5/0031 ,  A61B5/042 ,  A61B5/7239 ,  A61N1/36564

摘要： Methods and systems are presented for using an ICD to detect myocardial ischemia. In one embodiment, a method includes sensing a signal indicative of cardiac pressure, measuring a height of the sensed signal at a peak amplitude of the sensed signal, and measuring a duration of the sensed signal. The method further includes indicating an ischemia based on a comparison of a ratio of the height to the duration with a predetermined value. In another embodiment, a method includes sensing a signal indicative of cardiac pressure, determining a derivative signal that is a first derivative of the sensed signal, measuring a maximum positive value of the derivative signal, and measuring a maximum negative value of the derivative signal. The method further includes indicating an ischemia based on a comparison of a ratio of the maximum positive value to the maximum negative value with a predetermined value.

摘要翻译： 提出了使用ICD检测心肌缺血的方法和系统。 在一个实施例中，一种方法包括感测指示心脏压力的信号，以感测信号的峰值幅度测量感测信号的高度，以及测量感测信号的持续时间。 该方法还包括基于将高度与持续时间的比率与预定值的比较来指示缺血。 在另一个实施例中，一种方法包括感测指示心脏压力的信号，确定作为感测信号的一阶导数的导数信号，测量导数信号的最大正值，以及测量导数信号的最大负值。 该方法还包括基于将最大正值与最大负值的比率与预定值进行比较来指示缺血。

公开(公告)号：US07630078B1

公开(公告)日：2009-12-08

申请号：US11683521

申请日：2007-03-08

申请人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

发明人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

IPC分类号： G01B9/08

CPC分类号： A61B5/14542 ,  A61B5/02028 ,  A61B5/14535 ,  A61B5/1459 ,  A61B2560/0223 ,  A61N1/36557

摘要： A measurement light detector detects light transmitted by a light source of an implantable system that is scattered back into an implantable housing, and produces a measurement signal indicative of the intensity of the light detected by the measurement light detector. A calibration light detector detects a portion of the transmitted light that has not exited the housing, and produces a calibration signal that is indicative of the intensity of the light detected by the calibration light detector, which is indicative of the intensity of the light transmitted by the light source. Changes in the intensity of the transmitted light are compensated for based on the calibration signal produced by the calibration light detector. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

摘要翻译： 测量光检测器检测由可植入系统的光源透射的光，其被散射回到可植入的壳体中，并且产生指示由测量光检测器检测到的光的强度的测量信号。 校准光检测器检测未离开壳体的透射光的一部分，并且产生指示由校准光检测器检测的光的强度的校准信号，该校准信号指示由光学器件发射的光的强度 光源。 基于由校准光检测器产生的校准信号来补偿透射光强度的变化。 本说明书不是对本发明的完整描述或限制本发明的范围。 本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

公开(公告)号：US07613508B2

公开(公告)日：2009-11-03

申请号：US11871873

申请日：2007-10-12

申请人： Peter Boileau ,  Gene A. Bornzin ,  Jong Gill

发明人： Peter Boileau ,  Gene A. Bornzin ,  Jong Gill

IPC分类号： A61B5/042

CPC分类号： A61N1/3702 ,  A61B5/04018 ,  A61B5/042 ,  A61B5/0452 ,  A61N1/368

摘要： An implantable cardiac system including an implantable cardiac stimulation device provides a heart activity signal of a heart facilitating measurement of slowly changing electrogram features. The system comprises at least one implantable electrode arrangement that senses cardiac electrical activity and provides an intracardiac electrogram signal, a first high pass filter that filters the electrogram and an equalizer that filters the filtered electrogram signal. The equalizer has a transfer function that is non-decreasing for frequencies up to a lower frequency breakpoint that is less than the upper frequency breakpoint, decreasing for frequencies between the lower frequency breakpoint and the upper frequency breakpoint, and generally flat for frequencies above the upper frequency breakpoint through a bandpass region of interest.

摘要翻译： 包括可植入心脏刺激装置的可植入心脏系统提供心脏的心脏活动信号，便于测量缓慢变化的电描绘图特征。 该系统包括感测心脏电活动并提供心内电描记图信号的至少一个可植入电极装置，对电描记图进行滤波的第一高通滤波器和对经滤波的电描记图信号进行滤波的均衡器。 均衡器具有对于低于较高频率断点的频率的频率不降低的传递函数，对于较低频率断点和较高频率断点之间的频率而言降低，并且对于高于上限频率的频率，通常平坦 频率断点通过感兴趣的带通区域。

公开(公告)号：US07590446B1

公开(公告)日：2009-09-15

申请号：US10986273

申请日：2004-11-10

申请人： Xiaoyi Min ,  Gene A. Bornzin

发明人： Xiaoyi Min ,  Gene A. Bornzin

IPC分类号： A61N1/362

CPC分类号： A61N1/3627 ,  A61N1/368

摘要： An exemplary method includes determining an atrial to ventricular activation time for a right ventricle; determining an atrial to ventricular activation time for a left ventricle; and determining a pacing sequence that paces the right ventricle prior to activation of the left ventricle if the time for the right ventricle exceeds the time for the left ventricle or that paces the left ventricle prior to activation of the right ventricle if the time for the left ventricle exceeds the time for the right ventricle, wherein, in the pacing sequence, pacing of the prior, paced ventricle occurs at a time based at least in part on a difference between the time for the right ventricle and the time for the left ventricle and an atrio-ventricular delay limit. Various other exemplary methods, devices and/or systems are also disclosed.

摘要翻译： 示例性方法包括确定右心室的心室至心室激活时间; 确定左心室的心室至心室激活时间; 并且如果右心室的时间超过左心室的时间或在右心室的激活之前步行左心室，则确定在左心室激活之前步行右心室的起搏序列，如果左侧时间 心室超过右心室的时间，其中，在起搏序列中，先前起搏的心室的起搏至少部分地基于右心室的时间与左心室的时间之间的差异发生，以及 房室延迟限制。 还公开了各种其它示例性方法，装置和/或系统。

公开(公告)号：US07529580B2

公开(公告)日：2009-05-05

申请号：US11202534

申请日：2005-08-11

申请人： Jong Gill ,  Gene A. Bornzin

发明人： Jong Gill ,  Gene A. Bornzin

IPC分类号： A61B5/02

CPC分类号： A61B5/0452 ,  A61B5/201 ,  A61N1/3702

摘要： Morphological features within electrical cardiac signals are tracked and feature changes are monitored to detect renal failure. The morphological feature may be an interval between corresponding polarization events such as the interval between QRS-complexes and peaks of corresponding T-waves (QTmax interval); the interval between QRS-complexes and ends of corresponding T-waves (QTend interval); or the interval between P-waves and corresponding QRS-complexes (PR interval). The feature may also be the elevation of a cardiac signal segment between corresponding polarization events, such as QRS-complexes and corresponding T-waves (ST segment); a duration of a polarization event, such as a QRS-complex (QRS width); or an amplitude of a polarization event, such as a T-wave (T-wave amplitude). The change in the feature may comprise a decrease in QTmax intervals, a decrease in QTend intervals, a deviation in ST segment elevation, an increase in QRS width, an increase in PR interval or a deviation in T-wave amplitude.

摘要翻译： 跟踪电心脏信号中的形态特征，并监测特征变化以检测肾衰竭。 形态特征可以是相应的极化事件之间的间隔，例如QRS-复合物之间的间隔和对应的T波的峰值（QTmax间隔）; QRS复合体与相应T波结束之间的间隔（QTend间隔）; 或P波与相应的QRS复合体之间的间隔（PR间隔）。 该特征还可以是对应的极化事件之间的心脏信号段的升高，例如QRS复合物和相应的T波（ST段）; 极化事件的持续时间，例如QRS复合（QRS宽度）; 或极化事件的振幅，例如T波（T波振幅）。 特征的变化可以包括QTmax间隔的减小，QTend间隔的减小，ST段抬高的偏差，QRS宽度的增加，PR间期的增加或T波幅度的偏差。

公开(公告)号：US07526338B1

公开(公告)日：2009-04-28

申请号：US11136268

申请日：2005-05-23

申请人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin

发明人： Jong Gill ,  Xiaoyi Min ,  Gene A. Bornzin

IPC分类号： A61N1/365 ,  A61B5/02

CPC分类号： A61B5/0215 ,  A61N1/3627 ,  A61N1/365 ,  A61N1/36564 ,  G06F19/3481 ,  G16H50/50

摘要： An implantable cardiac device is used to measure one or more parameters relating to cardiac activity of a patient's heart, from which diastolic heart failure (“DHF”) may be monitored and/or detected. These parameters are used to calculate ventricular isovolumetric relaxation time or a related time value. Heart conditions possibly having an influence on the ventricular isovolumetric relaxation time, other than heart conditions due to reduced compliance, may be detected and used to prevent an incorrect calculation of the ventricular isovolumetric relaxation time. The parameters may be measured and the relaxation time calculated multiple times over a period of time, which enables monitoring of the progression of change in the relaxation time. The relaxation time and the progression of change therein are indicators of DHF.

摘要翻译： 可植入心脏装置用于测量与患者心脏的心脏活动相关的一个或多个参数，可以从该心脏的心脏监测和/或检测舒张性心力衰竭（“DHF”）。 这些参数用于计算心室等容弛豫时间或相关时间值。 可能检测并用于可能对心室等容舒张时间（由于依从性降低而导致的心脏状况）影响的心脏状况，以防止心室等容性弛豫时间的错误计算。 可以测量参数并且在一段时间内多次计算松弛时间，这可以监测松弛时间的变化进展。 舒缓时间及其变化的进展情况是DHF的指标。