公开(公告)号：US5849797A

公开(公告)日：1998-12-15

申请号：US793912

申请日：1997-02-24

申请人： Shinichi Kondo ,  Yoko Ikeda ,  Tomio Takeuchi ,  Rie Shinei ,  Shuichi Gomi ,  Seiji Shibahara ,  Hiroo Hoshino

发明人： Shinichi Kondo ,  Yoko Ikeda ,  Tomio Takeuchi ,  Rie Shinei ,  Shuichi Gomi ,  Seiji Shibahara ,  Hiroo Hoshino

IPC分类号： A61K31/16 ,  A61P31/12 ,  A61P31/18 ,  A61P37/04 ,  C07C231/02 ,  C07C231/12 ,  C07C237/10 ,  C07C233/05

CPC分类号： C07C237/10

摘要： Now are provided (R)-3,6-diamino-N-(.omega.-aminoalkyl)-hexanamides which are novel compounds having the general formula (I): ##STR1## wherein n stands for 2-5, and which may be for example, (R)-3,6-diamino-N-(2-aminoethyl)hexanamide (n=2) and (R)-3,6-diamino-N-(3-aminopropyl)hexanamide (n=3). Their preparation process is also provided. These novel compounds and acid addition salts thereof have activities inhibitory against Gram-positive bacteria, Gram-negative bacteria and AIDS virus, as well as tumor cells and are chemically stable. These novel compounds and their salts are useful as chemotherapeutic agents for diseases caused by these bacteria or virus and also as antitumor agent.

摘要翻译： PCT No.PCT / JP95 / 01680 Sec。 371日期1997年2月24日 102（e）1997年2月24日PCT PCT 1995年8月24日PCT公布。 公开号WO96 / 06069 日期：1996年2月29日提供（R）-3,6-二氨基-N-（ω-氨基烷基） - 己酰胺，它们是具有通式（I）的新化合物：其中n代表2 -5，其可以是例如（R）-3,6-二氨基-N-（2-氨基乙基）己酰胺（n = 2）和（R）-3,6-二氨基-N-（3-氨基丙基 ）己酰胺（n = 3）。 还提供了他们的准备过程。 这些新化合物及其酸加成盐具有抑制革兰氏阳性菌，革兰氏阴性菌和艾滋病病毒以及肿瘤细胞的活性，并具有化学稳定性。 这些新化合物及其盐可用作由这些细菌或病毒引起的疾病的化学治疗剂，也可用作抗肿瘤剂。

公开(公告)号：US5091371A

公开(公告)日：1992-02-25

申请号：US545696

申请日：1990-06-29

申请人： Tomio Takeuchi ,  Shinichi Kondo ,  Daishiro Ikeda

发明人： Tomio Takeuchi ,  Shinichi Kondo ,  Daishiro Ikeda

IPC分类号： C07H15/24 ,  A61K31/70 ,  A61K31/7028 ,  A61K31/7034 ,  A61K31/704 ,  A61P31/04 ,  A61P31/10 ,  A61P31/12 ,  A61P31/18 ,  C07H15/244

CPC分类号： C07H15/244

摘要： As a new antifungal and antiviral antibiotic is provided benanomicin A 4"'-O-sulfate or a salt thereof having formula (I) ##STR1## wherein M.sup.1 denotes a mono-valent alkali metal atom or a di-valent alkaline earth metal atom or a hydrogen atom and A denotes an organic base; n is zero when M.sup.1 is an alkali metal atom or alkaline earth metal atom but n is 1 or zero when M.sup.1 is a hydrogen atom, and M.sup.2 denotes a hydrogen atom or an alkali metal atom or an alkaline earth metal atom. This new compound is useful as antifungal agent to treat fungal infections in mammals and as antiviral agent to inhibitingly treat HIV.

摘要翻译： 作为新的抗真菌剂和抗病毒抗生素，提供了具有式（I）的苯那霉素A 4“' - O-硫酸盐或其盐，其中M1表示一价碱金属原子或二 碱式金属原子或氢原子，A表示有机碱; 当M1为碱金属原子或碱土金属原子，当M1为氢原子时，n为1或为零，m为氢原子或碱金属原子或碱土金属原子时，n为0。 这种新化合物可用作抗真菌剂，用于治疗哺乳动物的真菌感染，以及作为抗病毒剂来抑制HIV治疗。

公开(公告)号：US5055453A

公开(公告)日：1991-10-08

申请号：US264888

申请日：1988-10-31

申请人： Tomio Takeuchi ,  Takeshi Hara ,  Masa Hamada ,  Shinichi Kondo ,  Masaji Sezaki ,  Haruo Yamamoto ,  Shuichi Gomi

发明人： Tomio Takeuchi ,  Takeshi Hara ,  Masa Hamada ,  Shinichi Kondo ,  Masaji Sezaki ,  Haruo Yamamoto ,  Shuichi Gomi

IPC分类号： C07H15/24 ,  C12P19/56

CPC分类号： C12R1/01 ,  C07H15/24 ,  C12P19/56 ,  Y10S435/826

摘要： Two new antibiotics which are now nominated as benanomicin A and benanomicin B, respectively, are fermentatively produced by the cultivation of a new microorganism, designated as MH193-16F4 strain, of Actinomycetes. Benanomicins A and B each show antifungal activity and are useful as a therapeutic antifungal agent. A new compound, dexylosylbenanomicin B is now produced by chemical conversion of benanomicin B, and this semi-synthetic antibiotic also shows antifungal activity and is useful as a therapeutic antifungal agent.

公开(公告)号：US5028967A

公开(公告)日：1991-07-02

申请号：US494393

申请日：1990-03-16

申请人： Nobusuke Yamada ,  Koji Tsukuma ,  Tetsuo Fujii ,  Hideaki Segawa ,  Shinichi Kondo ,  Keishi Honta

发明人： Nobusuke Yamada ,  Koji Tsukuma ,  Tetsuo Fujii ,  Hideaki Segawa ,  Shinichi Kondo ,  Keishi Honta

IPC分类号： C03C3/06 ,  C03C3/076 ,  C03C3/089 ,  G02B1/00 ,  G02B13/14

CPC分类号： C03C3/076 ,  C03C3/06 ,  C03C3/089 ,  G02B1/00 ,  G02B13/143 ,  C03C2201/10 ,  C03C2201/12 ,  C03C2201/31

摘要： An achromatic lens for ultraviolet rays constituted by (A) high-purity silica glass having a purity of 99.9% or more, or fluorine-containing, high-purity silica glass having a purity of 99.9% or more; and (B) silica glass containing germanium dioxide or silica glass containing germanium dioxide and boron oxide.

摘要翻译： 由（A）纯度为99.9％以上的高纯度二氧化硅玻璃或纯度为99.9％以上的含氟高纯度二氧化硅玻璃构成的紫外线消色差透镜; 和（B）含有二氧化锗或含有二氧化锗和氧化硼的二氧化硅玻璃的二氧化硅玻璃。

公开(公告)号：US5028601A

公开(公告)日：1991-07-02

申请号：US184323

申请日：1988-04-21

申请人： Shinichi Kondo ,  Takashi Tsuruoka ,  Katsuyoshi Iwamatsu ,  Kiyoaki Katano ,  Satoru Nakabayashi ,  Hiroko Ogino ,  Takashi Yoshida ,  Masaji Sezaki

发明人： Shinichi Kondo ,  Takashi Tsuruoka ,  Katsuyoshi Iwamatsu ,  Kiyoaki Katano ,  Satoru Nakabayashi ,  Hiroko Ogino ,  Takashi Yoshida ,  Masaji Sezaki

IPC分类号： C07D501/00 ,  C07D501/20

CPC分类号： C07D501/00

摘要： Cephalosporin compounds of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and are a hydrogen atom or a lower alkyl group of 1-5 carbon atoms and A is a hydrogen atom or a nucleophilic compound residue or pharmacologically acceptable salts thereof have excellent antibacterial activity against Gram positive and Gram negative microorganisms.

公开(公告)号：US4981503A

公开(公告)日：1991-01-01

申请号：US488448

申请日：1990-02-27

申请人： Hideaki Segawa ,  Keiichiro Nishizawa ,  Shinichi Kondo

发明人： Hideaki Segawa ,  Keiichiro Nishizawa ,  Shinichi Kondo

IPC分类号： C03B32/00 ,  C03C17/22 ,  C03C23/00

CPC分类号： C03C23/007 ,  C03B32/00 ,  C03C17/22 ,  C03C17/225 ,  C03C2217/281 ,  C03C2217/282 ,  C03C2218/17

摘要： High-hardness silica glass having transparency substantially on the same level as silica glass and a Vickers hardness of 12-20 GPa is produced by covering silica glass with powder and treating the silica glass at a temperature of 1400.degree.-2500.degree. C. and a pressure of 10-300 MPa in an atmosphere of an inert gas or a nitrogen gas.

公开(公告)号：US4971961A

公开(公告)日：1990-11-20

申请号：US266050

申请日：1988-11-02

申请人： Kaysuyoshi Iwamatsu ,  Kenji Sakagami ,  Kunio Atsumi ,  Takashi Yoshida ,  Seiji Shibahara ,  Takashi Tsuruoka ,  Shinichi Kondo

发明人： Kaysuyoshi Iwamatsu ,  Kenji Sakagami ,  Kunio Atsumi ,  Takashi Yoshida ,  Seiji Shibahara ,  Takashi Tsuruoka ,  Shinichi Kondo

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36

CPC分类号： C07D501/00 ,  Y02P20/55

摘要： This invention provides cephalosporin compounds represented by the following general formula: ##STR1## wherein R.sup.1 and R.sup.2 are same or different hydrogen atom or a lower alkyl group of 1 to 5 carbon atoms; R.sup.3 is a lower alkyl group which may optionally be substituted with a halogen atome (or atoms), an alkenyl group, or a cycloalkylmethyl group of 3 to 6 carbon atoms; and A is hydrogen atom or residue of a nucleophilic compound and pharmacologically acceptable salts thereof. These compounds have broad-spectrum antibacterial activity against Gram-positive and -negative bacteria including Pseudomonas aeruginosa, as well as against a great variety of .beta.-lactamase-producing strains.

公开(公告)号：US4950660A

公开(公告)日：1990-08-21

申请号：US240950

申请日：1988-09-06

申请人： Kunio Atsumi ,  Yuichi Yamamoto ,  Kenji Sakagami ,  Ken Nishihata ,  Shinichi Kondo

发明人： Kunio Atsumi ,  Yuichi Yamamoto ,  Kenji Sakagami ,  Ken Nishihata ,  Shinichi Kondo

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/57

CPC分类号： C07D501/57 ,  Y02P20/55

摘要： The present invention relates to a cephem compound of formula (III) shown in the description. The compound is useful as an intermediate for the synthesis of .beta.-lactam antibiotics of new class and also to a process for producing the same. The cephem compound (III) is produced by reacting a cephem compound of formula (I) with a nitrogen-containing compound of formula (II) under acid-capturing conditions. The process can be performed easily under mild conditions.

摘要翻译： 本发明涉及说明书中所示的式（III）的头孢烯化合物。 该化合物可用作合成新类β-内酰胺抗生素的中间体，也可用于生产该类β-内酰胺抗生素的方法。 头孢烯化合物（III）通过在酸捕获条件下使式（I）的头孢烯化合物与式（II）的含氮化合物反应来制备。 该方法可以在温和的条件下容易地进行。

公开(公告)号：US4929633A

公开(公告)日：1990-05-29

申请号：US203888

申请日：1988-06-08

申请人： Seiji Shibahara ,  Yukiko Takahashi ,  Yuji Matsuhashi ,  Mitsugu Hachisu ,  Shinichi Kondo ,  Tomio Takeuchi ,  Takaaki Aoyagi

发明人： Seiji Shibahara ,  Yukiko Takahashi ,  Yuji Matsuhashi ,  Mitsugu Hachisu ,  Shinichi Kondo ,  Tomio Takeuchi ,  Takaaki Aoyagi

IPC分类号： A61K31/40 ,  A61P25/28 ,  C07D207/08

CPC分类号： C07D207/08

摘要： As new compounds are provided a class of derivatives of actinonin represented by the general formula ##STR1## where R is a hydrogen or a lower alkyl group, which can exhibit the enzyme-inhibitory activities to a limited range of peptidases and show a remarkable enzyme-specificity, and which are effective to treat a cycloheximide-induced experimental amnesia in mice and are expectable to be useful to treat an amnesia in a mammalian animal, including human.

公开(公告)号：US4679176A

公开(公告)日：1987-07-07

申请号：US673945

申请日：1984-11-21

申请人： Toshio Ogawa ,  Shinichi Kondo ,  Shinichiro Umemura ,  Kageyoshi Katakura

发明人： Toshio Ogawa ,  Shinichi Kondo ,  Shinichiro Umemura ,  Kageyoshi Katakura

IPC分类号： G01S7/52 ,  G10K11/34 ,  G01S3/80

CPC分类号： G01S7/52025 ,  G10K11/346

摘要： In an ultrasonic imaging apparatus, when a sampling time space determined corresponding to the respective phases of receiving signals from transducer elements adjacent to each other is shorter than the settling time of sample and hold circuits, these receiving signals are sampled at the same time. Noise is prevented from being mixed with the sample and hold values of these signals.

摘要翻译： 在超声波成像装置中，当相应于来自相邻的换能器元件的接收信号的相位确定的采样时间空间比采样和保持电路的建立时间短时，这些接收信号被同时采样。 防止噪声与这些信号的采样和保持值混合。