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公开(公告)号：US20050214308A1
公开(公告)日：2005-09-29
申请号：US10964263
申请日：2004-10-12
申请人： Avi Ashkenazi , Karim Helmy , Sherman Fong , Audrey Goddard , Austin Gurney , Kenneth Katschke , Mary Napier , Daniel Tumas , Menno Lookeren , William Wood
发明人： Avi Ashkenazi , Karim Helmy , Sherman Fong , Audrey Goddard , Austin Gurney , Kenneth Katschke , Mary Napier , Daniel Tumas , Menno Lookeren , William Wood
IPC分类号： A61K39/395 , C07K14/705 , C07K16/28
CPC分类号： C07K14/70503 , A61K2039/505 , C07K16/2803 , C07K2317/76 , C07K2319/30 , Y10S424/809 , Y10S424/81
摘要： The present invention concerns a recently discovered macrophage specific receptor, STIgMA, and its use in the treatment of complement-associated disorders.
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体STIgMA及其在补体相关疾病的治疗中的应用。
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公开(公告)号：US20050191725A1
公开(公告)日：2005-09-01
申请号：US11100289
申请日：2005-04-05
申请人： Audrey Goddard , Paul Godowski , Austin Gurney , Timothy Stewart , William Wood
发明人： Audrey Goddard , Paul Godowski , Austin Gurney , Timothy Stewart , William Wood
CPC分类号： C07K14/47
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050176046A1
公开(公告)日：2005-08-11
申请号：US11046650
申请日：2005-01-28
申请人： Avi Ashkenazi , Dan Eaton , Audrey Goddard , Austin Gurney , William Wood , Thomas Wu
发明人： Avi Ashkenazi , Dan Eaton , Audrey Goddard , Austin Gurney , William Wood , Thomas Wu
IPC分类号： C07K16/44 , C07K16/46 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于哺乳动物肿瘤诊断和治疗的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20050159591A1
公开(公告)日：2005-07-21
申请号：US11021329
申请日：2004-12-21
申请人： Wei-Qiang Gao , Audrey Goddard , Austin Gurney , Colin Watanabe , William Wood
发明人： Wei-Qiang Gao , Audrey Goddard , Austin Gurney , Colin Watanabe , William Wood
IPC分类号： A61K39/395 , C07H21/04 , C07K14/705 , C07K16/30 , C12N1/18 , C12N5/06 , C12Q1/68
CPC分类号： A61K39/395 , C07H21/04 , C07K14/705 , C07K16/30 , C12N1/18 , C12N5/06 , C12Q1/68
摘要： The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20050124789A9
公开(公告)日：2005-06-09
申请号：US09978824
申请日：2001-10-16
申请人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Mickey Williams , William Wood
发明人： Avi Ashkenazi , Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , J. Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Sophia Kuo , Mary Napier , James Pan , Nicholas Paoni , Margaret Roy , David Shelton , Timothy Stewart , Daniel Tumas , P. Mickey Williams , William Wood
IPC分类号： A61K31/17 , A61K38/00 , A61K38/17 , A61K38/43 , A61K39/395 , A61K48/00 , C07H21/02 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/52 , C07K14/54 , C07K14/705 , C07K16/18 , C07K16/28 , C07K16/40 , C12N5/06 , C12N9/00 , C12P21/02 , C12Q1/68 , G01N33/53 , G01N33/574 , G01N33/68
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/4702 , C07K14/4703 , C07K14/475 , C07K14/52 , C07K14/521 , C07K14/54 , C07K14/705 , C07K14/70503 , C07K14/70578 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2319/00 , C07K2319/30 , C12N9/00 , C12N2799/026 , C12N2799/027 , G01N33/573 , G01N33/57484 , G01N33/68 , G01N2333/99 , G01N2800/042
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050118635A1
公开(公告)日：2005-06-02
申请号：US11040809
申请日：2005-01-21
申请人： Audrey Goddard , Paul Godowski , Austin Gurney , Victoria Smith , William Wood
发明人： Audrey Goddard , Paul Godowski , Austin Gurney , Victoria Smith , William Wood
IPC分类号： A61K38/00 , A61K38/17 , C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C07K17/00 , C12N5/06 , C12N9/00 , C12N9/02 , C12N15/00 , C12N15/12 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6886 , G01N33/53 , G01N33/574 , G01N33/68
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050079582A1
公开(公告)日：2005-04-14
申请号：US10963467
申请日：2004-10-11
申请人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
发明人： Avi Ashkenazi , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Ellen Filvaroff , Sherman Fong , Wei-Qiang Gao , Hanspeter Gerber , Mary Gerritsen , Audrey Goddard , Paul Godowski , Christopher Grimaldi , Austin Gurney , Kenneth Hillan , Ivar Kljavin , Jennie Mather , James Pan , Nicholas Paoni , Margaret Roy , Timothy Stewart , Daniel Tumas , P. Williams , William Wood
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050059115A1
公开(公告)日：2005-03-17
申请号：US10943353
申请日：2004-09-17
申请人： David Botstein , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Margaret Roy , William Wood
发明人： David Botstein , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Margaret Roy , William Wood
IPC分类号： A61K38/00 , A61K38/17 , C07H21/02 , C07H21/04 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/18 , C12N1/21 , C12N5/06 , C12N9/00 , C12P21/02 , C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： C07K14/475 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C07K2319/02 , C12N2799/026 , G01N33/5005 , G01N33/5008 , G01N33/5011 , G01N33/5085 , G01N33/57484 , G01N33/68
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050043520A1
公开(公告)日：2005-02-24
申请号：US10012149
申请日：2001-12-07
申请人： Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , James Pan , Nicholas Paoni , Margaret Roy , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood
发明人： Kevin Baker , David Botstein , Luc Desnoyers , Dan Eaton , Napoleone Ferrara , Sherman Fong , Wei-Qiang Gao , Audrey Goddard , Paul Godowski , J. Grimaldi , Austin Gurney , Kenneth Hillan , James Pan , Nicholas Paoni , Margaret Roy , Victoria Smith , Timothy Stewart , Daniel Tumas , Colin Watanabe , P. Williams , William Wood
IPC分类号： A61K38/17 , C07H21/04 , C07K14/435 , C07K16/40 , C07K16/44 , C12N5/06 , C12N9/00 , C12P21/02 , G01N33/53
CPC分类号： C07K14/47 , C07K14/575 , C07K2319/30 , C07K2319/40
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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90.发明申请NS4 nucleic acids and polypeptides and methods of use for the treatment of body weight disorders 审中-公开NS4核酸和多肽以及用于治疗体重障碍的方法公开(公告)号：US20050032170A1
公开(公告)日：2005-02-10
申请号：US10942659
申请日：2004-09-16
申请人： James Pan , Audrey Goddard , William Wood
发明人： James Pan , Audrey Goddard , William Wood
IPC分类号： A01K67/027 , A61K38/00 , A61K38/17 , A61K39/00 , A61K39/395 , A61P1/14 , A61P3/00 , A61P3/04 , A61P3/06 , A61P7/00 , C07H21/04 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/46 , C07K19/00 , C12N20060101 , C12N1/19 , C12N1/21 , C12N5/00 , C12N5/06 , C12N5/10 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/62 , C12N15/63 , C12P21/02 , C12P21/08 , C12Q20060101 , C12Q1/02 , G01N33/15 , G01N33/50 , G01N33/53 , G01N33/566 , G01N33/68
CPC分类号： C07K14/47 , G01N33/6893 , G01N2800/02
摘要： The present invention is directed to novel polypeptides NS4 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Furthermore, methods of treating body weight disorders (e.g., obesity, cachexia or anorexia) are provided.
摘要翻译： 本发明涉及新型多肽NS4和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 此外，提供了治疗体重紊乱（例如肥胖症，恶病质或厌食症）的方法。
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