公开(公告)号：US08048421B2

公开(公告)日：2011-11-01

申请号：US12294171

申请日：2007-03-20

申请人： Masayuki Kai ,  Kazuhiro Motoki ,  Shiro Kataoka ,  Hideaki Yoshida ,  Tetsuya Hagiwara

发明人： Masayuki Kai ,  Kazuhiro Motoki ,  Shiro Kataoka ,  Hideaki Yoshida ,  Tetsuya Hagiwara

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K2039/505 ,  C07K14/524 ,  C07K14/715 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/72 ,  C07K2317/74 ,  Y10S424/801 ,  Y10S424/809

摘要： This invention provides an agonist antibody to a human thrombopoietin receptor (alias: human c-Mpl). More particularly, this invention provides an agonist antibody to a human thrombopoietin receptor, wherein the agonist antibody comprises: antibody constant regions comprising (1) amino acid sequences in a heavy chain constant region and a light chain constant region of a human antibody, (2) an amino acid sequence of a heavy chain constant region with a domain substituted between human antibody subclasses, and an amino acid sequence of a light chain constant region of a human antibody, or (3) amino acid sequences comprising a deletion(s), substitution(s), addition(s), or insertion(s) of one or several amino acid residues in the amino acid sequences of (1) or (2) above; and antibody variable regions capable of binding to and activating a human thrombopoietin receptor; and wherein the agonist antibody has the properties: (a) that the antibody induces colony formation at a concentration of 10,000 ng/ml or lower as determined by the CFU-MK colony formation assay using human umbilical-cord-blood-derived CD34+ cells; and (b) that the antibody has a maximal activity at least 50% higher than that of PEG-rHuMGDF and an 50% effective concentration (EC50) of 100 nM or less in the cell proliferation assay using UT7/TPO cell. Also provided is a pharmaceutical composition for treating thrombocytopenia comprising said antibody.

摘要翻译： 本发明提供了对人血小板生成素受体（别名：人c-Mpl）的激动剂抗体。 更具体地，本发明提供了对人血小板生成素受体的激动剂抗体，其中所述激动剂抗体包含：抗体恒定区，其包含（1）重链恒定区中的氨基酸序列和人抗体的轻链恒定区，（2 ）具有在人抗体亚类和人抗体轻链恒定区的氨基酸序列之间取代的重链恒定区的氨基酸序列，或（3）包含缺失的氨基酸序列， 上述（1）或（2）的氨基酸序列中一个或几个氨基酸残基的取代，添加或插入; 和能够结合并激活人血小板生成素受体的抗体可变区; 并且其中所述激动剂抗体具有以下性质：（a）所述抗体通过使用人脐带血衍生的CD34 +细胞通过CFU-MK集落形成测定法测定，浓度为10,000ng / ml或更低的浓度形成; 和（b）在使用UT7 / TPO细胞的细胞增殖测定中，抗体具有比PEG-rHuMGDF高至少50％的最大活性和100nM或更低的50％有效浓度（EC 50）。 还提供了用于治疗血小板减少症的药物组合物，其包含所述抗体。

公开(公告)号：US20110224558A1

公开(公告)日：2011-09-15

申请号：US13112398

申请日：2011-05-20

申请人： Tatsuya Kobayashi ,  Hironori Sato ,  Toshihiko Ogura ,  Hideaki Yoshida ,  Kenji Fujii

发明人： Tatsuya Kobayashi ,  Hironori Sato ,  Toshihiko Ogura ,  Hideaki Yoshida ,  Kenji Fujii

IPC分类号： A61B5/022

CPC分类号： A61B5/022 ,  A61B5/02125

摘要： In the measurement device, the blood pressure of the upper arm and the blood pressure of the lower limb are measured using cuffs attached to the upper arm and the lower limb (ankle), respectively. The pulse wave of the upper arm and the pulse wave of the lower limb are measured in synchronization using such cuffs. The upper arm-lower limb pulse wave propagation velocity (baPWV) is calculated based on the appearance time difference of the two pulse waves. The upper arm pulse wave propagation velocity (upper arm PWV) is calculated based on the appearance time difference of the ejection wave and the reflection wave in the upper arm pulse wave. If the values of such propagation velocities are different, a warning is issued.

摘要翻译： 在测量装置中，使用附接到上臂和下肢（脚踝）的袖带来测量上臂的血压和下肢的血压。 使用这种袖口同步测量上臂的脉搏波和下肢的脉搏波。 根据两个脉搏波的出现时间差计算上臂 - 下肢脉搏波传播速度（baPWV）。 基于喷射波和上臂脉波中的反射波的出现时间差计算上臂脉搏波传播速度（上臂PWV）。 如果这种传播速度的值不同，则发出警告。

公开(公告)号：US20090128622A1

公开(公告)日：2009-05-21

申请号：US11995522

申请日：2006-07-25

申请人： Tadashi Uchiumi ,  Yasutaka Wakabayashi ,  Ken Mashitani ,  Hideaki Yoshida ,  Hidehiko Sekizawa

发明人： Tadashi Uchiumi ,  Yasutaka Wakabayashi ,  Ken Mashitani ,  Hideaki Yoshida ,  Hidehiko Sekizawa

IPC分类号： H04N13/04

CPC分类号： H04N13/398 ,  H04N13/139 ,  H04N13/161 ,  H04N13/178 ,  H04N13/183 ,  H04N13/296

摘要： In 3D information creation means 102, 3D information including information on an image identifier and arrangement position of the image identifier is input from control means 101. According to the 3D information, which has been input, an identification mark is created and output together with the arrangement position information to image integration means 103. The image integration means 103 integrates a right-eye image and a left-eye image, which are input, and the identification mark according to the arrangement position information to create image data and outputs the same. Thus, an identifier indicating a stereoscopic image is provided in stereoscopic image data and observation is not disturbed when stereoscopically displayed.

摘要翻译： 在3D信息创建装置102中，从控制装置101输入包括图像标识符和图像标识符的布置位置的信息的3D信息。根据输入的3D信息，创建识别标记并与 图像合成装置103根据排列位置信息对输入的右眼图像和左眼图像以及识别标记进行积分以产生图像数据并输出。 因此，在立体图像数据中提供指示立体图像的标识符，并且当立体显示时观察不被干扰。

公开(公告)号：US20090109281A1

公开(公告)日：2009-04-30

申请号：US11988032

申请日：2006-07-04

申请人： Ken Mashitani ,  Toshio Nomura ,  Tadashi Uchiumi ,  Hidehiko Sekizawa ,  Hideaki Yoshida

发明人： Ken Mashitani ,  Toshio Nomura ,  Tadashi Uchiumi ,  Hidehiko Sekizawa ,  Hideaki Yoshida

IPC分类号： H04N13/00

CPC分类号： H04N19/597 ,  G02B27/2228 ,  G03B35/24 ,  H04N13/139 ,  H04N13/204

摘要： A stereoscopic image processing method capable of preventing occurrence of undesirable cutout of image when a stereoscopic combined image is printed out is provided.A stereoscopic combined image can be created and recorded using a digital still camera 1. This stereoscopic combined image is a single image formed by arranging a plurality of view-point images. At first, left view-point image data and right view-point image data are stored in a memory by performing photographing twice. Then, the data of the two images are arranged laterally into a single image. Through this processing, original stereoscopic combined image data is created. Padding areas (dummy areas) are added to the original stereoscopic combined image data at the upper and lower sides thereof. Namely, a processed image containing the original stereoscopic combined image is created.

摘要翻译： 提供了一种立体图像处理方法，其能够在打印出立体视觉组合图像时能够防止出现图像不期望的切除。 可以使用数字静态相机1来创建和记录立体组合图像。该立体组合图像是通过布置多个视点图像而形成的单个图像。 首先，通过两次拍摄将左视点图像数据和右视点图像数据存储在存储器中。 然后，将两张图像的数据横向排列成单张图像。 通过该处理，创建原始立体组合图像数据。 填充区域（虚拟区域）被添加到原始立体组合图像数据的上侧和下侧。 即，创建包含原始立体组合图像的处理图像。

公开(公告)号：US20090018519A1

公开(公告)日：2009-01-15

申请号：US10594663

申请日：2005-03-30

申请人： Hideaki Yoshida

发明人： Hideaki Yoshida

IPC分类号： A61F13/15

CPC分类号： A61F13/495

摘要： A comfortably wearable development type paper diaper comprises a back sheet, a first absorbent, a second absorbent and a liquid-permeable top sheet in the recited order. The first absorbent extends, when worn, from the back side through the crotch to the abdomen side of the user. The second absorbent extends, when worn, from the back side to the crotch of the user. A leakage preventing sheet allowing no liquid permeation is interposed between the first absorbent and the second absorbent. The second absorbent leaves the first absorbent from the crotch to the back side thereby to form a pocket PO for holding the excrement between the first absorbent and the second absorbent. The leakage preventing sheet is arranged to contact in the pocket PO with the second absorbent. The top sheet is so conformed to the shape of the pocket PO as to cover the leakage preventing sheet.

摘要翻译： 一种舒适可佩戴的显影型纸尿布包括按照顺序的背片，第一吸收剂，第二吸收剂和透液性顶片。 第一种吸收剂在穿戴时从背侧延伸穿过裆部到使用者的腹部侧。 第二吸收剂在穿戴时从使用者的背侧延伸到裆部。 在第一吸收剂和第二吸收剂之间插入不能透液的防漏片。 第二吸收剂将第一吸收剂从裆部离开到后侧，从而形成用于将排泄物保持在第一吸收剂和第二吸收剂之间的口袋PO。 泄漏防止片被布置成在袋PO中与第二吸收剂接触。 顶片符合口袋PO的形状，以覆盖防漏片。

公开(公告)号：US07365783B2

公开(公告)日：2008-04-29

申请号：US10098081

申请日：2002-03-14

申请人： Hitoshi Hashimoto ,  Keiichi Mori ,  Takayuki Kijima ,  Hideaki Yoshida

发明人： Hitoshi Hashimoto ,  Keiichi Mori ,  Takayuki Kijima ,  Hideaki Yoshida

IPC分类号： H04N9/64 ,  H04N5/217

CPC分类号： H04N5/3675

摘要： An imaging apparatus comprises an imaging element, an imaging optical system configured to input an image of an object to the imaging element, a non-volatile memory part for storing defect data concerning the imaging element, and includes a first memory area storing initial defect data concerning the imaging element, and a second memory area different from the first memory area, a defect detection part for detecting defect data concerning the imaging element, and a control part for controlling reading and writing of the defect data on the imaging element from and to the non-volatile memory part, the control part writing, to the second memory area, defect data detected by the defect detection part.

摘要翻译： 一种成像装置，包括成像元件，被配置为将成像元件的图像输入到成像元件的成像光学系统，用于存储关于成像元件的缺陷数据的非易失性存储器部分，并且包括存储初始缺陷数据的第一存储区域 关于成像元件以及与第一存储区域不同的第二存储区域，用于检测关于成像元件的缺陷数据的缺陷检测部分，以及用于控制成像元件上的缺陷数据的读取和写入的控制部件， 非易失性存储器部分，控制部分向第二存储区域写入由缺陷检测部分检测到的缺陷数据。

公开(公告)号：US07253520B2

公开(公告)日：2007-08-07

申请号：US10940783

申请日：2004-09-15

申请人： Hideaki Yoshida ,  Tae Yamane

发明人： Hideaki Yoshida ,  Tae Yamane

IPC分类号： H01L23/48 ,  H01L23/12 ,  H01L23/367 ,  H01L23/485 ,  H01L23/34

CPC分类号： H01L24/10 ,  H01L23/3677 ,  H01L24/13 ,  H01L29/0657 ,  H01L2224/05001 ,  H01L2224/13 ,  H01L2224/13099 ,  H01L2224/16 ,  H01L2924/01004 ,  H01L2924/01005 ,  H01L2924/01006 ,  H01L2924/01013 ,  H01L2924/01022 ,  H01L2924/01023 ,  H01L2924/01029 ,  H01L2924/01033 ,  H01L2924/01074 ,  H01L2924/014 ,  H01L2924/10158 ,  H01L2924/00

摘要： A semiconductor device comprises a semiconductor chip which has a first surface, a pad which is formed directly on the first surface, an oxide film which is formed on the first surface, an insulating film which is formed on the oxide film and a part of the pad, a conductive film which is formed on the insulating film and the pad, a sealing material which covers a part of the conductive film and the insulating film and a bump which is formed over the conductive film, wherein the bump is exposed from a surface of the sealing material.

摘要翻译： 半导体器件包括半导体芯片，其具有第一表面，直接形成在第一表面上的焊盘，形成在第一表面上的氧化物膜，形成在氧化物膜上的绝缘膜， 衬垫，形成在绝缘膜和衬垫上的导电膜，覆盖导电膜和绝缘膜的一部分的密封材料和形成在导电膜上的凸块，其中凸块从表面露出 的密封材料。

公开(公告)号：US20070139404A1

公开(公告)日：2007-06-21

申请号：US11705478

申请日：2007-02-12

申请人： Masami Kidono ,  Hideaki Yoshida

发明人： Masami Kidono ,  Hideaki Yoshida

IPC分类号： G09G5/00

CPC分类号： H04N9/045 ,  H01L27/14868 ,  H04N5/23245 ,  H04N5/347 ,  H04N5/3728

摘要： A plurality of pixel sets each of 16 pixels are vertically provided successively one after another. A vertical transfer path 2 has two groups a and b of transfer electrodes 1a, 1b to 16a, 16b. Two like sequence transfer electrodes in the two electrode groups are provided for each of the pixels in each set. Each pixel is connected via a shift gate 3 to each transfer channel corresponding to each of the transfer electrodes in the electrode group a. To the transfer electrodes in the electrode group a, independent shift/transfer pulse application lead lines 4A are connected for applying independent gate pulses to the individual shift gates in addition to transfer pulses. Common lead lines are connected to the transfer electrodes 2a and 4a, 5a and 7a, 10a, 12a, and 13a and 15a. Transfer pulse application lead lines 4B are connected to the transfer electrodes in the electrode group b. Thus, a CCD imaging device is constructed, which is capable of performing a desired read-out operation by 4-phase driving. The invention realizes a solid-state imaging device capable of reducing the numbers of lead lines for shift gate control gate electrodes for charge read-out to a vertical transfer path and external circuit connection terminals and is capable of a special read-out, such as a multiple rate read-out.

摘要翻译： 16个像素中的多个像素组逐个地依次垂直地提供。 垂直传送路径2具有传送电极1a，1b至16a，16b的两组a和b。 为每组中的每个像素提供两个电极组中的两个像序列转移电极。 每个像素经由移位栅极3连接到对应于电极组a中的每个传输电极的每个传输通道。 对于电极组a中的转印电极，连接独立的移位/转印脉冲施加引线4A以除了转移脉冲之外，还将独立的栅极脉冲施加到各个移位门。 公共引线连接到转印电极2a和4a，5a和7a，10a，12a和13a和15a。 转移脉冲施加引线4B连接到电极组b中的转印电极。 因此，构成了能够通过4相驱动进行期望的读出动作的CCD摄像装置。 本发明实现了一种固态成像装置，其能够将用于电荷读出的移位栅极控制栅电极的引线数量减少到垂直传输路径和外部电路连接端子，并且能够进行特殊读出，例如 多率读数。

公开(公告)号：US20070129700A1

公开(公告)日：2007-06-07

申请号：US10580694

申请日：2004-11-26

申请人： Hideaki Yoshida

发明人： Hideaki Yoshida

IPC分类号： A61F13/15

CPC分类号： A61F13/5644 ,  A61F2013/5683 ,  A61F2013/582 ,  A61F2013/583

摘要： [Problem]To provide a disposable paper diaper, which has fastening sheets on the two side portions of a back side and which can cope at will with not only the ordinary fastening method but also a cross fastening method. [Means for Solving the Problem]A disposable paper diaper comprising fastening sheets 5 and 5 individually formed on the two side portions of the back side of the paper diaper and each including: joint ears 8a and 8a formed to extend from the outer side edges of one sheet and to protrude sideward at two upper and lower stages; and facing fasteners 9 disposed on the inner sides of said joint ears 8a and 8a, whereby the disposable paper diaper is worn on a body by fixing said joint ears 8a and 8a on the surface of the abdomen side of the paper diaper. Perforations 10 leading from the outer side edge to the inner side are formed in the portion of a fastening base sheet 8 between said joint ears 8a and 8a. In said perforations 10, a first perforation section 10a from the outer side edge to an intermediate point P is a high tearing strength section S0 having a relatively coarse perforation interval, and a second perforation section 10b from said intermediate point P to the inner end is a low tearing strength section SI having a relatively fine perforation interval.

摘要翻译： 本发明提供一种一次性纸尿布，其具有在背面的两侧部分上的紧固片，并且不仅可以通过普通的紧固方法，而且可以用十字紧固方法随意处理。 解决问题的手段一次性纸尿布，其包括分别形成在纸尿布的背侧的两侧部分上的紧固片5和5，每个包括：接合耳8a和8a，其形成为从外侧 一个片材的边缘并且在两个上部和下部阶段侧向突出; 并且设置在所述接头耳部8a和8a的内侧上的紧固件9，由此通过将所述接头耳部8a和8a固定在纸尿布的腹部侧的表面上而将一次性纸尿布佩戴在主体上 。 从外侧边缘到内侧的穿孔10形成在紧固基片8的位于所述接头耳部8a和8a之间的部分中。 在所述穿孔10中，从外侧边缘到中间点P的第一穿孔部分10a是具有相对粗糙的穿孔间隔的高撕裂强度部分S 0，以及来自 所述中间点P到内端是具有相对较好的穿孔间隔的低撕裂强度部分S 1。

公开(公告)号：US20070019086A1

公开(公告)日：2007-01-25

申请号：US11519823

申请日：2006-09-13

申请人： Hideaki Yoshida ,  Hatsuo Shimizu

发明人： Hideaki Yoshida ,  Hatsuo Shimizu

IPC分类号： H04N9/04

CPC分类号： H04N9/045

摘要： A color image pickup device including: a pixel group placed in an array of a plurality of pixels of photoelectric conversion elements; and a color coding array corresponding to the pixel group, the color coding array arranged in a randomized array, or arranged in a randomized array satisfying predetermined array restricting conditions, or arranged in a randomized array satisfying predetermined color distributing conditions. Thereby an object image can be picked up in accordance with a randomized color coding array having no regularity, making it possible without using an optical low-pass filter to achieve a color image pickup device and color image pickup apparatus using the color image pickup device capable of keeping color moire from occurring even of an object having a cyclic luminance change.

摘要翻译： 一种彩色图像拾取装置，包括：放置在光电转换元件的多个像素的阵列中的像素组; 以及与像素组对应的颜色编码阵列，以随机数排列的颜色编码阵列，或者以满足规定的阵列限制条件的随机阵列排列，或以满足规定的颜色分布条件的随机化阵列排列。 因此，可以根据不规则的随机化的颜色编码阵列来拾取对象图像，使得可以在不使用光学低通滤波器来实现彩色图像拾取装置和使用能够使用的彩色图像拾取装置的彩色图​​像拾取装置 即使是具有循环亮度变化的物体也能保持颜色莫尔条纹。