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81.发明申请公开(公告)号：US20100125211A1
公开(公告)日：2010-05-20
申请号：US12566432
申请日：2009-09-24
CPC分类号： A61B5/0215 , A61B5/02007
摘要： Methods and systems for assessing pulmonary or systemic vascular resistance in a patient using pressure measurements are disclosed. An illustrative method of measuring pulmonary vascular resistance includes electrically inducing a retrograde pressure pulse within the heart, sensing at least one arterial pressure parameter in response to the retrograde pressure pulse using a pressure sensor located within a pulmonary artery, and computing a value of the pulmonary vascular resistance using the at least one sensed arterial pressure parameter. Data from multiple pulmonary vascular resistance assessments can be taken over an extended period of time within the patient to aid in detecting an underlying cardiac or pulmonary condition such as cardiogenic pulmonary edema.
摘要翻译： 公开了使用压力测量来评估患者肺或全身血管阻力的方法和系统。 测量肺血管阻力的示例性方法包括电诱导心脏内的逆行压力脉冲，使用位于肺动脉内的压力传感器响应于逆行压力脉冲感测至少一个动脉压参数，以及计算肺动脉压 使用所述至少一个感测到的动脉压参数的血管阻力。 来自多个肺血管阻力评估的数据可以在患者内延长的时间段内进行，以帮助检测潜在的心脏或肺部疾病如心源性肺水肿。
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公开(公告)号：US07662104B2
公开(公告)日：2010-02-16
申请号：US11037275
申请日：2005-01-18
IPC分类号： A61B5/02
CPC分类号： A61B7/04 , A61B5/1116 , A61B8/0883 , A61N1/3627 , A61N1/36535 , A61N1/36578 , A61N1/36585
摘要： A system to monitor heart sounds. The system comprises an implantable heart sound sensor operable to produce an electrical signal representative of at least one heart sound, a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, an implantable posture sensor operable to produce an electrical signal representative of a patient's posture, and a controller circuit, coupled to the heart sound sensor interface circuit and the posture circuit. The controller circuit is operable to measure at least one heart sound in correspondence with at least one sensed patient posture.
摘要翻译： 监听心音的系统 该系统包括可植入的心音传感器，其可操作以产生表示至少一个心音的电信号，耦合到心音传感器以产生心音信号的心音传感器接口电路，可操作以产生电声 代表患者姿势的信号，以及耦合到心脏声音传感器接口电路和姿势电路的控制器电路。 控制器电路可操作以对应于至少一个感测到的患者姿势来测量至少一个心音。
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83.发明申请MANAGING PRELOAD RESERVE BY TRACKING THE VENTRICULAR OPERATING POINT WITH HEART SOUNDS 有权通过用心脏声音追踪心室操作点来管理前端保留公开(公告)号：US20090312659A1
公开(公告)日：2009-12-17
申请号：US12547207
申请日：2009-08-25
IPC分类号： A61B5/02
CPC分类号： A61N1/36585 , A61B5/021 , A61B5/0452 , A61B7/04 , A61M5/1723 , A61N1/37
摘要： A system and method for managing preload reserve and tracking the inotropic state of a patient's heart. The S1 heart sound is measured as a proxy for direct measurement of stroke volume. The S3 heart sound may be measured as a proxy for direct measurement of preload level. The S1-S3 pair yield a point on a Frank Starling type of curve, and reveal information regarding the patient's ventricular operating point and inotropic state. As an alternative, or in addition to, measurement of the S3 heart sound, the S4 heart sound may be measured or a direct pressure measurement may be made for the sake of determining the patient's preload level. The aforementioned measurements may be made by a cardiac rhythm management device, such as a pacemaker or implantable defibrillator.
摘要翻译： 一种用于管理预负荷储备并跟踪患者心脏的变力状态的系统和方法。 测量S1心音作为直接测量行程体积的代理。 可以将S3心音测量为用于直接测量预载水平的代理。 S1-S3对在Frank Starling曲线上产生一个点，并显示关于患者的心室手术点和变力状态的信息。 作为S3心音的测量或除了测量S3心音之外，也可以测量S4心音，或者为了确定患者的预压水平可以进行直接的压力测量。 上述测量可以由诸如起搏器或可植入除颤器的心律管理装置进行。
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公开(公告)号：US07559901B2
公开(公告)日：2009-07-14
申请号：US10900570
申请日：2004-07-28
IPC分类号： A61B5/02
CPC分类号： A61N1/36542 , A61B7/00 , A61N1/36535 , A61N1/36578
摘要： A system for determining a patient's posture by monitoring heart sounds. The system comprises an implantable medical device that includes a sensor operable to produce an electrical signal representative of heart sounds, a sensor interface circuit coupled to the sensor to produce a heart sound signal, and a controller circuit coupled to the sensor interface circuit. The heart sounds are associated with mechanical activity of a patient's heart and the controller circuit is operable to detect a posture of the patient from a heart sound signal.
摘要翻译： 通过监测心脏声音来确定患者姿势的系统。 该系统包括可植入医疗装置，其包括可操作以产生表示心脏声音的电信号的传感器，耦合到传感器以产生心音信号的传感器接口电路，以及耦合到传感器接口电路的控制器电路。 心脏声音与患者心脏的机械活动相关联，并且控制器电路可操作以从心脏声音信号检测患者的姿势。
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85.发明申请公开(公告)号：US20080294212A1
公开(公告)日：2008-11-27
申请号：US12220710
申请日：2008-07-28
IPC分类号： A61N1/365
CPC分类号： A61N1/36514 , A61B7/023 , A61N1/3627
摘要： Described is an implantable device configured to monitor for changes in the intensity and/or duration of a systolic murmur such as mitral regurgitation by means of an acoustic sensor. Such changes may be taken to indicate a change in a patient's heart failure status. Upon detection of a worsening in the patient's heart failure statue, the device may be programmed to alert clinical personnel over a patient management network and/or make appropriate adjustments to pacing therapy.
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公开(公告)号：US20080262368A1
公开(公告)日：2008-10-23
申请号：US11736055
申请日：2007-04-17
IPC分类号： A61B5/02
CPC分类号： A61B7/04 , A61B7/00 , A61N1/3627 , A61N1/36514 , A61N1/36521 , A61N1/36585 , A61N1/368
摘要： A system and method provide heart sound tracking, including an input circuit, configured to receive heart sound information, and a heart sound recognition circuit. The heart sound recognition circuit can be coupled to the input circuit and can be configured to recognize, within a particular heart sound of a particular heart sound waveform, a first intra heart sound energy indication and a corresponding first intra heart sound time indication using the heart sound information from the particular heart sound waveform and the heart sound information from at least one other heart sound waveform. The particular heart sound can include at least a portion of one of S1, S2, S3, and S4. Further, the first intra heart sound energy indication and the corresponding first intra heart sound time indication can correspond to the at least a portion of one of S1, S2, S3, and S4, respectively.
摘要翻译： 一种系统和方法提供心脏跟踪，包括被配置为接收心脏声音信息的输入电路和心脏声音识别电路。 心脏声音识别电路可以耦合到输入电路，并且可以被配置为在特定心脏声音波形的特定心脏声音内识别第一心脏心脏声能指示和使用心脏的对应的第一心脏心脏音频指示 来自特定心脏声音波形的声音信息和来自至少一个其他心脏声音波形的心脏声音信息。 特定的心音可以包括S1，S2，S3和S4中的一个的至少一部分。 此外，第一心内心音能量指示和对应的第一心脏心音时间指示可以分别对应于S1，S2，S3和S4中的一个的至少一部分。
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公开(公告)号：US20080103399A1
公开(公告)日：2008-05-01
申请号：US11553179
申请日：2006-10-26
IPC分类号： A61B5/02
CPC分类号： A61B5/0265 , A61B5/0031 , A61B5/029 , A61B5/042 , A61B5/0456 , A61B5/053 , A61B5/0538 , A61B5/4836 , A61B5/686 , A61B5/7239 , A61B5/7282 , A61B7/00 , A61B7/04 , A61N1/36521 , A61N1/36571 , A61N1/36578 , A61N1/36585
摘要： A system and method provide for systolic interval analysis. In an example, an implantable device measures a cardiac impedance signal. A transformation of the cardiac impedance interval is generated. The device also measures a heart sound signal. A time interval between a point on the transformed signal of the cardiac impedance signal and a point on the heart sound signal is calculated.
摘要翻译： 系统和方法提供收缩期间隔分析。 在一个示例中，可植入装置测量心脏阻抗信号。 产生心脏阻抗间隔的变换。 该装置还测量心音信号。 计算心脏阻抗信号的变换信号上的点与心音信号上的点之间的时间间隔。
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88.发明授权公开(公告)号：US07260429B2
公开(公告)日：2007-08-21
申请号：US10307900
申请日：2002-12-02
IPC分类号： A61B5/04
CPC分类号： A61B7/04 , A61N1/3627 , A61N1/36514 , A61N1/3682 , A61N1/3684
摘要： A cardiac rhythm management system provides a phonocardiographic image indicative of a heart's mechanical events related to hemodynamic performance. The phonocardiographic image includes a stack of acoustic sensor signal segments representing multiple cardiac cycles. Each acoustic sensor signal segment includes heart sounds indicative of the heart's mechanical events and representations of the heart's electrical events. The stack of acoustic sensor signal segments are aligned by a selected type of the heart's mechanical or electrical events and are grouped by a cardiac timing parameter for presentation.
摘要翻译： 心律管理系统提供指示与血液动力学性能相关的心脏的机械事件的心音图像。 心音图像包括表示多个心动周期的一组声传感器信号段。 每个声学传感器信号段包括指示心脏的机械事件的心脏声音和心脏电气事件的表示。 声学传感器信号段的堆叠通过所选择的心脏的机械或电气事件的类型对准，并且通过心脏定时参数分组以进行呈现。
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公开(公告)号：US08636669B2
公开(公告)日：2014-01-28
申请号：US12985055
申请日：2011-01-05
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译： 心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。 监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。 该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。 由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应 心脏恶化
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90.发明授权Biventricular-triggered pacing in the context of multi-site left ventricular pacing 有权在多局部左心室起搏背景下的双心室触发起搏公开(公告)号：US08600501B2
公开(公告)日：2013-12-03
申请号：US13327442
申请日：2011-12-15
申请人： Jeffrey E. Stahmann , James O. Gilkerson , Krzysztof Z. Siejko , James Kalgren , Yinghong Yu , Kenneth L. Baker
发明人： Jeffrey E. Stahmann , James O. Gilkerson , Krzysztof Z. Siejko , James Kalgren , Yinghong Yu , Kenneth L. Baker
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61N1/3627 , A61N1/3684
摘要： Biventricular-triggered pacing is a pacing mode that can employ in cardiac resynchronization pacing at elevated heart rates. Described herein are methods and devices for implementing biventricular pacing in the context of multi-site left ventricular pacing.
摘要翻译： 双心室触发起搏是起搏模式，可以在升高的心率下采用心脏再同步起搏。 本文描述了在多局部左心室起搏背景下实现双心室起搏的方法和装置。
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