-
公开(公告)号：US20060025410A1
公开(公告)日：2006-02-02
申请号：US11149105
申请日：2005-06-08
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
IPC分类号： A61K31/538 , C07D413/02
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
-
公开(公告)号：US20050038243A1
公开(公告)日：2005-02-17
申请号：US10858343
申请日：2004-06-01
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
IPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61P1/00 , A61P11/06 , A61P17/00 , A61P27/02 , A61P27/14 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07D239/48 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/02 , C07D498/02
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括 在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。
-
公开(公告)号：US09346765B2
公开(公告)日：2016-05-24
申请号：US14672679
申请日：2015-03-30
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
IPC分类号： C07D239/30 , C07D239/42 , C07D239/48 , A61K31/519 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/551 , A61K45/06 , C07D498/04 , C07D265/36 , A61K31/5395 , C07D495/04 , C07F5/02 , C07D498/14 , C07D407/14
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
-
公开(公告)号：US09145433B2
公开(公告)日：2015-09-29
申请号：US14046834
申请日：2013-10-04
申请人： Somasekhar Bhamidipati , Marina Gelman , Pingyu Ding , Rajinder Singh , Jeffrey Clough , Todd Kinsella , Donald Payan
发明人： Somasekhar Bhamidipati , Marina Gelman , Pingyu Ding , Rajinder Singh , Jeffrey Clough , Todd Kinsella , Donald Payan
IPC分类号： C07D513/04 , C07D405/04 , C07D487/04 , C07D401/04 , C07F9/6503 , C07D417/04 , C07D471/04 , C07D405/14 , C07D401/14 , C07D213/26 , C07D498/04 , C07D413/04 , C07D417/14 , C07D453/02
CPC分类号： C07D401/04 , C07D213/26 , C07D401/14 , C07D405/04 , C07D405/14 , C07D413/04 , C07D417/04 , C07D417/14 , C07D453/02 , C07D471/04 , C07D487/04 , C07D498/04 , C07D513/04 , C07F9/65038
摘要： Described are GCF-8 inhibitors of the formula (I), and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R5, R6, X and Z are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for inhibiting GDF-8 in a cell and methods for treating a patient suffering from a disease or disorder, wherein the patient would therapeutically benefit from an increase in mass or strength of muscle tissue.
摘要翻译： 描述了式（I）的GCF-8抑制剂及其药学上可接受的盐，其中n，R1，R2，R5，R6，X和Z如本文所定义。 还提供了包含其的药物组合物。 这样的化合物和组合物可用于抑制细胞中的GDF-8的方法和用于治疗患有疾病或病症的患者的方法，其中患者将从肌肉组织的质量或强度的增加中治疗获益。
-
公开(公告)号：US20150266828A1
公开(公告)日：2015-09-24
申请号：US14672679
申请日：2015-03-30
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
IPC分类号： C07D239/48 , C07D413/12 , C07D413/14 , C07D409/14 , C07D407/14 , C07D403/14
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
-
公开(公告)号：US20150126504A1
公开(公告)日：2015-05-07
申请号：US14594862
申请日：2015-01-12
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
IPC分类号： C07D239/48 , C07D401/12 , C07D413/14 , C07D413/12 , C07D401/14 , C07D498/04 , C07D405/12 , C07D403/12
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括 在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。
-
公开(公告)号：US09018204B1
公开(公告)日：2015-04-28
申请号：US14594862
申请日：2015-01-12
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
IPC分类号： C07D239/48 , C07D401/12 , C07D403/12 , C07D413/12 , A61K31/506 , C07D405/12 , C07D401/14 , C07D498/04 , C07D413/14
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
-
公开(公告)号：US20150005297A1
公开(公告)日：2015-01-01
申请号：US14485045
申请日：2014-09-12
申请人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
发明人： Rajinder Singh , Ankush Argade , Donald Payan , Susan Molineaux , Sacha Holland , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander Rossi
IPC分类号： C07D239/48 , C07D409/12 , C07D413/12 , C07D403/12 , C07D401/12 , C07D405/12
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
-
公开(公告)号：US08846908B2
公开(公告)日：2014-09-30
申请号：US13119950
申请日：2009-09-23
IPC分类号： C07D239/48 , C07D265/36 , C07D263/62 , C07D413/14 , A61K31/506 , A61K31/538 , A61K31/5383 , A61K31/423 , A61P35/00 , C07D413/12
CPC分类号： C07D417/14 , A61K31/423 , A61K31/506 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K45/06 , C07D239/48 , C07D263/62 , C07D265/36 , C07D413/12 , C07D413/14
摘要： The present disclosure relates to 2,4-pyrimidinediamines substituted with tricyclic carbamates and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, such as JAK2 or JAK3, is therapeutically useful.
摘要翻译： 本公开涉及用三环氨基甲酸酯取代的2,4-嘧啶基和使用这些化合物的组合物和方法，用于治疗JAK途径的调节或JAK激酶（例如JAK2或JAK3）的抑制在治疗上有用的条件。
-
90.发明授权公开(公告)号：US08735418B2
公开(公告)日：2014-05-27
申请号：US13619843
申请日：2012-09-14
申请人： Somasekhar Bhamidipati , Jeffrey Clough , Ankush Argade , Rajinder Singh , Vadim Markovtosov , Pingyu Ding , Jiaxin Yu , Andy Atuegbu , Hui Hong , Ihab Darwish , Sambiah Thota
发明人： Somasekhar Bhamidipati , Jeffrey Clough , Ankush Argade , Rajinder Singh , Vadim Markovtosov , Pingyu Ding , Jiaxin Yu , Andy Atuegbu , Hui Hong , Ihab Darwish , Sambiah Thota
IPC分类号： A61K31/505 , A61K31/506
CPC分类号： C07D487/08 , C07D451/00 , C07D451/04 , C07D491/08 , C07D519/00
摘要： This invention is directed to compounds of formula (I): where n, m, Y, R1, R2, R3, R4 and R5 are disclosed herein, as isolated stereoisomers or mixtures thereof, or pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.
摘要翻译： 本发明涉及式（I）的化合物：其中n，m，Y，R 1，R 2，R 3，R 4和R 5在本文中公开，作为其分离的立体异构体或其混合物或其药学上可接受的盐; 包含式（I）化合物的药物组合物; 以及使用化合物和药物组合物治疗与JAK2活性相关的疾病或病症的方法。
-
-
-
-
-
-
-
-
-
搜索结果
145 条记录 (耗时 0.104 秒)
