公开(公告)号：US07667606B2

公开(公告)日：2010-02-23

申请号：US11928800

申请日：2007-10-30

申请人： Tom Packert ,  Jay Pierce ,  Robert J. Griffin ,  John K. Stevens

发明人： Tom Packert ,  Jay Pierce ,  Robert J. Griffin ,  John K. Stevens

IPC分类号： G08B23/00

CPC分类号： H04B5/0062

摘要： Activities of individuals and the movements/usage of products are monitored in an operating room during a surgical procedure by disposing in the operating room a first transceiver operating in a long wavelength mode in which 99.99% or more of radiated energy is in the form of a magnetic field, for example 131 KHz. A distinguishable radio frequency-enabled identification tag is associated with each of a plurality of persons assigned to the surgical procedure, including for example, doctors, nurses, and/or the patient, and optionally with products to be monitored. A signal is transmitted from the first transceiver and responses from the identification tags are monitored. A log is created from the monitored responses indicative activities of each of the persons in the operating room or of movements of tagged products.

摘要翻译： 个人的活动和产品的运动/使用在外科手术过程中在手术室中进行监测，通过在手术室中放置以长波长模式操作的第一收发器，其中99.99％或更多的辐射能量为 磁场，例如131KHz。 可分辨的无线电频率识别标签与分配给外科手术的多个人中的每一个相关联，包括例如医生，护士和/或患者，以及可选地与待监测的产品。 信号从第一收发器发送，并且来自识别标签的响应被监视。 记录是从监控的响应中创建的，指示手术中每个人的指示性活动或标记产品的移动。

公开(公告)号：US07597256B2

公开(公告)日：2009-10-06

申请号：US11276506

申请日：2006-03-02

申请人： John K. Stevens

发明人： John K. Stevens

IPC分类号： G06K15/00 ,  G06Q30/00 ,  G06F17/00 ,  A47G29/12 ,  G08B13/14

CPC分类号： G06Q10/08 ,  G06Q30/00 ,  G06Q30/0601 ,  G06Q99/00 ,  G07B2017/00209 ,  G07C9/00039 ,  G07C9/00103 ,  G07C9/00166 ,  G07C9/00571 ,  G07C9/00896 ,  G07C9/00912 ,  G07C2009/00793 ,  G07F17/12

摘要： A wireless key (6), capable of transmitting an ultra-low frequency radio wave signal (5), is used to gain access to a secure receptacle (1), the wireless key (6) and receptacle (1) comprising a system to ensure the secure transfer or delivery of items between parties typically engaging in e-commerce. The wireless key (6) possesses a means to discriminate against the unauthorized entry of the receptacle, such as through the use of buttons to enter a secure access code. The wireless key (6) accepts an access code entry from the user desiring entry to the receptacle (1) and subsequently transmits an ultra-low frequency signal (5) to a receiving and processing means (4). If the analysis of the signal indicates the user of the wireless key (6) is authorized to gain entry to the receptacle (1), the receptacle's locking mechanism (3) is disengaged to allow entry.

摘要翻译： 使用能够发送超低频无线电波信号（5）的无线键（6）来访问安全插座（1），无线键（6）和插座（1）包括系统 确保通常从事电子商务的各方之间安全地转移或交付物品。 无线键（6）具有用于区分插座的未授权进入的手段，例如通过使用按钮来输入安全的访问代码。 无线键（6）接受来自用户期望进入插座（1）的访问代码条目，并随后向接收和处理装置（4）发送超低频信号（5）。 如果信号分析指示无线键（6）的用户被授权进入插座（1），则插座的锁定机构（3）被分离以允许进入。

公开(公告)号：US07541928B2

公开(公告)日：2009-06-02

申请号：US11563126

申请日：2006-11-24

申请人： John K. Stevens

发明人： John K. Stevens

IPC分类号： G08B13/14

CPC分类号： G06Q10/087

摘要： A system for use by a bricks-and-mortar retailer has RF tags on items of merchandise (“item tags”) and has large antennas in large areas of a retail space. Intermediate tags are communicatively coupled to the large antennas and also to the item tags. The locations of the intermediate tags are known, and thus the location of an item is known because it is communicatively coupled with one of the intermediate tags. A customer visits a web site and orders an item for later pickup at the store. Store personnel then go to the location of the item, pick the item, and put it at a store location for later pickup. The customer can travel to the store and present an identifying card and pick up the item.

摘要翻译： 实体零售商使用的系统在商品项目上具有RF标签（“商品标签”），并且在零售空间的大面积内具有大的天线。 中间标签通信地耦合到大天线以及物品标签。 中间标签的位置是已知的，因此项目的位置是已知的，因为它与一个中间标签通信地耦合。 客户访问一个网站并订购一个商品，以便以后在商店取货。 商店人员然后转到物品的位置，选择物品，并将其放在商店位置以备以后取货。 客户可以前往商店并出示识别卡并拿起物品。

公开(公告)号：US20080001716A1

公开(公告)日：2008-01-03

申请号：US11459647

申请日：2006-07-25

申请人： John K. Stevens ,  Paul Watohouse ,  Florin Tarcoci

发明人： John K. Stevens ,  Paul Watohouse ,  Florin Tarcoci

IPC分类号： H04Q5/22

CPC分类号： G06K19/0723

摘要： An area-reading antenna (in RF linkage with myriad RF tags) is dynamically tuned. It may be dynamically tuned as to its transmission of a power/clock field, or dynamically tuned as to its transmission of a data signal, or dynamically tuned as to its reception of a data signal, or some combination of all three. In this way, a base station has an improved ability to communicate with a greater fraction of the RF tags within its reading area, despite detuning of individual tags due to proximity of detuning influences such as metal or liquids.

摘要翻译： 动态地调整区域读取天线（与无数RF标签的RF联动）。 可以动态调整其功率/时钟域的传输，或者动态地调整其数据信号的传输，或者动态地调整其数据信号的接收，或三者的某种组合。 以这种方式，尽管由于诸如金属或液体的失谐影响的接近，基站在其读取区域内具有与更大部分的RF标签通信的改善的能力。

公开(公告)号：US07028339B2

公开(公告)日：2006-04-11

申请号：US10415502

申请日：2001-08-28

申请人： John K. Stevens

发明人： John K. Stevens

IPC分类号： G06F7/04 ,  G06F1/26

CPC分类号： G06Q10/08 ,  G06Q30/00 ,  G06Q30/0601 ,  G06Q99/00 ,  G07B2017/00209 ,  G07C9/00039 ,  G07C9/00103 ,  G07C9/00166 ,  G07C9/00571 ,  G07C9/00896 ,  G07C9/00912 ,  G07C2009/00793 ,  G07F17/12

摘要： A wireless key (6), capable of transmitting an ultra-low frequency radio wave signal (5), is used to gain access to a secure receptacle (1), the wireless key (6) and receptacle (1) comprising a system to ensure the secure transfer or delivery of items between parties typically engaging in e-commerce. The wireless key (6) possesses a means to discriminate against the unauthorized entry of the receptacle, such as through the use of buttons to enter a secure access code. The wireless key (6) accepts an access code entry from the user desiring entry to the receptacle (1) and subsequently transmits an ultra-low frequency signal (5) to a receivin and processing means (4). If the analysis of the signal indicates the user of the wireless key (6) is authorized to gain entry to the receptacle (1), the receptacle's locking mechanism (3) is disengaged to allow entry.

摘要翻译： 使用能够发送超低频无线电波信号（5）的无线键（6）来访问安全插座（1），无线键（6）和插座（1）包括系统 确保通常从事电子商务的各方之间安全地转移或交付物品。 无线键（6）具有用于区分插座的未授权进入的手段，例如通过使用按钮来输入安全的访问代码。 无线键（6）接受来自用户期望进入插座（1）的访问代码条目，并且随后将超低频信号（5）发送到接收机和处理装置（4）。 如果对信号的分析指示无线键（6）的用户被授权进入插座（1），则插座的锁定机构（3）被分离以允许进入。

公开(公告)号：US6013436A

公开(公告)日：2000-01-11

申请号：US699628

申请日：1996-08-19

申请人： May Hui ,  James M. Dunn ,  John K. Stevens ,  Denis Capatos ,  David E. Matthews

发明人： May Hui ,  James M. Dunn ,  John K. Stevens ,  Denis Capatos ,  David E. Matthews

IPC分类号： C07K14/47 ,  C07K16/18 ,  C12Q1/68 ,  C07H21/04 ,  C12P19/34

CPC分类号： C12Q1/6827 ,  C07K14/4703 ,  C07K16/18 ,  C12Q1/6858 ,  C12Q1/6886 ,  C12Q2600/16

摘要： The instant invention relates to methods and products for the diagnosis of mutations in the von Hippel-Lindau tumor suppressor gene. More specifically, the products are DNA oligonucleotides for use in amplifying and sequencing genomic DNA and kits including these oligonucleotides. The method of the invention relates to a hierarchical system for cost-effective diagnosis of von Hippel-Lindau tumor suppressor disease-associated mutations.

摘要翻译： 本发明涉及用于诊断von Hippel-Lindau肿瘤抑制基因突变的方法和产品。 更具体地，产物是用于扩增和测序基因组DNA的DNA寡核苷酸，包括这些寡核苷酸的试剂盒。 本发明的方法涉及用于von Hippel-Lindau肿瘤抑制因子相关突变的成本效益诊断的分层系统。

公开(公告)号：US6007689A

公开(公告)日：1999-12-28

申请号：US836268

申请日：1997-05-01

申请人： John A. Renfrew ,  Eric Steinbach ,  John K. Stevens ,  Henryk Zaleski

发明人： John A. Renfrew ,  Eric Steinbach ,  John K. Stevens ,  Henryk Zaleski

IPC分类号： G01N27/447 ,  G01N27/26

CPC分类号： G01N27/44704

摘要： An apparatus for the rapid preparation of electrophoresis gels comprises: (a) a housing; (b) a support fixture removably disposed within the housing and adapted to receive a gel holder having an internal gel compartment, the support fixture being optionally adapted to permit filling of the gel holder within the housing; (c) an optional injection system, which is connectible to a reservoir for holding a polymerizable solution; (d) an optional solution injection connector adapted to couple the injection system to a gel holder placed within the filling fixture, (e) an optional controller for the injection system, which causes the injection system to inject polymerizable solution from the reservoir into the gel compartment; and (f) a radiation source disposed within the housing in a location effective to irradiate polymierizable solution within the gel compartment of a gel holder in the support fixture. The support fixture may be mounted on a drawer which is slidable between a position inside the housing, and a position outside the housing to permit easy placement of a gel holder into the support fixture.

摘要翻译： PCT No.PCT / US95 / 13955 Sec。 371日期1997年5月1日 102（e）日期1997年5月1日PCT提交1995年10月31日PCT公布。 出版物WO96 / 日期：1996年5月9日。一种用于快速制备电泳凝胶的设备包括：（a）壳体; （b）可移除地设置在所述壳体内并适于接收具有内部凝胶隔室的凝胶保持器的支撑固定件，所述支撑固定件可选地适于允许在所述壳体内填充所述凝胶保持器; （c）可选的注射系统，其可连接到储存器以保持可聚合溶液; （d）可选的溶液注入连接器，其适于将注射系统耦合到置于填充夹具内的凝胶保持器，（e）用于注射系统的可选控制器，其使注射系统将可聚合溶液从储存器注入凝胶 隔间 以及（f）辐射源，其设置在所述壳体内的有效照射所述支撑夹具中的凝胶保持器的凝胶室内的可聚合溶液的位置。 支撑固定件可以安装在可在壳体内的位置和壳体外部的位置之间滑动的抽屉上，以允许将凝胶保持器容易地放置到支撑夹具中。

公开(公告)号：US5552283A

公开(公告)日：1996-09-03

申请号：US388381

申请日：1995-02-14

申请人： Eleftherios Diamandis ,  James M. Dunn ,  John K. Stevens

发明人： Eleftherios Diamandis ,  James M. Dunn ,  John K. Stevens

IPC分类号： G01N33/50 ,  C12N15/09 ,  C12Q1/68 ,  G01N33/53 ,  G01N33/566 ,  C07H21/02 ,  C07H21/04 ,  C12P19/34

CPC分类号： C12Q1/6827 ,  C12Q1/6858 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/16

摘要： Rapid and cost effective diagnosis of p53 mutations of a sample of patients is achieved by employing a selected plurality of diagnostic tools, in a hierarchy of increasing accuracy and cost per tool, in which each tool detects essentially no false positives. Diagnostic tests that may be included among the plurality of tests selected include, in order of increasing accuracy and cost:(a) immunoassays,(b) analysis of DNA from a patient sample by quantitative amplification of p53 exons using amplification primers complementary to intron regions flanking each exon and examination of the length or quantity of each amplified fragment for nucleotide insertions or deletions relative to the normal p53 gene. Preferably, the amplification primers are multiplexed so that more than one DNA fragment is amplified in a single vessel, using sets of primers which provide gene fragments of distinctive lengths when used to amplify a normal p53 gene; and(c) analysis of DNA from a patient sample by DNA sequencing of the p53 gene beginning with the sequencing of those regions most likely to harbor point mutations, and proceeding to sequence regions less likely to harbor point mutations.

摘要翻译： 通过采用所选择的多种诊断工具，以提高每个工具的精度和成本的等级来实现对患者样品的p53突变的快速和成本有效的诊断，其中每个工具基本上不检测到假阳性。 可以包括在所选择的多个测试中的诊断测试包括：提高准确性和成本的顺序：（a）免疫测定，（b）使用与内含子区域互补的扩增引物定量扩增p53外显子来分析来自患者样品的DNA 侧翼于每个外显子，并检查每个扩增片段的长度或数量，用于相对于正常p53基因的核苷酸插入或缺失。 优选地，扩增引物被多重化，使得在单个容器中扩增多于一个DNA片段，使用提供用于扩增正常p53基因的特异长度的基因片段的引物组; 和（c）通过对最可能存在点突变的那些区域的测序开始的p53基因的DNA测序从患者样品中分析DNA，并且进行到不太可能存在点突变的序列区域。

公开(公告)号：US08159345B2

公开(公告)日：2012-04-17

申请号：US12429835

申请日：2009-04-24

申请人： John K. Stevens

发明人： John K. Stevens

IPC分类号： G08B21/00

CPC分类号： G06Q10/087

摘要： A system for identifying, monitoring, and tracking a plurality of tools includes: a pad for placing the tools, wherein the pad includes a plurality of appropriately-sized cutouts for nesting each of the tools; a sensor in each cutout that detects placement and removal of the tool in the cutout; and a low frequency radio tag placed in the pad and operatively coupled with each sensor for reading each sensor. The low frequency radio tag operates at a low clock frequency and is configured to receive and transmit data signals within a peer-to-peer network with any low frequency radiating transceiver. The low frequency radio tag includes: a tag antenna operable at a low radio frequency not exceeding 450 kilohertz, a transceiver, a data storage device for storing data for identifying the tools, a processor for processing the data; and a connector for a power source.

摘要翻译： 用于识别，监测和跟踪多个工具的系统包括：用于放置工具的垫，其中垫包括用于嵌套每个工具的多个适当大小的切口; 每个切口中的传感器，其检测所述切口中的所述工具的放置和移除; 以及放置在垫中的低频无线电标签，并与每个传感器可操作地耦合以读取每个传感器。 低频无线电标签以低时钟频率工作，并被配置为使用任何低频辐射收发器在对等网络内接收和发送数据信号。 低频无线电标签包括：可在不超过450千赫兹的低射​​频操作的标签天线，收发器，用于存储用于识别工具的数据的数据存储装置，用于处理数据的处理器; 和用于电源的连接器。

公开(公告)号：US20090267769A1

公开(公告)日：2009-10-29

申请号：US12429835

申请日：2009-04-24

申请人： John K. Stevens

发明人： John K. Stevens

IPC分类号： G08B13/14

CPC分类号： G06Q10/087

摘要： A system for identifying, monitoring, and tracking a plurality of tools includes: a pad for placing the tools, wherein the pad includes a plurality of appropriately-sized cutouts for nesting each of the tools; a sensor in each cutout that detects placement and removal of the tool in the cutout; and a low frequency radio tag placed in the pad and operatively coupled with each sensor for reading each sensor. The low frequency radio tag operates at a low clock frequency and is configured to receive and transmit data signals within a peer-to-peer network with any low frequency radiating transceiver. The low frequency radio tag includes: a tag antenna operable at a low radio frequency not exceeding 450 kilohertz, a transceiver, a data storage device for storing data for identifying the tools, a processor for processing the data; and a connector for a power source.

摘要翻译： 用于识别，监测和跟踪多个工具的系统包括：用于放置工具的垫，其中垫包括用于嵌套每个工具的多个适当大小的切口; 每个切口中的传感器，其检测所述切口中的所述工具的放置和移除; 以及放置在垫中的低频无线电标签，并与每个传感器可操作地耦合以读取每个传感器。 低频无线电标签以低时钟频率工作，并被配置为使用任何低频辐射收发器在对等网络内接收和发送数据信号。 低频无线电标签包括：可在不超过450千赫兹的低射​​频操作的标签天线，收发器，用于存储用于识别工具的数据的数据存储装置，用于处理数据的处理器; 和用于电源的连接器。