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81.发明授权公开(公告)号：US08277389B2
公开(公告)日：2012-10-02
申请号：US13178945
申请日：2011-07-08
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61N1/36564 , A61N1/36578 , A61N1/375
摘要： An implantable device and method for monitoring S1 heart sounds with a remotely located accelerometer. The device includes a transducer that converts heart sounds into an electrical signal. A control circuit is coupled to the transducer. The control circuit is configured to receive the electrical signal, identify an S1 heart sound, and to convert the S1 heart sound into electrical information. The control circuit also generates morphological data from the electrical information. The morphological data relates to a hemodynamic metric, such as left ventricular contractility. A housing may enclose the control circuit. The housing defines a volume coextensive with an outer surface of the housing. The transducer is in or on the volume defined by the housing.
摘要翻译： 一种用远程位置加速度计监测S1心音的可植入装置和方法。 该装置包括将心音转换为电信号的换能器。 控制电路耦合到换能器。 控制电路被配置为接收电信号，识别S1心音，并将S1心音转换为电信息。 控制电路还从电信息生成形态数据。 形态学数据涉及血流动力学指标，如左心室收缩力。 壳体可以包围控制电路。 壳体限定与壳体的外表面共同延伸的体积。 传感器位于由外壳限定的体积中。
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82.发明申请公开(公告)号：US20120158087A1
公开(公告)日：2012-06-21
申请号：US13327400
申请日：2011-12-15
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A refractory period for a pacemaker sensing channel refers to a period of time during which the sensing channel is either blind to incoming electrical signals, termed a blanking interval, and/or during which the device is configured to ignore such signals for purposes of sense event detection. Methods and devices for implementing refractory periods in the context of multi-site left ventricular pacing are described.
摘要翻译： 用于起搏器感测通道的不适期是指感测通道对于被称为消隐间隔的输入电信号而言是盲目的，和/或在该时间段期间，设备被配置为忽略这些信号以用于感觉事件 检测。 描述了在多站点左心室起搏背景下实施不应期的方法和装置。
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83.发明申请BIVENTRICULAR-TRIGGERED PACING IN THE CONTEXT OF MULTI-SITE LEFT VENTRICULAR PACING 有权在多场左心室的背景下的双向触发的皮肤公开(公告)号：US20120158085A1
公开(公告)日：2012-06-21
申请号：US13327442
申请日：2011-12-15
申请人： Jeffrey E. Stahmann , James O. Gilkerson , Krzysztof Z. Siejko , James Kalgren , Yinghong Yu , Kenneth L. Baker
发明人： Jeffrey E. Stahmann , James O. Gilkerson , Krzysztof Z. Siejko , James Kalgren , Yinghong Yu , Kenneth L. Baker
IPC分类号： A61N1/365
CPC分类号： A61N1/36592 , A61N1/3627 , A61N1/3684
摘要： Biventricular-triggered pacing is a pacing mode that can employ in cardiac resynchronization pacing at elevated heart rates. Described herein are methods and devices for implementing biventricular pacing in the context of multi-site left ventricular pacing.
摘要翻译： 双心室触发起搏是起搏模式，可以在升高的心率下采用心脏再同步起搏。 本文描述了在多局部左心室起搏背景下实现双心室起搏的方法和装置。
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公开(公告)号：US20120089040A1
公开(公告)日：2012-04-12
申请号：US13325654
申请日：2011-12-14
申请人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
发明人： Jeffrey E. Stahmann , Krzysztof Z. Siejko , Carlos Haro , Abhilash Patangay , Gerrard M. Carlson , Andres Belalcazar
IPC分类号： A61B7/00
CPC分类号： A61N1/36514 , A61B5/0031 , A61B5/021 , A61B5/024 , A61B5/053 , A61B5/08 , A61B5/0816 , A61B5/1116 , A61B5/4806 , A61B5/686 , A61B5/7275 , A61B7/04 , A61N1/36578
摘要： A system and method to sense heart sounds with one or more implantable medical devices according to one or more signal processing parameters. The method alters one or more of the parameters as a function of one or more physiologic triggering events. The method then senses heart sounds with the one or more implantable medical devices according to at least the one or more altered signal processing parameters.
摘要翻译： 根据一个或多个信号处理参数用一个或多个可植入医疗装置感测心脏声音的系统和方法。 该方法将一个或多个参数改变为一个或多个生理触发事件的函数。 该方法然后根据至少一个或多个改变的信号处理参数用一个或多个可植入医疗装置感测心脏声音。
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公开(公告)号：US20120035685A1
公开(公告)日：2012-02-09
申请号：US13198499
申请日：2011-08-04
申请人： Sunipa Saha , Kenneth N. Hayes , Keith L. Herrmann , James Kalgren , Aaron R. McCabe , Holly Rockweiler , Shibaji Shome , Krzysztof Z. Siejko
发明人： Sunipa Saha , Kenneth N. Hayes , Keith L. Herrmann , James Kalgren , Aaron R. McCabe , Holly Rockweiler , Shibaji Shome , Krzysztof Z. Siejko
CPC分类号： A61N1/37247 , A61N1/056 , A61N1/36185 , A61N1/3686 , A61N1/37241
摘要： An interactive representation of electrostimulation electrodes or vectors can be provided, such as for configuring combinations of electrostimulation electrodes. In an example, electrodes or test parameters can be presented graphically or in a table. A user interface can be configured to receive user-input designating electrode combinations or vectors for test or for use in programming an implantable or ambulatory medical device. The interface can be used to indicate suggested electrode combinations or vectors in response to a first selection of an electrode. Tests can be performed on electrode combinations and vectors, and the results of the tests can be presented to a user using the interactive representation. In an example, test results can be analyzed by a processor and optionally used to program an implantable or ambulatory medical device.
摘要翻译： 可以提供电刺激电极或载体的交互式表示，例如用于配置电刺激电极的组合。 在一个示例中，电极或测试参数可以图形化或在表中呈现。 用户界面可以被配置为接收用户输入的指定电极组合或矢量，用于测试或用于编程可植入或动态医疗设备。 该界面可用于响应于电极的第一选择来指示建议的电极组合或载体。 可以对电极组合和载体进行测试，并且可以使用交互式表示向使用者呈现测试结果。 在一个示例中，测试结果可以由处理器分析，并且可选地用于编程可植入或动态医疗设备。
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86.发明申请CARDIAC MECHANICAL VIBRATION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION 有权使用信号指示铅运动的心脏机械振动监测器公开(公告)号：US20110319782A1
公开(公告)日：2011-12-29
申请号：US13168547
申请日：2011-06-24
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods to monitor cardiac mechanical vibrations using information indicative of lead motion are described. In an example, a system including an implantable medical device can include an excitation circuit configured to provide a non-tissue stimulating, non-therapeutic electrical excitation signal to a portion of an implantable lead. A receiver circuit can be configured to obtain information indicative of a mechanical vibration of the implantable lead due at least in part to one or more of an impact of at least a portion of the heart to the implantable lead, or friction contact between the implantable lead and cardiac tissue. The system can include a processor circuit configured to determine one or more of a lead mechanical status, or information indicative of valvular activity using the information indicative of the mechanical vibration of the implantable lead.
摘要翻译： 描述使用指示引导运动的信息来监测心脏机械振动的系统和方法。 在一个示例中，包括可植入医疗装置的系统可以包括被配置为向可植入引线的一部分提供非组织刺激的非治疗电激励信号的激励电路。 接收器电路可以被配置为获得指示可植入引线的机械振动的信息，其至少部分地由至少一部分心脏到可植入引线的冲击或可植入引线之间的摩擦接触 和心脏组织。 该系统可以包括处理器电路，其被配置为使用指示可植入引线的机械振动的信息来确定引导机械状态或指示瓣膜活动的信息中的一个或多个。
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公开(公告)号：US20110319779A1
公开(公告)日：2011-12-29
申请号：US13168481
申请日：2011-06-24
IPC分类号： A61B5/0452 , A61B5/02 , A61N1/365
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods for rhythm discrimination using the motion of an implantable lead are described. In an example, an implantable medical device can include a receiver circuit configured to be electrically coupled to an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The device can include an arrhythmia detection circuit configured to determine an arrhythmia status using the information indicative of the movement of the implantable lead and an arrhythmia classification circuit configured to determine one or more of a location or a type of an arrhythmia, using the information indicative of the movement of the implantable lead, when the arrhythmia status indicates that an arrhythmia is occurring or has occurred.
摘要翻译： 描述使用可植入引线的运动进行节律辨别的系统和方法。 在一个示例中，可植入医疗设备可以包括被配置为电耦合到可植入引线的接收器电路，并且被配置为获得至少部分地基于心脏的运动而指示可植入引线的运动的信息。 该装置可以包括心律失常检测电路，其被配置为使用指示可植入引线的移动的信息来确定心律失常状态，以及心律失常分类电路，其被配置为使用所述信息指示来确定心律不齐的位置或类型中的一个或多个 当心律失常状态表示发生心律失常或发生心律失常时，可植入性铅的运动。
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公开(公告)号：US08034000B2
公开(公告)日：2011-10-11
申请号：US12510962
申请日：2009-07-28
申请人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina V. Brockway , Krzysztof Z. Siejko
发明人： Yi Zhang , Richard Fogoros , Carlos Haro , Yousufali Dalal , Marina V. Brockway , Krzysztof Z. Siejko
IPC分类号： A61B5/04
CPC分类号： A61N1/3627 , A61B5/0031 , A61B5/024 , A61B5/0452 , A61B5/0456 , A61B7/04 , A61N1/36578 , A61N1/395
摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.
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公开(公告)号：US07972275B2
公开(公告)日：2011-07-05
申请号：US10334694
申请日：2002-12-30
IPC分类号： A61B5/02
CPC分类号： A61B5/02028 , A61B7/00 , A61N1/36514 , A61N1/36528
摘要： A cardiac rhythm management system provides for ambulatory monitoring of hemodynamic performance based on quantitative measurements of heart sound related parameters for diagnostic and therapeutic purposes. Monitoring of such heart sound related parameters allows the cardiac rhythm management system to determine a need for delivering a therapy and/or therapy parameter adjustments based on conditions of a heart. This monitoring also allows a physician to observe or assess the hemodynamic performance for diagnosing and making therapeutic decisions. Because the conditions of the heart may fluctuate and may deteriorate significantly between physician visits, the ambulatory monitoring, performed on a continuous or periodic basis, ensures a prompt response by the cardiac rhythm management system that may save a life, prevent hospitalization, or prevent further deterioration of the heart.
摘要翻译： 心律管理系统基于用于诊断和治疗目的的心音相关参数的定量测量，提供对血液动力学性能的动态监测。 监测这种心脏声音相关参数允许心律管理系统基于心脏的情况来确定递送治疗和/或治疗参数调整的需要。 该监测还允许医师观察或评估用于诊断和作出治疗决定的血液动力学性能。 由于心脏的状况可能波动，并且可能在医师访问之间显着恶化，所以在连续或周期性的基础上进行的动态监测可确保心律管理系统能够节省生命，预防住院或进一步防止心律失常的迅速反应 心脏恶化
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90.发明授权Trending of systolic murmur intensity for monitoring cardiac disease with implantable device 有权用植入式装置监测心脏病的收缩期杂音强度的趋势公开(公告)号：US07963926B2
公开(公告)日：2011-06-21
申请号：US12220710
申请日：2008-07-28
IPC分类号： A61B5/02
CPC分类号： A61N1/36514 , A61B7/023 , A61N1/3627
摘要： Described is an implantable device configured to monitor for changes in the intensity and/or duration of a systolic murmur such as mitral regurgitation by means of an acoustic sensor. Such changes may be taken to indicate a change in a patient's heart failure status. Upon detection of a worsening in the patient's heart failure statue, the device may be programmed to alert clinical personnel over a patient management network and/or make appropriate adjustments to pacing therapy.
摘要翻译： 描述了被配置为通过声学传感器监测收缩期杂音如二尖瓣反流的强度和/或持续时间的变化的可植入装置。 可以采取这种改变来指示患者心力衰竭状态的变化。 当检测到患者的心力衰竭雕像恶化时，该装置可以被编程以通过患者管理网络警告临床人员和/或对起搏治疗进行适当的调整。
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