公开(公告)号：US20120165748A1

公开(公告)日：2012-06-28

申请号：US13321313

申请日：2010-05-28

申请人： David Plumptre

发明人： David Plumptre

IPC分类号： A61M5/31 ,  B23P17/04

CPC分类号： A61M5/31551 ,  A61M5/24 ,  A61M5/31535 ,  A61M5/31548 ,  A61M5/31561 ,  A61M5/347 ,  A61M5/348 ,  A61M2005/2407 ,  A61M2005/3104 ,  Y10T29/49826

摘要： A dose setting mechanism of a drug delivery device and a respective method of assembling said dose setting mechanism. The dose setting mechanism includes an inner housing having a helical groove along an external surface of the housing. The inner housing includes a rotational stop member near one end of the helical groove. The dose setting mechanism also includes a dial sleeve rotatably engaged with the helical groove of the inner housing. When a user rotates the dial sleeve to select a dose, the rotational stop member prevents the user from selecting a dose greater than a pre-defined maximum selectable dose.

摘要翻译： 药物输送装置的剂量设定机构和组装所述剂量设定机构的各自的方法。 剂量设定机构包括沿壳体的外表面具有螺旋槽的内壳体。 内壳体包括在螺旋槽的一端附近的旋转止动构件。 剂量设定机构还包括与内壳的螺旋槽可旋转地接合的表盘。 当用户旋转拨盘套筒以选择剂量时，旋转止动构件防止使用者选择大于预定义的最大可选择剂量的剂量。

公开(公告)号：US20120160047A1

公开(公告)日：2012-06-28

申请号：US13375199

申请日：2010-05-28

申请人： David Plumptre

发明人： David Plumptre

IPC分类号： F16H55/02 ,  F16H55/08

CPC分类号： A61M5/31511 ,  A61M5/24 ,  A61M5/31541 ,  A61M5/31543 ,  A61M5/31551 ,  A61M5/31558 ,  A61M5/31575 ,  A61M5/31585 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/2492 ,  A61M2005/3152 ,  Y10T74/19721 ,  Y10T74/19953

摘要： A spindle (242; 414; 542; 642) for driving a bung of a cartridge is provided. The spindle includes a generally circular shaft having an outer surface (560). The generally circular shaft extends from a distal end to a proximal end of said circular shaft. A first helical groove (219; 519; 619) is provided along a first portion of the outer surface. The first helical groove having a first pitch. A second helical groove (221; 521; 621) provided along a second portion of the outer surface of the generally circular shaft. The second helical groove overlapping the first helical groove. The second helical groove having a second pitch.

摘要翻译： 提供了一种用于驱动盒的塞子的主轴（242; 414; 542; 642）。 主轴包括具有外表面（560）的大致圆形的轴。 大致圆形的轴从所述圆形轴的远端延伸到近端。 第一螺旋槽（219; 519; 619）沿着外表面的​​第一部分设置。 第一螺旋槽具有第一间距。 沿着大致圆形轴的外表面的第二部分设置的第二螺旋槽（221; 521; 621）。 第二螺旋槽与第一螺旋槽重叠。 第二螺旋槽具有第二间距。

公开(公告)号：US20120046643A1

公开(公告)日：2012-02-23

申请号：US13140131

申请日：2009-12-18

申请人： David Plumptre ,  Christopher James Smith

发明人： David Plumptre ,  Christopher James Smith

IPC分类号： A61M5/31

CPC分类号： A61M5/31585 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31558 ,  A61M5/3156 ,  A61M2005/3152 ,  A61M2205/581 ,  A61M2205/582

摘要： An injection device (1) for administering a fixed dose of a medication is provided. The injection device (1) comprises a housing (2) wherein a drive mechanism comprising a drive member (3) is at least partially enclosed and a dosing element (34) which is fixed relative to the drive member (3). Here, a dose can be set by rotating the dosing element (34) relative to the housing (2) in a dose setting direction (s) and the dose can be dispensed by pushing the dosing element (34) towards the housing (2). Moreover, a method is provided for operating an injection device (1) for the administration of a fixed dose of a medication: A dose can be set by rotating a dosing element (34), a dose can be dispensed by pushing the dosing element (34) towards the housing (2) and a dose can be cancelled by rotating the dosing element (34) in a direction opposite to the dose setting direction (s).

摘要翻译： 提供了一种用于施用固定剂量的药物的注射装置（1）。 注射装置（1）包括壳体（2），其中包括驱动构件（3）的驱动机构至少部分地封闭，并且相对于驱动构件（3）固定的计量元件（34）。 这里，可以通过以剂量设定方向相对于壳体（2）旋转计量元件（34）来设定剂量，并且可以通过朝向壳体（2）推动剂量元件（34）来分配剂量， 。 此外，提供了一种用于操作用于施用固定剂量的药物的注射装置（1）的方法：剂量可以通过旋转剂量元件（34）来设定，剂量可以通过推动剂量元件（ 34）朝向壳体（2），并且可以通过沿与剂量设定方向相反的方向旋转定量配料元件（34）来消除剂量。

公开(公告)号：US20060144259A1

公开(公告)日：2006-07-06

申请号：US11220190

申请日：2005-09-01

申请人： David Plumptre

发明人： David Plumptre

IPC分类号： B21J13/02

CPC分类号： B30B9/3071 ,  B29B17/0052 ,  B29B2017/0057 ,  B29B2017/0068 ,  B30B9/321 ,  Y02W30/62 ,  Y10S100/902

摘要： An apparatus for crushing containers, comprising a die defining an opening, a punch, and means for displacing the die and punch relative to each other. The punch may be fixed and the die may be moved from a first position spaced apart from the punch such that a container to be crushed can be placed between the punch and die and a second position in which the punch extends into the die opening to define an annular gap between the punch and die opening. The arrangement is such that a container crushed between the die and punch as a result of displacement of the die to the second position is at least in part forced into and deformed within the annular gap.

摘要翻译： 一种用于破碎容器的装置，包括限定开口的模具，冲头以及用于相对于彼此移动模具和冲头的装置。 冲头可以是固定的，并且模具可以从与冲头隔开的第一位置移动，使得要被压碎的容器可以被放置在冲头和模具之间，并且第二位置中冲头延伸到模具开口中以限定 冲头和模具开口之间的环形间隙。 这种布置使得由于模具移动到第二位置的结果，在模具和冲头之间被压碎的容器至少部分地被迫进入并在环形间隙内变形。

公开(公告)号：US09974905B2

公开(公告)日：2018-05-22

申请号：US13879112

申请日：2011-10-11

申请人： Joseph Butler ,  David Plumptre

发明人： Joseph Butler ,  David Plumptre

IPC分类号： A61M5/315 ,  A61M5/24 ,  A61M5/32 ,  A61M5/34

CPC分类号： A61M5/31501 ,  A61M5/24 ,  A61M5/31525 ,  A61M5/31535 ,  A61M5/31551 ,  A61M5/31561 ,  A61M5/31563 ,  A61M5/3158 ,  A61M5/31581 ,  A61M5/3202 ,  A61M5/347 ,  A61M5/348 ,  A61M2005/31508 ,  A61M2005/3151 ,  A61M2005/3215

摘要： The present invention relates to a dose setting mechanism for a drug delivery device and a method of using same. The mechanism comprises a housing, a mechanism member movable in a first axial direction relative to the housing during dose setting and movable in a second, opposite axial direction relative to the housing during injection, wherein the mechanism member is designed and arranged such that the mechanism member is able to change its condition between a first condition preventing movement in the second axial direction and a second condition allowing movement in the second axial direction, and a switching member forcing the mechanism member to change from its second condition into its first condition at a predefined position of the movement in the first axial direction during dose setting.

公开(公告)号：US09835279B2

公开(公告)日：2017-12-05

申请号：US13522491

申请日：2011-01-21

申请人： David Plumptre ,  Christopher Nigel Langley ,  Richard James Vincent Avery ,  Joseph Butler

发明人： David Plumptre ,  Christopher Nigel Langley ,  Richard James Vincent Avery ,  Joseph Butler

IPC分类号： A61M5/24 ,  F16L55/00 ,  A61M5/31

CPC分类号： F16L55/00 ,  A61M5/24 ,  A61M5/3135 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/2492 ,  A61M2205/276 ,  A61M2205/6045 ,  Y10T137/598

摘要： A coded cartridge holder for use with a drug delivery device is provided. The cartridge holder includes a fastener that becomes operative based in part on a length of a cartridge or a diameter of the cartridge. In one embodiment, the cartridge holder is coupled to the drug delivery device. The cartridge holder comprises a first blocking feature. The drug delivery device includes a cartridge detector comprising a second blocking feature. This feature may be a pin, for engagement with the first blocking feature of the cartridge holder when the cartridge acts on the cartridge detector. The cartridge holder may further include a fastening mechanism configured to fasten the cartridge holder to the drug delivery device only when the second blocking feature engages the first blocking feature.

公开(公告)号：US09687613B2

公开(公告)日：2017-06-27

申请号：US13454784

申请日：2012-04-24

申请人： David Plumptre ,  Christopher Jones

发明人： David Plumptre ,  Christopher Jones

IPC分类号： A61M5/315 ,  A61M5/24

CPC分类号： A61M5/31543 ,  A61M5/31511 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31558 ,  A61M5/31575 ,  A61M5/31585 ,  A61M2005/2407 ,  A61M2005/2488 ,  A61M2005/2492 ,  A61M2005/3152

摘要： A resettable dose setting mechanism for a drug delivery device comprising a driver for driving a spindle of the drug delivery device is provided. Said driver comprises a first component and a second component rotationally coupled to said first component. During resetting of said drug delivery device, said first component is rotationally decoupled from said second component.

公开(公告)号：US09199040B2

公开(公告)日：2015-12-01

申请号：US12788658

申请日：2010-05-27

申请人： David Plumptre

发明人： David Plumptre

IPC分类号： A61M5/00 ,  A61M5/315

CPC分类号： A61M5/31551 ,  A61M5/31511 ,  A61M5/31541

摘要： A method and system for limiting a maximum dose that may be set in a drug delivery device. A dose setting mechanism, which is operable to be coupled to a medication cartridge, comprises a lock-out mechanism that prevents one from setting a dose greater than the medication in the cartridge. The lock-out mechanism comprises a rotatable shaft. A helical groove having a first pitch is provided along a first portion of the rotatable shaft and a second pitch provided along a second portion of the rotatable shaft. The first pitch is different from the second pitch. A third pitch may be provided on a third portion of the shaft. This third pitch is provided at the end of the second pitch and is preferably different than the second pitch. The lock-out mechanism further comprises a non-rotating member disposed on the helical groove of said shaft. During dose setting, the shaft is rotated relative to the non-rotating member while the non-rotating member traverses along the groove from a proximal end of the shaft towards a distal end of the shaft.

摘要翻译： 用于限制药物递送装置中可设定的最大剂量的方法和系统。 可操作以联接到药物盒的剂量设定机构包括一个锁定机构，其阻止一个剂量大于药筒中药物的剂量。 锁定机构包括可旋转的轴。 沿着可旋转轴的第一部分设置具有第一间距的螺旋槽，并且沿着可旋转轴的第二部分设置第二间距。 第一音调与第二音高不同。 可以在轴的第三部分上设置第三间距。 该第三间距设置在第二间距的末端，优选地与第二间距不同。 锁定机构还包括设置在所述轴的螺旋槽上的非旋转构件。 在剂量设定期间，轴相对于非旋转构件旋转，而非旋转构件沿着凹槽从轴的近端朝向轴的远端横移。

公开(公告)号：US09101721B2

公开(公告)日：2015-08-11

申请号：US13878555

申请日：2011-10-11

申请人： Joseph Butler ,  David Plumptre

发明人： Joseph Butler ,  David Plumptre

IPC分类号： A61M5/315 ,  A61M5/31

CPC分类号： A61M5/31535 ,  A61M5/3146 ,  A61M5/31525 ,  A61M5/31551 ,  A61M5/31585 ,  A61M2005/3126

摘要： A method and system for preventing delivery of less than a predetermined minimum dose of a medicament by providing a dose setting mechanism having a spindle nut and a sprung lock nut. The mechanism includes a housing and a dose dial component positioned in the housing. The dose dial component is rotatable during a dose setting step. The mechanism further includes a drive sleeve positioned within the dose dial component. The drive sleeve is configured to drive a rotatable spindle during a dose administration step. The spindle nut is coupled to the spindle and the sprung lock nut is removably coupled to the drive sleeve and rotationally fixed to the housing. In one arrangement, when the dose dial component is rotated to select a dose less than a preselected minimum dose, the sprung lock nut allows the spindle nut to rotate thereby preventing the dose from being administered.

摘要翻译： 一种用于通过提供具有心轴螺母和弹簧锁定螺母的剂量设定机构来防止小于预定最小剂量的药物的递送的方法和系统。 该机构包括定位在壳体中的壳体和剂量拨号部件。 在剂量设定步骤期间，剂量拨号组件可旋转。 该机构还包括位于剂量拨号部件内的驱动套筒。 驱动套筒构造成在剂量给药步骤期间驱动可旋转的主轴。 主轴螺母联接到主轴，弹簧锁定螺母可拆卸地联接到驱动套筒并旋转地固定到壳体。 在一种布置中，当剂量拨号组件旋转以选择小于预选的最小剂量的剂量时，弹簧锁定螺母允许主轴螺母旋转，从而防止施用该剂量。

公开(公告)号：US08945069B2

公开(公告)日：2015-02-03

申请号：US13140131

申请日：2009-12-18

申请人： David Plumptre ,  Christopher James Smith

发明人： David Plumptre ,  Christopher James Smith

IPC分类号： A61M5/00 ,  A61M5/315

CPC分类号： A61M5/31585 ,  A61M5/31541 ,  A61M5/31551 ,  A61M5/31558 ,  A61M5/3156 ,  A61M2005/3152 ,  A61M2205/581 ,  A61M2205/582

摘要： An injection device (1) for administering a fixed dose of a medication is provided. The injection device (1) comprises a housing (2) wherein a drive mechanism comprising a drive member (3) is at least partially enclosed and a dosing element (34) which is fixed relative to the drive member (3). Here, a dose can be set by rotating the dosing element (34) relative to the housing (2) in a dose setting direction (s) and the dose can be dispensed by pushing the dosing element (34) towards the housing (2). Moreover, a method is provided for operating an injection device (1) for the administration of a fixed dose of a medication: A dose can be set by rotating a dosing element (34), a dose can be dispensed by pushing the dosing element (34) towards the housing (2) and a dose can be cancelled by rotating the dosing element (34) in a direction opposite to the dose setting direction (s).

摘要翻译： 提供了一种用于施用固定剂量的药物的注射装置（1）。 注射装置（1）包括壳体（2），其中包括驱动构件（3）的驱动机构至少部分地封闭，并且相对于驱动构件（3）固定的计量元件（34）。 这里，可以通过以剂量设定方向相对于壳体（2）旋转计量元件（34）来设定剂量，并且可以通过朝向壳体（2）推动剂量元件（34）来分配剂量， 。 此外，提供了一种用于操作用于施用固定剂量的药物的注射装置（1）的方法：剂量可以通过旋转剂量元件（34）来设定，剂量可以通过推动剂量元件（ 34）朝向壳体（2），并且可以通过沿与剂量设定方向相反的方向旋转定量配料元件（34）来消除剂量。