摘要:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia Formula (I).
摘要:
A portable energy generation and humidity control system includes an engine and a humidity control system within a portable frame. The engine includes two containers in communication through a connecting arm having a central hollow bore. A volume of a low boiling point liquid is disposed in the bottom container, and a wire coil extends along the connecting arm. A buoyant permanent magnet is disposed in the central hollow bore. An active heat exchanger is capable of transferring heat to and removing heat from the bottom container. The active heat exchanger includes at least one internal heat exchanger portion and at least one external heat exchanger portion in communication with the internal heat exchanger portion. A humidity control system is supported within the portable frame and is in communication with the engine. The humidity control system and the engine maintain a desired humidity level in the ambient environment.
摘要:
A custom-fitted handgun holster is made using a sleeve of heat-shrinkable polymeric material which has been size-reduced by heating into conformity with at least a portion of a particular handgun. The sleeve may be attached to a holder and decoratively covered if desired.
摘要:
The present invention is directed to methods of preparing a conjugate of a cell-binding agent and a drug (such as a cytotoxic compound). The methods comprise the use of an imine reactive compound to enable efficient conjugations of cytotoxic compounds with cell binding agents.
摘要:
The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK-2 kinase is involved.
摘要:
Substituted cyclopropyl compounds of the formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the G-protein coupled receptor GPR-119. Pharmaceutical compositions and methods of treatment are also included.
摘要:
A seatback-motion controller in accordance with the present disclosure is mounted on a vehicle seat in a vehicle. The vehicle seat includes a seat base and a seat back mounted for pivotable movement relative to the seat base between an upright use position and a forward-leaning easy-entry position.
摘要:
A resistive switching memory element including a doped silicon electrode is described, including a first electrode comprising doped silicon having a first work function, a second electrode having a second work function that is different from the first work function by between 0.1 and 1.0 electron volts (eV), a metal oxide layer between the first electrode and the second electrode, the metal oxide layer switches using bulk-mediated switching and has a bandgap of greater than 4 eV, and the memory element switches from a low resistance state to a high resistance state and vice versa.
摘要:
A method and system for deploying content to devices is provided. The method and system can be used to deploy markup content to web browser applications on wireless devices. The wireless devices may included, for example, WAP phones, HDML phones, Palm VII, Palm V, etc. The method and system can also be used in conjunction with wired systems. A translator receives data, in a variety of formats, from the wireless devices. The translator then translates the data into a standardized format. A content provider interface receives the data in the standardized format and provides content data, also in the standardized format. The content data in the standardized format is provided to a transformer. The transformer transforms the content data into the pre-selected format for the particular wireless device. The content data can then be utilized and manipulated by the wireless device.
摘要:
It is an object of the invention to provide a VCSEL having both a high beam quality or a low M2-factor, respectively, and a reduced mirror thickness which improves the heat dissipation due to the reduced thickness and the production cost. It is suggested to employ a Bragg-reflector in combination with a metal reflector terminating the distal side of the Bragg-reflector as seen from the laser cavity, wherein the metal reflector layer is localized at the center around the optical axis.