利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

205 条记录 (耗时 0.044 秒)

    Process for the sulfinylation of a pyrazole derivative
    83.
    发明授权
    Process for the sulfinylation of a pyrazole derivative 有权
    吡唑衍生物亚硫酰化的方法

    公开(公告)号：US08263783B2

    公开(公告)日：2012-09-11

    申请号：US12514098

    申请日：2007-11-05

    申请人： Martin Sukopp ,  Oliver Kuhn ,  Carsten Gröning ,  Michael Keil ,  Jon J. Longlet

    发明人： Martin Sukopp ,  Oliver Kuhn ,  Carsten Gröning ,  Michael Keil ,  Jon J. Longlet

    IPC分类号： C07D231/18

    CPC分类号： C07D231/44

    摘要： The present invention relates to a process for the sulfinylation of a pyrazole derivative, characterized in that 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonitrile (II) is reacted with a sulfinylating agent selected from trifluoromethylsulfinic acid, trifluoromethylsulfinic acid anhydride, and a trifluoromethylsulfinate alkaline or alkaline earth metal salt and mixtures of the acid and/or the salt(s), in the presence of at least one amine acid complex wherein the amine(s) are selected from tertiary amines and the acid(s) are selected from hydrofluoric, hydrochloric, hydrobromic and hydroiodic acid and sulfonic acid derivatives, and with the addition of a halogenating agent.

    摘要翻译： 本发明涉及吡唑衍生物亚硫酰化的方法，其特征在于5-氨基-1- [2,6-二氯-4-（三氟甲基）苯基] -1H-吡唑-3-甲腈（II）是 与选自三氟甲基亚磺酸，三氟甲基亚磺酸酐和三氟甲基亚硫酸盐碱金属或碱土金属盐的亚磺酰化剂以及酸和/或盐的混合物在至少一种胺酸络合物的存在下反应，其中胺 选自叔胺，酸选自氢氟酸，盐酸，氢溴酸和氢碘酸以及磺酸衍生物，并加入卤化剂。

    LANCET DEVICE WITH OPTIONALLY REUSABLE LANCETS STORED IN A MAGAZINE
    84.
    发明申请
    LANCET DEVICE WITH OPTIONALLY REUSABLE LANCETS STORED IN A MAGAZINE 有权
    具有存储在杂志中的可选择的可重复使用的LANCET设备

    公开(公告)号：US20120143235A1

    公开(公告)日：2012-06-07

    申请号：US13308141

    申请日：2011-11-30

    申请人： Hans-Juergen Kuhr ,  Michael Keil ,  Hans List

    发明人： Hans-Juergen Kuhr ,  Michael Keil ,  Hans List

    IPC分类号： A61B17/32

    CPC分类号： A61B5/15146 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150412 ,  A61B5/150503 ,  A61B5/15113 ,  A61B5/15117 ,  A61B5/15163

    摘要： An inventive lancet device for producing a puncture wound, in particular for collecting a sample of a body fluid which has a magazine holder for a lancet magazine containing a plurality of lancets. The lancet device can be alternatively operated such that either a new lancet is used for each puncture process by automatically advancing the lancet magazine stepwise or the automatic stepwise advance of the lancet magazine can be suppressed or deactivated so that, if desired, several punctures can be carried out with the last used lancet before an unused lancet is used at a desired time.

    摘要翻译： 一种本发明的刺血针装置，用于产生穿刺伤口，特别是用于收集体液样品，该体液具有用于包含多个刺血针的柳叶刀匣的药筒保持器。 柳叶刀装置可选择地操作，使得通过逐步自动推进柳叶刀刀库来使每个穿刺过程使用新的刺血针，或者可以抑制或去激活柳叶刀刀库的自动逐步前进，使得如果需要，可以进行若干穿刺 在所需时间使用未使用的柳叶刀之前，用最后使用的柳叶刀进行。

    Analysis system for determining an analyte in a body fluid and disposable integrated sample acquisition and analysis element
    85.
    发明授权
    Analysis system for determining an analyte in a body fluid and disposable integrated sample acquisition and analysis element 有权
    用于确定体液中的分析物和一次性综合样品采集和分析元件的分析系统

    公开(公告)号：US08114028B2

    公开(公告)日：2012-02-14

    申请号：US12548479

    申请日：2009-08-27

    申请人： Hans List ,  Volker Zimmer ,  Michael Keil

    发明人： Hans List ,  Volker Zimmer ,  Michael Keil

    IPC分类号： A61B5/00

    CPC分类号： A61B5/157 ,  A61B5/150022 ,  A61B5/150175 ,  A61B5/150358 ,  A61B5/150435 ,  A61B5/150511 ,  A61B5/150572 ,  A61B5/15186 ,  A61B2562/0295

    摘要： An analyte determination analysis system with a disposable integrated sample acquisition and analysis element is disclosed. A piercing element has a tip for generating a bodily puncture wound and a test strip having a body fluid sample receiving zone to perform an analysis on a body fluid sample. A reusable analysis instrument comprises a coupling unit that couples the integrated sample acquisition and analysis element to a drive that drives a piercing element in a piercing movement comprising two phases: a propulsion phase wherein the piercing element moves on a puncture path in a puncture direction and a retraction phase wherein the piercing element moves opposite to the puncture direction after reaching a reversal point. A measuring and analysis unit measures a variable characteristic for the determination of the analyte and determines a desired analysis result on the basis of the measurement. The sample receiving zone of the test strip forms a sample contact. The piercing element, located parallel to the test strip, moves on a movement path relative to the test strip a puncture path. The piercing element, located adjacent to the sample contact, has a capillary channel with a sample inlet for body fluid entry after the piercing and a sample outlet for body fluid exit. The piercing element movement has a sample transfer position wherein the sample outlet is adjacent to the sample receiving zone such that the body fluid may be transferred from the capillary channel through the sample outlet to the sample receiving zone.

    摘要翻译： 公开了一种具有一次性集成样品采集和分析元件的分析物测定分析系统。 穿刺元件具有用于产生身体穿刺伤口的尖端和具有体液样品接收区以对体液样品进行分析的测试条。 一种可重复使用的分析仪器包括耦合单元，该耦合单元将集成采样和分析元件耦合到驱动器，该驱动器以穿刺运动的方式驱动穿刺元件，所述穿孔运动包括两相：推进阶段，其中穿刺元件在穿刺方向上在穿刺路径上移动， 其中穿刺元件在达到反转点之后与穿刺方向相反移动。 测量和分析单元测量用于测定分析物的可变特性，并且基于测量确定期望的分析结果。 测试条的样品接收区形成样品接触。 刺穿元件平行于测试条移动，相对于测试条在穿刺路径上移动。 位于邻近样品接触处的刺穿元件具有毛细通道，其具有用于在穿刺之后进入体液的样品入口和用于体液排出的样品出口。 穿刺元件移动具有样品转移位置，其中样品出口与样品接收区相邻，使得体液可以从毛细通道通过样品出口转移到样品接收区。

    REUSE PROTECTION FOR LANCET SYSTEM
    86.
    发明申请
    REUSE PROTECTION FOR LANCET SYSTEM 有权
    重新保护LANCET系统

    公开(公告)号：US20120035639A1

    公开(公告)日：2012-02-09

    申请号：US13210795

    申请日：2011-08-16

    申请人： Richard Forster ,  Susanne Gentsch ,  Andreas Gorshoefer ,  Michael Keil ,  Thomas Weiss

    发明人： Richard Forster ,  Susanne Gentsch ,  Andreas Gorshoefer ,  Michael Keil ,  Thomas Weiss

    IPC分类号： A61B5/151

    CPC分类号： A61B5/15153 ,  A61B5/1411 ,  A61B5/150022 ,  A61B5/150412 ,  A61B5/150519 ,  A61B5/150572 ,  A61B5/150824 ,  A61B5/15115 ,  A61B5/15163 ,  A61B5/15176 ,  A61B5/1518

    摘要： A lancet magazine for use in a lancing aid is described comprising a plurality of lancets each having a lancet body at the proximal end of the lancet and a lancet tip at the distal end of the lancet, where the proximal end of the lancet points in the direction of the proximal end of the housing of the lancet magazine and the distal end of the lancet is aligned in the direction of the distal end of the housing and the lancets in the unused state are completely surrounded by the housing. Furthermore, an extension unit is movably connected to the housing in such a manner that the housing can be extended by movement of the extension unit in the direction of the distal end of the housing such that the lancet is prevented from emerging from the lancet magazine.

    摘要翻译： 一种用于穿刺辅助装置的柳叶刀盒，其特征在于，包括多个在柳叶刀的近端具有刺血针主体的柳叶刀和位于柳叶刀前端的刺血针头，其中， 柳叶刀盒的壳体的近端的方向和柳叶刀的前端在壳体的远端的方向上对准，未使用状态的刺血针被壳体完全包围。 此外，延伸单元以这样的方式可移动地连接到壳体，使得可以通过延伸单元在壳体的远端的方向上的移动来延伸壳体，使得防止柳叶刀从刺血针盒中出来。

    Method for the production of benzophenonen
    88.
    发明申请
    Method for the production of benzophenonen 有权
    二苯甲酮生产方法

    公开(公告)号：US20060009659A1

    公开(公告)日：2006-01-12

    申请号：US10535710

    申请日：2003-12-01

    申请人： Volker Maywald ,  Nico Hoffmann ,  Michael Keil ,  Uwe Vogelbacher ,  Jan Wevers

    发明人： Volker Maywald ,  Nico Hoffmann ,  Michael Keil ,  Uwe Vogelbacher ,  Jan Wevers

    IPC分类号： C07C45/46

    CPC分类号： C07C51/363 ,  C07C45/46 ,  C07C45/81 ,  C07C51/60 ,  C07C49/84 ,  C07C65/21

    摘要： A process for preparing benzophenones of the formula I, where X may be chlorine, hydroxyl, methoxy or C1-C6-alkylcarbonyloxy, and Y may be chlorine or bromine, by reacting an acid chloride of the formula II where X and Y are as defined above with 3,4,5-trimethoxytoluene, which comprises carrying out the reaction in the presence of a) an aromatic hydrocarbon as a diluent and b) from 0.01 to 0.2 mol % of an iron catalyst, based on the acid chloride, c) at a temperature between 60° C. and the boiling point of the particular diluent.

    摘要翻译： 制备式I的二苯甲酮的方法，其中X可以是氯，羟基，甲氧基或C 1 -C 6 - 烷基羰氧基，Y可以是氯或溴， 通过使式II的酰氯与其中X和Y如上所定义的酰氯与3,4,5-三甲氧基甲苯反应，其包括在a）芳族烃作为稀释剂存在下进行反应，和b）从0.01至 0.2mol％的铁催化剂，基于酰氯，c）在60℃和特定稀释剂的沸点之间的温度下。

    Process for the preparation of O-substituted hydroxylammonium salts
    89.
    发明授权
    Process for the preparation of O-substituted hydroxylammonium salts 失效
    制备O-取代羟基铵盐的方法

    公开(公告)号：US5585520A

    公开(公告)日：1996-12-17

    申请号：US592351

    申请日：1996-01-11

    申请人： Ulrich Klein ,  Ernst Buschmann ,  Michael Keil ,  Norbert G otz ,  Albrecht Harreus

    发明人： Ulrich Klein ,  Ernst Buschmann ,  Michael Keil ,  Norbert G otz ,  Albrecht Harreus

    IPC分类号： C07C239/20 ,  C07C213/00

    CPC分类号： C07C239/20

    摘要： Preparation of O-substituted hydroxylammonium salts IR.sup.1 --CHX--O--NH.sub.2.HL (I)(L=halogen, hydrogensulfate; X=H, alkyl; R.sup.1 =unsubst. or subst. phenyl, thienyl, furanyl, pyrrolyl or --CR.sup.2 .dbd.CR.sup.3 R.sup.4 ; R.sup.2, R.sup.3, R.sup.4 =H, halogen or alkyl) by reaction of an acetone oxime O-allyl or --O--benzyl ether II ##STR1## with water and a mineral acid H--L with continuous removal of the acetone formed in this process, by carrying out the hydrolysis batchwise at 0.degree.-50.degree. C. and under a pressure of 10-500 mbar is described.The O-substituted hydroxylammonium salts I are intermediates for plant protection agents and pharmaceuticals.

    摘要翻译： PCT No.PCT / EP94 / 02239 Sec。 371日期1996年1月11日 102（e）日期1996年1月11日PCT提交1994年7月8日PCT公布。 第WO95 / 04032号公报。 日期：1995年2月9日O-取代羟基铵盐IR1-CHX-O-NH2HL（I）（L =卤素，硫酸氢盐; X = H，烷基; R1 =未取代的苯基，噻吩基，呋喃基， 吡咯基或-CR2 = CR3R4; R2，R3，R4 = H，卤素或烷基），通过丙酮肟O-烯丙基或-O-苄基醚II（II）与水和无机酸HL与连续 描述了在该方法中形成的丙酮的去除方法，在0-50℃和10-500mbar的压力下间歇地进行水解。 O-取代的羟基铵盐I是植物保护剂和药物的中间体。