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154 条记录 (耗时 0.047 秒)

    Regulator of gene transcription
    81.
    发明授权
    Regulator of gene transcription 失效
    基因转录调节子

    公开(公告)号：US5965706A

    公开(公告)日：1999-10-12

    申请号：US66262

    申请日：1998-04-24

    申请人： Jennifer L. Hillman ,  Surya K. Goli ,  David G. Streeter

    发明人： Jennifer L. Hillman ,  Surya K. Goli ,  David G. Streeter

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N15/12 ,  C07K5/00

    CPC分类号： C07K14/4702 ,  A61K38/00

    摘要： The present invention provides a human regulator of gene transcription (HRGT) and polynucleotides which encode HRGT. The invention also provides expression vectors, host cells, agonists, antisense molecules, antibodies, or antagonists. The invention also provides methods for treating disorders associated with expression of HRGT.

    摘要翻译： 本发明提供编码HRGT的人基因转录调节子（HRGT）和多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，反义分子，抗体或拮抗剂。 本发明还提供了治疗与HRGT表达相关的疾病的方法。

    Human clathrin-associated protein
    83.
    发明授权
    Human clathrin-associated protein 失效
    人网格蛋白相关蛋白

    公开(公告)号：US5922565A

    公开(公告)日：1999-07-13

    申请号：US806877

    申请日：1997-02-25

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C12Q1/68 ,  C12P21/06 ,  C07H21/04 ,  C12N1/20 ,  C12N15/00

    CPC分类号： C12Q1/6883 ,  C12Q2600/158

    摘要： The present invention provides a human clathrin-associated protein (HAP19) and polynucleotides which identify and encode HAP19. The invention also provides expression vectors and host cells and a method for producing HAP19. The invention also provides antibodies or antagonists specifically binding HAP19, and their use, in the prevention and treatment of diseases associated with expression of HAP19. The invention also provides diagnostic assays.

    摘要翻译： 本发明提供了人类网格蛋白相关蛋白（HAP19）和识别和编码HAP19的多核苷酸。 本发明还提供表达载体和宿主细胞以及生产HAP19的方法。 本发明还提供了特异性结合HAP19的抗体或拮抗剂及其在预防和治疗与HAP19表达相关的疾病中的用途。 本发明还提供诊断测定。

    Nucleic acids encoding novel regulators of G-protein signaling
    84.
    发明授权
    Nucleic acids encoding novel regulators of G-protein signaling 失效
    核酸编码G蛋白信号传导的新型调控因子

    公开(公告)号：US5882890A

    公开(公告)日：1999-03-16

    申请号：US829110

    申请日：1997-03-31

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N1/21 ,  C12N15/12

    CPC分类号： C07K14/4702 ,  A61K38/00

    摘要： The present invention provides two regulators of G-protein signaling (designated individually as RGPS-1 and RGPS-2, and collectively as RGPS) and polynucleotides which identify and encode RGPS. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention also provides methods for producing RGPS and for treating or preventing disorders associated with expression of RGPS.

    摘要翻译： 本发明提供了两种G蛋白信号调控因子（分别称为RGPS-1和RGPS-2，统称为RGPS）以及鉴定和编码RGPS的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 此外，本发明还提供了用于产生RGPS并用于治疗或预防与RGPS表达相关的疾病的方法。

    Human transmembrane 4 superfamily protein
    85.
    发明授权
    Human transmembrane 4 superfamily protein 失效
    人类跨膜4超家族蛋白

    公开(公告)号：US5863735A

    公开(公告)日：1999-01-26

    申请号：US807044

    申请日：1997-02-24

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P35/00 ,  A61P35/04 ,  C07K14/705 ,  C07K16/28 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/12 ,  C12Q1/68 ,  C07H21/04

    CPC分类号： C07K14/70596 ,  A61K38/00

    摘要： The present invention provides a novel human integral membrane (TMP-1) and polynucleotides which identify and encode TMP-1. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TMP-1 and a method for producing TMP-1. The invention also provides for agonists, antibodies, or antagonists specifically binding TMP-1, and their use, in the prevention and treatment of diseases associated with expression of TMP-1. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TMP-1 for the treatment of diseases associated with the expression of TMP-1. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TMP-1.

    摘要翻译： 本发明提供一种新型人体内膜（TMP-1）和识别和编码TMP-1的多核苷酸。 本发明还提供了包含编码TMP-1的核酸序列的基因工程表达载体和宿主细胞以及产生TMP-1的方法。 本发明还提供了特异性结合TMP-1的激动剂，抗体或拮抗剂及其在预防和治疗与TMP-1表达相关的疾病中的用途。 此外，本发明提供了将反义分子用于编码TMP-1的多核苷酸用于治疗与TMP-1表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合TMP-1的抗体的诊断测定法。

    Human mitochondrial membrane protein
    86.
    发明授权
    Human mitochondrial membrane protein 失效
    人线粒体膜蛋白

    公开(公告)号：US5854414A

    公开(公告)日：1998-12-29

    申请号：US812645

    申请日：1997-03-07

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C07K14/47 ,  C12N1/21 ,  C12N15/12 ,  C07H21/04 ,  C12N15/63

    CPC分类号： C07K14/47

    摘要： The present invention provides a human mitochondrial membrane protein (HuTIM17) and polynucleotides which identify and encode HuTIM17. The invention also provides expression vectors and host cells and a method for producing HuTIM17. The invention also provides for antibodies or antagonists specifically binding HuTIM17, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of HuTIM17 in identifying antifungal and antiprotozoal therapeutics.

    摘要翻译： 本发明提供了人线粒体膜蛋白（HuTIM17）和识别和编码HuTIM17的多核苷酸。 本发明还提供了表达载体和宿主细胞以及生产HuTIM17的方法。 本发明还提供了特异性结合HuTIM17的抗体或拮抗剂及其在预防和治疗癌症中的用途。 本发明还提供诊断测定。 本发明还提供了使用HuTIM17鉴定抗真菌和抗原虫治疗药物。

    Prostate-associated kallikrein
    87.
    发明授权
    Prostate-associated kallikrein 失效
    前列腺相关激肽释放酶

    公开(公告)号：US5840871A

    公开(公告)日：1998-11-24

    申请号：US790137

    申请日：1997-01-29

    申请人： Jennifer L. Hillman ,  Surya K. Goli

    发明人： Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C12N15/09 ,  A61K38/00 ,  A61K39/395 ,  A61K45/00 ,  A61P13/08 ,  A61P35/00 ,  C07K16/40 ,  C12N1/21 ,  C12N9/64 ,  C12N15/57 ,  C12P21/02 ,  C12Q1/68 ,  C07H21/04 ,  C12N15/00 ,  C12P21/06

    CPC分类号： C12N9/6445 ,  A61K38/00

    摘要： The present invention provides a human prostate-associated kallikrein (HPAK) and polynucleotides which identify and encode HPAK. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPAK and a method for producing HPAK. The invention also provides for antibodies or antagonists specifically binding HPAK, and their use, in the prevention and treatment of diseases associated with expression of HPAK. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPAK for the treatment of diseases associated with the expression of HPAK. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPAK.

    摘要翻译： 本发明提供了人前列腺相关的激肽释放酶（HPAK）和识别和编码HPAK的多核苷酸。 本发明还提供了遗传工程改造的表达载体和包含编码HPAK的核酸序列的宿主细胞和用于产生HPAK的方法。 本发明还提供了特异性结合HPAK的抗体或拮抗剂及其在预防和治疗与HPAK表达相关的疾病中的用途。 另外，本发明提供了反义分子用于编码HPAK的多核苷酸用于治疗与HPAK表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合HPAK的抗体的诊断测定法。