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公开(公告)号：US08298776B2
公开(公告)日：2012-10-30
申请号：US12829256
申请日：2010-07-01
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
IPC分类号： G01N33/53
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因024P4C12（也称为24P4C12）及其编码蛋白及其变体，其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断， 癌症的预后，预防和/或治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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82.发明授权Nucleic acids and corresponding proteins entitled 158P3D2 useful in treatment and detection of cancer 失效题为158P3D2的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US07811575B2
公开(公告)日：2010-10-12
申请号：US10994106
申请日：2004-11-19
申请人： Arthur B. Raitano , Aya Jakobovits , Pia M. Challita-Eid , Steven B. Kanner , Wangmao Ge , Juan J. Perez-Villar , Robert Kendall Morrison
发明人： Arthur B. Raitano , Aya Jakobovits , Pia M. Challita-Eid , Steven B. Kanner , Wangmao Ge , Juan J. Perez-Villar , Robert Kendall Morrison
IPC分类号： A61K39/00
CPC分类号： C07K14/4748 , A61K39/00 , C07K16/30
摘要： A novel gene 158P3D2 and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因158P3D2及其编码的蛋白及其变体，其中158P3D2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，158P3D2提供诊断，预后，预防和/ 或癌症的治疗靶标。 158P3D2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与158P3D2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20100204453A1
公开(公告)日：2010-08-12
申请号：US12694209
申请日：2010-01-26
申请人： Arthur B. RAITANO , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. RAITANO , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因024P4C12（也称为24P4C12）及其编码蛋白及其变体，其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断， 癌症的预后，预防和/或治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US08779111B2
公开(公告)日：2014-07-15
申请号：US13620170
申请日：2012-09-14
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因024P4C12（也称为24P4C12）及其编码蛋白及其变体，其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断， 癌症的预后，预防和/或治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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85.发明授权Nucleic acids and corresponding proteins entitled 158P3D2 useful in treatment and detection of cancer 失效题为158P3D2的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US08524872B2
公开(公告)日：2013-09-03
申请号：US13481637
申请日：2012-05-25
申请人： Arthur B. Raitano , Aya Jakobovits , Pia M. Challita-Eid , Steven B. Kanner , Wangmao Ge , Juan J. Perez-Villar , Robert Kendall Morrison
发明人： Arthur B. Raitano , Aya Jakobovits , Pia M. Challita-Eid , Steven B. Kanner , Wangmao Ge , Juan J. Perez-Villar , Robert Kendall Morrison
IPC分类号： C07K14/00
CPC分类号： C07K14/4748 , A61K39/00 , C07K16/30
摘要： A novel gene 158P3D2 and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因158P3D2及其编码的蛋白及其变体，其中158P3D2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，158P3D2提供诊断，预后，预防和/ 或癌症的治疗靶标。 158P3D2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与158P3D2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20130090376A1
公开(公告)日：2013-04-11
申请号：US13620170
申请日：2012-09-14
申请人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Karen Jane Meyrick Morrison , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A01K2217/05 , A01K2267/03 , A61K38/1709 , A61K48/00 , C07K14/705 , C12N2799/026 , C12N2799/027 , G01N33/57492
摘要： A novel gene 024P4C12 (also designated 24P4C12) and its encoded protein, and variants thereof, are described wherein 24P4C12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 24P4C12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 24P4C12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 24P4C12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因024P4C12（也称为24P4C12）及其编码蛋白及其变体，其中24P4C12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，24P4C12提供诊断， 癌症的预后，预防和/或治疗靶标。 24P4C12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与24P4C12反应的抗体或T细胞可用于主动或被动免疫。
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87.发明申请NUCLEIC ACIDS AND CORRESPONDING PROTEINS ENTITLED 58P1D12 USEFUL IN TREATMENT AND DETECTION OF CANCER 审中-公开核酸和对照蛋白58P1D12有效治疗和检测癌症公开(公告)号：US20110008393A1
公开(公告)日：2011-01-13
申请号：US12836449
申请日：2010-07-14
IPC分类号： A61K39/00 , C12N5/10 , C12N5/071 , C12N1/21 , C12N1/19 , C12N15/63 , C07K14/00 , C07K16/44 , C07H21/04 , A61P35/00
CPC分类号： C07K14/7056 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/30 , C07K2317/73 , C12N2799/026 , C12N2799/027 , C12Q1/6881 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/574 , G01N33/57434 , G01N2500/04
摘要： A novel gene 58P1D12 and its encoded protein, and variants thereof, are described wherein 58P1D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 58P1D12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 58P1D12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 58P1D12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因58P1D12及其编码的蛋白及其变体，其中58P1D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，58P1D12提供诊断，预后，预防和/ 或癌症的治疗靶标。 58P1D12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与58P1D12反应的抗体或T细胞可用于主动或被动免疫。
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88.发明授权Nucleic acids and corresponding proteins entitled 58P1D12 useful in treatment and detection of cancer 失效题为58P1D12的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US07842458B2
公开(公告)日：2010-11-30
申请号：US10919654
申请日：2004-08-16
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574 , C07H21/04 , C07K14/435
CPC分类号： C07K14/7056 , A01K2217/05 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K16/30 , C07K2317/73 , C12N2799/026 , C12N2799/027 , C12Q1/6881 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , G01N33/574 , G01N33/57434 , G01N2500/04
摘要： A novel gene 58P1D12 and its encoded protein, and variants thereof, are described wherein 58P1D12 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 58P1D12 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 58P1D12 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 58P1D12 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因58P1D12及其编码的蛋白及其变体，其中58P1D12在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，58P1D12提供诊断，预后，预防和/ 或癌症的治疗靶标。 58P1D12基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与58P1D12反应的抗体或T细胞可用于主动或被动免疫。
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89.发明授权公开(公告)号：US08853364B2
公开(公告)日：2014-10-07
申请号：US12561832
申请日：2009-09-17
IPC分类号： C07K16/00 , C12P21/08 , A61K39/00 , A61K51/10 , C07K16/30 , C07K14/705 , G01N33/574 , C07K14/47 , G01N33/566
CPC分类号： C07K14/4748 , A61K39/0011 , A61K51/1051 , A61K51/1054 , A61K51/1057 , A61K51/106 , A61K51/1072 , A61K2039/53 , C07K14/705 , C07K16/30 , C07K16/3069 , C07K2317/73 , G01N33/566 , G01N33/57415 , Y02A50/466
摘要： PSCA and its encoded protein, and variants thereof, are described wherein PSCA exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, PSCA provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The PSCA gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with PSCA can be used in active or passive immunization.
摘要翻译： 描述了PSCA及其编码的蛋白及其变体，其中PSCA在正常成人组织中显示组织特异性表达，并且在表I中列出的癌症中异常表达。因此，PSCA提供诊断，预后，预防和/或治疗靶标 为癌症。 PSCA基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与PSCA反应的抗体或T细胞可用于主动或被动免疫。
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90.发明授权公开(公告)号：US08460881B2
公开(公告)日：2013-06-11
申请号：US12405166
申请日：2009-03-16
申请人： Arthur B. Raitano , Aya Jakobovits , Pia M. Challita-Eid , Wangmao Ge , Juan J. Perez-Villar , Steven B. Kanner
发明人： Arthur B. Raitano , Aya Jakobovits , Pia M. Challita-Eid , Wangmao Ge , Juan J. Perez-Villar , Steven B. Kanner
IPC分类号： G01N33/53 , G01N33/567 , G01N33/574
CPC分类号： C07K14/47
摘要： A novel gene 254P1D6B and its encoded protein, and variants thereof, are described wherein 254P1D6B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 254P1D6B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 254P1D6B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 254P1D6B can be used in active or passive immunization.
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