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99 条记录 (耗时 0.041 秒)

    Pyrazine Derivatives for Bioconjugation
    81.
    发明申请
    Pyrazine Derivatives for Bioconjugation 有权
    吡嗪衍生物用于生物共轭

    公开(公告)号：US20120134930A1

    公开(公告)日：2012-05-31

    申请号：US13344930

    申请日：2012-01-06

    申请人： Raghavan Rajagopalan ,  Richard B. Dorshow

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow

    IPC分类号： A61K49/00 ,  C07D403/12 ,  C07K7/08 ,  C07D241/28

    CPC分类号： A61K41/0057 ,  A61K47/64 ,  A61K49/0021 ,  A61K49/0056 ,  C07D241/26 ,  C07D403/12

    摘要： Provided are compounds and compositions of general Formula IX: E1-L-Ar-X-PA, that may be utilized in bioconjugation procedures, where Ar is a chromophore and PA is a functional group capable of being attached to any bioactive molecule of interest. The present invention provides Formulas I-III that are capable of being attached to a bioactive vector for the selective delivery of said photoactive pyrazine derivatives to a desired biological target.

    摘要翻译： 提供通式IX的化合物和组合物：E1-L-Ar-X-PA，其可用于生物缀合方法，其中Ar是发色团，PA是能够连接到任何目的生物活性分子的官能团。 本发明提供能够连接到生物活性载体上的式I-III，用于将所述光活性吡嗪衍生物选择性递送到期望的生物靶。

    Receptor-avid exogenous optical contrast and therapeutic agents
    83.
    发明授权
    Receptor-avid exogenous optical contrast and therapeutic agents 有权
    受体 - 狂热的外源性光学对比和治疗剂

    公开(公告)号：US07790144B2

    公开(公告)日：2010-09-07

    申请号：US10800531

    申请日：2004-03-15

    申请人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph Bugaj ,  Muthunadar P. Periasamy

    发明人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph Bugaj ,  Muthunadar P. Periasamy

    IPC分类号： A61B5/00 ,  A61B10/00

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056 ,  C07D209/12 ,  C07D405/14 ,  C09B23/0066 ,  C09B23/0075 ,  C09B23/08 ,  C09B23/086

    摘要： Cyanine dye bioconjugates useful for diagnostic imaging and therapy are disclosed. The conjugates include several cyanine dyes with a variety of bis- and tetrakis (carboxylic acid) homologes. The compounds are be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of the compounds allows more favorable delivery to tumor cells as compared to larger molecular weight imaging agents. The various dyes are useful over the range of 350 to 1,300 nm, the exact range being dependent upon the particular dye. The use of a biocompatible organic solvent such as dimethylsulfoxide helps to maintain the fluorescence of the compounds. The inventive compounds are useful for diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 公开了可用于诊断成像和治疗的花青染料生物缀合物。 缀合物包括几种具有多种双和四（羧酸）同系物的花青染料。 化合物与生物活性肽，碳水化合物，激素，药物或其他生物活性剂缀合。 与较大的分子量成像剂相比，化合物的小尺寸允许更有利于肿瘤细胞的递送。 各种染料在350至1,300nm的范围内是有用的，精确的范围取决于特定的染料。 使用生物相容性有机溶剂如二甲基亚砜有助于维持化合物的荧光。 本发明化合物可用于诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗。

    Pyrazine Derivatives and Uses Thereof in Renal Monitoring
    85.
    发明申请
    Pyrazine Derivatives and Uses Thereof in Renal Monitoring 有权
    吡嗪衍生物及其在肾脏监测中的应用

    公开(公告)号：US20090198053A1

    公开(公告)日：2009-08-06

    申请号：US11995223

    申请日：2007-06-20

    申请人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann

    发明人： Raghavan Rajagopalan ,  Richard B. Dorshow ,  William L. Neumann

    IPC分类号： C07D413/02 ,  C07D241/10

    CPC分类号： A61K31/4965 ,  A61K31/5377 ,  A61K49/0021 ,  A61K49/0052 ,  A61K49/0054 ,  C07D241/26

    摘要： The present invention relates to pyrazine derivatives such as those represented by Formulas (I) and (II) below. X1 to X4 of the compounds of Formulas I and II may be characterized as electron withdrawing groups. In contrast, Y1 to Y4 of the compounds of Formulas I and II may be characterized as electron donating groups. Pyrazine derivatives of the present invention may be utilized in assessing renal function. In particular, an effective amount of a pyrazine derivative of the invention may be administered into a body of a patient. The pyrazine derivative that is in the body may be exposed to visible and/or infrared light to cause spectral energy to emanate from the pyrazine derivative. This emanating spectral energy may be detected and utilized to determine renal function of the patient.

    摘要翻译： 本发明涉及吡嗪衍生物，例如由下式（I）和（II）表示的衍生物。 式I和II化合物的X 1至X 4可以表征为吸电子基团。 相反，式I和II化合物的Y1至Y4可以表征为给电子基团。 本发明的吡嗪衍生物可用于评估肾功能。 特别地，有效量的本发明的吡嗪衍生物可以施用于患者体内。 身体中的吡嗪衍生物可能暴露于可见光和/或红外光，导致光谱能量从吡嗪衍生物中发出。 这种发出的光谱能量可以被检测并用于确定患者的肾功能。

    Dendrimer precursor dyes for imaging
    88.
    发明授权
    Dendrimer precursor dyes for imaging 有权
    用于成像的树枝状染料前体染料

    公开(公告)号：US06395257B1

    公开(公告)日：2002-05-28

    申请号：US09484322

    申请日：2000-01-18

    申请人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    发明人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    IPC分类号： A61B500

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056 ,  C09B23/0066 ,  C09B23/08

    摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel cyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 通过使用高吸收性染料作为造影剂可以提高光学模态的灵敏度和特异性。 公开了在电磁光谱的近红外区域吸收和发光的新型花青染料。 这些染料可用于各种疾病状态的成像，诊断和治疗。 特别地，本发明的分子可用于光学诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗 。

    Versatile hydrophilic dyes
    89.
    发明授权
    Versatile hydrophilic dyes 失效
    多用途亲水染料

    公开(公告)号：US06183726B2

    公开(公告)日：2001-02-06

    申请号：US09484321

    申请日：2000-01-18

    申请人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    发明人： Samuel Achilefu ,  Raghavan Rajagopalan ,  Richard B. Dorshow ,  Joseph E. Bugaj

    IPC分类号： A61B1000

    CPC分类号： A61K49/0032 ,  A61K41/0033 ,  A61K41/0057 ,  A61K49/0056

    摘要： The sensitivity and specificity of the optical modality can be enhanced by the use of highly absorbing dyes as contrast agents. Novel cyanine dyes that absorb and emit light in the near infrared region of electromagnetic spectrum are disclosed. These dyes are useful for imaging, diagnosis and therapy of various diseased states. Particularly, the molecules of the invention are useful for optical diagnostic imaging and therapy, in endoscopic applications for the detection of tumors and other abnormalities, for localized therapy, for photoacoustic tumor imaging, detection and therapy, and for sonofluorescence tumor imaging, detection and therapy.

    摘要翻译： 通过使用高吸收性染料作为造影剂可以提高光学模态的灵敏度和特异性。 公开了在电磁光谱的近红外区域吸收和发光的新型花青染料。 这些染料可用于各种疾病状态的成像，诊断和治疗。 特别地，本发明的分子可用于光学诊断成像和治疗，用于检测肿瘤和其他异常的内窥镜应用，局部治疗，光声肿瘤成像，检测和治疗以及用于声发射肿瘤成像，检测和治疗 。