公开(公告)号：US08184882B2

公开(公告)日：2012-05-22

申请号：US13072006

申请日：2011-03-25

申请人： Zengpin Yu ,  Shih-Ping Wang

发明人： Zengpin Yu ,  Shih-Ping Wang

IPC分类号： G06K9/00 ,  G06Q10/00 ,  G06Q50/00

CPC分类号： G06K9/00 ,  A61B6/502 ,  A61B6/5235 ,  A61B6/5247 ,  A61B8/0825 ,  A61B8/4405 ,  A61B8/5238 ,  G06F19/00 ,  G06Q10/06311 ,  G06Q10/063116 ,  G06Q50/22 ,  G06Q50/24

摘要： A system, computer program product, and related methods are described for obtaining, processing, and/or and archiving full-field breast image data, such as full-field breast ultrasound (FFBU) data, in a manner that promotes ready integration with current x-ray mammogram-based breast cancer screening methodologies, and which can alternatively be used to support a full-field-only environment. Two-dimensional thick-slice images computed from a three-dimensional data volume are used to facilitate efficient archiving for a breast imaging session, the two-dimensional thick-slice images corresponding to slab-like subvolumes of the breast. Clinician data overload problems that can arise from the existence of large amounts of three-dimensional full-field breast image data are reduced. Archive space is also preserved while still providing sufficient information data for future reference purposes. Related adjunctive full-field workflow methods are also described. The described embodiments are applicable to FFBU imaging and other full-field breast imaging modalities such as MRI, CT, PET, and others.

摘要翻译： 描述了用于获得，处理和/或归档全场乳房图像数据（例如全场乳房超声（FFBU）数据）的系统，计算机程序产品和相关方法，以促进与当前的现场集成的方式 基于X射线乳腺X线摄影的乳腺癌筛查方法，可替代地可用于支持全场仅有的环境。 使用从三维数据体积计算的二维厚片图像来促进乳房成像会话的有效归档，对应于乳房的板状子体积的二维厚片图像。 减少了由存在大量三维全场乳房图像数据引起的临床医生数据过载问题。 存档空间也得到保留，同时仍然提供足够的信息数据以备将来参考。 还描述了相关的辅助全字段工作流程方法。 所描述的实施例可应用于FFBU成像和其他全场乳房成像模式，例如MRI，CT，PET等。

公开(公告)号：US20110190613A1

公开(公告)日：2011-08-04

申请号：US13004393

申请日：2011-01-11

申请人： Wei ZHANG ,  Zengpin Yu ,  Shih-Ping Wang

发明人： Wei ZHANG ,  Zengpin Yu ,  Shih-Ping Wang

IPC分类号： A61B5/1455

CPC分类号： A61B5/1455

摘要： Systems, methods, and related computer program products for non-invasive NIR spectrophotometric (NIRS) monitoring of total blood hemoglobin levels and/or other blood constituent levels based on a hybrid combination of phase modulation spectrophotometry (PMS) and continuous wave spectrophotometry (CWS) are described. PMS-based measurements including both amplitude and phase information used in the determination of a non-pulsatile component of an absorption property for each of at least three distinct wavelengths are processed to compute PMS-derived intermediate information at least partially representative of a scattering characteristic. CWS-based measurements including amplitude information is processed in conjunction with the PMS-derived intermediate information to compute a pulsatile component of the absorption property. A metric representative of at least one chromophore level, such as the total blood hemoglobin level, is computed from the pulsatile component of the absorption property at the at least three wavelengths and displayed on an output display.

摘要翻译： 基于相位调制分光光度法（PMS）和连续波分光光度法（CWS）的混合组合，用于非侵入式近红外分光光度计（NIRS）监测总血红蛋白水平和/或其他血液成分水平的系统，方法和相关计算机程序产品， 被描述。 处理包括用于确定至少三个不同波长中的每一个的吸收特性的非脉动分量的幅度和相位信息的基于PMS的测量，以计算至少部分代表散射特性的PMS衍生的中间信息。 结合PMS派生的中间信息来处理包括振幅信息的基于CWS的测量，以计算吸收特性的脉冲分量。 代表至少一个生色团水平的度量，例如总血液血红蛋白水平，是根据至少三个波长的吸收特性的脉动分量来计算的，并显示在输出显示器上。

公开(公告)号：US20100256500A1

公开(公告)日：2010-10-07

申请号：US12769440

申请日：2010-04-28

申请人： Tor C. Anderson ,  Jiaya Chen ,  Shih-Ping Wang

发明人： Tor C. Anderson ,  Jiaya Chen ,  Shih-Ping Wang

IPC分类号： A61B8/14

CPC分类号： A61B8/0825 ,  A61B8/406 ,  A61B8/4218 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/462 ,  A61B8/483

摘要： Automated ultrasonic scanning of a chestwardly compressed breast of a supine patient uses a scanning assembly that moves down to compress the breast through a membrane that is secured to the assembly across a bottom opening. A motorized ultrasound transducer moves across the breast while the breast remains downwardly compressed against the patient's chest, sending and receiving ultrasound energy through the membrane. The membrane is porous with respect to an acoustic coupling liquid that impregnates it. The transducer outputs ultrasound information that is processed to form initial planar images and then reconstructed slice images of breast tissue.

摘要翻译： 仰卧患者胸部压缩乳房的自动超声波扫描使用向下移动的扫描组件，以通过穿过底部开口固定到组件的膜来压缩乳房。 电动超声波换能器穿过乳房，同时乳房保持向下压迫患者的胸部，通过膜发送和接收超声能量。 相对于浸渍它的声耦合液体，膜是多孔的。 传感器输出被处理以形成初始平面图像，然后重建乳腺组织切片图像的超声信息。

公开(公告)号：US20100179429A1

公开(公告)日：2010-07-15

申请号：US12691915

申请日：2010-01-22

申请人： Ronald HO ,  Shih-Ping Wang

发明人： Ronald HO ,  Shih-Ping Wang

IPC分类号： A61B8/14

CPC分类号： A61B8/0825 ,  A61B8/4444 ,  A61B8/4461 ,  A61B8/4472 ,  A61B8/462 ,  A61B8/483

摘要： Systems, methods, and related computer program products for ultrasonic examination of a tissue volume, such as a human breast, are described. A handheld volumetric ultrasound scanning probe, which is characterized by a two-dimensional scan area with a substantially rigid cap extending across the two-dimensional scan area, is provided with a texturably couplant-porous material sheet covering the substantially rigid cap over at least a portion of the two-dimensional scan area. The texturably couplant-porous material sheet facilitates positional stability of the handheld volumetric ultrasound scanning probe while positioned against a skin surface of the tissue volume. Advantageously, while the texturably couplant-porous material sheet brings about a more stable physical interface at the skin surface, the texturably couplant-porous material sheet brings about little or no degradation in acquired image quality. Also described are systems and related methods for elastography imaging using the handheld volumetric ultrasound scanning probe.

摘要翻译： 描述了用于超声检查组织体积（例如人乳房）的系统，方法和相关的计算机程序产品。 手持式体积超声扫描探针的特征在于具有延伸穿过二维扫描区域的基本上刚性盖的二维扫描区域，其具有可纹理耦合的多孔材料片材，该片材覆盖至少一个 部分二维扫描区域。 可变形的耦合剂多孔材料片促进了手持式体积超声扫描探针的位置稳定性，同时针对组织体积的皮肤表面定位。 有利的是，尽管可变形的耦合剂多孔材料片在皮肤表面产生更稳定的物理界面，但是质构上的耦合剂 - 多孔材料片材在所获得的图像质量方面几乎不产生或不降低。 还描述了使用手持式体积超声扫描探针的弹性成像成像的系统和相关方法。

公开(公告)号：US07615008B2

公开(公告)日：2009-11-10

申请号：US10997293

申请日：2004-11-23

申请人： Wei Zhang ,  Shih-Ping Wang ,  Jiayu Chen ,  Zengpin Yu ,  Tommy Earl Cupples ,  Thomas P. Neff ,  Michael E. Reed

发明人： Wei Zhang ,  Shih-Ping Wang ,  Jiayu Chen ,  Zengpin Yu ,  Tommy Earl Cupples ,  Thomas P. Neff ,  Michael E. Reed

IPC分类号： A61B8/00

CPC分类号： A61B8/5238 ,  A61B6/463 ,  A61B6/502 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/0825 ,  A61B8/13 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/462 ,  A61B8/463 ,  A61B8/465 ,  A61B8/466 ,  A61B8/467 ,  A61B8/565

摘要： Displaying breast ultrasound information on an interactive user interface is described, the user interface being useful in adjunctive ultrasound mammography environments and/or ultrasound-only mammography environments. Bilateral comparison is facilitated by a pairwise display of thick-slice images corresponding to analogous slab-like subvolumes in the left and right breasts. Coronal thick-slice imaging and convenient navigation on and among coronal thick-slice images is described. In one preferred embodiment, a nipple marker is displayed the coronal thick-slice image representing a projection of a nipple location thereupon. A convenient breast icon is also displayed including a cursor position indicator variably disposed thereon in a manner that reflects a relative position between the cursor and the nipple marker. Preferably, the breast icon is configured to at least roughly resemble a clock face, the center of the clock face representing the nipple marker location. Bookmark-centric and CAD-marker-centric navigation within and among thick-slice images is also described.

摘要翻译： 描述了在交互式用户界面上显示乳房超声信息，用户界面在辅助超声乳腺X线照相术环境和/或仅超声乳腺X线照相术环境中有用。 通过成对显示对应于左乳房和右乳房中类似的板状子体积的双层比较来促进双边比较。 描述了冠状厚片成像和冠状厚片图像之间和之间方便的导航。 在一个优选实施例中，乳头标记被显示为表示其上的乳头位置的投影的冠状厚片图像。 还显示方便的胸部图标，包括以反映光标和乳头标记之间的相对位置的方式可变地设置在其上的光标位置指示器。 优选地，乳房图标配置为至少大致类似于时钟面，时钟面的中心表示乳头标记位置。 还描述了厚片图像内和书签中心和CAD标记为中心的导航。

公开(公告)号：US20080194959A1

公开(公告)日：2008-08-14

申请号：US11597196

申请日：2005-05-23

申请人： Shih-Ping Wang ,  Wei Zhang ,  Jiayu Chen ,  Zengpin Yu

发明人： Shih-Ping Wang ,  Wei Zhang ,  Jiayu Chen ,  Zengpin Yu

IPC分类号： A61B8/13

CPC分类号： A61B8/0825 ,  A61B8/406 ,  A61B8/4218 ,  A61B8/4281 ,  A61B8/483 ,  A61B8/54

摘要： An apparatus and related methods for scanning a breast are described, the apparatus comprising a frame defining an orifice shaped to allow the breast to be received therein, a compressive member secured to the frame across the orifice that compresses the received breast toward the patient's chest wall, and a transducer positioned in acoustic communication with the compressive member for imaging the breast therethrough. The frame holds a reservoir of acoustically conductive fluid that maintains the transducer in acoustic communication with the compressive member. In different preferred embodiments having different advantages, the compressive member comprises a flexible elastic membrane, a flexible inelastic membrane, or a rigid sonolucent plastic preformed into the shape of a chestwardly-compressed breast. Where the transducer comprises one or more linear array probes, various probe orientations and trajectories are described for generating a three-dimensional volumetric representation of the breast having reduced nipple shadow effects.

摘要翻译： 描述了一种用于扫描乳房的装置和相关方法，所述装置包括限定形状以允许乳房被容纳在其中的孔口的框架;压缩构件，其被固定到穿过所述孔口的框架，所述压缩构件将接收的乳房压缩到患者的胸壁 以及与所述压缩构件声学连通的换能器，用于使乳房通过其成像。 框架保持导电流体的储存器，其将换能器保持与压缩构件声学连通。 在具有不同优点的不同优选实施例中，压缩构件包括柔性弹性膜，柔性非弹性膜或预先形成胸部压缩乳房形状的刚性声光塑料。 在换能器包括一个或多个线性阵列探针的情况下，描述了用于产生具有降低的乳头阴影效应的乳房的三维体积表示的各种探针取向和轨迹。

公开(公告)号：US20080033288A1

公开(公告)日：2008-02-07

申请号：US11821601

申请日：2007-06-25

申请人： Shih-Ping Wang ,  Jiayu Chen ,  Hui Peng

发明人： Shih-Ping Wang ,  Jiayu Chen ,  Hui Peng

IPC分类号： A61B8/08

CPC分类号： A61B8/0825 ,  A61B8/406 ,  A61B8/4218 ,  A61B8/4281 ,  A61B8/483 ,  A61B8/54

摘要： Method and related apparatuses are described for performing automated ultrasound mammography with reduced nipple shadow effects. The breast is compressed in a direction generally toward the chest wall of the patient with one side of a compressive member which is preferably a membrane. The breast is scanned with an ultrasonic transducer array positioned in acoustic communication with the other side of the membrane. Beamsteering is used. The signals from the beamsteered energy are combined to generate one or more compound images having a reduced nipple shadow effect. An acoustic couplant is preferably applied between the breast and the membrane. The images of the sub-nipple region are also preferably enhanced by making comparisons with reference areas of the breast in areas away from the nipple shadow effected area. The images are preferably displayed to a user, either automatically or upon receiving a preference from the user.

摘要翻译： 描述了用于执行具有降低的乳头阴影效应的自动超声乳房X线照相术的方法和相关装置。 乳房沿着大致朝向患者胸壁的方向被压缩，压缩构件的一侧优选为膜。 用与膜的另一侧声学连通的超声波换能器阵列扫描乳房。 使用光束引导。 来自射束能量的信号被组合以产生具有降低的乳头阴影效应的一个或多个复合图像。 声学耦合剂优选地应用在乳房和膜之间。 子乳头区域的图像也优选通过在乳头阴影影响区域的区域中与乳房的参考区域进行比较来增强。 图像优选地自动地或者从用户接收到偏好来显示给用户。

公开(公告)号：US06434262B1

公开(公告)日：2002-08-13

申请号：US09798756

申请日：2001-03-02

申请人： Shih-Ping Wang

发明人： Shih-Ping Wang

IPC分类号： G06K900

摘要： An x-ray system acquires an initial low-contrast, wide latitude (G=2.5, or G=2 or less) x-ray image of a breast. A processing system automatically finds suspected abnormalities in the breast by processing the low contrast initial image, and then automatically converts the initial x-ray image to a high-contrast, narrow latitude image at the locations of the found abnormalities to thereby facilitate diagnosis and patient care. The technology includes effective ways to produce, process and display the various images, and can be extended to other types of images.

公开(公告)号：US4598369A

公开(公告)日：1986-07-01

申请号：US490457

申请日：1983-05-02

申请人： Shih-Ping Wang ,  Russell H. Morgan ,  Donald F. Specht

发明人： Shih-Ping Wang ,  Russell H. Morgan ,  Donald F. Specht

IPC分类号： G01N23/04 ,  G06T11/00 ,  G06F15/42 ,  G03B42/02 ,  H04N5/32 ,  H05G1/60

CPC分类号： G06T11/006 ,  G01N23/046 ,  G01N2223/419 ,  G01N2223/612

摘要： Tomographic images are obtained at a plane of interest by taking a series of x-ray exposures, producing a series of multiple images therefrom, arranging these multiple images so that points residing within a desired plane of interest are coincident to form a first order clarified image, repeating the step for a predetermined number of other planes which are parallel to the first plane of interest, to produce a first order clarified image for each of these planes, and then producing a smeared image for each of such planes, except one, by replicating the first order image for said plane a predetermined number of times and shifting each of the replicated images in the plane as a function of the distance between that particular plane and the x-ray source, the distance between that particular plane and the x-ray image device, the same distances but taken relative to a plane of interest, and the distance moved between exposures by the x-ray source. This smeared image for each particular plane is then multiplied by a coefficient and subtracted from the first order image of the plane of interest to form a second order clarified image of the plane of interest.

摘要翻译： 通过进行一系列x射线曝光，从其产生一系列多个图像，排列这些多个图像，使位于期望的感兴趣平面内的点一致以形成一阶澄清图像，在感兴趣的平面上获得层析图像 对于平行于所述第一感兴趣平面的预定数量的其它平面重复所述步骤，以产生用于这些平面中的每一个的一阶澄清图像，然后除了一个之外，通过 将所述平面的一阶图像复制预定次数，并且根据该特定平面和x射线源之间的距离将平面中的复制图像中的每一个移动，该特定平面与x射线源之间的距离， 射线图像装置，相对于感兴趣的平面相同的距离，并且由X射线源在曝光之间移动的距离。 然后将每个特定平面的该模糊图像乘以系数并从感兴趣平面的一阶图像中减去以形成感兴趣平面的二阶澄清图像。

公开(公告)号：USRE31691E

公开(公告)日：1984-10-02

申请号：US182694

申请日：1980-08-29

申请人： Shih-Ping Wang

发明人： Shih-Ping Wang

IPC分类号： H01J29/38 ,  H01J31/50

CPC分类号： H01J31/505 ,  H01J29/385

摘要： A panel shaped, proximity type, x-ray image intensifier tube for medical x-ray diagnostic use having all linear components and yet a high brightness gain, in the range of 500 to 20,000 cd-sec/m.sup.2 -R, the tube being comprised of a rugged metallic tube envelope, an inwardly concave, iron, nickel, chromium alloy input window, a full size output display screen, a halide activated alkaline-halide scintillator photocathode screen suspended on insulators within the envelope and in between the input window and the output screen, and a high Z glass output window to reduce x-ray backscatter inside and outside of the tube. The tube can be used in a direct view, photofluorographic mode, in a radiographic camera system and with a remote view T.V. system.