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    Spectrophotometric Monitoring Of Multiple Layer Tissue Structures
    1.
    发明申请
    Spectrophotometric Monitoring Of Multiple Layer Tissue Structures 审中-公开
    多层组织结构的分光光度监测

    公开(公告)号：US20120095305A1

    公开(公告)日：2012-04-19

    申请号：US12815696

    申请日：2010-06-15

    申请人： Ming Wang ,  Shih-Ping Wang ,  Zengpin Yu ,  Wei Zhang

    发明人： Ming Wang ,  Shih-Ping Wang ,  Zengpin Yu ,  Wei Zhang

    IPC分类号： A61B5/1455 ,  A61B6/00

    CPC分类号： A61B5/0075 ,  A61B5/103 ,  A61B5/14551

    摘要： Methods, systems, and related computer program products for the non-invasive spectrophotometric monitoring of a biological volume having multiple tissue layers are described. Aggregate absorption and scattering properties are measured for each of a plurality of predetermined source-detector separation distances along a surface of the biological volume, the measurement being based on a model of the biological volume as a single-layer, semi-infinite, homogeneous volume. A predetermined multi-layer tissue model is retrieved that characterizes a mathematical relationship among (a) absorption and scattering properties of each layer of a multi-layer tissue structure, and (b) aggregate absorption and scattering properties of the multi-layer tissue structure as would be measured at selected source-detector separation distances along a surface thereof. The measured aggregate absorption and scattering properties are processed in conjunction with the predetermined multi-layer tissue model to compute therefrom a deep-layer-specific absorption property corresponding to the relatively deep tissue layer.

    摘要翻译： 描述了用于非侵入式分光光度监测具有多个组织层的生物体积的方法，系统和相关的计算机程序产品。 测量沿着生物体积的表面的多个预定的源 - 检测器分离距离中的每一个的聚集吸收和散射性质，该测量基于生物体积的模型作为单层，半无限均质体​​积 。 检索预定的多层组织模型，其表征（a）多层组织结构的每层的吸收和散射性质之间的数学关系，以及（b）多层组织结构的聚集吸收和散射性质作为 将沿着其表面的选定的源 - 检测器间隔距离测量。 测量的聚集体吸收和散射性质与预定的多层组织模型结合进行处理，从而计算对应于相对较深的组织层的深层特异性吸收特性。

    Full-field breast ultrasound system and architecture
    2.
    发明授权
    Full-field breast ultrasound system and architecture 有权
    全场乳房超声系统和体系结构

    公开(公告)号：US08317702B2

    公开(公告)日：2012-11-27

    申请号：US10560200

    申请日：2004-06-18

    申请人： Zengpin Yu ,  Danhua Zhao ,  Thomas P. Neff ,  Wei Zhang ,  Shih-Ping Wang

    发明人： Zengpin Yu ,  Danhua Zhao ,  Thomas P. Neff ,  Wei Zhang ,  Shih-Ping Wang

    IPC分类号： A61B8/00

    CPC分类号： A61B8/4477 ,  A61B8/0825 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/5238 ,  Y10T29/49005

    摘要： A modular, flexible architecture for offering full-field breast ultrasound (FFBU) functionality and general-purpose ultrasound functionality in a single system is described. A conventional, general-purpose ultrasound system (202) is modified with an FFBU toolkit to create a dual-capability ultrasound system (200), the dual-capability ultrasound system (200) being able to accommodate both general-purpose ultrasound functionality and FFBU functionality, using a single ultrasound engine (112). Among other advantages, real-world clinical environments may enjoy cost savings for initial system procurement, space savings on clinic floors, easier and less expensive system upgrades, and the ability to use a single system and user interface for both FFBU screening and for follow-up diagnosis, biopsy, etc. Among other advantages from an ultrasound manufacturer's perspective are the ability to quickly and/or more easily come to market with an FFBU-related offering by modifying their existing general-purpose ultrasound systems (202) with FFBU toolkits to quickly create dual-capability ultrasound systems (200).

    摘要翻译： 描述了在单个系统中提供全场乳房超声（FFBU）功能和通用超声功能的模块化，灵活的架构。 传统的通用超声系统（202）用FFBU工具包修改以创建双能力超声系统（200），双能力超声系统（200）能够容纳通用超声功能和FFBU 功能，使用单个超声引擎（112）。 除了其他优点之外，现实世界的临床环境可以节省初始系统采购成本，临床楼层节省空间，更便宜和更便宜的系统升级，以及使用单个系统和用户界面进行FFBU筛选和跟踪的功能， 诊断，活检等。超声波制造商的观点还有其他优点，即通过使用FFBU工具包修改现有的通用超声波系统（202），通过与FFBU相关的产品快速和/或更容易上市。 快速创建双功能超声系统（200）。

    THICK-SLICE ULTRASOUND IMAGES DERIVED FROM ULTRASONIC SCANS OF A CHESTWARDLY-COMPRESSED BREAST OF A SUPINE PATIENT
    3.
    发明申请
    THICK-SLICE ULTRASOUND IMAGES DERIVED FROM ULTRASONIC SCANS OF A CHESTWARDLY-COMPRESSED BREAST OF A SUPINE PATIENT 有权
    超声波超声波超声波扫描的厚度超大的超声波扫描仪

    公开(公告)号：US20110098566A1

    公开(公告)日：2011-04-28

    申请号：US12890374

    申请日：2010-09-24

    申请人： Wei ZHANG ,  Shih-Ping Wang ,  Jiayu Chen ,  Zengpin Yu ,  Tommy Earl Cupples ,  Thomas P. Neff ,  Michael E. Reed

    发明人： Wei ZHANG ,  Shih-Ping Wang ,  Jiayu Chen ,  Zengpin Yu ,  Tommy Earl Cupples ,  Thomas P. Neff ,  Michael E. Reed

    IPC分类号： A61B8/14 ,  G06T15/20

    CPC分类号： A61B8/5238 ,  A61B6/463 ,  A61B6/502 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/0825 ,  A61B8/13 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/462 ,  A61B8/463 ,  A61B8/465 ,  A61B8/466 ,  A61B8/467 ,  A61B8/565

    摘要： Displaying breast ultrasound information on an interactive user interface is described, the user interface being useful in adjunctive ultrasound mammography environments and/or ultrasound-only mammography environments. Bilateral comparison is facilitated by a pairwise display of thick-slice images corresponding to analogous slab-like subvolumes in the left and right breasts. Coronal thick-slice imaging and convenient navigation on and among coronal thick-slice images is described. In one preferred embodiment, a nipple marker is displayed the coronal thick-slice image representing a projection of a nipple location thereupon. A convenient breast icon is also displayed including a cursor position indicator variably disposed thereon in a manner that reflects a relative position between the cursor and the nipple marker. Preferably, the breast icon is configured to at least roughly resemble a clock face, the center of the clock face representing the nipple marker location. Bookmark-centric and CAD-marker-centric navigation within and among thick-slice images is also described.

    摘要翻译： 描述了在交互式用户界面上显示乳房超声信息，用户界面在辅助超声乳腺X线照相术环境和/或仅超声乳腺X线照相术环境中有用。 通过成对显示对应于左乳房和右乳房中类似的板状子体积的双层比较来促进双边比较。 描述了冠状厚片成像和冠状厚片图像之间和之间方便的导航。 在一个优选实施例中，乳头标记被显示为表示其上的乳头位置的投影的冠状厚片图像。 还显示方便的胸部图标，包括以反映光标和乳头标记之间的相对位置的方式可变地设置在其上的光标位置指示器。 优选地，乳房图标被配置为至少大致类似于时钟面，时钟面的中心表示乳头标记位置。 还描述了厚片图像内和书签中心和CAD标记为中心的导航。

    NEAR INFRARED SPECTROPHOTOMETRY WITH ENHANCED SIGNAL TO NOISE PERFORMANCE
    5.
    发明申请
    NEAR INFRARED SPECTROPHOTOMETRY WITH ENHANCED SIGNAL TO NOISE PERFORMANCE 审中-公开
    近红外光谱测定与噪声性能的增强信号

    公开(公告)号：US20110060197A1

    公开(公告)日：2011-03-10

    申请号：US12832603

    申请日：2010-07-08

    申请人： Wei ZHANG ,  Shih-Ping Wang ,  Shuoming Zhou ,  Zengpin Yu

    发明人： Wei ZHANG ,  Shih-Ping Wang ,  Shuoming Zhou ,  Zengpin Yu

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/14553 ,  A61B5/6814 ,  A61B5/7239

    摘要： Methods, systems, and related computer program products for the non-invasive spectrophotometric monitoring of an optical property of a tissue volume are described. Multiple optical signals having different modulation frequencies are introduced into the tissue volume simultaneously and on a continuous basis throughout the monitoring session. Multiple optical signal portions incident upon each of a plurality of optical detectors are detected and separated based on their modulation frequency. Amplitude and phase signals corresponding to each optical signal portion are extracted and processed to determine the optical property of the tissue volume. In one preferred embodiment, a first optical detector includes an aperture having a central area, a first edge positioned nearer to a first optical source than the central area, and a second edge positioned farther from the first optical source than the central area. The first and second edges are each curved concavely toward the first optical source.

    摘要翻译： 描述了用于非侵入性分光光度监测组织体积的光学性质的方法，系统和相关的计算机程序产品。 具有不同调制频率的多个光信号在整个监视会话中同时并连续地引入到组织体积中。 入射到多个光学检测器中的每一个的多个光信号部分基于它们的调制频率被检测和分离。 提取和处理对应于每个光信号部分的幅度和相位信号，以确定组织体积的光学特性。 在一个优选实施例中，第一光学检测器包括具有中心区域的第一边缘，比中心区域更靠近第一光源的第一边缘以及比中心区域更远离第一光源的第二边缘。 第一和第二边缘各自朝向第一光源凹入弯曲。

    Processing and displaying breast ultrasound information
    7.
    发明申请
    Processing and displaying breast ultrasound information 有权
    处理和显示乳房超声信息

    公开(公告)号：US20050171430A1

    公开(公告)日：2005-08-04

    申请号：US10997293

    申请日：2004-11-23

    申请人： Wei Zhang ,  Shih-Ping Wang ,  Jiayu Chen ,  Zengpin Yu ,  Tommy Cupples ,  Thomas Neff ,  Michael Reed

    发明人： Wei Zhang ,  Shih-Ping Wang ,  Jiayu Chen ,  Zengpin Yu ,  Tommy Cupples ,  Thomas Neff ,  Michael Reed

    IPC分类号： A61B6/00 ,  A61B8/00 ,  A61B8/08 ,  A61B8/12 ,  A61B8/13 ,  A61B8/14

    CPC分类号： A61B8/5238 ,  A61B6/463 ,  A61B6/502 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/0825 ,  A61B8/13 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/462 ,  A61B8/463 ,  A61B8/465 ,  A61B8/466 ,  A61B8/467 ,  A61B8/565

    摘要： Displaying breast ultrasound information on an interactive user interface is described, the user interface being useful in adjunctive ultrasound mammography environments and/or ultrasound-only mammography environments. Bilateral comparison is facilitated by a pairwise display of thick-slice images corresponding to analogous slab-like subvolumes in the left and right breasts. Coronal thick-slice imaging and convenient navigation on and among coronal thick-slice images is described. In one preferred embodiment, a nipple marker is displayed the coronal thick-slice image representing a projection of a nipple location thereupon. A convenient breast icon is also displayed including a cursor position indicator variably disposed thereon in a manner that reflects a relative position between the cursor and the nipple marker. Preferably, the breast icon is configured to at least roughly resemble a clock face, the center of the clock face representing the nipple marker location. Bookmark-centric and CAD-marker-centric navigation within and among thick-slice images is also described.

    摘要翻译： 描述了在交互式用户界面上显示乳房超声信息，用户界面在辅助超声乳腺X线照相术环境和/或仅超声乳腺X线照相术环境中有用。 通过成对显示对应于左乳房和右乳房中类似的板状子体积的双层比较来促进双边比较。 描述了冠状厚片成像和冠状厚片图像之间和之间方便的导航。 在一个优选实施例中，乳头标记被显示为表示其上的乳头位置的突起的冠状厚片图像。 还显示方便的胸部图标，包括以反映光标和乳头标记之间的相对位置的方式可变地设置在其上的光标位置指示器。 优选地，乳房图标被配置为至少大致类似于时钟面，时钟面的中心表示乳头标记位置。 还描述了厚片图像内和书签中心和CAD标记为中心的导航。

    HYBRID SPECTROPHOTOMETRIC MONITORING OF BIOLOGICAL CONSTITUENTS
    8.
    发明申请
    HYBRID SPECTROPHOTOMETRIC MONITORING OF BIOLOGICAL CONSTITUENTS 审中-公开
    生物组织的杂交光谱测量监测

    公开(公告)号：US20110190613A1

    公开(公告)日：2011-08-04

    申请号：US13004393

    申请日：2011-01-11

    申请人： Wei ZHANG ,  Zengpin Yu ,  Shih-Ping Wang

    发明人： Wei ZHANG ,  Zengpin Yu ,  Shih-Ping Wang

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/1455

    摘要： Systems, methods, and related computer program products for non-invasive NIR spectrophotometric (NIRS) monitoring of total blood hemoglobin levels and/or other blood constituent levels based on a hybrid combination of phase modulation spectrophotometry (PMS) and continuous wave spectrophotometry (CWS) are described. PMS-based measurements including both amplitude and phase information used in the determination of a non-pulsatile component of an absorption property for each of at least three distinct wavelengths are processed to compute PMS-derived intermediate information at least partially representative of a scattering characteristic. CWS-based measurements including amplitude information is processed in conjunction with the PMS-derived intermediate information to compute a pulsatile component of the absorption property. A metric representative of at least one chromophore level, such as the total blood hemoglobin level, is computed from the pulsatile component of the absorption property at the at least three wavelengths and displayed on an output display.

    摘要翻译： 基于相位调制分光光度法（PMS）和连续波分光光度法（CWS）的混合组合，用于非侵入式近红外分光光度计（NIRS）监测总血红蛋白水平和/或其他血液成分水平的系统，方法和相关计算机程序产品， 被描述。 处理包括用于确定至少三个不同波长中的每一个的吸收特性的非脉动分量的幅度和相位信息的基于PMS的测量，以计算至少部分代表散射特性的PMS衍生的中间信息。 结合PMS派生的中间信息来处理包括振幅信息的基于CWS的测量，以计算吸收特性的脉冲分量。 代表至少一个生色团水平的度量，例如总血液血红蛋白水平，是根据至少三个波长的吸收特性的脉动分量来计算的，并显示在输出显示器上。

    Processing and displaying breast ultrasound information
    9.
    发明授权
    Processing and displaying breast ultrasound information 有权
    处理和显示乳房超声信息

    公开(公告)号：US07615008B2

    公开(公告)日：2009-11-10

    申请号：US10997293

    申请日：2004-11-23

    申请人： Wei Zhang ,  Shih-Ping Wang ,  Jiayu Chen ,  Zengpin Yu ,  Tommy Earl Cupples ,  Thomas P. Neff ,  Michael E. Reed

    发明人： Wei Zhang ,  Shih-Ping Wang ,  Jiayu Chen ,  Zengpin Yu ,  Tommy Earl Cupples ,  Thomas P. Neff ,  Michael E. Reed

    IPC分类号： A61B8/00

    CPC分类号： A61B8/5238 ,  A61B6/463 ,  A61B6/502 ,  A61B6/5247 ,  A61B6/563 ,  A61B8/0825 ,  A61B8/13 ,  A61B8/406 ,  A61B8/4281 ,  A61B8/4405 ,  A61B8/462 ,  A61B8/463 ,  A61B8/465 ,  A61B8/466 ,  A61B8/467 ,  A61B8/565

    摘要： Displaying breast ultrasound information on an interactive user interface is described, the user interface being useful in adjunctive ultrasound mammography environments and/or ultrasound-only mammography environments. Bilateral comparison is facilitated by a pairwise display of thick-slice images corresponding to analogous slab-like subvolumes in the left and right breasts. Coronal thick-slice imaging and convenient navigation on and among coronal thick-slice images is described. In one preferred embodiment, a nipple marker is displayed the coronal thick-slice image representing a projection of a nipple location thereupon. A convenient breast icon is also displayed including a cursor position indicator variably disposed thereon in a manner that reflects a relative position between the cursor and the nipple marker. Preferably, the breast icon is configured to at least roughly resemble a clock face, the center of the clock face representing the nipple marker location. Bookmark-centric and CAD-marker-centric navigation within and among thick-slice images is also described.

    摘要翻译： 描述了在交互式用户界面上显示乳房超声信息，用户界面在辅助超声乳腺X线照相术环境和/或仅超声乳腺X线照相术环境中有用。 通过成对显示对应于左乳房和右乳房中类似的板状子体积的双层比较来促进双边比较。 描述了冠状厚片成像和冠状厚片图像之间和之间方便的导航。 在一个优选实施例中，乳头标记被显示为表示其上的乳头位置的投影的冠状厚片图像。 还显示方便的胸部图标，包括以反映光标和乳头标记之间的相对位置的方式可变地设置在其上的光标位置指示器。 优选地，乳房图标配置为至少大致类似于时钟面，时钟面的中心表示乳头标记位置。 还描述了厚片图像内和书签中心和CAD标记为中心的导航。

    Breast Ultrasound Scanning Promoting Patient Comfort and Improved Imaging Near Chest Wall
    10.
    发明申请
    Breast Ultrasound Scanning Promoting Patient Comfort and Improved Imaging Near Chest Wall 审中-公开
    乳房超声扫描促进患者舒适度和改善近壁面成像

    公开(公告)号：US20080194959A1

    公开(公告)日：2008-08-14

    申请号：US11597196

    申请日：2005-05-23

    申请人： Shih-Ping Wang ,  Wei Zhang ,  Jiayu Chen ,  Zengpin Yu

    发明人： Shih-Ping Wang ,  Wei Zhang ,  Jiayu Chen ,  Zengpin Yu

    IPC分类号： A61B8/13

    CPC分类号： A61B8/0825 ,  A61B8/406 ,  A61B8/4218 ,  A61B8/4281 ,  A61B8/483 ,  A61B8/54

    摘要： An apparatus and related methods for scanning a breast are described, the apparatus comprising a frame defining an orifice shaped to allow the breast to be received therein, a compressive member secured to the frame across the orifice that compresses the received breast toward the patient's chest wall, and a transducer positioned in acoustic communication with the compressive member for imaging the breast therethrough. The frame holds a reservoir of acoustically conductive fluid that maintains the transducer in acoustic communication with the compressive member. In different preferred embodiments having different advantages, the compressive member comprises a flexible elastic membrane, a flexible inelastic membrane, or a rigid sonolucent plastic preformed into the shape of a chestwardly-compressed breast. Where the transducer comprises one or more linear array probes, various probe orientations and trajectories are described for generating a three-dimensional volumetric representation of the breast having reduced nipple shadow effects.

    摘要翻译： 描述了一种用于扫描乳房的装置和相关方法，所述装置包括限定形状以允许乳房被容纳在其中的孔口的框架;压缩构件，其被固定到穿过所述孔口的框架，所述压缩构件将接收的乳房压缩到患者的胸壁 以及与所述压缩构件声学连通的换能器，用于使乳房通过其成像。 框架保持导电流体的储存器，其将换能器保持与压缩构件声学连通。 在具有不同优点的不同优选实施例中，压缩构件包括柔性弹性膜，柔性非弹性膜或预先形成胸部压缩乳房形状的刚性声光塑料。 在换能器包括一个或多个线性阵列探针的情况下，描述了用于产生具有降低的乳头阴影效应的乳房的三维体积表示的各种探针取向和轨迹。