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    Sterilization of bioactive coatings
    86.
    发明授权
    Sterilization of bioactive coatings 失效
    生物活性涂料的灭菌

    公开(公告)号：US06787179B2

    公开(公告)日：2004-09-07

    申请号：US09897657

    申请日：2001-06-29

    Applicant: Debra A. Timm ,  Henry K. Hui ,  Mark B. Roller ,  Mora C. Melican ,  Syed Hossainy

    Inventor： Debra A. Timm ,  Henry K. Hui ,  Mark B. Roller ,  Mora C. Melican ,  Syed Hossainy

    IPC: A61L2700

    CPC classification number: A61L27/34 ,  A61L2/14 ,  A61L29/085 ,  A61L31/10 ,  A61M25/0009 ,  A61M25/0045

    Abstract: The invention provides a method for single-step surface modification, grafting and sterilization for bio-active coating on materials and biomaterials used in medical devices, such as catheters, tissue engineering scaffolds, or drug delivery carrier materials. This may include any medical device or implantable that could benefit from improved antithrombogenic and biocompatible surfaces. Other relevant device examples may include heparin or urokinase coated stents to reduce clotting and restenosis, dental or ophthamological implants. These materials may be comprised of a variety of polymeric compositions such as, polyurethane, polyester, polytetrafluoroethylene, polyethylene, polymethylmethacrylate, polyHEMA, polyvinyl alcohol, polysiloxanes, polylactic or glycolic acids, polycaprolactone, etc. The substrates can also be metal, ceramics or biologically derived materials.

    Abstract translation: 本发明提供了用于医疗装置（例如导管，组织工程支架或药物递送载体材料）中的材料和生物材料上的生物活性涂层的单步表面改性，接枝和灭菌的方法。 这可以包括可以从改进的抗血栓形成和生物相容性表面受益的任何医疗装置或植入物。 其他相关装置实例可包括用于减少凝血和再狭窄的肝素或尿激酶涂层的支架，牙科或眼科植入物。 这些材料可以由多种聚合物组合物，如聚氨酯，聚酯，聚四氟乙烯，聚乙烯，聚甲基丙烯酸甲酯，聚乙烯醇，聚乙烯醇，聚硅氧烷，聚乳酸或乙醇酸，聚己内酯等组成。基材也可以是金属，陶瓷或生物学 衍生材料。

    Transurethral volume reduction of the prostate (TUVOR)
    87.
    发明授权
    Transurethral volume reduction of the prostate (TUVOR) 失效
    经尿道前列腺体积减少（TUVOR）

    公开(公告)号：US06491672B2

    公开(公告)日：2002-12-10

    申请号：US09778651

    申请日：2001-02-07

    Applicant: Marvin J. Slepian ,  Daniel Yachia ,  Syed Hossainy ,  Baruch Levy ,  Zeev Sohn

    Inventor： Marvin J. Slepian ,  Daniel Yachia ,  Syed Hossainy ,  Baruch Levy ,  Zeev Sohn

    IPC: A61M2500

    CPC classification number: A61B17/320758 ,  A61B17/00491 ,  A61B17/320725 ,  A61B90/361 ,  A61B2017/00274 ,  A61B2017/00557 ,  A61B2017/22072 ,  A61B2017/3445 ,  A61B2018/00547

    Abstract: A process has been developed to reduce or relieve prostatic obstruction. The steps involved in the TUVOR Process include: 1. Transurethral Incision; 2. De-bulking and Intra-Prostatic Volume Reduction; 3. Intra-prostatic void exclusion and space filling with adhesive and/or therapeutic polymeric materials, alone or in combination with bioactive agents and/or mechanical means for closure; 4. Endourethral compression and prostatic mass remolding; 5. Endourethral Polymer Liner Layer. This liner formed from structurally supportive, yet eventually biodegradable, polymers further bolsters and supports the urethra and peri-urethral tissue during healing, eliminating the need for post-procedure catheter drainage. This step may be optional in specific clinical circumstances. The process is designed to allow outpatient treatment under local anesthesia for BPH.

    Abstract translation: 已经开发了一种减轻或缓解前列腺阻塞的过程。 TUVOR过程涉及的步骤包括：1.经尿道切口; 减少体重和体内前列腺减少; 3.用粘合剂和/或治疗性聚合物材料单独或与生物活性剂和/或用于封闭的机械装置组合的前列腺空洞排除和空间填充; 4.尿道压迫和前列腺体重重塑; 5.尿道内聚合物衬里层。 由结构支持但最终可生物降解的聚合物形成的衬垫在愈合过程中进一步支撑和支撑尿道和尿道周围组织，从而无需进行后路导管引流。 在特定临床情况下，此步骤可能是可选的。 该过程设计为允许门诊在局部麻醉下进行BPH治疗。

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