公开(公告)号：US08513836B2

公开(公告)日：2013-08-20

申请号：US12786660

申请日：2010-05-25

申请人： Yuji Zushi ,  Shinsuke Suzuki ,  Akihiro Ishii

发明人： Yuji Zushi ,  Shinsuke Suzuki ,  Akihiro Ishii

IPC分类号： H01H35/00 ,  H01H83/00 ,  H01H47/00 ,  H02H3/00

CPC分类号： G01R31/024 ,  G01R31/42 ,  H03K17/0822 ,  H03K17/18 ,  H03K2017/0806 ,  Y10T307/858

摘要： Provided is a drive control device capable of surely detecting, by a monitoring/controlling unit, an abnormality of a short circuit and a disconnection in a power supply circuit to an electric load, and of decreasing a load required for a quick response imposed on the monitoring/controlling unit. A switching element is controlled to open/close by a control output signal generated by a monitoring/controlling unit, and a determination storing circuit determines whether circuit opening and circuit closing have been correctly carried out and stores a result of the determination, and periodically reports to the monitoring/controlling unit. While the stored content of the determination is periodically reset, the determination operation is updated and continues. The monitoring/controlling unit does not need to immediately monitor the determination storing signal when the open/closing command is generated.

摘要翻译： 提供一种驱动控制装置，其能够通过监视/控制单元可靠地检测电力供应电路中的短路异常和电力负载的断开，并且减小对该负载施加的快速响应所需的负载 监控单元。 控制开关元件通过由监视/控制单元产生的控制输出信号进行开/关，并且确定存储电路确定电路断开和电路闭合是否已正确执行并存储确定结果，并周期性地报告 到监控单元。 虽然存储的确定内容被周期性地重置，但是确定操作被更新并继续。 当产生打开/关闭命令时，监视/控制单元不需要立即监视确定存储信号。

公开(公告)号：US20090240087A1

公开(公告)日：2009-09-24

申请号：US12089882

申请日：2006-10-04

申请人： Akihiro Ishii ,  Koji Ueda ,  Manabu Yasumoto

发明人： Akihiro Ishii ,  Koji Ueda ,  Manabu Yasumoto

IPC分类号： C07C33/46

CPC分类号： C07C29/095 ,  C07B57/00 ,  C07B2200/07 ,  C07C67/08 ,  C07C67/60 ,  C07C33/40 ,  C07C33/22 ,  C07C69/80

摘要： A fluorine-containing benzaldehyde is reacted with an alkyl Grignard reagent to convert it to a magnesium alkoxide of racemic, fluorine-containing, benzyl alcohol, and subsequently the magnesium alkoxide is reacted with phthalic anhydride to obtain a phthalate half ester of racemic, fluorine-containing, benzyl alcohol, and the half ester is optically resolved by optically active 1-phenylethylamine, and then the ester group is hydrolyzed, thereby producing an optically active, fluorine-containing, benzyl alcohol.

摘要翻译： 将含氟苯甲醛与烷基格氏试剂反应，将其转化成外消旋，含氟苄基醇的烷氧基镁，随后将烷氧基镁与邻苯二甲酸酐反应，得到外消旋， 通过光学活性1-苯基乙胺光学拆分半酯，然后将酯基水解，从而制备光学活性的含氟苄基醇。

公开(公告)号：US07462734B2

公开(公告)日：2008-12-09

申请号：US11597105

申请日：2005-08-05

申请人： Akihiro Ishii ,  Hideyuki Tsuruta ,  Takashi Ootsuka ,  Yokusu Kuriyama ,  Manabu Yasumoto ,  Kenjin Inomiya ,  Koji Ueda

发明人： Akihiro Ishii ,  Hideyuki Tsuruta ,  Takashi Ootsuka ,  Yokusu Kuriyama ,  Manabu Yasumoto ,  Kenjin Inomiya ,  Koji Ueda

IPC分类号： C07C69/76 ,  C07C69/63 ,  C07C33/46 ,  C07C31/34

CPC分类号： C07C67/307 ,  C07B2200/07 ,  C07C29/147 ,  C07C69/65 ,  C07C69/63 ,  C07C31/38

摘要： The present invention relates to a process for producing an optically active α-fluorocarboxylate derivative represented by the formula [2], by reacting an optically active α-hydroxycarboxylate derivative with trifluoromethanesulfonyl fluoride (CF3SO2F) in the presence of an organic base, in the formula [2], R represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 12; one of or two by any combination of aromatic hydrocarbon groups, unsaturated hydrocarbon groups, straight-chain or branched alkoxy groups of a carbon number of 1 to 6, aryloxy groups, halogen atoms (fluorine, chlorine, bromine and iodine), protected carboxyl groups, protected amino groups or protected hydroxyl group can be substituted on any carbon atoms of the alkyl group; R1 represents a straight-chain or branched-chain alkyl group of a carbon number of 1 to 8; any carbon atoms of the alkyl groups of R and R1 may form a covalent bond; and * represents an asymmetric carbon.

摘要翻译： 本发明涉及式（2）表示的光学活性α-氟代羧酸酯衍生物的制备方法，该方法通过在有机碱存在下使光学活性的α-羟基羧酸酯衍生物与三氟甲磺酰氟（CF 3 SO 2 F）在式 [2]中，R表示碳数为1〜12的直链或支链烷基; 碳数为1至6的芳族烃基，不饱和烃基，直链或支链烷氧基，芳氧基，卤素原子（氟，氯，溴和碘）的任意组合中的一个或两个，被保护的羧基 被保护的氨基或被保护的羟基可以在烷基的任何碳原子上被取代; R1表示碳数为1〜8的直链或支链烷基; R和R 1的烷基的任何碳原子可以形成共价键; 和*表示不对称碳。

公开(公告)号：US07459586B2

公开(公告)日：2008-12-02

申请号：US10591669

申请日：2005-02-21

申请人： Akihiro Ishii ,  Masatomi Kanai ,  Yokusu Kuriyama ,  Manabu Yasumoto ,  Kenjin Inomiya ,  Takashi Ootsuka ,  Katsuhide Suto ,  Koji Ueda

发明人： Akihiro Ishii ,  Masatomi Kanai ,  Yokusu Kuriyama ,  Manabu Yasumoto ,  Kenjin Inomiya ,  Takashi Ootsuka ,  Katsuhide Suto ,  Koji Ueda

IPC分类号： C07C209/62 ,  C07C211/00 ,  C07C251/00

CPC分类号： C07C251/24 ,  C07C209/52 ,  C07C209/62 ,  C07C211/29 ,  C07C249/02

摘要： The present invention relates to a method of producing an optically active 1-aryl-2-fluoro-substituted ethylamine compound of the formula [2] or a salt thereof by hydrogenolysis of an optically active secondary amine compound of the formula [1] or a salt thereof in the presence of a transition metal catalyst of Group VIII[Chem. 59] [where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon] [Chem. 60] [where Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon].

摘要翻译： 本发明涉及通过氢解式[1]的光学活性仲胺化合物或式[1]的光学活性的1-芳基-2-氟取代的乙胺化合物或其盐， 其盐在第VIII族的过渡金属催化剂存在下[Chem。 59]其中Ar表示芳基; n表示1或2的整数; 和*表示不对称碳] 60] [其中Ar表示芳基; n表示1或2的整数; 和*表示不对称碳]。

公开(公告)号：US07368609B2

公开(公告)日：2008-05-06

申请号：US11705089

申请日：2007-02-12

申请人： Akihiro Ishii ,  Masatomi Kanai ,  Yokusu Kuriyama ,  Manabu Yasumoto ,  Kenjin Inomiya ,  Takashi Ootsuka ,  Koji Ueda

发明人： Akihiro Ishii ,  Masatomi Kanai ,  Yokusu Kuriyama ,  Manabu Yasumoto ,  Kenjin Inomiya ,  Takashi Ootsuka ,  Koji Ueda

IPC分类号： C07C211/00

CPC分类号： C07C209/62 ,  C07B2200/07 ,  C07C211/29 ,  C07C217/58 ,  C07C249/02 ,  C07C251/24

摘要： An optically active 1-(fluoro-, trifluoromethyl- or trifluoromethoxy-substituted phenyl)alkylamine N-monoalkyl derivative represented by the formula 4 is produced by a process including (a) reacting an optically active secondary amine, represented by the formula 1, with an alkylation agent R2—X, in the presence of a base, thereby converting the secondary amine into an optically active tertiary amine represented by the formula 3; and (b) subjecting the tertiary amine to a hydrogenolysis, thereby producing the N-monoalkyl derivative, wherein R represents a fluorine atom, trifluoromethyl group or trifluoromethoxy group, n represents an integer of from 1 to 5, each of R1 and R2 independently represents an alkyl group having a carbon atom number of from 1 to 6, Me represents a methyl group, Ar represents a phenyl group or 1- or 2-naphthyl group, * represents a chiral carbon, and X represents a leaving group.

摘要翻译： 由式4表示的光学活性1-（氟 - ，三氟甲基 - 或三氟甲氧基取代的苯基）烷基胺N-单烷基衍生物通过以下方法制备，该方法包括：（a）使由式1表示的光学活性仲胺与式 烷基化剂R 2 -X在碱的存在下，由此将仲胺转化成由式3表示的光学活性叔胺; 和（b）使叔胺进行氢解，从而制备N-单烷基衍生物，其中R表示氟原子，三氟甲基或三氟甲氧基，n表示1〜5的整数，R 1 独立地表示碳原子数1〜6的烷基，Me表示甲基，Ar表示苯基或1-或2-萘基， *表示手性碳，X表示离去基团。

公开(公告)号：US07346002B2

公开(公告)日：2008-03-18

申请号：US10846876

申请日：2004-05-17

申请人： Kohji Hashimoto ,  Katsuya Nakamoto ,  Yuki Iwagami ,  Akihiro Ishii

发明人： Kohji Hashimoto ,  Katsuya Nakamoto ,  Yuki Iwagami ,  Akihiro Ishii

IPC分类号： G01R31/08

CPC分类号： G06F11/0757 ,  G06F11/221

摘要： A first control circuit section (master station) and a second control circuit section (substation) communicate with each other via series-parallel converters. The master station includes regular transmission device and transmission-permitting signal generation device; and the sub station includes regular report device, confirmation reply device relative to a transmission data from the master station, and an unprocessed data table. The unprocessed data table prevents jam-up in upstream communication from the sub station to the master station, enabling to carry out timely regular transmission and regular reporting. Transmission from the sub station to the master station is performed based on a transmission-permitting control signal that the master station generates. Consequently, it is possible to execute communication error processing and diminish communication control burden on the master station while properly performing the regular transmission and regular report between the master station and sub station.

摘要翻译： 第一控制电路部分（主站）和第二控制电路部分（变电站）通过串并联转换器彼此通信。 主站包括常规传输设备和传输许可信号发生设备; 并且子站包括相对于来自主站的传输数据的常规报告设备，确认回复设备和未处理的数据表。 未处理的数据表防止从子站到主站的上行通信中的卡住，能够及时定期传输和定期报告。 基于主站产生的发送允许控制信号，执行从子站到主站的传输。 因此，在主站和子站之间正常执行正常传输和定期报告的同时，可以执行通信错误处理并减少主站的通信控制负担。

公开(公告)号：US07287183B2

公开(公告)日：2007-10-23

申请号：US10788370

申请日：2004-03-01

申请人： Kohji Hashimoto ,  Katsuya Nakamoto ,  Yuki Iwagami ,  Akihiro Ishii

发明人： Kohji Hashimoto ,  Katsuya Nakamoto ,  Yuki Iwagami ,  Akihiro Ishii

IPC分类号： G06F11/00

CPC分类号： G05B23/0262 ,  B60W30/146 ,  G05B2219/24047

摘要： First and second control circuit sections that mutually communicate via a series-parallel converter comprise first and second adder-subtracter respectively. When any receiving error occurs in each control circuit section, a variation value 3 is added to the adder-subtracter on the receiving side. When data is normally received, a variation value 1 is subtracted from the adder-subtracter. Initial value of the adder-subtracter is set to 9. When a current value exceeds 11, first and second error detection signal is generated to carry out alarm display or initialization, and initialization and restart of the other-side control circuit section.

摘要翻译： 经由串并联转换器相互通信的第一和第二控制电路部分分别包括第一和第二加法器 - 减法器。 当在每个控制电路部分发生任何接收错误时，将变化值3添加到接收侧的加法器 - 减法器。 当正常接收到数据时，从加法器 - 减法器中减去变化值1。 加法器 - 减法器的初始值设置为9.当当前值超过11时，产生第一和第二错误检测信号，以进行报警显示或初始化，以及另一侧控制电路部分的初始化和重启。

公开(公告)号：US07189863B2

公开(公告)日：2007-03-13

申请号：US11347390

申请日：2006-02-06

申请人： Akihiro Ishii ,  Masatomi Kanai ,  Yokusu Kuriyama ,  Manabu Yasumoto ,  Kenjin Inomiya ,  Takashi Ootsuka ,  Koji Ueda

发明人： Akihiro Ishii ,  Masatomi Kanai ,  Yokusu Kuriyama ,  Manabu Yasumoto ,  Kenjin Inomiya ,  Takashi Ootsuka ,  Koji Ueda

IPC分类号： C07D319/06

CPC分类号： C07D317/22 ,  C07C43/315 ,  C07C45/57 ,  C07C45/59 ,  C07C45/60 ,  C07C49/84 ,  C07D317/16 ,  C07C49/80

摘要： A process for producing a brominated acetal (represented by the formula 3) includes (a) brominating a trifluoromethyl-substituted acetophenone by Br2 in the presence of an alkylene diol. It is optional to produce a trifluoromethyl-substituted 2-alkoxyacetophenone derivative (represented by the formula 9) by (b) reacting the brominated acetal with a metal alkoxide, thereby converting the brominated acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove an acetal group from the ether, thereby producing the 2-alkoxyacetophenone derivative. Alternatively, the 2-alkoxyacetophenone can be produced by (a) reacting a trifluoromethyl-substituted phenacyl halide with an acetalization agent, thereby converting the phenacyl halide into an acetal; (b) reacting the acetal with a metal alkoxide, thereby converting the acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove the acetal group from the ether

摘要翻译： 制备溴化缩醛的方法（由式3表示）包括（a）在亚烷基二醇的存在下用Br 2 H 3溴化三氟甲基取代的苯乙酮。 （b）使溴化缩醛与金属醇盐反应，从而将溴化缩醛转化成醚，任选地制备三氟甲基取代的2-烷氧基苯乙酮衍生物（由式9表示） 和（c）在酸催化剂的存在下水解醚，以从乙醚中除去缩醛基，从而制备2-烷氧基苯乙酮衍生物。 或者，2-烷氧基苯乙酮可以通过以下方法制备：（a）使三氟甲基取代的苯甲酰甲基卤化物与缩醛化剂反应，从而将苯甲酰甲酰卤转化成缩醛; （b）使缩醛与金属醇盐反应，从而将缩醛转化成醚; 和（c）在酸催化剂存在下水解该醚，以从乙醚中除去缩醛基

公开(公告)号：US20050276114A1

公开(公告)日：2005-12-15

申请号：US11033906

申请日：2005-01-13

申请人： Shoso Tsunekazu ,  Kohji Hashimoto ,  Yuki Iwagami ,  Akihiro Ishii

发明人： Shoso Tsunekazu ,  Kohji Hashimoto ,  Yuki Iwagami ,  Akihiro Ishii

IPC分类号： H04L12/40 ,  G06F13/38 ,  G11C16/06

CPC分类号： G06F13/385

摘要： In an electronic control unit, a control constant stored in a program memory is transmitted to a data memory via a serial communication circuit. First control circuit section (master station) and second control circuit section (substation) mutually communicate through series-parallel converters. The master station includes regular transmission device and storage constant confirmation processing device. The substation includes regular report device and confirmation reply device to a data transmitted from the master station. A constant set data transmitted from the master station by regular transmission device is stored in the data memory at the time of normal receiving. Confirmation information such as sum value of the entire data in the data memory is reported by regular report device. At the master station, if there is any error in the confirmation information, a constant set data is retransmitted with regular transmission device. Reliability of data in the data memory is improved.

摘要翻译： 在电子控制单元中，通过串行通信电路将存储在程序存储器中的控制常数发送到数据存储器。 第一控制电路部分（主站）和第二控制电路部分（变电站）通过串并联转换器相互通信。 主站包括常规传输设备和存储常数确认处理设备。 变电站对主站发送的数据包括常规报告设备和确认应答设备。 在正常接收时，从主站通过常规传输设备发送的恒定集合数据被存储在数据存储器中。 诸如数据存储器中的整个数据的和值的确认信息由常规报告装置报告。 在主站，如果确认信息中有任何错误，则会使用常规传输设备重传常数设置数据。 提高数据存储器中数据的可靠性。

公开(公告)号：US20050171363A1

公开(公告)日：2005-08-04

申请号：US10473399

申请日：2003-08-08

申请人： Akihiro Ishii ,  Masatomi Kanai ,  Yokusu Kuriyama ,  Manabu Yasumoto ,  Kenjin Inomiya ,  Takashi Ootsuka ,  Koji Ueda

发明人： Akihiro Ishii ,  Masatomi Kanai ,  Yokusu Kuriyama ,  Manabu Yasumoto ,  Kenjin Inomiya ,  Takashi Ootsuka ,  Koji Ueda

IPC分类号： C07C43/315 ,  C07C45/57 ,  C07C45/59 ,  C07C45/60 ,  C07C49/84 ,  C07D317/16 ,  C07D317/22 ,  C07D323/02

CPC分类号： C07D317/22 ,  C07C43/315 ,  C07C45/57 ,  C07C45/59 ,  C07C45/60 ,  C07C49/84 ,  C07D317/16 ,  C07C49/80

摘要： A process for producing a brominated acetal (represented by the formula 3) includes (a) brominating a trifluoromethyl-substituted acetophenone by Br2 in the presence of an alkylene diol. It is optional to produce a trifluoromethyl-substituted 2-alkoxyacetophenone derivative (represented by the formula 9) by (b) reacting the brominated acetal with a metal alkoxide, thereby converting the brominated acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove an acetal group from the ether, thereby producing the 2-alkoxyacetophenone derivative. Alternatively, the 2-alkoxyacetophenone can be produced by (a) reacting a trifluoromethyl-substituted phenacyl halide with an acetalization agent, thereby converting the phenacyl halide into an acetal; (b) reacting the acetal with a metal alkoxide, thereby converting the acetal into an ether; and (c) hydrolyzing the ether in the presence of an acid catalyst to remove the acetal group from the ether.

摘要翻译： 制备溴化缩醛的方法（由式3表示）包括（a）在亚烷基二醇的存在下用Br 2 H 3溴化三氟甲基取代的苯乙酮。 （b）使溴化缩醛与金属醇盐反应，从而将溴化缩醛转化成醚，任选地制备三氟甲基取代的2-烷氧基苯乙酮衍生物（由式9表示） 和（c）在酸催化剂的存在下水解醚，以从乙醚中除去缩醛基，从而制备2-烷氧基苯乙酮衍生物。 或者，2-烷氧基苯乙酮可以通过以下方法制备：（a）使三氟甲基取代的苯甲酰甲基卤化物与缩醛化剂反应，从而将苯甲酰甲酰卤转化成缩醛; （b）使缩醛与金属醇盐反应，从而将缩醛转化成醚; 和（c）在酸催化剂存在下水解该醚，以从乙醚中除去缩醛基。