中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

101 records (took 0.022 seconds)

    Reconfigurable fluidic manifold for a liquid chromatography system
    84.
    发明授权
    Reconfigurable fluidic manifold for a liquid chromatography system 有权

    公开(公告)号：US11275061B2

    公开(公告)日：2022-03-15

    申请号：US16545590

    申请日：2019-08-20

    Applicant: Waters Technologies Corporation

    Inventor： Jeffrey Musacchio ,  Keith Fadgen ,  Joseph D. Michienzi ,  Stanislaw Koziol

    IPC: G01N30/16 ,  G01N30/20 ,  G01N30/32 ,  G01N30/02

    Abstract: Described is a fluidic manifold that includes a block formed of multiple layers each bonded to at least one adjacent layer at a layer interface. Bonding may be achieved using a diffusion bonding process. The block includes one or more attachment surfaces and at least two fluidic channels. Each fluidic channel is at least partially disposed at one of the layer interfaces and has a first end at one of the attachment surfaces. Each attachment surface includes an attachment feature at the first end of one of the fluidic channels to enable a fluidic coupling of the two fluidic channels through a fluidic component. Attachment features include, for example, a compression fitting coupling body adapted to receive a conventional seal, such as a ferrule and compression screw, and a fitting body that permits a face seal or gasket seal between the fluidic component and the block.

    Multi-stage displacement pump
    86.
    发明授权
    Multi-stage displacement pump 有权

    公开(公告)号：US11181103B2

    公开(公告)日：2021-11-23

    申请号：US16444180

    申请日：2019-06-18

    Applicant: Waters Technologies Corporation

    Inventor： Wade P. Leveille ,  Jacob N. Fairchild ,  Jeffrey Musacchio ,  Joseph D. Michienzi

    IPC: F04B25/00 ,  F16K15/03 ,  F04B25/02 ,  F04B13/00 ,  F04B15/02

    Abstract: Described is a multi-stage pump having at least two stages. The multi-stage pump includes a first pump stage and a second pump stage each having a chamber of different diameter and volume. The multi-stage pump also includes a plunger having first and second plunger sections. The first plunger section has a first plunger diameter, a first end configured for coupling to a drive mechanism, and a second end opposite to the first end. The second plunger section has a second plunger diameter that is less than the first plunger diameter, a third end in contact with the second end of the first plunger, and a fourth end opposite the third end. Movement of the plunger produces a displacement volume for the first chamber that is different than a displacement volume produced for the second chamber. The multi-stage pump can be configured in different operational modes to provide different flow rates.

    ESTABLISHING FLUIDIC CONNECTIONS BETWEEN CHROMATOGRAPHY COMPONENTS
    87.
    发明申请
    ESTABLISHING FLUIDIC CONNECTIONS BETWEEN CHROMATOGRAPHY COMPONENTS 有权

    公开(公告)号：US20210341437A1

    公开(公告)日：2021-11-04

    申请号：US17239813

    申请日：2021-04-26

    Applicant: Waters Technologies Corporation

    Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Joseph D. Antocci ,  Jeffrey Musacchio

    IPC: G01N30/60

    Abstract: A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

    SEAL FOR SEPARATION DEVICE
    88.
    发明申请
    SEAL FOR SEPARATION DEVICE 有权

    公开(公告)号：US20210339166A1

    公开(公告)日：2021-11-04

    申请号：US17241480

    申请日：2021-04-27

    Applicant: Waters Technologies Corporation

    Inventor： Jonathan L. Belanger ,  Wade P. Leveille ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Jeffrey Musacchio

    IPC: B01D15/22 ,  F16J15/34

    Abstract: Described are apparatuses, devices, and systems implementing seals for separation devices. An apparatus for a separation device may include an end nut shaped to be positioned on one of an inlet side and an outlet side of the separation device. The end nut may be further shaped to mate with a connecting fitting. The apparatus may further include a face seal having a device side and a fitting side. The face seal may be positioned, at least in part, in the end nut on the device side of the face seal. The face seal may be positioned to interface with the connecting fitting on the fitting side of the face seal upon the end nut being mated with the connecting fitting. The apparatus may also include a face seal bore of the face seal being axially alignable with at least one of an inlet and an outlet of the separation device.

    System and method for sample introduction within a chromatography system
    89.
    发明授权
    System and method for sample introduction within a chromatography system 有权

    公开(公告)号：US11150224B2

    公开(公告)日：2021-10-19

    申请号：US16425004

    申请日：2019-05-29

    Applicant: Waters Technologies Corporation

    Inventor： Michael O. Fogwill ,  Joseph D. Michienzi

    IPC: G01N30/32 ,  G01N30/16 ,  G01N30/60

    Abstract: The present disclosure relates to methodologies, systems, apparatus, and kits for introducing a sample within a chromatography system. A makeup pump is configured to pump a makeup fluid through a first restrictor into the chromatography system upstream of the column and downstream of a mobile phase pump. The first restrictor is located upstream of a column and downstream of makeup pump and a sample fluid pump. Decreasing an output volume of the makeup pump can direct a sample fluid from the sample fluid pump through the first restrictor to the column. Increasing an output volume of the makeup pump can direct the sample fluid to a second restrictor located downstream of the makeup pump and in parallel with the column and the detector.

    Catalytic oxidation of polar modifiers in chromatographic mobile phases
    90.
    发明授权
    Catalytic oxidation of polar modifiers in chromatographic mobile phases 有权

    公开(公告)号：US10830742B2

    公开(公告)日：2020-11-10

    申请号：US16197601

    申请日：2018-11-21

    Applicant: Waters Technologies Corporation

    Inventor： Michael O. Fogwill ,  Joseph D. Michienzi ,  James P. Murphy

    IPC: G01N30/84 ,  G01N30/68 ,  G01N27/62

    Abstract: The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.

Patent Agency Ranking