公开(公告)号：US20230094740A1

公开(公告)日：2023-03-30

申请号：US18070859

申请日：2022-11-29

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Joseph D. Antocci ,  Francis Patrick Tracey ,  Charles H. Phoebe, JR.

IPC: G01N30/20 ,  G01N30/24 ,  G01N30/38

Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.

公开(公告)号：US20210302395A1

公开(公告)日：2021-09-30

申请号：US17209502

申请日：2021-03-23

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Joseph D. Antocci ,  Francis Patrick Tracey ,  Charles H. Phoebe, JR.

IPC: G01N30/20 ,  G01N30/38 ,  G01N30/24

Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.

公开(公告)号：US11573211B2

公开(公告)日：2023-02-07

申请号：US17209502

申请日：2021-03-23

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Joseph D. Antocci ,  Francis Patrick Tracey ,  Charles H. Phoebe, Jr.

IPC: G01N30/24 ,  G01N30/20 ,  G01N30/38 ,  G01N30/02

Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.

公开(公告)号：US12007371B2

公开(公告)日：2024-06-11

申请号：US16822769

申请日：2020-03-18

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Joseph D. Antocci ,  Wade P. Leveille, Sr.

IPC: F16L15/04 ,  G01N30/60 ,  G01N30/02

CPC classification number: G01N30/6026 ,  F16L15/04 ,  G01N2030/027

Abstract: A removable seal device for fluidic coupling includes a seal body extending between a first end and a second end, the seal body including an inner channel configured to receive a flow of a fluid. The first end of the seal body includes a first sealing surface configured to create a first seal with a fitting sealing surface of a receiver fitting, and the seal body includes a second sealing surface configured to create a second seal with an end of a fluidic tube. The removable seal is configured to be removably secured to at least one of the fluidic tube, a support feature fixed to the fluidic tube, and a compression screw, such that untightening of the compression screw from the receiver fitting causes the removable seal device to be removed from the receiver fitting.

公开(公告)号：US11965863B2

公开(公告)日：2024-04-23

申请号：US18070859

申请日：2022-11-29

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Joseph D. Antocci ,  Francis Patrick Tracey ,  Charles H. Phoebe, Jr.

IPC: G01N30/24 ,  G01N30/20 ,  G01N30/38 ,  G01N30/02

CPC classification number: G01N30/20 ,  G01N30/24 ,  G01N30/38 ,  G01N2030/027 ,  G01N2030/207

Abstract: A liquid chromatography system includes a solvent delivery system, a sample manager including a sample delivery system in fluidic communication with the solvent delivery system, the sample delivery system configured to inject a sample from a sample-vial into a chromatographic flow stream, a liquid chromatography column located downstream from the sample delivery system, and a detector located downstream from the liquid chromatography column. The sample delivery system further includes a first needle drive including a first sample needle configured to extract the sample from the sample-vial and deliver the sample to the liquid chromatography column, and a first syringe in communication with the first sample needle configured to meter extraction of the sample from the sample-vial. The sample manager further includes a sample automation system that includes a second needle drive including a second sample needle configured to add a volume of reagent to the sample-vial.

公开(公告)号：US20240044852A1

公开(公告)日：2024-02-08

申请号：US18491132

申请日：2023-10-20

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Joseph D. Antocci ,  Jeffrey Musacchio

IPC: G01N30/60

CPC classification number: G01N30/6026 ,  G01N30/6047

Abstract: A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：US11796516B2

公开(公告)日：2023-10-24

申请号：US17239813

申请日：2021-04-26

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Joseph D. Michienzi ,  Joseph D. Antocci ,  Jeffrey Musacchio

IPC: G01N30/60

CPC classification number: G01N30/6026 ,  G01N30/6047

Abstract: A clamp assembly includes a rail extending along the length and configured to receive a first fluidic assembly, and a carriage movably attachable to the rail such that the carriage moves along the rail, the carriage configured to receive a second fluidic assembly, the carriage including an actuator and a stop mechanism. The stop mechanism is configured to selectively prevent and allow movement of the carriage relative to the rail. The stop mechanism is configured to be independently operable from the actuator assembly, and the actuator is configured: to move a chromatography column received by the clamp assembly relative to the rail to create a first fluid tight seal between the chromatography column and the first fluidic assembly, and move the second fluidic assembly relative to the carriage body to create a second fluid tight seal between the second fluidic assembly and the chromatography column.

公开(公告)号：US20220128526A1

公开(公告)日：2022-04-28

申请号：US17513003

申请日：2021-10-28

Applicant: Waters Technologies Corporation

Inventor： Wade P. Leveille ,  Sylvain G. Cormier ,  Michael O. Fogwill ,  Joseph D. Michienzi ,  Jeffrey Musacchio ,  Joseph D. Antocci

IPC: G01N30/60 ,  B01D15/22

Abstract: Exemplary embodiments integrate a tee or valve into an outlet end fitting of a liquid chromatography column. The tee or valve is suitable for providing additional fluidic flow paths to ports of the end fitting and eliminates the need for post-column fluidic conduits connecting to tees or valves to insert fluidic inputs or divert flow to outputs. This integration decreases the distance that eluent from the liquid chromatography column has to travel to reach a detector relative to systems that use external tees or valves while providing tee/valve functionality and reducing the fluidic volume post-column. As a result, the exemplary embodiments help decrease sample dispersion.

公开(公告)号：US20200300821A1

公开(公告)日：2020-09-24

申请号：US16822769

申请日：2020-03-18

Applicant: Waters Technologies Corporation

Inventor： Sylvain Gilles Cormier ,  Joseph D. Antocci ,  Wade P. Leveille, Sr.

IPC: G01N30/60 ,  F16L15/04

Abstract: A removable seal device for fluidic coupling includes a seal body extending between a first end and a second end, the seal body including an inner channel configured to receive a flow of a fluid. The first end of the seal body includes a first sealing surface configured to create a first seal with a fitting sealing surface of a receiver fitting, and the seal body includes a second sealing surface configured to create a second seal with an end of a fluidic tube. The removable seal is configured to be removably secured to at least one of the fluidic tube, a support feature fixed to the fluidic tube, and a compression screw, such that untightening of the compression screw from the receiver fitting causes the removable seal device to be removed from the receiver fitting.

公开(公告)号：US20150184760A1

公开(公告)日：2015-07-02

申请号：US14408403

申请日：2013-06-03

Applicant: Waters Technologies Corporation

Inventor： Mark W. Moeller ,  Joseph D. Antocci ,  Robert A. Jencks

IPC: F16K5/04 ,  B29C45/56 ,  F16K11/085

CPC classification number: F16K5/045 ,  B29C45/561 ,  B29K2071/00 ,  B29K2507/04 ,  F16K11/0743 ,  F16K11/085 ,  G01N2030/202

Abstract: A shear valve assembly for use in a high performance liquid chromatography system. The shear valve assembly includes a stator having a plurality of first fluid-conveying features; and a rotor having one or more second fluid-conveying features. The rotor is movable, relative to the stator, between a plurality of discrete positions such that, in each of the discrete positions, at least one of the one or more second fluid-conveying features overlaps with multiple ones of the first fluid conveying features to provide for fluid communication therebetween. The rotor, including the second fluid-conveying features, is formed by injection-compression molding.

Abstract translation: 用于高效液相色谱系统的剪切阀组件。 剪切阀组件包括具有多个第一流体输送特征的定子; 以及具有一个或多个第二流体输送特征的转子。 转子可相对于定子在多个离散位置之间移动，使得在每个离散位置中，一个或多个第二流体输送特征中的至少一个与第一流体输送特征中的多个重叠， 提供其间的流体连通。 包括第二流体输送特征的转子通过注射压缩成型形成。