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公开(公告)号：US06656467B2
公开(公告)日：2003-12-02
申请号：US09771415
申请日：2001-01-26
IPC分类号： A61K3942
CPC分类号： C07K16/00 , A61K2039/505 , C07K16/1027 , C07K2317/24 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2319/00
摘要： Ultra high affinity antibodies with binding affinities in the range of 1010 M−1, and even 1011 M−1 are disclosed. Such antibodies include antibodies having novel high affinity complementarity determining regions (CDRs), especially those with framework and constant regions derived from either humans or mice. Methods of preparing and screening such antibodies, as well as methods of using them to prevent and/or treat disease, especially virus-induced diseases, are also disclosed.
摘要翻译： 公开了具有10 10 M -1，甚至10 11 M -1范围内的结合亲和力的超高亲和力抗体。 此类抗体包括具有新型高亲和力互补决定区（CDR）的抗体，特别是具有来自人或小鼠的骨架和恒定区的抗体。 还公开了制备和筛选这些抗体的方法，以及使用它们来预防和/或治疗疾病，特别是病毒诱导的疾病的方法。
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公开(公告)号：US06312693B1
公开(公告)日：2001-11-06
申请号：US09247352
申请日：1999-02-10
申请人： Alejandro A. Aruffo , Diane Hollenbaugh , Anthony W. Siadak , Karen K. Berry , Linda Harris , Barbara A. Thorne , Jurgen Bajorath , William D. Huse , Herren Wu , Jeffry D. Watkins
发明人： Alejandro A. Aruffo , Diane Hollenbaugh , Anthony W. Siadak , Karen K. Berry , Linda Harris , Barbara A. Thorne , Jurgen Bajorath , William D. Huse , Herren Wu , Jeffry D. Watkins
IPC分类号： A61K39395
CPC分类号： C07K16/2878 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： The Applicants have discovered humanized anti-human CD40 antibodies which block the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent antigens, collagen induced arthritis, and skin transplantation, and are also useful for their anti-inflammatory properties.
摘要翻译： 申请人已经发现阻断gp39和CD40之间相互作用的人源化抗人CD40抗体。 本发明的抗CD40抗体可有效调节针对T细胞依赖性抗原，胶原诱导的关节炎和皮肤移植的体液免疫应答，并且还可用于其抗炎性质。
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83.发明授权Crystals and structure of a human IgG Fc variant with enhanced FcRn binding 有权具有增强的FcRn结合的人IgG Fc变体的晶体和结构公开(公告)号：US08775090B2
公开(公告)日：2014-07-08
申请号：US13133845
申请日：2009-12-10
CPC分类号： C07K16/00 , C07K16/1027 , C07K2317/21 , C07K2317/52 , C07K2317/92
摘要： Provided herein are crystalline forms of a human IgG Fc variant comprising triple-mutation M252Y/S254T/T256E that provides for increased binding affinity to human neonatal Fc receptor, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. Also provided are machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them.
摘要翻译： 本文提供包含提供对人新生儿Fc受体的增加的结合亲和力的三突变M252Y / S254T / T256E的人IgG Fc变体的结晶形式，获得这种晶体的方法和高分辨率X射线衍射结构和原子结构坐标 。 还提供了嵌入人IgG Fc变体的三维原子结构坐标的机器可读介质以及使用它们的方法。
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公开(公告)号：US08604171B2
公开(公告)日：2013-12-10
申请号：US13559938
申请日：2012-07-27
申请人： Sanjaya Singh , Herren Wu , Catherine Foster
发明人： Sanjaya Singh , Herren Wu , Catherine Foster
CPC分类号： C07K16/18 , C07K16/005 , C07K16/4291 , C07K2317/24 , C07K2317/55 , C07K2317/565 , C07K2317/567 , G01N33/6854 , G01N2800/24 , Y10S435/81
摘要： The invention relates to high affinity human monoclonal antibodies, particularly those directed against isotypic determinants of immunoglobulin E (IgE), as well as direct equivalents and derivatives of these antibodies. These antibodies bind to their respective target with an affinity at least 100 fold greater than the original parent antibody. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
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公开(公告)号：US08481037B2
公开(公告)日：2013-07-09
申请号：US13007211
申请日：2011-01-14
申请人： Jennifer Lynne Reed , Herren Wu , Ying Tang , Julian Davies , Jeffry Watkins
发明人： Jennifer Lynne Reed , Herren Wu , Ying Tang , Julian Davies , Jeffry Watkins
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K2317/24 , C07K2317/76 , C07K2317/92 , G01N33/6869
摘要： The present invention provides novel antibodies that immunospecifically bind to an IL-9 polypeptide and compositions comprising said antibodies. The present invention also provides methods and compositions preventing, treating, managing, and/or ameliorating diseases and disorders associated with aberrant expression and/or activity of IL 9 or IL-9 receptor or subunits thereof, autoimmune diseases, inflammatory diseases, proliferative diseases, and infections comprising administration of one or more antibodies thereof that immunospecifically bind to an IL-9 polypeptide. The invention also encompasses methods and compositions for diagnosing, monitoring, and prognosing these disorders. The present invention further relates to articles of manufacture and kits comprising antibodies that immunospecifically bind to an IL-9 polypeptide.
摘要翻译： 本发明提供免疫特异性结合IL-9多肽的新型抗体和包含所述抗体的组合物。 本发明还提供了预防，治疗，治疗和/或改善与IL 9或IL-9受体或其亚基的异常表达和/或活性相关的疾病和病症的方法和组合物，自身免疫性疾病，炎性疾病，增殖性疾病， 以及感染，其包括施用一种或多种免疫特异性结合IL-9多肽的抗体。 本发明还包括用于诊断，监测和预测这些疾病的方法和组合物。 本发明还涉及包含免疫特异性结合IL-9多肽的抗体的制品和试剂盒。
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86.发明授权Method of identifying membrane Ig specific antibodies and use thereof for targeting immunoglobulin-producing precursor cells 有权鉴定膜Ig特异性抗体的方法及其用于靶向产生免疫球蛋白的前体细胞的用途公开(公告)号：US08404236B2
公开(公告)日：2013-03-26
申请号：US13372170
申请日：2012-02-13
申请人： Herren Wu , Peter Kiener , Partha S. Chowdhury , James F. Young
发明人： Herren Wu , Peter Kiener , Partha S. Chowdhury , James F. Young
IPC分类号： A61K39/00
CPC分类号： G01N33/56972 , A61K2039/505 , C07K16/4291 , C07K2317/52 , C07K2317/55 , Y10S424/805 , Y10S530/862 , Y10S530/868
摘要： The present invention relates to the discovery of antibodies that bind to novel epitopes present on membrane-anchored immunoglobulins and which bind to these novel epitopes on the surface of B cells and plasma cells. In addition, the antibodies of the present invention can mediate ADCC and can be useful to deplete those B cells and plasma cells expressing the novel epitopes of the invention. The antibodies of the present invention can be useful for the treatment of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells. Accordingly the present invention also provides compositions and methods for the prevention, management, treatment or amelioration of B cell-mediated diseases and diseases caused by monoclonal expansion of B cells.
摘要翻译： 本发明涉及结合存在于膜锚定的免疫球蛋白上并与B细胞和浆细胞表面上的这些新表位结合的抗体的发现。 此外，本发明的抗体可以介导ADCC，并且可用于消耗表达本发明的新表位的那些B细胞和浆细胞。 本发明的抗体可用于治疗由B细胞的单克隆扩增引起的B细胞介导的疾病和疾病。 因此，本发明还提供了用于预防，治疗或改善由B细胞的单克隆扩增引起的B细胞介导的疾病和疾病的组合物和方法。
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公开(公告)号：US08372403B2
公开(公告)日：2013-02-12
申请号：US13461253
申请日：2012-05-01
申请人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
发明人： Ling-Ling An , Sek Chung Fung , Robert F. Kelley , Henry B. Lowman , Sanjaya Singh , Herren Wu
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C07K2317/24 , C07K2317/50 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The invention relates to humanized anti-human Factor D monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease.
摘要翻译： 本发明涉及人源化抗人因子D单克隆抗体，其核酸和氨基酸序列，携带这些抗体的细胞和载体及其在制备用于治疗与过度或不受控制的疾病和病症的组合物和药物中的用途 补体激活。 这些抗体可用于疾病的诊断，预防和治疗。
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88.发明申请CRYSTALS AND STRUCTURE OF A HUMAN IgG Fc VARIANT WITH ENHANCED FcRn BINDING 有权具有增强FcRn结合的人IgG Fc变体的晶体和结构公开(公告)号：US20110288276A1
公开(公告)日：2011-11-24
申请号：US13133845
申请日：2009-12-10
CPC分类号： C07K16/00 , C07K16/1027 , C07K2317/21 , C07K2317/52 , C07K2317/92
摘要： Provided herein are crystalline forms of a human IgG Fc variant comprising triple-mutation M252Y/S254T/T256E that provides for increased binding affinity to human neonatal Fc receptor, methods of obtaining such crystals and high-resolution X-ray diffraction structures and atomic structure coordinates. Also provided are machine readable media embedded with the three-dimensional atomic structure coordinates of the human IgG Fc variant and methods of using them.
摘要翻译： 本文提供包含提供对人新生儿Fc受体的增加的结合亲和力的三突变M252Y / S254T / T256E的人IgG Fc变体的结晶形式，获得这种晶体的方法和高分辨率X射线衍射结构和原子结构坐标 。 还提供了嵌入人IgG Fc变体的三维原子结构坐标的机器可读介质以及使用它们的方法。
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公开(公告)号：US20110280892A1
公开(公告)日：2011-11-17
申请号：US12974953
申请日：2010-12-21
申请人： Michael S. Kinch , Herren Wu , Christine Bachy , David Tice , Changshou Gao , Peter D. Senter
发明人： Michael S. Kinch , Herren Wu , Christine Bachy , David Tice , Changshou Gao , Peter D. Senter
CPC分类号： C07K16/2866 , A61K47/6811 , A61K47/6849 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/75 , C07K2317/77
摘要： The present invention relates to compositions and methods for inducing cell death or stasis in cancer cells or other hyperproliferative cells using anti-EphA2 or anti-EphA4 antibodies conjugated to toxins.
摘要翻译： 本发明涉及使用与毒素缀合的抗EphA2或抗EphA4抗体诱导癌细胞或其它过度增殖细胞中的细胞死亡或停滞的组合物和方法。
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公开(公告)号：US07790655B2
公开(公告)日：2010-09-07
申请号：US11580005
申请日：2006-10-13
申请人： Changshou Gao , Herren Wu
发明人： Changshou Gao , Herren Wu
CPC分类号： C07K16/00 , C07K16/005 , C07K16/22 , C07K16/2842 , C07K16/2848 , C07K16/2866 , C07K2317/21 , C07K2317/622 , C07K2317/71 , C07K2317/732 , C07K2317/734 , C07K2319/03 , C07K2319/035 , C07K2319/30 , C12N15/1037
摘要： The present invention relates to a viral vector encoding for a library of antibodies or antibody fragments that are displayed on the cell membrane when expressed in a cell. The present invention provides cells comprising the viral vector nucleic acids and methods of screening the libraries for antibodies or antibody fragments with desired characteristics.
摘要翻译： 本发明涉及编码当在细胞中表达时在细胞膜上显示的抗体文库或抗体片段的病毒载体。 本发明提供了包含病毒载体核酸的细胞和筛选具有所需特征的抗体或抗体片段的文库的方法。
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