公开(公告)号：US08753325B2

公开(公告)日：2014-06-17

申请号：US13576461

申请日：2011-02-23

Applicant: Nimrod Lev ,  Amir Lev ,  Niv Ben Shalom

Inventor： Nimrod Lev ,  Amir Lev ,  Niv Ben Shalom

IPC: A61B19/00

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61J1/2055 ,  A61J1/2075 ,  A61J1/2082

Abstract: Liquid drug transfer devices including a vented vial adapter having a top wall, a downward depending skirt, and a dual lumen puncturing spike. The top wall includes vent apertures in flow communication with an underlying air filter and protective hoods for covering the vent apertures from splashes. The hood-like hoods are preferably quarter sphere shaped with hood apertures facing radial outwards.

Abstract translation: 液体药物转移装置包括具有顶壁，向下悬垂的裙部和双腔穿刺尖端的通气小瓶适配器。 顶壁包括与下面的空气过滤器流动连通的通气孔和用于覆盖通风孔的飞溅的防护罩。 罩状罩优选为四分之一球形，其中罩面孔径向向外。

公开(公告)号：US08752598B2

公开(公告)日：2014-06-17

申请号：US14005751

申请日：2012-04-17

Applicant: Igor Denenburg ,  Nimrod Lev ,  Mordechai Bukhman

Inventor： Igor Denenburg ,  Nimrod Lev ,  Mordechai Bukhman

IPC: B67C3/00

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2065 ,  A61J1/2072 ,  A61J1/2086 ,  A61J1/2089

Abstract: Liquid drug transfer assemblies for use with a drug vial having a drug vial opening stopped by a drug vial stopper. The liquid drug transfer assemblies include a drug vial stopper puncturing member for puncturing a drug vial stopper. The liquid drug transfer assemblies also include a drug vial adapter having a drug vial adapter skirt, an upright drug vial adapter port and a drug vial adapter sleeve downward depending opposite the upright drug vial adapter port and in flow communication therewith. The drug vial adapter is slidingly disposed on the drug vial stopper puncturing member such that on mounting the liquid drug transfer assembly on the drug vial, the drug vial stopper puncturing member punctures the drug vial stopper to form a throughgoing puncture bore and the drug vial adapter sleeve lines the puncture bore.

Abstract translation: 用于药物小瓶的液体药物转移组件，其具有由药瓶停止的药物小瓶开口。 液体药物转移组件包括用于刺穿药瓶塞的药瓶停止穿刺构件。 液体药物转移组件还包括具有药物瓶适配器裙部的药物瓶适配器，直立药物瓶适配器端口和药物瓶适配器套筒，其向下垂直于药物药瓶适配器端口并与其流动连通。 药物瓶适配器滑动地设置在药瓶停止穿刺构件上，使得在将液体药物转移组件安装在药物小瓶上时，药瓶停止穿刺构件穿刺药瓶塞以形成通过的穿刺孔，并且药瓶适配器 套管穿刺穿孔。

公开(公告)号：US20140020793A1

公开(公告)日：2014-01-23

申请号：US14005751

申请日：2012-04-17

Applicant: Igor Denenburg ,  Nimrod Lev ,  Mordechai Bukhman

Inventor： Igor Denenburg ,  Nimrod Lev ,  Mordechai Bukhman

IPC: A61J1/20

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2065 ,  A61J1/2072 ,  A61J1/2086 ,  A61J1/2089

Abstract: Liquid drug transfer assemblies for use with a drug vial having a drug vial opening stopped by a drug vial stopper. The liquid drug transfer assemblies include a drug vial stopper puncturing member for puncturing a drug vial stopper. The liquid drug transfer assemblies also include a drug vial adapter having a drug vial adapter skirt, an upright drug vial adapter port and a drug vial adapter sleeve downward depending opposite the upright drug vial adapter port and in flow communication therewith. The drug vial adapter is slidingly disposed on the drug vial stopper puncturing member such that on mounting the liquid drug transfer assembly on the drug vial, the drug vial stopper puncturing member punctures the drug vial stopper to form a throughgoing puncture bore and the drug vial adapter sleeve lines the puncture bore.

Abstract translation: 用于药物小瓶的液体药物转移组件，其具有由药瓶停止的药物小瓶开口。 液体药物转移组件包括用于刺穿药瓶塞的药瓶停止穿刺构件。 液体药物转移组件还包括具有药物瓶适配器裙部的药物瓶适配器，直立药物瓶适配器端口和药物瓶适配器套筒，其向下垂直于药物药瓶适配器端口并与其流动连通。 药物瓶适配器滑动地设置在药瓶停止穿刺构件上，使得在将液体药物转移组件安装在药物小瓶上时，药瓶停止穿刺构件穿刺药瓶塞以形成通过的穿刺孔，并且药瓶适配器 套管穿刺穿孔。

公开(公告)号：US08597232B2

公开(公告)日：2013-12-03

申请号：US13518036

申请日：2010-12-22

Applicant: Nimrod Lev ,  Zvika Zinger ,  Moshe Gilboa

Inventor： Nimrod Lev ,  Zvika Zinger ,  Moshe Gilboa

IPC: A61M3/02 ,  A61M5/00

CPC classification number: A61J1/2096 ,  A61J1/2031 ,  A61J1/2058

Abstract: Medical apparatus (10) for use with single use kits (100) containing a flow control device (101), a syringe (40), and one or more vials (60A, 608, 60C), for reconstituting a liquid drug dosage and administrating same. The flow control devices (101) include a core member (116) having an inlet port (107) and a flow control member (117) rotatably mounted on the core member (116) and having at least one vial port (112,113,114) for attachment of a vial and an outlet port (109). Flow control devices (101) are designed to ensure an inlet port (107) is in flow communication with a single port (112,113,114) at each flow control position of at least two predetermined flow control positions of a flow control member (117) relative to a core member (116). The medical apparatus (10) includes a housing (11) having a syringe support (12) for horizontally supporting a syringe (40) and a flow control device support (13) for horizontally supporting a flow control device (101). The medical apparatus (10) can be designed for either manual operation or automatic operation.

Abstract translation: 用于包含流量控制装置（101），注射器（40）和一个或多个小瓶（60A，608,60C）的单一使用试剂盒（100）的医疗装置（10），用于重建液体药物剂量并施用 相同。 流量控制装置（101）包括具有可旋转地安装在芯构件（116）上的入口（107）和流量控制构件（117）的芯构件（116），并且具有用于附接的至少一个小瓶端口（112,113,114） 的小瓶和出口（109）。 流量控制装置（101）被设计成确保入口端口（107）在流动控制构件（117）的至少两个预定流量控制位置的相应流动控制位置处与单个端口（112,113,114）流动连通 芯构件（116）。 医疗设备（10）包括具有用于水平支撑注射器（40）的注射器支撑件（12）和用于水平支撑流量控制装置（101）的流量控制装置支撑件（13）的壳体（11）。 医疗设备（10）可以设计为手动操作或自动操作。

公开(公告)号：US20130190691A1

公开(公告)日：2013-07-25

申请号：US13521181

申请日：2011-01-19

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61M5/145

CPC classification number: A61M5/14566 ,  A61M5/1452 ,  A61M5/1456 ,  A61M5/2425 ,  A61M2005/14506

Abstract: A cartridge interface assembly (80) characterised by a driving plunger (82) including an outer shaft (84), and a driver (86) including an inner shaft (88) movable telescopically with respect to the outer shaft (84), wherein rotation of the driver (86) causes the driving plunger (82) to advance in a direction away from the driver (86), and wherein the cartridge interface assembly (80) is inserted in a cartridge (22) in which a plunger (24) is slidingly disposed, and rotation of the driver (86) causes the driving plunger (82) to advance distally in the cartridge (22) until abutting against the plunger (24).

Abstract translation: 一种盒式接口组件（80），其特征在于包括外轴（84）的驱动柱塞（82）和包括相对于外轴（84）可伸缩地移动的内轴（88）的驱动器（86），其中旋转 驱动器（86）使得驱动柱塞（82）沿远离驱动器（86）的方向前进，并且其中盒式接口组件（80）插入到其中柱塞（24）的盒（22）中， 滑动地设置，并且驱动器（86）的旋转导致驱动柱塞（82）在盒（22）中向远侧前进直到抵靠柱塞（24）。

公开(公告)号：US08317743B2

公开(公告)日：2012-11-27

申请号：US12678928

申请日：2008-07-15

Applicant: Igor Denenburg

Inventor： Igor Denenburg

IPC: A61M37/00

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61J1/2037 ,  A61J1/2051 ,  A61J1/2055 ,  A61J1/2089

Abstract: A method for mixing and injection and an apparatus for performing the method includes the use of a needle and a needle base, a syringe attachment element and a mixing chamber engagement assembly including a needle chamber surrounding the needle and a first liquid conduit portion, sealed from the needle chamber. A mixing chamber engagement portion includes a second liquid conduit portion communicating with the first liquid conduit portion and a mixing chamber. When the syringe attachment element and the needle base are in a first relative engagement orientation liquid can flow between an interior of the syringe and the first liquid conduit portion and upon axially displacing the needle base and syringe attachment element to a second relative engagement orientation, liquid can flow between an interior of the syringe and the needle.

Abstract translation: 混合注射的方法和用于执行该方法的装置包括使用针和针座，注射器安装元件和混合室接合组件，其包括围绕针的针室和第一液体导管部分， 针室。 混合室接合部分包括与第一液体导管部分和混合室连通的第二液体导管部分。 当注射器附接元件和针座处于第一相对接合方向时，液体可以在注射器的内部和第一液体导管部分之间流动，并且在将针座和注射器附接元件轴向移位到第二相对接合方向时，液体 可以在注射器的内部和针之间流动。

公开(公告)号：US20120220978A1

公开(公告)日：2012-08-30

申请号：US13505790

申请日：2010-10-19

Applicant: Nimrod Lev ,  Niv Ben Shalom

Inventor： Nimrod Lev ,  Niv Ben Shalom

IPC: A61J1/20

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61J1/2055

Abstract: The present invention is directed toward fluid transfer devices including a vial adapter having a top wall and a cannula with a cannula tip, and an elastic O-ring like sealing element sealingly encircling the cannula and initially disposed towards the cannula tip and spaced apart from the top wall, the sealing element being brought into initial contact with the vial stopper subsequent to the cannula tip contacting the vial stopper at a puncture site and thereafter being slidingly urged towards the top wall and continuously sealing the puncture site during snap fit mounting the vial adapter on the vial.

Abstract translation: 本发明涉及流体输送装置，其包括具有顶壁和具有套管尖端的插管的小瓶适配器，以及密封地环绕套管的弹性O形圈状密封元件，并且最初设置成朝向套管末端并与 顶壁，密封元件在插管尖端在穿刺部位接触药瓶塞子之后与瓶塞初始接触，然后被滑动地朝向顶壁推动并且在卡扣配合期间连续密封穿刺部位，安装小瓶适配器 在小瓶上。

公开(公告)号：US08152779B2

公开(公告)日：2012-04-10

申请号：US12345818

申请日：2008-12-30

Applicant: Oz Cabiri

Inventor： Oz Cabiri

IPC: A61M5/31 ,  A61M5/20

CPC classification number: A61M5/14248 ,  A61M2005/14252

Abstract: A needle assembly adapted for fluid communication with a vial containing a substance to be delivered to a subject, the needle assembly including a needle held in a needle holder, the needle holder confined to move in a housing, and an activation mechanism for activating delivery of the substance through the needle, the activation mechanism including a safety latch that initially impedes movement of the needle holder, wherein when the safety latch is placed on the subject, the safety latch moves to a position that permits moving the needle holder to cause the needle to protrude outwards of the housing to pierce the subject to allow administration of the substance to the subject.

Abstract translation: 一种针组件，其适于与包含要递送到被检体的物质的小瓶流体连通，所述针组件包括保持在针保持器中的针，所述针保持器限定在壳体中移动，以及用于激活输送的活动机构 所述物质通过所述针，所述致动机构包括最初阻止所述针保持器的运动的安全闩锁，其中当所述安全闩锁被放置在所述被检体上时，所述安全闩锁移动到允许移动所述针架以使所述针头 突出到外壳的外面以刺穿受试者，以允许物质向受试者施用。

公开(公告)号：US08016809B2

公开(公告)日：2011-09-13

申请号：US12679676

申请日：2008-09-24

Applicant: Freddy Zinger ,  Niv Ben Shalom

Inventor： Freddy Zinger ,  Niv Ben Shalom

IPC: A61M5/32

CPC classification number: A61J1/2096 ,  A61J1/201 ,  A61J1/2055 ,  A61M5/162 ,  A61M39/223

Abstract: Liquid drug delivery device includes a housing with a syringe port for sealingly receiving a syringe having a syringe tip ending at a widened distal tip, a vial adapter port with a vial adapter for snap fit receiving a vial, and a drug administration port for administering a liquid drug. The vial adapter is intended to be rotationally detached after a mixing procedure for discarding together with a spent vial. The syringe port additionally includes a single use locking mechanism for securing the syringe to preclude inadvertent syringe detachment under normal use including agitation for reconstitution purposes. The drug administration port has a distal tip preferably similar to a syringe's widened distal tip for the same purpose of preventing conventional needles with a female Luer connector being slidingly mounted thereon.

Abstract translation: 液体药物输送装置包括具有注射器端口的壳体，用于密封地接收具有终止于加宽的远端尖端的注射器末端的注射器，具有用于卡扣配合的小瓶适配器的小瓶适配器端口接纳小瓶，以及用于施用 液体药物。 小瓶适配器旨在在混合程序之后旋转分离，以与废样品瓶一起丢弃。 注射器端口另外包括用于固定注射器的单次使用的锁定机构，以防止在正常使用下的无意的注射器分离，包括用于重建目的的搅动。 药物给药口具有优选类似于注射器加宽的远侧末端的远端，用于防止在其上滑动地安装有母Luer连接器的常规针。

公开(公告)号：US07862537B2

公开(公告)日：2011-01-04

申请号：US11816185

申请日：2006-02-13

Applicant: Freddy Zinger ,  Igor Denenburg

Inventor： Freddy Zinger ,  Igor Denenburg

IPC: A61M37/00

CPC classification number: A61J1/2089 ,  A61J1/201 ,  A61J1/2037 ,  A61J1/2058

Abstract: Medical device for in situ liquid drug reconstitution in medicinal vessels containing drug contents. The medical device includes a body member having a vessel port for insertion into a medicinal vessel containing drug contents, and a syringe port for receiving a syringe containing a diluent for reconstituting the drug contents into a reconstituted liquid drug. The medical device includes a one-way flow restriction mechanism between the two ports for positively restricting injection of diluent into a medicinal vessel and only slightly restricting aspiration of reconstituted liquid drug therefrom, if at all.

Abstract translation: 用于含有药物含量的医用血管中的原位液体药物重建的医疗装置。 该医疗装置包括具有用于插入含有药物内容物的医药容器的血管口的主体部件和用于接收含有用于将药物成分重构成重构液体药物的稀释剂的注射器的注射器端口。 医疗装置包括在两个端口之间的单向流动限制机构，用于积极地限制将稀释剂注射到医疗容器中，并且仅仅稍微限制重新吸收的液体药物的抽吸（如果有的话）。