公开(公告)号：US08518227B2

公开(公告)日：2013-08-27

申请号：US13233180

申请日：2011-09-15

Applicant: Shizhi Qian ,  Ali Beskok

Inventor： Shizhi Qian ,  Ali Beskok

IPC: G01F1/64

CPC classification number: B82Y40/00 ,  G01N33/48721

Abstract: A nanoparticle translocation device includes a first reservoir having a first reservoir electrode, a second reservoir having a second reservoir electrode, and at least one nanopore providing fluid communication between the first and second reservoirs. The device also includes one or more inner electrode portions on an inner wall of the nanopore and one or more outer electrode portions disposed on an outer wall of the nanopore. The device further includes at least one DC voltage supply for selectively applying a DC voltage to each of the first reservoir electrode, the second reservoir electrode, and the outer electrode layer, where the inner electrode portions, the outer electrode portions, and the nanopore are in a substantially coaxial arrangement.

Abstract translation: 纳米颗粒易位装置包括具有第一储存器电极的第一储存器，具有第二储存器电极的第二储存器和提供第一和第二储存器之间的流体连通的至少一个纳米孔。 该装置还包括在纳米孔的内壁上的一个或多个内部电极部分和设置在纳米孔的外壁上的一个或多个外部电极部分。 该装置还包括至少一个DC电压源，用于选择性地向第一储存电极，第二储存电极和外电极层中的每一个施加DC电压，其中内部电极部分，外部电极部分和纳米孔是 以基本上同轴的布置。

公开(公告)号：US20130172884A1

公开(公告)日：2013-07-04

申请号：US13822010

申请日：2011-09-09

Applicant: Karl Schoenbach ,  Richard Heller

Inventor： Karl Schoenbach ,  Richard Heller

IPC: A61B18/14

CPC classification number: A61B18/14 ,  A61B18/1206 ,  A61B2018/0016 ,  A61B2018/124 ,  A61B2018/143 ,  A61B2018/1467

Abstract: Systems and methods for treating or manipulating biological tissues are provided. In the systems and methods, a biological tissue is placed in contact with an array of electrodes. Electrical pulses are then applied between a bias voltage bus and a reference voltage bus of a distributor having switching elements associated with each of the electrodes. The switching elements provide a first contact position for coupling electrodes to bias voltage bus, a second contact position for coupling electrodes to the reference voltage bus, and a third contact position for isolating electrodes from the high and reference voltage buses. The switching elements are operated over various time intervals to provide the first contact position for first electrodes, a second contact position for second electrodes adjacent to the first electrodes, and a third contact position for a remainder of the electrodes adjacent to the first and second electrodes.

Abstract translation: 提供了用于治疗或操纵生物组织的系统和方法。 在系统和方法中，将生物组织放置成与电极阵列接触。 然后将电脉冲施加在具有与每个电极相关联的开关元件的分配器的偏置电压总线和参考电压总线之间。 开关元件提供用于将电极耦合到偏置电压总线的第一接触位置，用于将电极耦合到参考电压总线的第二接触位置以及用于将电极与高电压和参考电压母线隔离的第三接触位置。 开关元件在不同的时间间隔上操作以提供第一电极的第一接触位置，与第一电极相邻的第二电极的第二接触位置，以及与第一和第二电极相邻的电极的其余部分的第三接触位置 。

公开(公告)号：US20120302806A1

公开(公告)日：2012-11-29

申请号：US13470649

申请日：2012-05-14

Applicant: Patrick G. Hatcher

Inventor： Patrick G. Hatcher

IPC: C10G1/00

CPC classification number: C08H8/00 ,  C10G1/02 ,  C10G1/047 ,  C10G2300/1014 ,  Y02P30/20

Abstract: Disclosed herein is the use of terrestrial plant materials (e.g., leaves and bark) that contain biopolymer materials to produce hydrocarbon-rich crude oils that can be refined further into hydrocarbon-based biofuels, via the hydrous pyrolysis method, which involves heating to subcritical temperatures and pressures in an aqueous medium. One can also isolate the aliphatic biopolymers and utilize them as feedstocks for production of the hydrocarbon-rich crude via hydrous pyrolysis.

Abstract translation: 本文公开了含有生物聚合物材料的陆生植物材料（例如，叶和树皮）的用途，以生产可通过含水热解法进一步精炼成烃类生物燃料的富烃原油，其涉及加热至亚临界温度 和水介质中的压力。 人们还可以分离脂族生物聚合物，并利用它们作为通过含水热解生产富含烃的原油的原料。

公开(公告)号：US08175855B2

公开(公告)日：2012-05-08

申请号：US12221857

申请日：2008-08-07

Applicant: Zhili Hao

Inventor： Zhili Hao

IPC: G06F17/10

CPC classification number: G06F17/5009 ,  G06F2217/16 ,  G06F2217/80

Abstract: A method and system for predicting the quality factor of a mechanical resonant (MR) device. The system and method simulates uncoupled elastic vibration of the MR device to produce simulated dilatation and collects data relating to the dilatation and maximum stored elastic vibration energy. It determines the internal heat source data of the MR device caused by dilatation based on the thermal expansion effect of the MR device material, conveying the internal heat source data along with transient heat conduction data to a simulation engine, which simulates and determines the temperature variation. Thermoelastic damping over one cycle of vibration is determined, enabling the prediction of the quality factor relating to thermoelastic damping over one cycle of vibration of the MR device, and the maximum elastic vibration energy stored over one cycle of vibration.

Abstract translation: 一种用于预测机械谐振（MR）装置的品质因子的方法和系统。 该系统和方法模拟MR装置的非耦合弹性振动，以产生模拟扩张，并收集与膨胀和最大存储的弹性振动能量有关的数据。 它决定了基于MR装置材料的热膨胀效应的膨胀引起的MR装置的内部热源数据，将内部热源数据与瞬态热传导数据一起传送到模拟引擎，模拟引擎模拟和确定温度变化 。 确定一个振动循环的热弹性阻尼，使得能够预测与MR装置的一个振动循环相关的热弹性阻尼的质量因子，以及在一个振动周期上存储的最大弹性振动能。

公开(公告)号：US20120097539A1

公开(公告)日：2012-04-26

申请号：US13233180

申请日：2011-09-15

Applicant: Shizhi Qian ,  Ali Beskok

Inventor： Shizhi Qian ,  Ali Beskok

IPC: C25B9/00 ,  B81B1/00 ,  C25B15/00 ,  B82Y99/00

CPC classification number: B82Y40/00 ,  G01N33/48721

Abstract: A nanoparticle translocation device includes a first reservoir having a first reservoir electrode, a second reservoir having a second reservoir electrode, and at least one nanopore providing fluid communication between the first and second reservoirs. The device also includes one or more inner electrode portions on an inner wall of the nanopore and one or more outer electrode portions disposed on an outer wall of the nanopore. The device further includes at least one DC voltage supply for selectively applying a DC voltage to each of the first reservoir electrode, the second reservoir electrode, and the outer electrode layer, where the inner electrode portions, the outer electrode portions, and the nanopore are in a substantially coaxial arrangement.

Abstract translation: 纳米颗粒易位装置包括具有第一储存器电极的第一储存器，具有第二储存器电极的第二储存器和提供第一和第二储存器之间的流体连通的至少一个纳米孔。 该装置还包括在纳米孔的内壁上的一个或多个内部电极部分和设置在纳米孔的外壁上的一个或多个外部电极部分。 该装置还包括至少一个DC电压源，用于选择性地向第一储存电极，第二储存电极和外电极层中的每一个施加DC电压，其中内部电极部分，外部电极部分和纳米孔是 以基本上同轴的布置。

公开(公告)号：US08139339B2

公开(公告)日：2012-03-20

申请号：US12050009

申请日：2008-03-17

Applicant: Andrei Pakhomov ,  Karl Schoenbach ,  Juergen Kolb ,  Ravindra Joshi

Inventor： Andrei Pakhomov ,  Karl Schoenbach ,  Juergen Kolb ,  Ravindra Joshi

IPC: F41B15/04 ,  H01T23/00

CPC classification number: A61N1/08 ,  A61N1/36014 ,  A61N1/36189 ,  A61N1/40

Abstract: A system for producing maximal, but reversible bioeffects, for neuromuscular disruption. Methods for facilitation of neuromuscular functions in diseases and conditions of decreased excitability are provided.

Abstract translation: 用于产生神经肌肉破坏的最大但可逆的生物效应的系统。 提供了在兴奋性降低的疾病和条件下促进神经肌肉功能的方法。

公开(公告)号：US20120035511A1

公开(公告)日：2012-02-09

申请号：US13145220

申请日：2010-01-20

Applicant: Karl H. Schoenbach ,  Shu Xiao

Inventor： Karl H. Schoenbach ,  Shu Xiao

IPC: A61B18/18 ,  A61N5/02 ,  A61N5/00 ,  A61M35/00 ,  A61N7/02

CPC classification number: A61B18/18 ,  A61B18/1815 ,  A61N7/02

Abstract: A method of inducing local cell death in patient tissue is provided. The method includes generating first and second radiation, conveying the radiation to a focusing element, and focusing the radiation on a target with the focusing element. A system for inducing local cell death in patient tissue is also provided. The system includes a power source for generating narrow-band and/or ultra-wideband radiation, and a focusing element for focusing the radiation on a target.

Abstract translation: 提供了一种在患者组织中诱导局部细胞死亡的方法。 该方法包括产生第一和第二辐射，将辐射传送到聚焦元件，并且将辐射与聚焦元件聚焦在靶上。 还提供了用于诱导患者组织中的局部细胞死亡的系统。 该系统包括用于产生窄带和/或超宽带辐射的电源，以及用于将辐射聚焦在目标上的聚焦元件。

公开(公告)号：US20120034410A1

公开(公告)日：2012-02-09

申请号：US13265427

申请日：2010-04-23

Applicant: Helmut Baumgart ,  Gon Namkoong ,  Diefeng Gu ,  Tarek Abdel-Fattah

Inventor： Helmut Baumgart ,  Gon Namkoong ,  Diefeng Gu ,  Tarek Abdel-Fattah

IPC: B32B3/02 ,  C23C16/44 ,  B29C71/00 ,  G01N7/00 ,  G01D21/00 ,  C23C16/04 ,  C23C16/56 ,  B82Y40/00

CPC classification number: B01D61/427 ,  B01D67/0062 ,  B01D67/0072 ,  B01D69/02 ,  B01D71/02 ,  B01D71/022 ,  B01D71/024 ,  B01D2313/345 ,  B01D2325/08 ,  C23C16/01 ,  C23C16/403 ,  F04B19/006

Abstract: Multiple walled nested coaxial nanostructures, methods for making multiple walled nested coaxial nanostructures, and devices incorporating the coaxial nanostructures are disclosed. The coaxial nanostructures include an inner nanostructure, a first outer nanotube disposed around the inner nanostructure, and a first annular channel between the inner nanostructure and the first outer nanotube. The coaxial nanostructures have extremely high aspect ratios, ranging from about 5 to about 1,200, or about 300 to about 1200.

Abstract translation: 公开了多壁嵌套同轴纳米结构，制备多壁嵌套同轴纳米结构的方法以及并入同轴纳米结构的装置。 同轴纳米结构包括内部纳米结构，围绕内部纳米结构设置的第一外部纳米管和内部纳米结构与第一外部纳米管之间的第一环形通道。 同轴纳米结构具有非常高的纵横比，范围为约5至约1200，或约300至约1200。

公开(公告)号：US08080679B2

公开(公告)日：2011-12-20

申请号：US12336707

申请日：2008-12-17

Applicant: Patrick G. Hatcher ,  Zhanfei Liu

Inventor： Patrick G. Hatcher ,  Zhanfei Liu

IPC: C11C1/00

CPC classification number: C11C3/04 ,  C10G2300/1011 ,  C10L1/026 ,  Y02E50/13 ,  Y02P30/20

Abstract: Disclosed is the direct conversion process for producing biodiesel from a biomass. The direct conversion process for producing biodiesel from a biomass comprises reacting a feed stock comprising a biomass and an alkylation reagent in a substantially oxygen free environment at a temperature sufficient to hydrolyze one or more lipid glycerides in the biomass and alkylated one or more fatty acids in the reaction. The process may comprise reacting a feed stock comprising an algal biomass and tetramethylammonium hydroxide in a substantially oxygen free environment at a temperature between 250° C. and 500° C. The direct conversion process for producing biodiesel may further comprise reacting oil containing lipid glycerides with an alkylation reagent at a sufficient temperature to esterify the oil. The fatty acid alkyl esters produced from the reacted feed stock are recovered. The recovered fatty acid alkyl esters, as an essential component of biodiesel, may be formulated into biodiesel.

Abstract translation: 公开了从生物质生产生物柴油的直接转化过程。 从生物质生产生物柴油的直接转化方法包括在足够水解生物质中的一种或多种脂质甘油酯和烷基化的一种或多种脂肪酸的温度下，将基本上无氧的环境中含有生物质和烷基化试剂的原料反应 反应。 该方法可以包括在250℃和500℃之间的温度下在基本上不含氧的环境中使包含藻类生物质和四甲基氢氧化铵的原料反应。用于生产生物柴油的直接转化方法还可包括使含有脂肪甘油酯的油与 在足够的温度下使烷基化试剂酯化油。 回收由反应原料生产的脂肪酸烷基酯。 回收的脂肪酸烷基酯作为生物柴油的必需组分可以配制成生物柴油。

公开(公告)号：US20110288545A1

公开(公告)日：2011-11-24

申请号：US13092518

申请日：2011-04-22

Applicant: Stephen J. Beebe ,  Xinhua Chen ,  Karl H. Schoenbach

Inventor： Stephen J. Beebe ,  Xinhua Chen ,  Karl H. Schoenbach

IPC: A61B18/18

CPC classification number: A61B18/1477 ,  A61B2018/00613

Abstract: Methods and devices designed to eliminate and/or ablate cancer or other abnormal growths of cells or tissues or eliminate and/or ablate cells or tissue with abnormal functions. In particular, using sub-microsecond electric pulses to treat cancer cells by, inter alia, inducing programmed cell death or other type of cell death. These methods and devices are expected to greatly improve the prevention, treatment and management of cancer by increasing the effectiveness of cancer treatments and development of resistance to new cancer growth.

Abstract translation: 旨在消除和/或消除细胞或组织的癌症或其他异常生长或消除和/或消融具有异常功能的细胞或组织的方法和装置。 特别地，使用亚微秒电脉冲通过尤其诱导程序性细胞死亡或其它类型的细胞死亡来治疗癌细胞。 预计这些方法和手段将通过提高癌症治疗的有效性和发展抵抗新的癌症生长而大大改善癌症的预防，治疗和管理。