公开(公告)号：US5231101A

公开(公告)日：1993-07-27

申请号：US821803

申请日：1992-01-17

申请人： Haruyoshi Honda ,  Hiroyuki Mizuno ,  Kinichi Mogi ,  Yoshikuni Ito ,  Yasushi Kaneko ,  Naokata Taido ,  Susumu Sato ,  Tadayuki Kuraishi

发明人： Haruyoshi Honda ,  Hiroyuki Mizuno ,  Kinichi Mogi ,  Yoshikuni Ito ,  Yasushi Kaneko ,  Naokata Taido ,  Susumu Sato ,  Tadayuki Kuraishi

IPC分类号： A61K31/445 ,  A61K31/4427 ,  A61P37/08 ,  A61P43/00 ,  C07D401/04 ,  C07D401/14

CPC分类号： C07D401/04

摘要： Benzo[5,6]cyclohepta[1,2-b]pyridine derivatives of the following formula: ##STR1## wherein R.sup.1 represents a cyano, carbamoyl, alkylsulfoxy, alkylsulfonyl, tetrazolyl or sulfonic acid group, and R.sup.2 represents a hydrogen atom, a cyano, phenyl, aralkyl, alkoxycarbonylalkyl, aminoalkylcarbamoylalkyl or lower alkyl group, or a group ##STR2## or --X--R.sub.4, X being an oxygen or sulfur atom, R.sup.3 standing for a hydrogen atom or a substituted or unsubstituted lower alkyl, phenyl or aralkyl group, and R.sup.4 being a substituted or unsubstituted lower alkyl, phenyl or aralkyl group or an aminoalkyl group, and salts thereof. Antiallergic and antihistamic agents containing one of the above derivatives or salts as an active ingredient are also described.

公开(公告)号：US5082948A

公开(公告)日：1992-01-21

申请号：US484368

申请日：1990-02-22

申请人： Minoru Tokizawa ,  Takemitsu Asaoka ,  Hideaki Matsuda ,  Tatsuhiko Katori

发明人： Minoru Tokizawa ,  Takemitsu Asaoka ,  Hideaki Matsuda ,  Tatsuhiko Katori

IPC分类号： C07D233/60 ,  C07D521/00

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56

摘要： Novel imidazole derivatives and their acid adducts are disclosed. The imidazole derivatives are represented by formula: ##STR1## wherein R.sub.1 represents an alkyl group, R.sub.2 represents a hydrogen atom, an alkyl group which may have a substituent, or an aralkyl group which may have a substituent, provided that R.sub.1 and R.sub.2 are not both methyl groups at the same time. They have strong antimicrobial activity, especially against those fungi belonging to the genera Candida, Trichophyton, Microsporum, and Epidermorphyton, as well as against Gram-positive bacteria, and thus is useful as an antimicrobial agent.

公开(公告)号：US5082663A

公开(公告)日：1992-01-21

申请号：US639758

申请日：1991-01-11

申请人： Ryoji Konishi ,  Akihito Oji ,  Toshikuni Kawaji ,  Osami Makaya ,  Manabu Ishihara ,  Akira Iwasa

发明人： Ryoji Konishi ,  Akihito Oji ,  Toshikuni Kawaji ,  Osami Makaya ,  Manabu Ishihara ,  Akira Iwasa

IPC分类号： A61K9/70 ,  A61K31/56 ,  A61K31/57 ,  A61L15/44 ,  A61L26/00

CPC分类号： A61K9/7053 ,  A61K9/7061 ,  A61K9/7076 ,  A61L15/44 ,  A61L26/0066 ,  A61L2300/222 ,  Y10S514/861 ,  Y10S514/863

摘要： An external adhesive preparation comprising a steroid for treatment of skin diseases in admixture with an adhesive gel base comprising as essential components a water-soluble high molecular weight compound, water and a water-retaining agent. The external adhesive preparation is useful for treatment of skin diseases by applying the preparation spread on a soft support directly to diseased parts on the skin, thereby administering the contained steroid to the skin.

摘要翻译： PCT No.PCT / JP87 / 00618 Sec。 371日期：1988年4月20日 102（e）1988年4月20日PCT PCT 1987年8月20日PCT公布。 出版物WO88 / 01170 日期：1988年2月25日。一种外用粘合剂制剂，其包含用于治疗皮肤疾病的类固醇，其与包含水溶性高分子量化合物，水和保水剂的粘合凝胶基质混合。 外用粘合剂可用于通过将软支撑物上展开的制剂直接施用于皮肤上的病变部位来治疗皮肤疾病，从而将所含的类固醇施用于皮肤。

公开(公告)号：US5047428A

公开(公告)日：1991-09-10

申请号：US365368

申请日：1989-06-13

申请人： Yoshikuni Itoh ,  Hiroyuki Mizuno ,  Chikako Kiyohara ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Yoshikuni Itoh ,  Hiroyuki Mizuno ,  Chikako Kiyohara ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： A61K31/195 ,  A61K31/198 ,  A61P11/10 ,  C07C323/58

CPC分类号： A61K31/195 ,  Y10S514/855

摘要： An expectorant comprising a hydroxyalkylcysteine derivative of the following formula (I) is disclosed. ##STR1## wherein n represents an integer of 1 to 4. The expectorant is stabile, has little side effects and toxicity, and exhibits an excellent expectorant effect.

公开(公告)号：US4977275A

公开(公告)日：1990-12-11

申请号：US333239

申请日：1989-04-05

申请人： Hiroshi Hasegawa ,  Kinichi Mogi ,  Noriaki Shioiri ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Hiroshi Hasegawa ,  Kinichi Mogi ,  Noriaki Shioiri ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： A61K31/40 ,  A01N43/36 ,  A61K31/4025 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P17/00 ,  C07D207/34 ,  C07D401/12 ,  C07D409/12

CPC分类号： C07D207/34

摘要： A pyrrole derivative having excellent anti-microbial activities is disclosed. This compound is represented by the following formula (I): ##STR1## wherein X.sub.1 and X.sub.2 are the same or different and mean individually a halogen atom, R.sub.1 denotes an alkyl, cycloalkyl, haloalkyl, alkenyl, substituted or unsubstituted phenyl, substituted or unsubstituted aralkyl group or a group --COR.sub.3 in which R.sub.3 is an alkyl group having at least five carbon atoms or a cycloalkyl, haloalkyl, alkenyl, substituted or unsubstituted phenyl, substituted or unsubstituted aralkyl, or heterocyclic group, and R.sub.2 stands for a hydrogen or halogen atom or an alkyl group, with a proviso that R.sub.1 is other than a hydrogen atom or methyl group when X.sub.1, X.sub.2 and R.sub.2 are each a bromine atom.

公开(公告)号：US4968825A

公开(公告)日：1990-11-06

申请号：US418169

申请日：1989-10-06

申请人： Koichi Yokoi ,  Kinichi Mogi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Koichi Yokoi ,  Kinichi Mogi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： C07F15/00

CPC分类号： C07F15/0093

摘要： A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.

公开(公告)号：US4876359A

公开(公告)日：1989-10-24

申请号：US103415

申请日：1987-10-01

申请人： Hiroshi Hasegawa ,  Noriaki Shioiri ,  Tadashi Narita ,  Tatsuhiko Katori

发明人： Hiroshi Hasegawa ,  Noriaki Shioiri ,  Tadashi Narita ,  Tatsuhiko Katori

IPC分类号： C07K5/02

CPC分类号： C07K5/0222

摘要： Novel .gamma.-butyrolactone derivatives having strong ACE inhibitory activity are provided. They are represented by the following general formula (I): ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and mean individually a hydrogen atom or a straight-chain or branched alkyl or cycloalkyl group, or R.sup.1 and R.sup.2 are bonded together to mean an alkylene group having 2-6 carbon atoms, R.sup.3 denotes a hydrogen atom or a lower alkyl, aralkyl, amino lower alkyl or lower alkoxycarbonylamino lower alkyl group, R.sup.4 means a lower alkyl, cycloalkyl or aralkyl group, R.sup.5 means a hydrogen atom or a lower alkyl group, or R.sub.4 and R.sub.5 are bonded together to denote an alkylene group having 2-4 carbon atoms, and R.sup.6 stands for a hydrogen atom or a lower alkyl or aralkyl group; or a pharmacologically acceptable salt thereof.

摘要翻译： 提供了具有强ACE抑制活性的新型γ-丁内酯衍生物。 它们由以下通式（I）表示：其中R 1和R 2可以相同或不同，并且分别表示氢原子或直链或支链烷基或环烷基，或者R1和R2 键合在一起表示具有2-6个碳原子的亚烷基，R3表示氢原子或低级烷基，芳烷基，氨基低级烷基或低级烷氧基羰基氨基低级烷基，R4表示低级烷基，环烷基或芳烷基，R5表示 氢原子或低级烷基，或者R4和R5键合在一起，表示具有2-4个碳原子的亚烷基，R6代表氢原子或低级烷基或芳烷基; 或其药理学上可接受的盐。

公开(公告)号：US4740601A

公开(公告)日：1988-04-26

申请号：US941318

申请日：1986-12-15

申请人： Masaki Ogawa ,  Hideaki Matsuda ,  Takemitsu Asaoka ,  Junji Oono ,  Tatsuhiko Katori

发明人： Masaki Ogawa ,  Hideaki Matsuda ,  Takemitsu Asaoka ,  Junji Oono ,  Tatsuhiko Katori

IPC分类号： A01N43/50 ,  A61K31/415 ,  A61P31/04 ,  C07D233/60 ,  C07D405/06 ,  C07D405/12 ,  C07D521/00 ,  C07D233/04 ,  C07D233/54

CPC分类号： C07D231/12 ,  A01N43/50 ,  C07D233/56 ,  C07D249/08

摘要： An imidazole derivative having antimicrobial activities against bacteria, fungi, yeast, pathogenic plant fungi and the like represented by the following general formula (I): ##STR1## wherein R.sub.1 means a hydrogen or halogen atom or a lower alkyl group, R.sub.2 denotes a hydrogen atom or an alkyl, alkenyl, haloalkyl or substituted or unsubstituted benzyl group, R.sub.3 stands for a hydrogen or halogen atom, and R.sub.4 is a substituted or unsubstituted benzylthio group, a phenylthio, alkylthio, alkenylthio, furfurylthio, alkoxy or phenoxy group or a halogen atom; or an acid addition salt thereof.

摘要翻译： 由下列通式（I）表示的具有抗细菌，真菌，酵母，致病植物真菌等的抗微生物活性的咪唑衍生物：其中R1表示氢或卤原子或低级烷基，R2 表示氢原子或烷基，烯基，卤代烷基或取代或未取代的苄基，R3表示氢或卤素原子，R4表示取代或未取代的苄硫基，苯硫基，烷硫基，烯硫基，糠硫基，烷氧基或苯氧基 或卤素原子; 或其酸加成盐。