公开(公告)号：US4977275A

公开(公告)日：1990-12-11

申请号：US333239

申请日：1989-04-05

申请人： Hiroshi Hasegawa ,  Kinichi Mogi ,  Noriaki Shioiri ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Hiroshi Hasegawa ,  Kinichi Mogi ,  Noriaki Shioiri ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： A61K31/40 ,  A01N43/36 ,  A61K31/4025 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61P17/00 ,  C07D207/34 ,  C07D401/12 ,  C07D409/12

CPC分类号： C07D207/34

摘要： A pyrrole derivative having excellent anti-microbial activities is disclosed. This compound is represented by the following formula (I): ##STR1## wherein X.sub.1 and X.sub.2 are the same or different and mean individually a halogen atom, R.sub.1 denotes an alkyl, cycloalkyl, haloalkyl, alkenyl, substituted or unsubstituted phenyl, substituted or unsubstituted aralkyl group or a group --COR.sub.3 in which R.sub.3 is an alkyl group having at least five carbon atoms or a cycloalkyl, haloalkyl, alkenyl, substituted or unsubstituted phenyl, substituted or unsubstituted aralkyl, or heterocyclic group, and R.sub.2 stands for a hydrogen or halogen atom or an alkyl group, with a proviso that R.sub.1 is other than a hydrogen atom or methyl group when X.sub.1, X.sub.2 and R.sub.2 are each a bromine atom.

公开(公告)号：US4904809A

公开(公告)日：1990-02-27

申请号：US245222

申请日：1988-09-16

申请人： Koichi Yokoi ,  Kinichi Mogi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Koichi Yokoi ,  Kinichi Mogi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： C07F15/00

CPC分类号： C07F15/0093

摘要： A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.

公开(公告)号：US4968825A

公开(公告)日：1990-11-06

申请号：US418169

申请日：1989-10-06

申请人： Koichi Yokoi ,  Kinichi Mogi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

发明人： Koichi Yokoi ,  Kinichi Mogi ,  Kazuhiko Irinoda ,  Hidehiko Kohya ,  Susumu Sato ,  Tatsuhiko Katori

IPC分类号： C07F15/00

CPC分类号： C07F15/0093

摘要： A platinum complex having a superior antitumor activity is disclosed. The platinum complex has a structure represented by the formula: ##STR1## wherein A and B independently represent a lower alkanoyloxy group which may have a halogen atom substituent, or in combination represent a group: ##STR2## wherein R.sub.1 and R.sub.2 independently represent a hydrogen atom, a hydroxyl group, or a lower alkyl group, or in combination with each other and with the adjacent carbon atom a cyclobutane ring, and R.sub.3 represents a hydrogen atom, a lower alkyl group, a lower alkoxy group, a halogen atom, a sulfo group, or nitro group.

公开(公告)号：US06362203B1

公开(公告)日：2002-03-26

申请号：US09698041

申请日：2000-10-30

申请人： Kinichi Mogi ,  Yoshihiko Kanamaru ,  Noriyuki Kawamoto ,  Teruo Komoto ,  Norimitsu Umehara ,  Susumu Sato ,  Tetsuo Oka

发明人： Kinichi Mogi ,  Yoshihiko Kanamaru ,  Noriyuki Kawamoto ,  Teruo Komoto ,  Norimitsu Umehara ,  Susumu Sato ,  Tetsuo Oka

IPC分类号： C07D21152

CPC分类号： C07D211/52

摘要： Described is a 4-hydroxy-4-phenylpiperidine derivative represented by the following formula (1): [wherein, R1 and R2 are the same or different and each independently represents a hydrogen atom, a lower alkyl, or the like, R3 represents a hydrogen atom or a group —(CR4R5)n—Y (in which, R4 and R5 each represents a hydrogen atom or a lower alkyl group, Y represents a group —COOR6, —CONR7R8, —OR9 or —OCOR10 (in which R6, R9 and R10 each independently represents a hydrogen atom, a lower alkyl group, or the like, R7 and R8 are the same or different and each independently represents a hydrogen atom, a lower alkyl group, or the like), and n stands for 1 to 6)], or salt thereof. The compound exhibits excellent peripheral analgesic action.

摘要翻译： 描述了由下式（1）表示的4-羟基-4-苯基哌啶衍生物：[其中，R 1和R 2相同或不同，各自独立地表示氢原子，低级烷基等，R 3表示 氢原子或基团 - （CR 4 R 5）n Y（其中，R 4和R 5各自表示氢原子或低级烷基，Y表示-COOR 6，-CONR 7 R 8，-OR 9或-OCOR 10（其中R 6，R 9和 R 10各自独立地表示氢原子，低级烷基等，R 7和R 8相同或不同，各自独立地表示氢原子，低级烷基等），n表示1〜6 ）]或其盐。该化合物表现出优异的外周镇痛作用。

公开(公告)号：US5902826A

公开(公告)日：1999-05-11

申请号：US997061

申请日：1997-12-23

申请人： Kinichi Mogi ,  Hidehiko Koya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato

发明人： Kinichi Mogi ,  Hidehiko Koya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato

IPC分类号： A61K31/55 ,  C07F15/00 ,  A61K31/28

CPC分类号： C07F15/0093

摘要： A diamine-platinum (IV) complex represented by the following formula (1): ##STR1## wherein R.sup.1 and R.sup.2 together represent R.sup.5 O--CH(CH.sub.2 NH.sub.2).sub.2 (R.sup.5 represents hydrogen, acetyl, trifluoroacetyl, benzoyl, cycloalkylcarbonyl or methanesulfonyl) or a C.sub.5-8 1,2-cycloalkanediamine; R.sup.3 and R.sup.4 each represents hydrogen or R.sup.6 CO-- (R.sup.6 represents alkyl, halogenoalkyl, cycloalkyl, aryl or aralkyl); and two X's together represent a malonic acid residue or glycolic acid residue which may have a substituent capable of coordinating to the platinum in formula (1) by an O,O-coordination or an N-acylamino acid residue coordinating to the platinum in formula (1) by an O,N-coordination; and a pharmaceutical composition comprising as an active ingredient the above-described diamine-platinum (IV) complex.

摘要翻译： 由下式（1）表示的二胺 - 铂（IV）络合物：其中R1和R2一起表示R5O-CH（CH2NH2）2（R5代表氢，乙酰基，三氟乙酰基，苯甲酰基，环烷基羰基或甲磺酰基）或C5-8 1,2-环烷二胺; R3和R4各自表示氢或R6CO-（R6表示烷基，卤代烷基，环烷基，芳基或芳烷基）; 两个X一起代表丙二酸残基或乙醇酸残基，其可以具有能够通过与式（1）中的铂配位的O，O-配位体或N-酰基氨基酸残基与式（1）中的铂配位的取代基， 1）通过O，N-配位; 以及包含上述二胺 - 铂（IV）络合物作为活性成分的药物组合物。

公开(公告)号：US5498780A

公开(公告)日：1996-03-12

申请号：US454825

申请日：1995-05-31

申请人： Koichi Yokoi ,  Kinichi Mogi ,  Hidehiko Kohya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato ,  Tadayuki Kuraishi

发明人： Koichi Yokoi ,  Kinichi Mogi ,  Hidehiko Kohya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato ,  Tadayuki Kuraishi

IPC分类号： A61K33/24 ,  A61K31/28 ,  A61K31/282 ,  A61P35/00 ,  C07C239/08 ,  C07F15/00

CPC分类号： C07F15/0093

摘要： A diamine-platinum complex represented by the following formula (1): ##STR1## wherein the all definitions are defined in the disclosure, and a malignant tumor treating drug which contains the above complex as an active ingredient. The diamine-platinum complex has a high water solubility and an excellent antitumor effect.

摘要翻译： 由下式（1）表示的二胺 - 铂络合物：其中全部定义在本公开中定义，以及含有上述络合物作为活性成分的恶性肿瘤治疗药物。 二胺 - 铂络合物具有高水溶性和优异的抗肿瘤效果。

公开(公告)号：US6028081A

公开(公告)日：2000-02-22

申请号：US141374

申请日：1998-08-27

申请人： Yoshihisa Sada ,  Shigeru Adegawa ,  Kinichi Mogi ,  Haruyoshi Honda ,  Hiromichi Eto ,  Shinichi Morimoto ,  Junji Okawa ,  Norimitsu Umehara ,  Susumu Sato

发明人： Yoshihisa Sada ,  Shigeru Adegawa ,  Kinichi Mogi ,  Haruyoshi Honda ,  Hiromichi Eto ,  Shinichi Morimoto ,  Junji Okawa ,  Norimitsu Umehara ,  Susumu Sato

IPC分类号： A61K31/47 ,  A61K31/495 ,  A61K31/535 ,  A61P1/04 ,  A61P31/04 ,  C07D215/42 ,  C07D215/44 ,  C07D215/46 ,  C07D401/04 ,  C07D501/12 ,  A61K31/55 ,  C07D215/16

CPC分类号： C07D401/04 ,  C07D215/42 ,  C07D215/44 ,  C07D215/46

摘要： Substituted quinolone derivatives represented by the following formula: ##STR1## wherein R.sup.1 represents a substituted or unsubstituted (hetero)aryl group, R.sup.2 represents H or an alkoxycarbonyl, substituted aminocarbonyl, cyano or like group, and R.sup.3 and R.sup.4 each independently represent H or a substituted alkyl, aryl, amino or like group, and salts thereof; pharmaceuticals containing the same. These derivatives and salts have excellent anti-ulcer activities.

摘要翻译： 由下式表示的取代喹诺酮衍生物：其中R1表示取代或未取代的（杂）芳基，R2表示H或烷氧基羰基，取代氨基羰基，氰基或类似基团，R3和R4各自独立地表示H或取代的烷基， 芳基，氨基或类似基团，及其盐; 含有相同药物。 这些衍生物和盐具有优异的抗溃疡活性。

公开(公告)号：US5962509A

公开(公告)日：1999-10-05

申请号：US169989

申请日：1998-10-13

申请人： Fumio Ishii ,  Kinichi Mogi ,  Hiromichi Eto ,  Susumu Sato ,  Hideaki Matsuda

发明人： Fumio Ishii ,  Kinichi Mogi ,  Hiromichi Eto ,  Susumu Sato ,  Hideaki Matsuda

IPC分类号： A61K31/385 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07D339/06 ,  C07D339/02

CPC分类号： C07D339/06

摘要： Disclosed are dithiolylidene acetamide derivatives represented by the following formula: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each independently represent a hydrogen atom or an alkyl group, or salts thereof; and pharmaceuticals containing them as effective ingredients. The dithiolylidene acetamide derivatives and their salts show AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.

摘要翻译： 公开了由下式表示的二亚噻吩基乙酰胺衍生物：其中R1和R2可以相同或不同，各自独立地表示氢原子或烷基，或其盐; 和含有它们作为有效成分的药物。 二硫代亚乙酰胺衍生物及其盐显示AGE形成抑制作用，可用作糖尿病并发症的预防药物和治疗剂。

公开(公告)号：US5585511A

公开(公告)日：1996-12-17

申请号：US578490

申请日：1995-12-26

申请人： Koichi Yokoi ,  Kinichi Mogi ,  Hidehiko Kohya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato ,  Tadayuki Kuraishi

发明人： Koichi Yokoi ,  Kinichi Mogi ,  Hidehiko Kohya ,  Mari Ohtsuka ,  Hiroyuki Mizuno ,  Susumu Sato ,  Tadayuki Kuraishi

IPC分类号： A61K33/24 ,  A61K31/28 ,  A61K31/282 ,  A61P35/00 ,  C07F15/00

CPC分类号： C07F15/0093

摘要： A platinum complex represented by the following formula (1): ##STR1## wherein the all symbols are defined in the disclosure; and a malignant tumor treating drug which contains the complex as an active ingredient. The platinum complex is excellent in antitumor effects and safety and is highly soluble in water, and therefore it is useful as an agent for use in the treatment of various malignant tumors.

摘要翻译： 由下式（1）表示的铂络合物：其中全部符号在本公开中定义; 和含有复合物作为活性成分的恶性肿瘤治疗药物。 铂络合物具有优异的抗肿瘤效果和安全性，并且高度可溶于水，因此可用作治疗各种恶性肿瘤的药剂。

公开(公告)号：US5231101A

公开(公告)日：1993-07-27

申请号：US821803

申请日：1992-01-17

申请人： Haruyoshi Honda ,  Hiroyuki Mizuno ,  Kinichi Mogi ,  Yoshikuni Ito ,  Yasushi Kaneko ,  Naokata Taido ,  Susumu Sato ,  Tadayuki Kuraishi

发明人： Haruyoshi Honda ,  Hiroyuki Mizuno ,  Kinichi Mogi ,  Yoshikuni Ito ,  Yasushi Kaneko ,  Naokata Taido ,  Susumu Sato ,  Tadayuki Kuraishi

IPC分类号： A61K31/445 ,  A61K31/4427 ,  A61P37/08 ,  A61P43/00 ,  C07D401/04 ,  C07D401/14

CPC分类号： C07D401/04

摘要： Benzo[5,6]cyclohepta[1,2-b]pyridine derivatives of the following formula: ##STR1## wherein R.sup.1 represents a cyano, carbamoyl, alkylsulfoxy, alkylsulfonyl, tetrazolyl or sulfonic acid group, and R.sup.2 represents a hydrogen atom, a cyano, phenyl, aralkyl, alkoxycarbonylalkyl, aminoalkylcarbamoylalkyl or lower alkyl group, or a group ##STR2## or --X--R.sub.4, X being an oxygen or sulfur atom, R.sup.3 standing for a hydrogen atom or a substituted or unsubstituted lower alkyl, phenyl or aralkyl group, and R.sup.4 being a substituted or unsubstituted lower alkyl, phenyl or aralkyl group or an aminoalkyl group, and salts thereof. Antiallergic and antihistamic agents containing one of the above derivatives or salts as an active ingredient are also described.