公开(公告)号：US12076342B2

公开(公告)日：2024-09-03

申请号：US16091266

申请日：2017-04-07

申请人： THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO

发明人： Peter W. Zandstra ,  Shreya Shukla

IPC分类号： A61K35/17 ,  C12N5/074 ,  C12N5/0783 ,  C12N5/0789 ,  A61P7/00 ,  A61P35/00

CPC分类号： A61K35/17 ,  C12N5/0607 ,  C12N5/0636 ,  C12N5/0647 ,  C12N5/0696 ,  A61P7/00 ,  A61P35/00 ,  C12N2500/38 ,  C12N2500/99 ,  C12N2501/115 ,  C12N2501/125 ,  C12N2501/145 ,  C12N2501/155 ,  C12N2501/165 ,  C12N2501/2307 ,  C12N2501/25 ,  C12N2501/42 ,  C12N2501/58 ,  C12N2501/998 ,  C12N2502/1171 ,  C12N2533/52 ,  C12N2533/90

摘要： The present disclosure provides a method for generating progenitor T cells from stem and/or progenitor cells comprising exposing the stem and/or progenitor cells to Notch ligand Delta-like-4 (DL4) and vascular adhesion molecule 1 (VCAM-1) under conditions suitable to generate progenitor T cells. The method provided is suitable for in vitro and in vivo pro-T cell generation. In vitro, the pro-T cells are generated under serum-free conditions. Cells produced using the method are provided as well as methods of using same.

公开(公告)号：US11999967B2

公开(公告)日：2024-06-04

申请号：US17168461

申请日：2021-02-05

申请人： CHILDREN'S NATIONAL MEDICAL CENTER

发明人： Catherine M. Bollard ,  Conrad Russell Cruz ,  Patrick J. Hanley ,  Michael Keller

IPC分类号： C12N5/0783 ,  A61K35/17 ,  A61P15/00 ,  A61P31/00 ,  A61P37/04 ,  C07K14/54 ,  C07K14/55 ,  C07K14/705 ,  C07K14/73

CPC分类号： C12N5/0636 ,  A61K35/17 ,  A61P15/00 ,  A61P31/00 ,  A61P37/04 ,  C07K14/5412 ,  C07K14/5418 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/55 ,  C07K14/70514 ,  C07K14/70517 ,  C07K14/70521 ,  C12N2501/2302 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/59 ,  C12N2502/1121 ,  C12N2502/1157

摘要： Safe, rapid and efficient methods for producing antigen-specific T cells recognizing human papilloma virus or HPV antigens.

公开(公告)号：US20240156961A1

公开(公告)日：2024-05-16

申请号：US18334820

申请日：2023-06-14

申请人： BioNTech US Inc.

发明人： Michael Steven Rooney ,  Lauren Elizabeth Stopfer

IPC分类号： A61K39/00 ,  A61P35/00 ,  A61P37/04 ,  C12N5/0783

CPC分类号： A61K39/4632 ,  A61K39/0011 ,  A61K39/001193 ,  A61K39/4611 ,  A61K39/4644 ,  A61P35/00 ,  A61P37/04 ,  C12N5/0636 ,  A61K2039/53 ,  C12N2501/2301 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/25 ,  C12N2501/26

摘要： Provided herein are compositions relating to tissue-specific antigens, and methods for identifying tissue-specific antigens. Also provided herein are pharmaceutical compositions and methods of treatment that relate to tissue-specific antigens.

公开(公告)号：US20240156927A1

公开(公告)日：2024-05-16

申请号：US18423189

申请日：2024-01-25

申请人： GOOD T CELLS, INC.

发明人： Jung Ho Kim ,  Beom Seok Kim

IPC分类号： A61K39/00 ,  A61K35/17 ,  A61K38/16 ,  A61K38/17 ,  C12N5/0783 ,  C12N15/869

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K38/162 ,  A61K38/1774 ,  C12N5/0636 ,  C12N15/869 ,  C12N2501/22 ,  C12N2501/2302 ,  C12N2501/2304 ,  C12N2501/2307 ,  C12N2501/2312 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2502/1107 ,  C12N2502/1114 ,  C12N2502/1121 ,  C12N2502/1157

摘要： The present invention relates to a cancer-specific tumor antigen neoepitope represented by any one of SEQ ID NOs: 1 to 184, an antigen-presenting cell loaded with the neoepitope, and a method for activating T cells for cancer treatment using the antigen-presenting cell. An antigen-presenting cell, that is, a dendritic cell, loaded with a cancer-specific tumor antigen epitope provided in the present invention enables rapid and effective induction of differentiation and proliferation of cancer antigen-specific T cells, preferably memory T cells, and the memory T cells thus activated can treat a cancerous or neoplastic condition or prevent recurrence, progression, or metastasis of cancer while avoiding the defense mechanism of cancer cells.

公开(公告)号：US20240082398A1

公开(公告)日：2024-03-14

申请号：US18272403

申请日：2022-01-18

申请人： City of Hope

发明人： Jianhua Yu ,  Michael A. Caligiuri

IPC分类号： A61K39/00 ,  A61P35/02 ,  C07K16/28 ,  C12N5/078

CPC分类号： A61K39/4611 ,  A61K39/4622 ,  A61K39/4637 ,  A61K39/4643 ,  A61K39/464411 ,  A61K39/464419 ,  A61K39/464429 ,  A61K39/46444 ,  A61P35/02 ,  C07K16/2827 ,  C12N5/0634 ,  A61K2239/48 ,  C12N2501/2302 ,  C12N2501/2307 ,  C12N2502/30

摘要： Provided herein are, inter alia, compositions comprising ex vivo expanded ILC1 cells, methods of preparing the compositions, and methods useful for treating cancer and leukemia.

公开(公告)号：US11918634B2

公开(公告)日：2024-03-05

申请号：US16638055

申请日：2018-08-10

申请人： GOOD T CELLS, INC.

发明人： Jung Ho Kim ,  Beom Seok Kim

IPC分类号： A61K35/17 ,  A61P35/00 ,  A61K39/00 ,  C12N5/0783 ,  A61K38/16 ,  A61K38/17 ,  C12N15/869

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K38/162 ,  A61K38/1774 ,  C12N5/0636 ,  C12N15/869 ,  C12N2501/22 ,  C12N2501/2302 ,  C12N2501/2304 ,  C12N2501/2307 ,  C12N2501/2312 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/24 ,  C12N2501/25 ,  C12N2502/1107 ,  C12N2502/1114 ,  C12N2502/1121 ,  C12N2502/1157

摘要： The present invention relates to a cancer-specific tumor antigen neoepitope represented by any one of SEQ ID NOs: 1 to 184, an antigen-presenting cell loaded with the neoepitope, and a method for activating T cells for cancer treatment using the antigen-presenting cell. An antigen-presenting cell, that is, a dendritic cell, loaded with a cancer-specific tumor antigen epitope provided in the present invention enables rapid and effective induction of differentiation and proliferation of cancer antigen-specific T cells, preferably memory T cells, and the memory T cells thus activated can treat a cancerous or neoplastic condition or prevent recurrence, progression, or metastasis of cancer while avoiding the defense mechanism of cancer cells.

公开(公告)号：US11913025B2

公开(公告)日：2024-02-27

申请号：US16497805

申请日：2018-03-29

申请人： CYTOARM CO., LTD

发明人： Kuo-Hsiang Chuang ,  Yi-Jou Chen ,  Michael Chen

IPC分类号： A61K35/17 ,  C12N5/0783 ,  A61P35/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  C07K16/40

CPC分类号： C12N5/0638 ,  A61K35/17 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2827 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/3007 ,  C07K16/3069 ,  C07K16/32 ,  C07K16/40 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622 ,  C12N2501/15 ,  C12N2501/2302 ,  C12N2501/2307 ,  C12N2501/515 ,  C12N2501/599

摘要： Provided are methods of inducing differentiation and/or proliferation of T cells and uses thereof. In the present method, peripheral blood mononuclear cells (PBMCs) isolated from a subject are cultivated with bi-specific antibodies (BsAbs) in a culture medium so as to differentiate the PBMCs into the T cells. Each of the T cells has an anti-tumor antigen moiety and an anti-CD3 moiety on its surface. Also provided are methods and pharmaceutical kits for treating subjects suffering from cancers.

公开(公告)号：US20240060041A1

公开(公告)日：2024-02-22

申请号：US18259611

申请日：2021-12-29

申请人： Shanghai Cellular Biopharmaceutical Group Ltd.

发明人： Jia LI ,  Jiyan HOU ,  Zizhen GONG ,  Yijie QU ,  Shichao QIN ,  Shenchen WANG ,  Wangqin SHU ,  Junfeng WU ,  Fei WANG ,  Li ZHANG

IPC分类号： C12N5/078 ,  A61P35/00

CPC分类号： C12N5/0634 ,  A61P35/00 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  C12N2501/734 ,  C12N2501/73 ,  C12N2501/2302

摘要： Provided are methods for expanding tumor-infiltrating lymphocytes (TILs), which include co-culturing an initial cell population containing TILs with first feeder cells to obtain a first expanded cell population; and then co-culturing the first expanded cell population with second feeder cells to obtain an expanded TIL population. The methods can quickly produce a large number of TILs from a small tumor sample.

公开(公告)号：US11844827B2

公开(公告)日：2023-12-19

申请号：US17531897

申请日：2021-11-22

申请人： Yeda Research and Development Co. Ltd.

发明人： Yair Reisner ,  Noga Or-Geva ,  Eran Ophir ,  Yaki Eidelstein ,  Rotem Gidron Budovsky

IPC分类号： A61K39/00 ,  A61K35/17 ,  C12N5/078 ,  C12N5/0783 ,  A61P31/00 ,  A61P35/04 ,  A61K39/395 ,  C07K16/28 ,  A61K35/12

CPC分类号： A61K39/001 ,  A61K35/17 ,  A61K39/39566 ,  A61P31/00 ,  A61P35/04 ,  C07K16/2896 ,  C12N5/0636 ,  C12N5/0637 ,  C12N5/0648 ,  A61K2035/122 ,  A61K2039/5158 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/2321 ,  Y02A50/30

摘要： An isolated cell having a central memory T-lymphocyte (Tcm) phenotype, the cell being tolerance-inducing cell and capable of homing to the lymph nodes following transplantation, the cell being transduced to express a cell surface receptor comprising a T cell receptor signaling module is disclosed. Methods of generating same and using same are also disclosed.

公开(公告)号：US20230398218A1

公开(公告)日：2023-12-14

申请号：US18007096

申请日：2021-08-12

申请人： BioNTech US Inc.

发明人： Vikram Juneja

IPC分类号： A61K39/00 ,  C12N5/0783 ,  C07K14/725 ,  A61P35/00

CPC分类号： A61K39/464401 ,  C12N5/0636 ,  A61K39/4611 ,  C07K14/7051 ,  A61P35/00 ,  C12N2502/1121 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/26 ,  C12N2501/2301 ,  C12N2501/25

摘要： Compositions and methods for preparing T cell compositions and uses thereof are described, including methods for treating cancer in a subject in need thereof by administering T cells induced with peptides comprising at least one of KRAS epitope having a sequence GACGVGKSA that binds to a protein encoded by an HLA allele C03:04; or having a sequence GAVGVGKSA that binds to a protein encoded by an HLA allele C03:03 wherein the respective protein encoded by the HLA allele is expressed in a cell of the subject. Also included are immunogenic compositions comprising peptide(s) comprising an epitope described above, or antigen presenting cells loaded with the peptide(s) comprising the epitope.