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    Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence
    81.
    发明申请
    Method for producing catalytic antibodies (variants), antigens for immunization and nucleotide sequence 失效
    生产催化抗体（变体），免疫抗原和核苷酸序列的方法

    公开(公告)号：US20070178109A1

    公开(公告)日：2007-08-02

    申请号：US11644907

    申请日：2006-12-26

    申请人： Alexandr Gabibov ,  Natalya Ponomarenko ,  Alexandr Kolesnikov ,  Ivan Vorobiev ,  Elena Alexandrova ,  Alexandr Demin

    发明人： Alexandr Gabibov ,  Natalya Ponomarenko ,  Alexandr Kolesnikov ,  Ivan Vorobiev ,  Elena Alexandrova ,  Alexandr Demin

    IPC分类号： A61K39/42 ,  C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C12N5/06

    CPC分类号： C07K14/005 ,  A61K38/00 ,  C07K14/4713 ,  C07K16/1063 ,  C07K2319/00 ,  C12N9/0002 ,  C12N2740/16122

    摘要： A method for producing catalytic antibodies to proteins and peptides, in particular to gp120, using animals having spontaneous and induced autoimmune pathologies. The method makes it possible to create a catalytic vaccine which can when injected to a patient to exhibits adhesive properties in relation to antigen simultaneously with a destructive function, thereby suspending the progression of disease. The method for the autoimmunisation of animal lines SJL by fused proteins containing classical peptide epitope which develops pathology of an animal by protein fragments gp120 accompanied with an interest target catalytic antibody is disclosed. Also the method for immunising autoimmune animals by highly reactive chemical compositions which can perform a covalent selection of catalytic clones containing peptide fragments of potential resected portions gp120 is disclosed.

    摘要翻译： 使用具有自发和诱导的自身免疫病理学的动物产生蛋白质和肽特别是gp120的催化抗体的方法。 该方法使得可以产生一种催化疫苗，该疫苗可以在注射到患者体内，同时具有抗原功能而具有与抗原相关的粘合性质，从而暂停疾病进展。 公开了通过伴随感兴趣靶催化抗体的蛋白质片段gp120产生动物病理学的含经典肽表位的融合蛋白自动免疫动物系SJL的方法。 还公开了通过能够进行包含潜在切除部分gp120的肽片段的催化克隆的共价选择的高反应性化学组合来免疫自身免疫动物的方法。

    Catalytic antibodies
    82.
    发明授权
    Catalytic antibodies 失效
    催化抗体

    公开(公告)号：US07205136B1

    公开(公告)日：2007-04-17

    申请号：US08447924

    申请日：1995-05-23

    申请人： Gerald Schochetman ,  Richard J. Massey

    发明人： Gerald Schochetman ,  Richard J. Massey

    IPC分类号： C12N9/00

    CPC分类号： B82Y5/00 ,  C07K16/1063 ,  C07K16/4241 ,  C07K16/44 ,  C12N9/0002 ,  C12P1/00 ,  C12P13/227 ,  C12P17/10 ,  C12P19/34 ,  C12P41/004 ,  C12Q1/25 ,  G01N33/535 ,  G01N33/542 ,  G01N2333/16 ,  G01N2333/96472

    摘要： A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal antibody under conditions permitting the formation of a complex between the antibody and the reactant. The complexed reactant is converted to the product which is then released from the complex. The monoclonal antibody may employ a cofactor and may be directed to a known substrate of an enzyme. Methods for preparing such monoclonal antibodies are also disclosed.

    摘要翻译： 提高涉及将至少一种反应物转化为至少一种产物的化学反应速率的方法包括在允许抗体和反应物之间形成复合物的条件下使反应物与合适的单克隆抗体接触。 将络合的反应物转化成产物，然后将其从络合物中释放出来。 单克隆抗体可以使用辅因子并且可以被引导到酶的已知底物。 还公开了制备这种单克隆抗体的方法。

    Recombinant catalytic polypeptides and their uses
    84.
    发明申请
    Recombinant catalytic polypeptides and their uses 审中-公开
    重组催化多肽及其用途

    公开(公告)号：US20060088883A1

    公开(公告)日：2006-04-27

    申请号：US11239308

    申请日：2005-09-28

    申请人： Vaughn Smider ,  James Larrick

    发明人： Vaughn Smider ,  James Larrick

    IPC分类号： C40B40/10 ,  C12N9/00 ,  C12P21/06

    CPC分类号： C12N9/0002 ,  C07K16/22 ,  C07K16/241 ,  C07K2317/21 ,  C07K2317/56

    摘要： The present invention provides a recombinant catalytic polypeptide for cleaving a target protein, the nucleic acid encoding the recombinant catalytic polypeptide, a cell hosting the nucleic acid encoding the recombinant catalytic polypeptide, and a non-human transgenic mammal that is capable of producing a heterologous antibody with proteolytic activity. The invention also provides methods of cleaving a target protein using the recombinant catalytic polypeptides both in vitro and in vivo. The invention further provides a library of recombinant catalytic polypeptides with altered enzymatic activity and a method to alter enzymatic activity of the recombinant catalytic polypeptides.

    摘要翻译： 本发明提供了用于切割靶蛋白的重组催化多肽，编码重组催化多肽的核酸，承载编码重组催化多肽的核酸的细胞和能够产生异源抗体的非人转基因哺乳动物 具有蛋白水解活性。 本发明还提供了在体外和体内使用重组催化多肽切割靶蛋白的方法。 本发明还提供了具有改变的酶活性的重组催化多肽文库和改变重组催化多肽的酶活性的方法。

    Novel process for producing antibody enzyme, novel antibody enzyme and utilization thereof
    85.
    发明申请
    Novel process for producing antibody enzyme, novel antibody enzyme and utilization thereof 审中-公开
    制备抗体酶的新方法，新型抗体酶及其应用

    公开(公告)号：US20060030015A1

    公开(公告)日：2006-02-09

    申请号：US11037199

    申请日：2005-01-19

    申请人： Taizo Uda ,  Emi Hifumi

    发明人： Taizo Uda ,  Emi Hifumi

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N9/00 ,  C12N15/74

    CPC分类号： C07K16/2866 ,  C07K16/40 ,  C07K2317/56 ,  C12N9/0002

    摘要： A process for producing an antibody enzyme which involves an antibody structure analysis step of confirming the presence of a catalyst triplet residue structure wherein a serine residue, an aspartate residue and a histidine residue or a glutamate residue are located stereostructurally close to each other in the stereostructure of an antibldy anticipated based on its amino acid sequence. Since the above-described catalyst triplet residue structure is a structure specific to an antibody enzyme, an antibody enzyme can be efficiently screened by using the same. Examples of the antibody enzyme as described above include an antibody enzyme against Helicobacter pylori urease and an antibody enzyme against chemokine receptor CCR-5.

    摘要翻译： 一种制备抗体酶的方法，其涉及确认催化三联残基结构的存在的抗体结构分析步骤，其中丝氨酸残基，天冬氨酸残基和组氨酸残基或谷氨酸残基在立体结构中立体地彼此靠近地定位 基于其氨基酸序列预期的抗体。 由于上述催化剂三重态残基结构是抗体酶特异性结构，所以可以通过使用抗体酶来有效地筛选抗体。 如上所述的抗体酶的实例包括针对幽门螺杆菌脲酶的抗体酶和针对趋化因子受体CCR-5的抗体酶。

    Aldol consensations by catalytic antibodies
    88.
    发明授权
    Aldol consensations by catalytic antibodies 失效
    通过催化抗体的Aldol认可

    公开(公告)号：US06589766B1

    公开(公告)日：2003-07-08

    申请号：US09965512

    申请日：2001-09-25

    申请人： Carlos F. Barbas ,  Richard A. Lerner ,  Guofu Zhong ,  Benjamin List

    发明人： Carlos F. Barbas ,  Richard A. Lerner ,  Guofu Zhong ,  Benjamin List

    IPC分类号： C12P726

    CPC分类号： C12P7/26 ,  C12N9/0002

    摘要： Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent dehydration to yield aldol condensation products. A number of intramolecular aldol reactions have also been defined. Catalysis of all intramolecular aldol reactions examined yields the corresponding condensation products.

    摘要翻译： 包括38C2和33F12在内的催化抗体能够有效地催化各种酮 - 酮，酮 - 醛，醛 - 酮和醛 - 醛分子间醛醇反应，并且在某些情况下催化它们随后的脱水以产生醛醇缩合 产品。 还定义了许多分子内醛醇反应。 所检测的所有分子内醛醇反应的催化产生相应的缩合产物。

    Immunological control of &bgr;-amyloid levels in vivo
    89.
    发明授权
    Immunological control of &bgr;-amyloid levels in vivo 有权
    体内β-淀粉样蛋白水平的免疫控制

    公开(公告)号：US06582945B1

    公开(公告)日：2003-06-24

    申请号：US09594366

    申请日：2000-06-15

    申请人： Victor Raso

    发明人： Victor Raso

    IPC分类号： C12N900

    CPC分类号： C07K16/18 ,  A61K38/00 ,  A61K39/0007 ,  A61K39/3955 ,  C07K2317/34 ,  C12N9/0002 ,  Y10S977/729 ,  Y10S977/896 ,  Y10S977/915 ,  Y10S977/918

    摘要： Disclosed are antibodies which catalyze hydrolysis of &bgr;-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using &bgr;-amyloid peptides which incorporate transition state analogs are also provided. Also disclosed is a vectorized antibody which is characterized by the ability to cross the blood brain barrier, and is further characterized by the ability to catalyze the hydrolysis of &bgr;-amyloid. The vectorized antibody can take the form of a bispecific antibody, which has a first specificity for the transferrin receptor and a second specificity for a transition state adopted by &bgr;-amyloid during hydrolysis.

    摘要翻译： 公开了催化β-淀粉样蛋白水解的抗体。 产生的抗体的特征在于它们水解的酰胺键。 还提供了通过使用结合过渡态类似物的β-淀粉样肽产生抗体的方法。 还公开了一种载体化抗体，其特征在于穿过血脑屏障的能力，其特征还在于催化β-淀粉样蛋白的水解的能力。 载体化抗体可以采用双特异性抗体的形式，其具有转铁蛋白受体的第一特异性，并且在水解期间由β-淀粉样蛋白所采用的过渡态的第​​二特异性。