公开(公告)号：US20060049090A1

公开(公告)日：2006-03-09

申请号：US11180958

申请日：2005-07-13

申请人： Franco Spoldi ,  Charles Laub

发明人： Franco Spoldi ,  Charles Laub

IPC分类号： B01D15/08

CPC分类号： G01N30/6021 ,  B01D15/22 ,  G01N2030/522 ,  Y10T29/496

摘要： A chromatographic device comprises a tube, a chromatographic medium, a piston assembly, and a locking mechanism. The tube comprises first and second opposite ends and an inner surface. The inner surface of the tube at least in part defines an intermediate region. The intermediate region is generally between the first and second ends. The chromatographic medium is within the intermediate region. The piston assembly is within the tube and is positioned generally between the first end of the tube and the chromatographic medium. The piston assembly defines a passage for flow of process fluid. The piston assembly comprises a piston body portion. The locking mechanism is adjacent the piston assembly and is in engagement with the inner surface of the tube in a manner to prevent movement of the piston assembly relative to the tube axially toward the first end of the tube without preventing movement of the piston assembly relative to the tube axially toward the second end of the tube.

公开(公告)号：US07008532B2

公开(公告)日：2006-03-07

申请号：US10122275

申请日：2002-04-12

申请人： Yehuda Shalon ,  Charles F. Laub

发明人： Yehuda Shalon ,  Charles F. Laub

IPC分类号： B01D15/08

CPC分类号： G01N30/6021 ,  G01N2030/522 ,  G01N2030/565

摘要： A chromatographic device comprises a chromatographic tube, a chromatographic medium, a piston assembly, an elongate rod, and a threaded member. The piston assembly is within the tube and is positioned generally between a first end of the tube and the chromatographic medium. The chromatographic medium is generally between the piston assembly and a second end of the tube. The elongate rod extends partially into the chromatographic tube such that the piston assembly is between the elongate rod and the second end of the chromatographic tube. The elongate rod has a threaded outer surface. The threaded member is threaded to the threaded outer surface of the elongate rod. The treaded member is operatively secured to the chromatographic tube.

摘要翻译： 色谱装置包括色谱管，色谱介质，活塞组件，细长杆和螺纹构件。 活塞组件位于管内，通常位于管的第一端和色谱介质之间。 色谱介质通常在活塞组件和管的第二端之间。 细长杆部分地延伸到色谱管中，使得活塞组件位于细长杆和色谱管的第二端之间。 细长杆具有螺纹外表面。 螺纹构件螺纹连接到细长杆的螺纹外表面。 踏板构件可操作地固定到色谱管上。

公开(公告)号：US20040164012A1

公开(公告)日：2004-08-26

申请号：US10373293

申请日：2003-02-24

发明人： John Graham Dunkley ,  Neil Francis Frazer ,  Melvyn John Gill

IPC分类号： B01D015/08

CPC分类号： G01N30/56 ,  B01D15/20 ,  B01D15/22 ,  G01N30/6021 ,  G01N30/6047 ,  G01N30/6082 ,  G01N2030/522 ,  G01N2030/562 ,  Y10T29/49721 ,  G01N30/6004

摘要： The present invention relates to a chromatography column that removes the longitudinal load from the column tube altogether and transfers it to a yoke and stanchion arrangement situated around but external to the column tube. By using the yoke/stanchion system, the central adjuster can be used to move the top end into and out of the housing. Thus, when internal pressure is applied to the column, the tube experiences no longitudinal load. Additionally, the yoke and stanchion design allows for complete removal of the end from the tube without cumbersome disassembly. Moreover, the yoke provides a place to retain the end while the tube is being filled, emptied, cleaned or repaired.

摘要翻译： 本发明涉及一种色谱柱，其色谱柱一直从柱管中除去纵向载荷，并将其转移到位于柱管周围但位于柱管周围的轭和支柱装置。 通过使用轭/支柱系统，中央调节器可用于将顶端移入和移出壳体。 因此，当向柱施加内部压力时，管不经受纵向载荷。 另外，轭和支柱设计允许从管中完全移除端部而不需要麻烦的拆卸。 此外，轭提供了在管被填充，清空，清洁或修理时保持端部的位置。

公开(公告)号：US20030217973A1

公开(公告)日：2003-11-27

申请号：US10393674

申请日：2003-03-19

发明人： Jeffrey A. Horsman ,  Omar Mneimne ,  Shahnaz Ghassemi Jamalabadi

IPC分类号： B01D015/08

CPC分类号： G01N30/08 ,  B01D15/14 ,  G01N30/60 ,  G01N30/6017 ,  G01N30/6021 ,  G01N30/6026 ,  G01N30/6069 ,  G01N30/6091 ,  G01N35/1095 ,  G01N2030/009 ,  G01N2030/062 ,  G01N2030/085 ,  G01N2030/167 ,  G01N2030/522

摘要： Techniques for chromatography, including a method for introducing a sample into a chromatography column having the following steps. A liquid reaction mixture is provided including a sample dissolved in a solvent. A chromatography sample module including a separation media is at least partially immersed in the liquid reaction mixture, such that the liquid reaction mixture is drawn into the sample module by capillary action. The sample module including the sample is inserted into a chromatography column.

摘要翻译： 色谱技术，包括将样品导入具有以下步骤的色谱柱的方法。 提供液体反应混合物，其包括溶解在溶剂中的样品。 包括分离介质的色谱样品模块至少部分浸没在液体反应混合物中，使得液体反应混合物通过毛细管作用被吸入样品模块中。 将包含样品的样品模块插入色谱柱。

公开(公告)号：US20020153294A1

公开(公告)日：2002-10-24

申请号：US10172466

申请日：2002-06-14

申请人： Biotage, Inc., a Delaware corporation

发明人： Peter J. Leavesley ,  Peter C. Van Davelaar ,  Robert D. Lockman ,  Ivan Hargro ,  Jeffrey A. Horsman ,  Peter C. Rahn

IPC分类号： B01D015/08

CPC分类号： G01N30/6091 ,  B01D15/08 ,  G01N30/461 ,  G01N30/6017 ,  G01N30/6021 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6069 ,  G01N2030/085 ,  G01N2030/167 ,  G01N2030/522

摘要： An apparatus for use in liquid chromatography involves a column filled with media bounded axially by first and second porous plates. The column has an inlet end with an inflow region between the inlet end and the first porous plate. The column also has an outlet end with an outflow region between the outlet end and the second porous plate. The inflow region may be substantially longer than the outflow region. The porous plates may be moveable under pressure so as to compress the media.

摘要翻译： 用于液相色谱的装置包括填充有由第一和第二多孔板轴向界定的介质的柱。 该塔具有入口端，入口端在入口端和第一多孔板之间具有流入区域。 该柱还具有在出口端和第二多孔板之间具有流出区域的出口端。 流入区域可以比流出区域大得多。 多孔板可以在压力下移动以压缩介质。

公开(公告)号：US06436284B1

公开(公告)日：2002-08-20

申请号：US09687801

申请日：2000-10-13

申请人： Peter J. Leavesley ,  Peter C. Van Davelaar ,  Robert D. Lockman ,  Ivan Hargo ,  Jeffrey A. Horsman ,  Peter C. Rahn

发明人： Peter J. Leavesley ,  Peter C. Van Davelaar ,  Robert D. Lockman ,  Ivan Hargo ,  Jeffrey A. Horsman ,  Peter C. Rahn

IPC分类号： B01D1508

CPC分类号： G01N30/6091 ,  B01D15/08 ,  G01N30/461 ,  G01N30/6017 ,  G01N30/6021 ,  G01N30/6026 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6069 ,  G01N2030/085 ,  G01N2030/167 ,  G01N2030/522

摘要： An apparatus for use in liquid chromatography involves a column filled with media bounded axially by at least one porous member. The column has an inlet end with an inflow region between the inlet and a porous member. The inflow region may be sufficiently long so that a chromatography sample module may be disposed therein. The column may be sufficiently long so that a chromatography sample module may be disposed therein. The column may also have an outlet end with an outflow region between the outlet end and a second porous member. The inflow region may be substantially longer than the outflow region. The porous members may be moveable relative to the column.

摘要翻译： 用于液相色谱的装置包括填充有至少一个多孔构件轴向界定的介质的柱。 该柱具有入口端，入口端在入口和多孔构件之间具有流入区域。 流入区域可以足够长，以便可以在其中设置色谱样品模块。 该柱可以足够长，使得可以在其中设置色谱法样品模块。 该柱还可以具有在出口端和第二多孔构件之间具有流出区域的出口端。 流入区域可以比流出区域大得多。 多孔构件可以相对于柱移动。

公开(公告)号：US06280616B1

公开(公告)日：2001-08-28

申请号：US08894130

申请日：1997-08-13

申请人： Conny Pettersson

发明人： Conny Pettersson

IPC分类号： B01D1508

CPC分类号： G01N30/6021 ,  B01D15/22 ,  G01N30/02 ,  G01N30/6017 ,  G01N30/603 ,  G01N2030/027 ,  B01D15/34

摘要： Disclosed is a chromatography column having adapters that include an end-plate and a perforated plate such as to form a gap between the end-plate and the perforated plate. The column is particularly suited for large-scale chromatography in which matrices of small particle sizes are used.

摘要翻译： 公开了一种色谱柱，其具有包括端板和多孔板的适配器，以在端板和多孔板之间形成间隙。 该柱特别适用于使用小粒径的基质的大规模色谱法。

公开(公告)号：US6132605A

公开(公告)日：2000-10-17

申请号：US137019

申请日：1998-08-20

申请人： Peter J. Leavesley ,  Peter C. Van Davelaar ,  Robert D. Lockman

发明人： Peter J. Leavesley ,  Peter C. Van Davelaar ,  Robert D. Lockman

IPC分类号： B01D15/00 ,  B01D15/08 ,  G01N30/46 ,  G01N30/52 ,  G01N30/60

CPC分类号： G01N30/6091 ,  G01N30/6026 ,  G01N2030/522 ,  G01N30/461 ,  G01N30/6017 ,  G01N30/6021 ,  G01N30/603 ,  G01N30/6039 ,  G01N30/6069

摘要： An apparatus and method for sealing cartridges used in liquid chromatography. Such cartridges are commonly filled with media beds that are bounded axially by porous plates. The invention involves one or two sealing heads. Each sealing head comprises two slidably connected head pieces and an elastomeric sealing member. The head pieces and the elastomeric sealing member are sized to slide easily into an open end of a cartridge when the elastomeric sealing member is uncompressed. After insertion, relative movement of the head pieces compresses the elastomeric sealing member and causes the elastomeric sealing member to expand laterally so that it forms a seal against the cartridge, when the sealing head is pressed against the media bed or porous plate. An alternate sealing head comprises a plurality of head pieces and a plurality of annular elastomeric sealing members. One of the head pieces contains a body portion on which the other head pieces and the sealing members are slidably mounted. The sealing apparatus may employ a sample module that fits within an open end of a column or cartridge. At least one of the sealing members fits within the sample module and creates a seal when compressed.

摘要翻译： 一种用于液相色谱中使用的墨盒的装置和方法。 这种筒通常填充有多孔板轴向界定的介质床。 本发明涉及一个或两个密封头。 每个密封头包括两个可滑动连接的头部件和弹性密封件。 当弹性体密封件未被压缩时，头部件和弹性体密封件的尺寸设计成能够容易地滑入盒的开口端。 在插入之后，头部件的相对运动压缩弹性体密封构件，并且使得弹性体密封构件横向膨胀，使得当密封头压靠在介质床或多孔板上时，其形成密封件。 另一个密封头包括多个头部件和多个环形弹性密封件。 头部中的一个包含主体部分，其上的头部件和密封件可滑动地安装在主体部分上。 密封装置可以采用装配在柱或筒的开口端内的样品模块。 至少一个密封构件装配在样品模块内，并在压缩时形成密封。

公开(公告)号：US5366621A

公开(公告)日：1994-11-22

申请号：US144456

申请日：1993-10-28

申请人： Christopher R. Bidell ,  Colin K. Lanyl ,  Anthony F. Mann ,  Phillip Stafford

发明人： Christopher R. Bidell ,  Colin K. Lanyl ,  Anthony F. Mann ,  Phillip Stafford

IPC分类号： B01D15/00 ,  B01D15/08 ,  G01N30/56 ,  G01N30/60

CPC分类号： G01N30/56 ,  G01N30/6021 ,  G01N30/6026

摘要： A chromatography column piston 14 is adjustable in height within the column tube 4 by means of a friction clamp 22 which furthermore includes a threaded engagement with the associated end cap 8 of the column. As a result, with the friction clamp released the piston rod 16 can be rapidly traversed to or near a desired position, and the clamp then engaged following which cooperation of said threads allows fine tuning of the level of the piston 14 by fine adjustment of the position of the friction clamp relative to the end cap 8.

摘要翻译： 色谱柱活塞14通过摩擦夹具22在柱管4内可调节高度，该摩擦夹具还包括与柱的相关联的端盖8的螺纹接合。 结果，当释放摩擦夹具时，活塞杆16能够快速地移动到所需位置或靠近所需位置，然后夹紧器接合，随后所述螺纹的协作允许通过精细调节活塞14的水平来微调活塞14的水平 摩擦夹具相对于端盖8的位置。

公开(公告)号：US5266193A

公开(公告)日：1993-11-30

申请号：US932972

申请日：1992-08-20

申请人： Masaru Kimura ,  Hiromi Kochi

发明人： Masaru Kimura ,  Hiromi Kochi

IPC分类号： G01N30/60 ,  B01D15/08

CPC分类号： G01N30/6021

摘要： A syringe type column used for liquid chromatography, wherein a stationary phase (4) and a solvent for development (5) are placed in a cylindrical barrel (1), and an air vent (2a) extends through a plunger (2) which is inserted in the barrel. Development is effected, while the air vent (2a) is closed to prevent air leakage therethrough, by pushing down the plunger (2). When the plunger (2) is drawn out in order to supplement the solvent for development, air flows into the cylindrical barrel (1) through the air vent (2a) so that an inner space of the barrel (1 ) is not held under a negative pressure and the stationary phase (4) is not disturbed.

摘要翻译： 用于液相色谱法的注射器型柱，其中固定相（4）和显影用溶剂（5）放置在圆柱形筒体（1）中，并且排气孔（2a）延伸穿过柱塞（2） 插入枪管。 通过按压柱塞（2），排气口（2a）被关闭以防止空气泄漏。 当柱塞（2）被拉出以补充用于显影的溶剂时，空气通过排气口（2a）流入圆柱形筒体（1），使得筒体（1）的内部空间不被保持在 负压和固定相（4）不受干扰。