Biomarker method
    87.
    发明授权

    公开(公告)号:US09953417B2

    公开(公告)日:2018-04-24

    申请号:US15027183

    申请日:2014-10-03

    摘要: A spatial distribution of cells or sub-cellular structures of a subject is quantified by receiving image data that includes a plurality of biomarkers and processing the image data to obtain a set of coordinates. Each coordinate denotes the location of a cell or sub-cellular structure represented by a biomarker or combination of biomarkers. The set of coordinates is processed into a two-dimensional symmetric matrix. Each element of the matrix indicates the frequency of a cell or sub-cellular structure represented by a first biomarker or combination of biomarkers being observed within an interaction distance of a cell or sub-cellular structure represented by a second biomarker or combination of biomarkers. A classifier assigns the subject to a group or category based on the matrix. A toxicity and/or efficacy of one or more interventions is assessed based on a comparison of the spatial distribution to one or more predetermined reference or control distributions.