公开(公告)号：US06434414B1

公开(公告)日：2002-08-13

申请号：US09609486

申请日：2000-07-05

申请人： Oliver Heid

发明人： Oliver Heid

IPC分类号： A61B5055

CPC分类号： G01R33/28

摘要： In a method and a device for suppressing stimulations in a living examination subject as a result of switched gradients during data scans for producing magnetic resonance images, at least two electrodes, which are connected to one another by at least one electrically conductive connection, are attached to the skin of the examination subject for bridging at least one region of the examination subject that is of lower electrical conductivity than the regions surrounding it.

摘要翻译： 在用于产生磁共振图像的数据扫描期间由于切换梯度来抑制在活检测对象中的刺激的方法和装置中，通过至少一个导电连接彼此连接的至少两个电极被附接 到考试对象的皮肤，以桥接考试对象的至少一个区域，该区域的电导率低于其周围的区域。

公开(公告)号：US06397096B1

公开(公告)日：2002-05-28

申请号：US09540341

申请日：2000-03-31

申请人： Kecheng Liu ,  Paul M. Margosian ,  Jian Lin

发明人： Kecheng Liu ,  Paul M. Margosian ,  Jian Lin

IPC分类号： A61B5055

CPC分类号： G01R33/563 ,  G01R33/5608 ,  G01R33/5617

摘要： A black blood magnetic resonance angiogram is produced by exciting dipoles (52) and repeatedly inverting the resonance (541, 542, . . . ) to produce a series of magnetic resonance echoes (561, 562, . . . ). Early echoes (e.g., (561, . . . , 568)) are more heavily proton density weighted than later echoes (e.g., (569, . . . , 5616)), which are more heavily T2 weighted. The magnetic resonance echoes are received and demodulated (38) into a series of data lines. The data lines are sorted (60) between the more heavily proton density weighted data lines and T2 weighted data lines which are reconstructed into a proton density weighted image representation and a T2 weighted image representation. The proton density weighted and T2 weighted image representations are combined (90) to emphasize the black blood from the T2 weighted images and the static tissue from the proton density weighted image. The combination processor (90) scales (92) the PDW and T2W images to a common maximum intensity level. The PDW and T2W image representations are then combined, e.g. averaged, together (94) to form a combined or averaged image. An edge image (96) is computed from the T2W image and a threshold mask (98) is applied. The edge image (96) is combined (100) with the combined image (94) to form an edge enhanced image. Optionally, a minimum projection intensity algorithm (102) is applied to the enhanced image. Preferably, the enhanced image is a black blood magnetic resonance angiogram with emphasized blood vessel edges.

摘要翻译： 通过激发偶极子（52）并重复地反转谐振（541,542 ...）来产生黑色血液磁共振血管造影图，以产生一系列磁共振回波（561,562 ......）。 早期的回波（例如，（561，...，568））比后来的回波（例如，（569，...，5616））加权的质子密度更重，T2加权更重。 磁共振回波被接收和解调（38）成一系列数据线。 数据线在重质子密度加权数据线和被重建为质子密度加权图像表示和T2加权图像表示的T2加权数据线之间被排序（60）。 将质子密度加权和T2加权图像表示组合（90）以强调来自T2加权图像的黑血和来自质子密度加权图像的静态组织。 组合处理器（90）将PDW和T2W图像缩放（92）到共同的最大强度水平。 然后组合PDW和T2W图像表示。 平均，一起（94）以形成组合或平均图像。 从T2W图像计算边缘图像（96），并应用阈值掩码（98）。 边缘图像（96）与组合图像（94）组合（100）以形成边缘增强图像。 可选地，将最小投影强度算法（102）应用于增强图像。 优选地，增强图像是具有强调的血管边缘的黑色血液磁共振血管造影。

公开(公告)号：US06372194B1

公开(公告)日：2002-04-16

申请号：US09381176

申请日：1999-09-17

申请人： Toshihiro Akaike ,  Masahito Mikawa ,  Atsushi Maruyama ,  Naoto Miwa

发明人： Toshihiro Akaike ,  Masahito Mikawa ,  Atsushi Maruyama ,  Naoto Miwa

IPC分类号： A61B5055

CPC分类号： A61K49/085 ,  A61K49/12 ,  A61K49/128

摘要： This relates to a contrast medium containing a complex of a gadolinium (Gd) type contrast agent and a polymer. More particularly, the contrast medium wherein the polymer capable of phase transit in response to environmental changes, particularly, pH, light or temperature, to develop a different water solubility, and a method for imaging by the use of this contrast medium. By binding a polymer responsive to microenvironmental changes with a Gd type MRI contrast agent, on-off switching of MRI imaging capability is enabled, wherein imaging occurs only on the target sites. Consequently, a highly specific MRI contrast medium can be obtained, whereby a highly specific MRI diagnosis is made possible, wherein only the target sites such as a tumor and a particular site are imaged and otherwise at the site where imaging is not necessary.

摘要翻译： 这涉及含有钆（Gd）型造影剂和聚合物的复合物的造影剂。 更具体地，其中响应于环境变化，特别是pH，光或温度而相转移的聚合物以形成不同的水溶性的造影剂，以及通过使用该造影剂进行成像的方法。 通过用Gd型MRI造影剂结合响应于微环境变化的聚合物，能够进行MRI成像能力的开 - 关切换，其中成像仅在靶位点上发生。 因此，可以获得高度特异性的MRI造影剂，由此可以进行高度特异性的MRI诊断，其中只有目标部位如肿瘤和特定部位成像，否则在不需要成像的部位进行成像。

公开(公告)号：US06368574B1

公开(公告)日：2002-04-09

申请号：US09488785

申请日：2000-01-21

申请人： Per Akeson ,  Lars Johansson

发明人： Per Akeson ,  Lars Johansson

IPC分类号： A61B5055

CPC分类号： G01R33/5601 ,  G01R33/56341

摘要： This invention relates to a method of contrast agent-enhanced magnetic resonance imaging of perfusion in vasculated tissue within a human or non-human animal body in which a bolus comprising a contrast-enhancing amount of a magnetic resonance imaging contrast agent is administered into the vascular system of said body, and said body is subjected to a magnetic resonance imaging procedure whereby signals or images representative of first pass of said contrast agent bolus through tissue of interest are generated, characterised in that (i) said contrast agent is capable of exhibiting simultaneous, determinable T1 and T2* reducing effects under the imaging procedure employed and (ii) a T1-weighted imaging procedure is used (a) to visualise the first pass of said contrast agent bolus through said tissue by virtue of its signal lowering T2* effect and (b) to obtain a T1-weighted contrast agent-enhanced image of said tissue.

摘要翻译： 本发明涉及在人或非人动物体内的血管组织中的灌注造影剂增强磁共振成像的方法，其中将包含对比度增强量的磁共振成像造影剂的推注物施用于血管 系统，并且所述身体经受磁共振成像过程，由此产生表示通过感兴趣组织的所述造影剂推注的第一次通过的信号或图像，其特征在于（i）所述造影剂能够同时显示 ，所采用的成像程序下的可确定的T1和T2 *降低效应和（ii）T1加权成像程序（a）通过其信号降低T2 *效应使所述造影剂推注通过所述组织的第一次通过 和（b）获得所述组织的T1加权造影剂增强图像。

公开(公告)号：US06361759B1

公开(公告)日：2002-03-26

申请号：US09105033

申请日：1998-06-25

申请人： Richard Frayne ,  Charles M. Strother ,  Orhan Unal ,  Zhihao Yang ,  Abukar Wehelie ,  Hyuk Yu

发明人： Richard Frayne ,  Charles M. Strother ,  Orhan Unal ,  Zhihao Yang ,  Abukar Wehelie ,  Hyuk Yu

IPC分类号： A61B5055

CPC分类号： A61K49/12 ,  A61K49/085 ,  A61K49/18 ,  A61L29/18 ,  A61L31/18

摘要： The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer complex that facilitates diagnostic and therapeutic techniques by readily visualizing medical devices coated with the complex.

公开(公告)号：US06345193B2

公开(公告)日：2002-02-05

申请号：US09141260

申请日：1998-08-27

申请人： Roberto Dutto ,  Orfeo Contrada ,  Fabio Rezzonico

发明人： Roberto Dutto ,  Orfeo Contrada ,  Fabio Rezzonico

IPC分类号： A61B5055

CPC分类号： A61B5/0555

摘要： An examination table, particularly in Nuclear Magnetic Resonance image detecting machines of the so-called dedicated type, i.e. designed for detecting images of specific body parts, has an at least one-degree-of-freedom constraint (5, 6) to the machine (1), and has supports (6, 7, 12, 402, 302) which allow the examination table (2) to be moved in at least one, preferably two or more degrees of freedom. Advantageously, the examination table (2) is mounted in such a way as to be able to slide (7, 6) on a stationary guide (5) which is fixed with a predetermined orientation with respect to the detection cavity (101) of the machine (1) and it may be further translated in both senses (6, 7) along said guide (5) and rotated (11, 12) about an axis (402) perpendicular to the direction it follows while sliding on the guide (5).

摘要翻译： 特别是在所谓的专用型的核磁共振图像检测机中的检查表，即设计用于检测特定身体部位的图像，具有至少一个自由度约束（5,6）到机器 （1），并且具有允许检查台（2）以至少一个，优选两个或更多个自由度移动的支撑件（6,7,12,402,302）。 有利地，检查台（2）安装成能够在固定导向件（5）上滑动（7,6），所述静止导轨（5）相对于所述检测腔（101）以预定取向固定 机器（1），并且可以沿着所述引导件（5）在两个感觉（6,7）中进一步平移并围绕垂直于其所遵循的方向的轴线（402）旋转（11,12），同时在引导件（5）上滑动 ）。

公开(公告)号：US06325989B1

公开(公告)日：2001-12-04

申请号：US08457694

申请日：1995-06-01

申请人： Jonathan S. Duke-Cohan ,  Chikao Morimoto ,  Stuart F. Schlossman

发明人： Jonathan S. Duke-Cohan ,  Chikao Morimoto ,  Stuart F. Schlossman

IPC分类号： A61B5055

摘要： A soluble form of CD26 isolated from human serum is disclosed. The serum form shares similar enzymatic and antigenic properties with the membrane form. However, in several biochemical aspects there are distinct differences. In particular, the soluble serum form has a molecular weight of 175 kDa (in contrast to the 105 kDa molecular weight of the membrane form), and it does not bind Adenosine Deaminase Type-1. Nevertheless, the soluble form expresses functional dipeptidylpeptidase IV activity and retains the ability to costimulate the T lymphocyte response to recall antigen. Although 105 kDa membrane type CD26 may be found in the serum in small amounts, the majority of serum DPPIV activity is provided by a novel peptidase structurally distinct from membrane C26/DPPIV.

摘要翻译： 公开了从人血清中分离的可溶形式的CD26。 血清形式与膜形式具有相似的酶和抗原性质。 然而，在几个生化方面有明显的差异。 特别地，可溶性血清形式的分子量为175kDa（与膜形式的105kDa分子量相反），并且不结合腺苷脱氨酶1型。 然而，可溶形式表达功能性二肽基肽酶IV活性，并保留共同刺激T淋巴细胞回忆抗原的能力。 尽管少量血清中可以发现105kDa的膜型CD26，但大部分血清DPPIV活性由结构不同于膜C26 / DPPIV的新型肽酶提供。

公开(公告)号：US06317619B1

公开(公告)日：2001-11-13

申请号：US09363349

申请日：1999-07-29

申请人： Peter Boernert ,  Tobias Richard Schaeffter ,  Steffen Weiss

发明人： Peter Boernert ,  Tobias Richard Schaeffter ,  Steffen Weiss

IPC分类号： A61B5055

CPC分类号： G01R33/341 ,  G01R33/34007 ,  G01R33/3806 ,  G01R33/543 ,  G01R33/546 ,  G01R33/58

摘要： Objects of this invention include provision of magnetic resonance (MR) imaging methods, MR apparatus, and radio-frequency (RF) receiving coil devices permitting interactive MR examination of a patient. In particular, this invention includes means for generating MR images by a moveable RF coil which can be moved across a patient during an MR examination. The MR apparatus includes a position detection system which detects the current position and orientation of the moveable RF coil. The coil can be hand held for manual movement or can be attached to mechanical manipulators for controlled movement. The imaging methods determine and generate magnetic gradient and RF pulse sequences to excite nuclear magnetization in a 3D region determined with respect to the current 3D position and 3D orientation of the moveable RF coil. The invention also includes moveable RF coils for receiving and transmitting which are configured and sized for convenient manipulation by an operator. A preferable moveable RF coil assembly includes markers necessary to interact with a particular position detection system, display means for displaying reconstructed images in real-time, and control means for operator entry of signals controlling the MR apparatus. This invention also includes a carrier medium with recorded program instructions for controlling a programmable MR apparatus to perform the disclosed methods.

摘要翻译： 本发明的目的包括提供磁共振（MR）成像方法，MR装置和允许患者的交互式MR检查的射频（RF）接收线圈装置。 具体地，本发明包括用于通过可移动RF线圈产生MR图像的装置，其可以在MR检查期间跨越患者移动。 MR装置包括检测可动RF线圈的当前位置和方向的位置检测系统。 线圈可以手持进行手动运动，也可以连接到机械操纵器上以进行控制运动。 成像方法确定并产生磁梯度和RF脉冲序列，以在相对于可移动RF线圈的当前3D位置和3D取向确定的3D区域中激发核磁化。 本发明还包括用于接收和发送的可移动RF线圈，其被配置和大小以便操作者方便操作。 优选的可动RF线圈组件包括与特定位置检测系统相互作用所需的标记，用于实时显示重建图像的显示装置和用于操作者输入控制该MR装置的信号的控制装置。 本发明还包括具有用于控制可编程MR装置以执行所公开的方法的记录的程序指令的载体介质。

公开(公告)号：US06295465B1

公开(公告)日：2001-09-25

申请号：US09251550

申请日：1999-02-17

申请人： Orlando P. Simonetti

发明人： Orlando P. Simonetti

IPC分类号： A61B5055

CPC分类号： G01R33/5601 ,  A61B5/055 ,  G01R33/563

摘要： Gadolinium-based MR contrast agent is administered to a patient. Acquisition of MR data begins at the latest when the bolus of MR contrast agent reaches the patient's heart and continues throughout the first-pass of contrast agent through the coronary circulation. Advantageously, the acquisition is carried out using a T1-weighted, three-dimensional gradient echo sequence that is synchronized to the patient's cardiac cycle to acquire MR data only during diastole, and a T1-weighting magnetization preparation such as inversion-recovery or saturation-recovery is used.

摘要翻译： 向患者施用基于钆的MR造影剂。 当MR造影剂的推注到达患者的心脏并且通过冠状动脉循环的造影剂的首次遍历时，MR数据的采集最迟开始。 有利的是，使用与患者心动周期同步的T1加权的三维梯度回波序列来进行采集，以仅在舒张期期间获取MR数据，以及T1加权磁化准备例如反转恢复或饱和 - 使用恢复。

公开(公告)号：US06275720B1

公开(公告)日：2001-08-14

申请号：US09270351

申请日：1999-03-16

申请人： Yiping Du ,  Thomas K. F. Foo

发明人： Yiping Du ,  Thomas K. F. Foo

IPC分类号： A61B5055

CPC分类号： G01R33/5676 ,  G01R33/56509

摘要： A method is disclosed for providing a time efficient and accurate measure of the absolute positional displacements of a reference structure in navigator echo MR imaging. The method comprises the steps of operating an MR system to acquire a reference navigator echo associated with the object at a specified reference position, and applying an MR sequence to the object to acquire a set of MR image data when the object is selectively displaced from the reference position. The data set includes an acquired navigator echo having a specified field of view. The method further comprises truncating the acquired navigator echo by means of a selectively positioned truncation window, calculating the difference between linear phase shifts respectively associated with acquired and reference navigator echoes, and displacing the truncation window by an amount representing or corresponding to the phase shift difference in spatial units. Thereupon, the truncating, difference calculation, and truncation window displacement steps are iteratively repeated a specified number of times or when the calculated displacements converge to zero, to provide a final phase shift difference value and an absolute spatial displacement of a reference structure. The final value is used to determine the displacement of the object from the specified reference position when the MR data set is acquired.

摘要翻译： 公开了一种用于提供导航回波MR成像中参考结构的绝对位置偏移的时间有效且准确的测量的方法。 该方法包括以下步骤：操作MR系统以在指定的参考位置处获取与对象相关联的参考导航器回波，以及当对象选择性地从该对象选择性地移位时，将MR序列应用于对象以获取一组MR图像数据 参考位置。 数据集包括具有指定视野的获取导航回波。 该方法还包括通过选择性定位的截断窗口截取所获取的导航回波，计算分别与获取的和参考导航回波相关联的线性相移之间的差异，以及将截断窗移位表示或对应于相移差的量 在空间单位。 因此，截断，差分计算和截断窗口位移步骤被迭代地重复指定次数，或者当计算的位移收敛到零时，提供参考结构的最终相移差值和绝对空间位移。 当获取MR数据集时，最终值用于确定对象与指定参考位置的位移。