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123 条记录 (耗时 0.014 秒)

    Method for preparing 10,10-difluoro prostacyclin intermediates and new compounds produced thereby
    82.
    发明授权
    Method for preparing 10,10-difluoro prostacyclin intermediates and new compounds produced thereby 失效
    制备10,10-二氟前列环素中间体的方法和由此制备的新化合物

    公开(公告)号：US4311644A

    公开(公告)日：1982-01-19

    申请号：US230133

    申请日：1981-01-30

    申请人： Jerome L. Moniot ,  Rita T. Fox ,  Peter W. Sprague ,  Martin F. Haslanger

    发明人： Jerome L. Moniot ,  Rita T. Fox ,  Peter W. Sprague ,  Martin F. Haslanger

    IPC分类号： C07C29/03 ,  C07C29/128 ,  C07C29/48 ,  C07D307/935 ,  C07D307/937

    CPC分类号： C07D307/935 ,  C07C29/03 ,  C07C29/1285 ,  C07C29/48 ,  C07D307/937 ,  C07B2200/07 ,  C07C2102/24

    摘要： A method is provided for preparing intermediates for use in 10,10-difluoro prostacyclin syntheses which method includes the steps of aceylating ketopinic acid or its acid halide to form the corresponding ketopinoyl diene ester intermediate, subjecting the diene ester to a Diels-Alder reaction by reacting same with cyclopentendione, subjecting the resulting chiral ester intermediate to a fluorination and reduction to form the corresponding chiral ester diol intermediate, subjecting the diol to solvolysis to form the chiral triol intermediate, hydroxylating the chiral triol to form a pentol intermediate, subjecting the pentol to a ring cleavage to form the difluoro dihydroxy prostacyclin intermediate ##STR1## and subjecting same to a Wittig reaction to form the difluoro dihydroxy prostacyclin intermediate ##STR2## All of the above-mentioned intermediates are novel compounds and thus are also provided.

    摘要翻译： 提供了一种用于制备用于10,10-二氟前列环素合成的中间体的方法，该方法包括以下步骤：将酮苯甲酸或其酰基卤乙酰化形成相应的酮戊二烯二烯酯中间体，使二烯酯通过 与环戊二酮反应，使得到的手性酯中间体进行氟化和还原反应，形成相应的手性酯二醇中间体，使二醇溶剂分解形成手性三醇中间体，羟基化手性三醇以形成戊酸中间体， 以形成二氟二羟基前列环素中间体“IMAGE”，并使其进行维蒂希反应以形成二氟二羟基前列环素中间体所有上述中间体都是新化合物，因此也被提供。

    Process for preparing benzylalcohols
    84.
    发明授权
    Process for preparing benzylalcohols 失效
    制备苄醇的方法

    公开(公告)号：US4283565A

    公开(公告)日：1981-08-11

    申请号：US974468

    申请日：1978-12-29

    申请人： Gunther Bernhardt ,  Gerhard Daum

    发明人： Gunther Bernhardt ,  Gerhard Daum

    IPC分类号： C07C27/02 ,  C07B31/00 ,  C07B41/02 ,  C07C27/00 ,  C07C29/128 ,  C07C31/18 ,  C07C67/00 ,  C07C67/03

    CPC分类号： C07C29/1285 ,  C07C67/03

    摘要： There is described an essentially two step process for the preparation of benzylalcohols including those benzylalcohols having substituents on the benzyene ring by reaction of a substituted or unsubstituted benzyl halide with a formate typically an alkali or alkaline earth metal formate to form the corresponding substituted or unsubstituted benzyl formate. In the second step of the process the benzyl formate is contacted with an alcohol whereby the same is converted into the desired benzylalcohol. Both steps can be performed employing catalysts. Described in the specification is the realization of the desired product in exceptionally high yields in a short period of time whereby the process is characterized by high space-time yields.

    摘要翻译： 描述了通过取代或未取代的苄基卤与通常为碱金属或碱土金属甲酸盐的甲酸盐反应形成相应的取代或未取代的苄基苄基的苄基醇，其中包括在苄基环上具有取代基的那些苄醇的基本上两步法 甲酸盐 在该方法的第二步中，将甲酸苄酯与醇接触，由此将其转化为所需的苄醇。 可以使用催化剂进行两个步骤。 在说明书中描述的是在短时间内以非常高的产量实现期望的产品，由此该方法的特征在于高的空时产率。

    System and process for co-producing dimethyl carbonate and ethylene glycol
    90.
    发明授权
    System and process for co-producing dimethyl carbonate and ethylene glycol 有权

    公开(公告)号：US11299450B2

    公开(公告)日：2022-04-12

    申请号：US16625376

    申请日：2017-09-14

    申请人： INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES

    发明人： Weiguo Cheng ,  Li Dong ,  Qian Su ,  Songsong Chen ,  Junping Zhang ,  Suojiang Zhang

    IPC分类号： B01J8/00 ,  B01J8/02 ,  C07C29/00 ,  C07C29/128 ,  C07C68/00 ,  C07C68/06 ,  C07C68/065

    摘要： A system and a process for co-producing dimethyl carbonate and ethylene glycol. The system comprises an interconnected ethylene carbonate preparation unit and an ethylene carbonate alcoholysis unit. The ethylene carbonate preparation unit comprises a fixed bed reactor and a light-component stripping column connected to each other. The fixed bed reactor is filled with a supported ionic liquid catalyst. The process comprises the steps of: reacting carbon dioxide and ethylene oxide as raw materials in the fixed bed reactor to produce ethylene carbonate, purifying the ethylene carbonate and then mixing it with an alcoholysis reaction catalyst, and reacting the mixture with methanol in a reactive distillation tower, producing dimethyl carbonate and ethylene glycol. The process increases the conversion rate of ethylene oxide and avoids the need for a process of separating conventional homogeneous catalysts from ethylene carbonate, thereby reducing process energy consumption and simplifying process procedures.