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公开(公告)号：US12129467B2
公开(公告)日：2024-10-29
申请号：US18410136
申请日：2024-01-11
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C07H21/04 , A61K9/107 , A61K9/50 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/54 , C12N15/113 , C12N15/88 , A61K9/127
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/543 , C12N15/88 , A61K9/1272 , A61K9/1274 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
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公开(公告)号：US20240316206A1
公开(公告)日：2024-09-26
申请号：US18646429
申请日：2024-04-25
发明人： Ed Yaworski , Stephen Reid , James Heyes , Adam Judge , Ian MacLachlan
IPC分类号： A61K47/44 , A61K9/00 , A61K9/127 , A61K31/713 , A61K47/54 , C12N15/11 , C12N15/113 , C12N15/88
CPC分类号： A61K47/44 , A61K9/0019 , A61K9/1272 , A61K31/713 , A61K47/543 , C12N15/111 , C12N15/1137 , C12N15/88 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2320/30 , C12N2320/32
摘要： The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.
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公开(公告)号：US12043833B2
公开(公告)日：2024-07-23
申请号：US17854575
申请日：2022-06-30
发明人： James Heyes , Richard J. Holland , Adam Judge , Amy C. H. Lee , Alan D. Martin , Nicholas Michael Snead , Emily P. Thi , Mark Wood , Xin Ye
IPC分类号： C12N15/113
CPC分类号： C12N15/1131 , C12N2310/14 , C12N2310/344 , C12N2310/346 , C12N2310/3515
摘要： The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
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公开(公告)号：US12037587B2
公开(公告)日：2024-07-16
申请号：US18410136
申请日：2024-01-11
发明人： Ed Yaworski , Lloyd B. Jeffs , Lorne R. Palmer
IPC分类号： C07H21/04 , A61K9/107 , A61K9/50 , A61K9/51 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/54 , C12N15/113 , C12N15/88 , A61K9/127
CPC分类号： C12N15/113 , A61K9/1075 , A61K9/5015 , A61K9/5123 , A61K31/7088 , A61K31/7105 , A61K31/712 , A61K31/713 , A61K47/14 , A61K47/543 , C12N15/88 , A61K9/1272 , A61K9/1274 , C12N2310/14 , C12N2310/321 , C12N2310/3515 , C12N2320/32
摘要： The present invention provides novel, stable lipid particles having a non-lamellar structure and comprising one or more active agents or therapeutic agents, methods of making such lipid particles, and methods of delivering and/or administering such lipid particles. More particularly, the present invention provides stable nucleic acid-lipid particles (SNALP) that have a non-lamellar structure and that comprise a nucleic acid (such as one or more interfering RNA), methods of making the SNALP, and methods of delivering and/or administering the SNALP.
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公开(公告)号：US11904052B2
公开(公告)日：2024-02-20
申请号：US17749657
申请日：2022-05-20
IPC分类号： A61K9/127 , A61P29/00 , A61K9/00 , A61K31/192 , A61K47/10 , A61K47/24 , C12N15/11 , A61K45/06
CPC分类号： A61K9/127 , A61K9/0019 , A61K31/192 , A61K47/10 , A61K47/24 , A61P29/00 , C12N15/111 , A61K45/06
摘要： Certain embodiments of the invention provide methods of ameliorating an infusion reaction in a mammal in need thereof.
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公开(公告)号：US20230110295A1
公开(公告)日：2023-04-13
申请号：US17854575
申请日：2022-06-30
发明人： James HEYES , Richard J. HOLLAND , Adam JUDGE , Amy C. H. LEE , Alan D. MARTIN , Nicholas Michael SNEAD , Emily P. THI , Mark WOOD , Xin YE
IPC分类号： C12N15/113
摘要： The invention provides certain nucleic acids (e.g., double stranded siRNA molecules), as well as conjugates that comprise a targeting moiety, a double stranded siRNA, and optional linking groups. Certain embodiments also provide synthetic methods useful for preparing the conjugates. The conjugates are useful to target therapeutic double stranded siRNA to the liver and to treat liver diseases including hepatitis (e.g. hepatitis B and hepatitis D).
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公开(公告)号：US11446383B2
公开(公告)日：2022-09-20
申请号：US16109130
申请日：2018-08-22
发明人： Ed Yaworski , Stephen Reid , James Heyes , Adam Judge , Ian MacLachlan
IPC分类号： C07H21/02 , C07H21/04 , A61K47/44 , A61K9/00 , A61K9/127 , A61K31/713 , C12N15/11 , C12N15/88 , A61K47/54 , C12N15/113
摘要： The present invention provides novel, serum-stable lipid particles comprising one or more active agents or therapeutic agents, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles. More particularly, the present invention provides serum-stable nucleic acid-lipid particles (SNALP) comprising a nucleic acid (e.g., one or more interfering RNA molecules), methods of making the SNALP, and methods of delivering and/or administering the SNALP (e.g., for the treatment of cancer). In particular embodiments, the present invention provides tumor-directed lipid particles that preferentially target solid tumors. The tumor-directed formulations of the present invention are capable of preferentially delivering a payload such as a nucleic acid to cells of solid tumors compared to non-cancerous cells.
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公开(公告)号：US20220133636A1
公开(公告)日：2022-05-05
申请号：US17291873
申请日：2019-11-08
发明人： Michael J. ABRAMS , James HEYES , Richard J. HOLLAND , Kieu Mong LAM , Mark WOOD
IPC分类号： A61K9/51 , A61K31/713 , C12N15/113 , C07F7/18
摘要： Certain embodiments of the invention provide a cationic lipid of formula (I): wherein R1, R2, R3 and R4 are defined as described herein, as well as methods of making these lipids. Certain embodiments of the invention also provide nucleic acid-lipid particles comprising a cationic lipid of formula (I), methods of making the lipid particles, and methods of delivering and/or administering the lipid particles.
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公开(公告)号：US20220079970A1
公开(公告)日：2022-03-17
申请号：US17244445
申请日：2021-04-29
发明人： Tatiana Novobrantseva , Akin Akinc , Tsukasa Sugo
IPC分类号： A61K31/713 , A61K9/127 , A61K47/69
摘要： The invention relates to the field of delivery of nucleic acid-based agents to immune cells.
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