公开(公告)号：US20220079970A1

公开(公告)日：2022-03-17

申请号：US17244445

申请日：2021-04-29

Applicant: ARBUTUS BIOPHARMA CORPORATION

Inventor： Tatiana Novobrantseva ,  Akin Akinc ,  Tsukasa Sugo

IPC: A61K31/713 ,  A61K9/127 ,  A61K47/69

Abstract: The invention relates to the field of delivery of nucleic acid-based agents to immune cells.

公开(公告)号：US10053689B2

公开(公告)日：2018-08-21

申请号：US14700938

申请日：2015-04-30

Applicant: Arbutus Biopharma Corporation

Inventor： Kevin Fitzgerald ,  Maria Frank-Kamenetsky ,  Akin Akinc ,  Martin A. Maier

IPC: C12N15/113 ,  A61K9/127 ,  C12N15/11 ,  C12N9/64 ,  A61K31/366 ,  A61K31/567 ,  A61K31/7088

CPC classification number: C12N15/113 ,  A61K9/127 ,  A61K31/366 ,  A61K31/567 ,  A61K31/7088 ,  C12N9/6454 ,  C12N15/111 ,  C12N15/1135 ,  C12N15/1136 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2320/31 ,  C12N2320/32 ,  C12Y304/21061

Abstract: This invention relates to methods for increasing the efficiency of siRNA administrations via pre-administration of an agent that lowers LDL receptor levels.

公开(公告)号：US20180065918A1

公开(公告)日：2018-03-08

申请号：US15492898

申请日：2017-04-20

Applicant: Arbutus Biopharma Corporation

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Akin Akinc ,  Jayaprakash K. Nair ,  Muthusamy Jayaraman ,  Martin Maier

IPC: C07C219/06 ,  C07C323/25 ,  C07C271/10 ,  C07C233/36 ,  A61K9/127 ,  C07C209/78 ,  A61K31/325 ,  A61K47/34

Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.

公开(公告)号：US20230174459A1

公开(公告)日：2023-06-08

申请号：US17863885

申请日：2022-07-13

Applicant: ARBUTUS BIOPHARMA CORPORATION

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Akin Akinc ,  Jayaprakash K. Nair ,  Muthusamy Jayaraman ,  Martin Maier

IPC: C07C219/06 ,  A61K9/127 ,  A61K31/325 ,  C07C209/78 ,  C07C233/36 ,  C07C271/10 ,  C07C323/25

CPC classification number: C07C219/06 ,  A61K9/1272 ,  A61K9/1273 ,  A61K31/325 ,  C07C209/78 ,  C07C233/36 ,  C07C271/10 ,  C07C323/25 ,  A61K47/34

Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.

公开(公告)号：US11420931B2

公开(公告)日：2022-08-23

申请号：US16713712

申请日：2019-12-13

Applicant: Arbutus Biopharma Corporation

Inventor： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Akin Akinc ,  Jayaprakash K. Nair ,  Muthusamy Jayaraman ,  Martin Maier

IPC: C07C219/06 ,  A61K9/127 ,  A61K31/325 ,  C07C209/78 ,  C07C233/36 ,  C07C271/10 ,  C07C323/25 ,  A61K47/34

Abstract: Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.

公开(公告)号：US20220074925A1

公开(公告)日：2022-03-10

申请号：US17221457

申请日：2021-04-02

Applicant: ARBUTUS BIOPHARMA CORPORATION

Inventor： Marco A. Ciufolini ,  Thomas D. Madden ,  Michael J. Hope ,  Barbara Mui ,  Antonin de Fougerolles ,  Tatiana Novobrantseva ,  Anna Borodovsky ,  Akin Akinc ,  Mark Tracy ,  Pieter Rutter Cullis

IPC: G01N33/50 ,  C12N15/11 ,  C12N15/113 ,  G01N33/86 ,  C12Q1/6876

Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject.

公开(公告)号：US20180209963A1

公开(公告)日：2018-07-26

申请号：US15693902

申请日：2017-09-01

Applicant: Arbutus Biopharma Corporation

Inventor： Marco A. Ciufolini ,  Thomas D. Madden ,  Michael J. Hope ,  Barbara Mui ,  Antonin de Fougerolles ,  Tatiana Novobrantseva ,  Anna Borodovsky ,  Akin Akinc ,  Mark Tracy ,  Pieter Rutter Cullis

IPC: G01N33/50 ,  C12N15/11 ,  C12N15/113 ,  G01N33/86 ,  C12Q1/6876

CPC classification number: G01N33/5088 ,  A01K2207/05 ,  A01K2227/105 ,  A01K2267/0381 ,  C12N15/111 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/10 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Y304/21021 ,  G01N33/5023 ,  G01N33/5067 ,  G01N33/86 ,  G01N2333/745 ,  G01N2333/96447

Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject.

公开(公告)号：US20170143631A1

公开(公告)日：2017-05-25

申请号：US15187633

申请日：2016-06-20

Applicant: Arbutus Biopharma Corporation

Inventor： Jianxin Chen ,  Steven Ansell ,  Akin Akinc ,  Joseph Robert Dorkin ,  Xiaojun Qin ,  William Cantley ,  Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Jayaprakash K. Nair ,  Muthusamy Jayaraman

IPC: A61K9/127 ,  A61K31/713 ,  A61K31/712 ,  C12N15/113

CPC classification number: A61K9/1272 ,  A61K9/1278 ,  A61K31/22 ,  A61K31/7088 ,  A61K31/712 ,  A61K31/713 ,  A61K38/1709 ,  A61K38/4846 ,  A61K47/14 ,  A61K47/549 ,  A61K47/551 ,  A61K47/6911 ,  A61K48/0033 ,  A61P9/00 ,  A61P25/28 ,  C07C29/58 ,  C07C227/18 ,  C07C227/40 ,  C07C229/12 ,  C07D475/04 ,  C12N15/113 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2310/3515 ,  C12N2320/32 ,  Y02A50/463 ,  A61K2300/00 ,  C12N2310/3521 ,  C12N2310/3533

Abstract: The invention features a cationic lipid of formula I, an improved lipid formulation comprising a cationic lipid of formula I and corresponding methods of use. Also disclosed are targeting lipids, and specific lipid formulations comprising such targeting lipids.

公开(公告)号：US20190153443A1

公开(公告)日：2019-05-23

申请号：US16036550

申请日：2018-07-16

Applicant: Arbutus Biopharma Corporation

Inventor： Kevin Fitzgerald ,  Maria Frank-Kamenetsky ,  Akin Akinc ,  Martin A. Maier

IPC: C12N15/113 ,  A61K31/366 ,  A61K9/127 ,  C12N9/64 ,  C12N15/11 ,  A61K31/7088 ,  A61K31/567

Abstract: This invention relates to methods for increasing the efficiency of siRNA administrations via pre-administration of an agent that lowers LDL receptor levels.

公开(公告)号：US20200225215A1

公开(公告)日：2020-07-16

申请号：US16442191

申请日：2019-06-14

Applicant: Arbutus Biopharma Corporation

Inventor： Marco A. Ciufolini ,  Thomas D. Madden ,  Michael J. Hope ,  Barbara Mui ,  Antonin de Fougerolles ,  Tatiana Novobrantseva ,  Anna Borodovsky ,  Akin Akinc ,  Mark Tracy ,  Pieter Rutter Cullis

IPC: G01N33/50 ,  C12N15/11 ,  C12N15/113 ,  G01N33/86 ,  C12Q1/6876

Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-dimethylaminomethyl-[1-3]-dioxolane by screening for an effect of the agent on the liver of a model subject.