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公开(公告)号：US10342762B2
公开(公告)日：2019-07-09
申请号：US14296992
申请日：2014-06-05
IPC分类号： A61K9/00 , A61K9/20 , A61J7/00 , A61J7/04 , A61K31/4535 , A61M15/00 , G07F17/00 , H01Q1/22 , G07C9/00
摘要： Small-volume oral transmucosal dosage forms or NanoTabs® comprising a predetermined amount of a pharmaceutically active drug are provided. Exemplary applications include use of the NanoTabs® to administer a drug for the treatment of acute, post-operative or breakthrough pain.
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公开(公告)号：US10245228B2
公开(公告)日：2019-04-02
申请号：US15655316
申请日：2017-07-20
摘要： Compositions, systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject for treatment of pain using a device are disclosed.
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3.发明申请STORAGE AND DISPENSING DEVICES FOR ADMINISTRATION OF ORAL TRANSMUCOSAL DOSAGE FORMS 审中-公开用于管理口服剂量形式的储存和分配装置公开(公告)号：US20140031975A1
公开(公告)日：2014-01-30
申请号：US14041963
申请日：2013-09-30
发明人： Andrew Poutiatine , Bruce Edwards , Charles Rampersaud , Pamela Palmer , Bradley Blackwood , Benjamin K. Yaffe
IPC分类号： G06F19/00
CPC分类号： G16H20/13 , A61J7/0053 , A61J7/0418 , A61J7/0436 , A61J7/0445 , A61J7/0463 , A61J2200/30 , A61J2205/50 , A61J2205/60 , G06F19/00 , G06F19/3462 , G06K19/07762 , G06K19/07783 , H04B5/0062
摘要： Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
摘要翻译： 提供了用于口腔粘膜给小剂量药物剂型口服粘膜的分配装置和系统。 分配装置可以是单剂量施用器（SDA），或者包括用于患者识别的装置的机电装置，例如腕部佩戴的RFID标签和环形双向天线以及锁定特征。
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4.发明申请Compositions and Methods for Mild Sedation, Anxiolysis and Analgesia in the Procedural Setting 审中-公开程序设置中轻度镇静，溶解和镇痛的组成和方法公开(公告)号：US20110091544A1
公开(公告)日：2011-04-21
申请号：US12580930
申请日：2009-10-16
申请人： Pamela Palmer
发明人： Pamela Palmer
IPC分类号： A61K9/20 , A61K31/5517 , A61P25/22 , A61P23/00 , A61P25/04
CPC分类号： A61K31/485 , A61K9/006 , A61K9/2054 , A61K31/5517 , A61K2300/00
摘要： Small tablets for use in procedural sedation, anxiolysis and analgesia comprising the combination sufentanil and triazolam administered via the oral transmucosal route and methods for using the same are provided.
摘要翻译： 提供了用于程序镇静，抗焦虑和镇痛的小片剂，其包括通过口服经粘膜途径施用的舒芬太尼和三唑仑组合及其使用方法。
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5.发明申请Small Volume Oral Transmucosal Dosage Forms Containing Sufentanil for Treatment of Pain 有权含有舒芬太尼治疗疼痛的小体积口腔粘膜粘膜剂量形式公开(公告)号：US20100105735A1
公开(公告)日：2010-04-29
申请号：US12521949
申请日：2007-12-28
申请人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
发明人： Pamela Palmer , Thomas Schreck , Stelios Tzannis , Larry Hamel , Andrew I. Poutiatine , Charles Rampersaud , Bruce Edwards
IPC分类号： A61K31/4535 , A61P25/00
CPC分类号： A61K9/006 , A61J7/0038 , A61J7/0053 , A61J7/0418 , A61J7/0445 , A61J7/0481 , A61J2200/30 , A61K9/2009 , A61K9/2018 , A61K9/2031 , A61K9/2072 , A61K31/4535 , A61M15/00 , A61M15/008 , A61M15/0081 , A61M15/0083 , A61M2205/276 , A61M2205/3561 , A61M2205/3584 , A61M2205/3592 , A61M2205/52 , A61M2205/583 , A61M2205/6054 , A61M2205/609 , A61M2209/086 , G07C9/00031 , G07F17/0092 , H01Q1/2208
摘要： Compositions, methods and systems for administration of small volume sufentanil-containing drug dosage forms to the oral mucosa of a subject are disclosed.
摘要翻译： 公开了用于向受试者的口腔粘膜施用小体积舒芬太尼的药物剂型的组合物，方法和系统。
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6.发明申请COMPOSITIONS AND METHODS FOR PROCEDURAL SEDATION AND ANALGESIA USING ORAL TRANSMUCOSAL DOSAGE FORMS 审中-公开使用口腔转移剂型的方法治疗和麻醉的组合物和方法公开(公告)号：US20090048237A1
公开(公告)日：2009-02-19
申请号：US12187937
申请日：2008-08-07
申请人： Pamela Palmer , Stelios Tzannis , Thomas Schreck
发明人： Pamela Palmer , Stelios Tzannis , Thomas Schreck
IPC分类号： A61K31/551 , A61P25/20
CPC分类号： A61K9/0056 , A61J7/0053 , A61J7/0061 , A61J7/0076 , A61K9/006 , A61K31/4535 , A61K31/5517 , B65D25/2811 , B65D83/0409 , B65D83/0847 , A61K2300/00
摘要： Dosage forms for procedural sedation and analgesia comprising the combination of an opioid such as sufentanil and a benzodiazepine such as triazolam for administration via the oral transmucosal route and methods for using the same are provided.
摘要翻译： 提供了用于通过口服经粘膜途径给药的阿片样物质如舒芬太尼和苯二氮卓类药物如三唑仑的组合的方法镇静和止痛的剂型及其使用方法。
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公开(公告)号：US20070207207A1
公开(公告)日：2007-09-06
申请号：US11650227
申请日：2007-01-05
IPC分类号： A61K31/485 , A61K31/445 , A61K9/20
CPC分类号： A61K9/006 , A61J3/005 , A61K9/2072
摘要： Formulations for controlled delivery of oral transmucosal medications are provided. The formulations are characterized as hydrogel-forming or eroding-types which are bioadhesive and provide for controlled and sustained release of the medication such that enhanced bioavailability and efficacy is provided.
摘要翻译： 提供了用于口服经粘膜药物的控制递送的制剂。 制剂的特征在于水凝胶形成或侵蚀型，其是生物粘附性的并且提供药物的受控和持续释放，从而提供增强的生物利用度和功效。
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公开(公告)号：US20190027241A1
公开(公告)日：2019-01-24
申请号：US16143046
申请日：2018-09-26
发明人： Andrew POUTIATINE , Bruce EDWARDS , Charles RAMPERSAUD , Pamela PALMER , Bradley BLACKWOOD , Benjamin K. YAFFE
摘要： Dispensing devices and systems for oral transmucosal administration of small volume drug dosage forms to the oral mucosa are provided. The dispensing device may be a single dose applicator (SDA), or an electromechanical device comprising a means for patient identification such as a wrist worn RFID tag and annular bidirectional antenna together with a lock-out feature.
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公开(公告)号：US20170259051A1
公开(公告)日：2017-09-14
申请号：US15589607
申请日：2017-05-08
发明人： Pamela PALMER , Andrew POUTIATINE , Charles RAMPERSAUD , Bruce EDWARDS , Edmond CHIU , Thomas SCHRECK , Stelios TZANNIS , Lawrence HAMEL , William KOLOSI , Sascha RETAILLEAU
摘要： Systems and methods for administration of small volume sufentanil drug dosage forms to the sublingual mucosa of a subject using a device are disclosed. The dispensing device includes a lock-out feature and a means to retard or prevent saliva and/or moisture ingress such that the drug dosage forms in the device remain dry prior to administration.
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10.发明授权Sufentanil solid dosage forms comprising oxygen scavengers and methods of using the same 有权包含除氧剂的舒芬太尼固体剂型及其使用方法公开(公告)号：US08945592B2
公开(公告)日：2015-02-03
申请号：US12275485
申请日：2008-11-21
申请人： Shamim Pushpala , Larry Hamel , Stelios Tzannis , Evangeline Cruz
发明人： Shamim Pushpala , Larry Hamel , Stelios Tzannis , Evangeline Cruz
IPC分类号： A61K9/00 , A61K31/445 , A61K31/4535 , A61K9/20
CPC分类号： A61K31/4535 , A61K9/2054
摘要： Compositions and methods effective to minimize or eliminate the presence of oxidative degradation products in solid dosage forms comprising sufentanil are provided.
摘要翻译： 提供了有效地最小化或消除包含舒芬太尼的固体剂型中氧化降解产物的存在的组合物和方法。
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