公开(公告)号：US20130064966A1

公开(公告)日：2013-03-14

申请号：US13669439

申请日：2012-11-05

Applicant: Advanced Cardiovascular System, Inc.

Inventor： Jason Van Sciver

IPC: B05C5/00 ,  B05D7/00

CPC classification number: B05B13/0221 ,  A61F2/82 ,  B05B13/0207 ,  B05B13/0228 ,  B05D1/002 ,  B05D1/02 ,  B05D1/32 ,  B05D3/0473

Abstract: A method of coating a stent comprises contacting a first axial portion of a stent with a support element, such that a second axial portion does not contact the support element or any other support element, applying a coating material to the second axial portion, and inhibiting or preventing application of the coating material on the first axial portion. A shuttle sheath can be used to push the stent off the support element.

Abstract translation: 一种涂覆支架的方法包括将支架的第一轴向部分与支撑元件接触，使得第二轴向部分不接触支撑元件或任何其它支撑元件，将涂层材料施加到第二轴向部分，并且抑制 或防止涂覆材料施加在第一轴向部分上。 穿梭护套可用于将支架推出支撑元件。

公开(公告)号：US5891154A

公开(公告)日：1999-04-06

申请号：US851111

申请日：1997-05-06

Applicant: Joseph P. Loeffler

Inventor： Joseph P. Loeffler

IPC: A61M25/00 ,  A61F2/06 ,  A61F2/82 ,  A61F2/84 ,  A61M25/01 ,  A61M29/02 ,  A61F11/00 ,  A61M29/00

CPC classification number: A61F2/958 ,  A61F2002/9517 ,  A61M2025/1097

Abstract: A stent delivery method and system are disclosed. The system generally includes an elongated delivery sheath and a perfusion catheter disposed within a sheath lumen of the sheath having an expandable member on its distal extremity. The sheath includes perfusion ports to maintain blood flow to perfusion ports in the catheter during delivery of the stent. A manipulating device is provided at the proximal end of the delivery system to effect relative axial movement between the sheath and the catheter so as to expose the stent mounted on the expandable member on the catheter within a body lumen such as a coronary artery and allow the expansion of the stent by the expansion of the expandable member.

Abstract translation: 公开了一种支架输送方法和系统。 该系统通常包括细长的输送护套和设置在鞘的鞘腔内的灌注导管，其在其远端具有可扩张构件。 护套包括灌注端口，以在输送支架期间维持血液流入导管中的灌注端口。 操纵装置设置在输送系统的近端处以实现护套和导管之间的相对轴向运动，以便将安装在可扩张构件上的支架暴露在诸如冠状动脉的体腔内的导管上，并允许 通过可扩张构件的膨胀来扩张支架。

公开(公告)号：US08017140B2

公开(公告)日：2011-09-13

申请号：US11804997

申请日：2007-05-21

Applicant: Syed Faiyaz Ahmed Hossainy ,  Gordon Stewart ,  Deborah Kilpatrick ,  Jeffrey Ellis ,  Gene Park ,  Gina Zhang ,  Paul Consigny ,  Yiwen Tang

Inventor： Syed Faiyaz Ahmed Hossainy ,  Gordon Stewart ,  Deborah Kilpatrick ,  Jeffrey Ellis ,  Gene Park ,  Gina Zhang ,  Paul Consigny ,  Yiwen Tang

IPC: A61F13/00 ,  A61F2/00 ,  A61K9/14

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/222 ,  A61L2300/416 ,  A61L2300/422 ,  A61L2300/43 ,  A61L2300/45

Abstract: Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.

Abstract translation: 提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。 支架可用于治疗诸如再狭窄和易损斑块的疾病。

公开(公告)号：US08367149B2

公开(公告)日：2013-02-05

申请号：US12887311

申请日：2010-09-21

Applicant: Veronica J. Santos ,  Santosh Prabhu

Inventor： Veronica J. Santos ,  Santosh Prabhu

IPC: A61L33/00 ,  B05D5/00 ,  B05D1/00 ,  A61F2/06

CPC classification number: A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2250/0068

Abstract: A method of coating a stent may comprise applying a composition including a drug and a polymer to the stent to form a coating. The release rate of the drug from the coating gradually increases along a length of the stent which extends axially from opposite ends of the stent. The variable drug release rate can be accomplished by varying the coating thickness, by applying a barrier region over the drug-containing composition, and/or by having different polymers in the coating, the polymers having different drug permeabilities.

Abstract translation: 涂覆支架的方法可以包括将包含药物和聚合物的组合物施用于支架以形成涂层。 来自涂层的药物的释放速率沿着从支架的相对端轴向延伸的支架的长度逐渐增加。 可通过改变涂层厚度，通过在含药物的组合物上施加屏障区域和/或通过在涂层中具有不同的聚合物来实现可变药物释放速率，所述聚合物具有不同的药物渗透性。

公开(公告)号：US20080175886A1

公开(公告)日：2008-07-24

申请号：US12056216

申请日：2008-03-26

Applicant: Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Lothar Kleiner

Inventor： Jessica Renee DesNoyer ,  Stephen Dirk Pacetti ,  Lothar Kleiner

IPC: A61F2/00 ,  A61K31/436

CPC classification number: A61L31/10 ,  A61L31/16 ,  A61L2300/606 ,  C08L77/12 ,  C08L2666/14

Abstract: Provided herein is a bioabsorbable implantable device comprising a bioactive agent and a poly(ester amide) (PEA) polymer blend.

Abstract translation: 本文提供了包含生物活性剂和聚（酯酰胺）（PEA）（PEA）聚合物共混物的生物可吸收可植入装置。

公开(公告)号：US6056776A

公开(公告)日：2000-05-02

申请号：US135222

申请日：1998-08-17

Applicant: Lilip Lau ,  William M. Hartigan ,  John J. Frantzen

Inventor： Lilip Lau ,  William M. Hartigan ,  John J. Frantzen

IPC: A61F2/00 ,  A61F2/86 ,  A61F2/88 ,  C23F1/02 ,  C23F1/04 ,  A61F2/03

CPC classification number: A61F2/86 ,  A61F2/88 ,  A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  C23F1/02 ,  C23F1/04 ,  A61F2/848 ,  A61F2/958 ,  A61F2002/91533 ,  A61F2002/9155 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2210/0019 ,  A61M2025/1081 ,  Y10S623/901 ,  Y10S623/903 ,  Y10S623/921 ,  Y10T29/49995

Abstract: The invention is directed to an expandable stent for implantation in a body lumen, such as an artery, and a method for making it from a single length of tubing. The stent consists of a plurality of radially expandable cylindrical elements generally aligned on a common axis and interconnected by one or more interconnective elements. The individual radially expandable cylindrical elements consist of ribbon-like material disposed in an undulating pattern. Portions of the expanded stent project outwardly into engagement with the vessel wall to more securely attach the stent.

公开(公告)号：US5980471A

公开(公告)日：1999-11-09

申请号：US948770

申请日：1997-10-10

Applicant: Mo Jafari

Inventor： Mo Jafari

IPC: A61B5/00 ,  A61M25/01 ,  A61M25/09

CPC classification number: A61M25/09 ,  A61M25/0905 ,  A61M2025/09083 ,  A61M2025/09175

Abstract: An improved guidewire for advancing a catheter within a body lumen which as a high strength proximal core section, a flexible distal core section preferably formed of pseudoelastic alloy and a connecting element to provide a torque transmitting coupling between the distal end of the proximal core section and the proximal end of the distal core section. The ends of the core sections are secured within the inner lumen of the connecting element by means of a hardened mass of bonding material. The wall of the connecting element is provided with an opening to facilitate the introduction of the hardenable bonding material in the pourable state into the inner lumen of the connecting element. Preferably at least one of the ends of the core sections are configured, e.g. enlarged in at least one dimension compared to an adjacent part of the core section, to develop a mechanical interlock within the mass of hardened material.

Abstract translation: 一种改进的导丝，用于将作为高强度近端芯部的体内腔中的导管推进，优选由假弹性合金形成的柔性远端芯部和连接元件，以在近端芯部的远端和 远侧芯部的近端。 芯部分的端部通过硬化的粘合材料块固定在连接元件的内腔内。 连接元件的壁设置有开口，以便于将可硬化接合材料以可倾倒状态引入连接元件的内腔中。 优选地，将芯部的端部中的至少一个构造为例如。 与芯部的相邻部分相比，在至少一个尺寸上扩大，以在硬化材料块内形成机械互锁。

公开(公告)号：US5558101A

公开(公告)日：1996-09-24

申请号：US324010

申请日：1994-10-14

Applicant: Dennis L. Brooks ,  Alfredo G. Bayot ,  Mina W. B. Chow ,  Paul F. Muller

Inventor： Dennis L. Brooks ,  Alfredo G. Bayot ,  Mina W. B. Chow ,  Paul F. Muller

IPC: A61M25/00 ,  A61M25/06 ,  A61M29/02 ,  A61B5/00

CPC classification number: A61M25/09 ,  A61M25/0662 ,  A61M2029/025 ,  A61M25/0041

Abstract: A method and system for maintaining the position of a guiding member, such as a guidewire, within a patient's vascular system, particularly within a guiding catheter disposed within the patient's vascular system, while an intravascular catheter slidably mounted on the guiding member is withdrawn and a replacement catheter is advanced over the guiding member. One presently preferred embodiment includes a guiding sheath having an inner lumen extending the length thereof with an engaging device slidably disposed with the guiding sheath. The guidewire engaging device is torqued from its proximal end which extends out of the proximal end of the guiding catheter so that the flexible distal end wraps around the guidewire tightly enough to maintain the position of the guidewire while withdrawing or advancing a catheter over the guidewire. The distal portion of the guidewire engaging device is preferably a pseudo elastic NiTi alloy which is in a stable austenite phase at body temperature (37.degree. C.) and which exhibits a stress-induced transformation from the austenite phase to a martensite phase.

Abstract translation: 一种方法和系统，用于在患者的血管系统内，特别是在设置在患者的血管系统内的引导导管内，保持引导构件（例如导丝）的位置，同时可滑动地安装在引导构件上的血管内导管被撤回， 置换导管在引导构件上前进。 一个目前优选的实施例包括引导护套，其具有使其长度延伸的内腔和可滑动地布置有引导护套的接合装置。 导线接合装置从其近端扭转，该近端延伸出导引导管的近端，使得柔性远端围绕导丝线紧密地卷绕，以便在将导管拉出或推进导丝线的同时保持导丝的位置。 导丝接合装置的前端部优选为假体弹性NiTi合金，其在体温（37℃）下处于稳定的奥氏体相，并且表现出从奥氏体相到马氏体相的应力诱导相变。

公开(公告)号：US20070249965A1

公开(公告)日：2007-10-25

申请号：US11783565

申请日：2007-04-10

Applicant: Robert Abrams ,  Sepehr Fariabi

Inventor： Robert Abrams ,  Sepehr Fariabi

IPC: A61M25/00

CPC classification number: A61L31/14 ,  A61L31/022 ,  A61L2400/16 ,  A61M25/09 ,  A61M2025/09008 ,  A61M2025/09083 ,  A61M2025/09141 ,  A61M2025/09175 ,  A61M2205/0266 ,  C22C14/00 ,  C22C30/00 ,  C22F1/006

Abstract: An improved guiding member for use within a body lumen having a unique combination of superelastic characteristics. The superelastic alloy material has a composition consisting of about 30% to about 52% (atomic) titanium, and about 38% to 52% nickel and may have one or more elements selected from the group consisting of iron, cobalt, platinum, palladium, vanadium, copper, zirconium, hafnium and niobium. The alloy material is subjected to thermomechanical processing which includes a final cold working of about 10 to about 75% and then a heat treatment at a temperature between about 450° and about 600° C. and preferably about 475° to about 550° C. Before the heat treatment the cold worked alloy material is preferably subjected to mechanical straightening. The alloy material is preferably subjected to stresses equal to about 5 to about 50% of the room temperature ultimate yield stress of the material during the thermal treatment. The guiding member using such improved material exhibits a stress-induced austenite-to-martensite phase transformation at an exceptionally high constant yield strength of over 90 ksi for solid members and over 70 ksi for tubular members with a broad recoverable strain of at least about 4% during the phase transformation. An essentially whip free product is obtained.

Abstract translation: 一种改进的引导构件，其用于具有超弹性特征的独特组合的体腔内。 超弹性合金材料具有由约30％至约52％（原子）钛和约38％至52％的镍组成的组成，并且可以具有一种或多种选自铁，钴，铂，钯， 钒，铜，锆，铪和铌。 对合金材料进行热机械加工，其包括约10至约75％的最终冷加工，然后在约450℃至约600℃，优选约475℃至约550℃的温度下进行热处理。 在热处理之前，冷加工合金材料优选进行机械矫直。 合金材料优选在热处理期间受到等于材料的室温极限屈服应力的约5至约50％的应力。 使用这种改进的材料的引导构件在固体构件的超过90ksi的异常高的恒定屈服强度下显示出应力诱发的奥氏体 - 马氏体相变，对于具有至少约4的广泛可恢复应变的管状构件，具有超过70ksi ％相变。 获得基本上无鞭状产品。

公开(公告)号：US07654979B2

公开(公告)日：2010-02-02

申请号：US11022494

申请日：2004-12-21

Applicant: John Arthur Simpson

Inventor： John Arthur Simpson

IPC: A61M29/00

CPC classification number: A61M25/10 ,  A61M2025/1093 ,  Y10T156/10 ,  Y10T156/1005

Abstract: The end cap is preferably formed of a relatively high durometer material with an inner surface on an outer surface of the shaft and on an outer surface of the balloon skirt section, and contacts a compression member on the balloon outer surface. The configuration prevents or inhibits failure at the balloon seals which otherwise results from the compression member moving or the balloon pulling off the shaft and out from under the compression member during inflation of the balloon. As a result, the balloon catheter of the invention has an improved consistent burst pressure and/or failure mode.

Abstract translation: 端帽优选地由相对高的硬度材料形成，其具有在轴的外表面上的内表面和球囊裙部的外表面上，并且与球囊外表面上的压缩构件接触。 该构造防止或抑制球囊密封件处的失效，否则气囊膨胀期间由压缩构件移动或气囊从轴承下拉并从压缩构件下方引起。 结果，本发明的气囊导管具有改进的一致的爆裂压力和/或失效模式。