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    Detection of the detachment of immobilized contrast agent in medical imaging applications
    1.
    发明授权
    Detection of the detachment of immobilized contrast agent in medical imaging applications 有权
    检测医疗成像应用中固定化造影剂的脱离

    公开(公告)号：US08512249B2

    公开(公告)日：2013-08-20

    申请号：US12520839

    申请日：2007-12-21

    申请人： Peter Frinking ,  Tristan Messager ,  Marcel Arditi ,  Nicolas Rognin

    发明人： Peter Frinking ,  Tristan Messager ,  Marcel Arditi ,  Nicolas Rognin

    IPC分类号： A61B5/05 ,  A61B6/00 ,  G06K9/00

    CPC分类号： G01S7/52041 ,  A61B8/481 ,  G01S7/52026 ,  G01S7/52038 ,  G01S7/52071 ,  G01S7/52074

    摘要： An input image includes a plurality of input values (i.e., pixel or voxel values), each input value indicative of a response to an interrogation signal of a corresponding location of a body-part, which possibly includes a contrast agent. At least one filtered image is generated from a plurality of selected input images and includes a filtered value for each of a plurality of selected ones of the locations. Each filtered value is indicative of the contrast agent leaving the selected location and is obtained by reducing a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or shorter than a first threshold and by reducing a contribution of the contrast agent that is substantially stationary for a period of time equal to or longer than a second higher threshold.

    摘要翻译： 输入图像包括多个输入值（即，像素或体元值），每个输入值指示对身体部位的相应位置的询问信号的响应，其可能包括造影剂。 从多个选择的输入图像生成至少一个滤波图像，并且包括针对多个选定位置中的每一个的滤波值。 每个滤波值表示离开所选择的位置的造影剂，并且是通过在所选择的输入图像的等于或小于第一阈值的时间段内减少基本上静止在选定位置的造影剂的贡献而获得的 并且通过减少在等于或长于第二较高阈值的时间段内基本静止的造影剂的贡献。

    Medical imaging system based on a targeted contrast agent
    3.
    发明授权
    Medical imaging system based on a targeted contrast agent 失效
    基于靶向造影剂的医学成像系统

    公开(公告)号：US07846100B2

    公开(公告)日：2010-12-07

    申请号：US11885723

    申请日：2006-03-03

    申请人： Emmanuel Gaud ,  Peter Frinking ,  Nicolas Rognin ,  Sibylle Pochon ,  Nathalie Biolluz ,  Marcel Arditi

    发明人： Emmanuel Gaud ,  Peter Frinking ,  Nicolas Rognin ,  Sibylle Pochon ,  Nathalie Biolluz ,  Marcel Arditi

    IPC分类号： A61B8/14

    CPC分类号： A61K49/223 ,  Y10S128/916

    摘要： A medical imaging system is proposed. The system includes means for providing a plurality of echo signals indicative of a response of a body part to a plurality of ultrasound pulsed waves having different acoustic pressures, the body part including a tissue being perfused with a contrast agent, and means for discriminating in the echo signals a contribution of a first type of contrast agent from a contribution of a second type of contrast agent and/or of the tissue, at least one harmonic component of the contribution of the first type of contrast agent having an acoustic power changing according to a first dependency law on the acoustic pressure and the at least one harmonic component of the contribution of the second type of contrast agent and/or of the tissue having an acoustic power changing according to at least one second dependency law on the acoustic pressure, wherein the means for discriminating includes means for significantly reducing the at least one harmonic component of the contribution of the second type of contrast agent and/or of the tissue with respect to the at least one harmonic component of the contribution of the first type of contrast agent according to the corresponding dependency laws.

    摘要翻译： 提出了一种医学成像系统。 该系统包括用于提供指示体部分对具有不同声压的多个超声脉冲波的响应的多个回波信号的装置，身体部分包括用造影剂灌注的组织，以及用于在 回波信号是来自第二类型的造影剂和/或组织的贡献的第一类型的造影剂的贡献，第一类型的造影剂的贡献的至少一个谐波分量具有根据 关于第二类造影剂和/或具有根据至少一个第二依赖规律改变声学力的组织的声压和至少一个谐波分量对声压的第一依赖规律，其中 用于鉴别的装置包括用于显着减少第二类型c的贡献的至少一个谐波分量的装置 根据相应的依赖规律相对于第一类型造影剂的贡献的至少一个谐波分量的组织和/或组织。

    Image registration method and apparatus for medical imaging based on multiple masks
    5.
    发明授权
    Image registration method and apparatus for medical imaging based on multiple masks 有权
    基于多个掩模的医学成像的图像配准方法和装置

    公开(公告)号：US07912259B2

    公开(公告)日：2011-03-22

    申请号：US11659887

    申请日：2005-08-05

    申请人： Marcel Arditi ,  Nicolas Rognin ,  Tristan Messager ,  Jean-Philippe Thiran ,  Ruth Campos

    发明人： Marcel Arditi ,  Nicolas Rognin ,  Tristan Messager ,  Jean-Philippe Thiran ,  Ruth Campos

    IPC分类号： G06K9/00

    CPC分类号： G06T7/35 ,  G06T2207/30048

    摘要： An image registration method for use in medical imaging includes the steps of: providing a sequence of images each one including a digital representation of a body-part under analysis, selecting a reference image within the sequence, the remaining images of the sequence defining moving images, and re-aligning at least one portion of a moving image with respect to the reference image. The step of re-aligning may include: defining a delimitation mask identifying a region on the reference image with which the at least one portion of the moving image has to be re-aligned, and a feature mask identifying a further region on the reference image within which the re-alignment is calculated, determining an optimized transformation for compensating a displacement of the moving image with respect to the reference image by optimizing a similarity measure, and transforming the at least one portion of the moving image according to the optimized transformation.

    摘要翻译： 用于医学成像的图像配准方法包括以下步骤：提供每个图像序列，每个图像序列包括正在分析的身体部位的数字表示，选择序列内的参考图像，定义运动图像的序列的剩余图像 并且相对于参考图像重新对准运动图像的至少一部分。 重新对准的步骤可以包括：定义标识在参考图像上必须重新对齐运动图像的至少一部分的参考图像上的区域的定界掩模，以及标识参考图像上的另外区域的特征掩模 在其中计算重新对准，通过优化相似性度量来确定用于补偿运动图像相对于参考图像的位移的优化变换，以及根据优化的变换来变换运动图像的至少一部分。

    Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography
    7.
    发明授权
    Stable microbubble suspensions comprising saturated phospholipids for ultrasound echography 失效
    稳定的微泡悬浮液，包括用于超声回波的饱和磷脂

    公开(公告)号：US5686060A

    公开(公告)日：1997-11-11

    申请号：US420677

    申请日：1995-04-12

    申请人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    发明人： Michel Schneider ,  Jean Brochot ,  Jerome Puginier ,  Feng Yan

    IPC分类号： A61K47/24 ,  A61B8/08 ,  A61B8/12 ,  A61B8/13 ,  A61K9/127 ,  A61K49/00 ,  A61K49/22 ,  B01F3/04 ,  B01J13/02

    CPC分类号： A61K49/225 ,  A61K49/223

    摘要： Disclosed are injectable suspensions of gas filled microbubbles in an aqueous carrier liquid usable as contrast agents in ultrasonic echography. The suspensions comprise amphipathic compounds of which at least one may be a laminarized phospholipid as a stabilizer of the microbubbles against collapse with time and pressure. The concentration of phospholipids in the carrier liquid is below 0.01% wt but is at least equal to or above that at which phospholipid molecules are present solely at the gas microbubble-liquid interface. Also disclosed is a method of preparation of the stable suspensions of air or gas filled microbubbles.

    摘要翻译： 公开了在超声波回波成像中可用作造影剂的水性载体液体中的气体填充微泡的可注射悬浮液。 悬浮液包含两亲性化合物，其中至少一种可以是层状磷脂作为微泡的稳定剂，以防止随时间和压力而塌陷。 载体液体中磷脂的浓度低于0.01％wt，但至少等于或高于磷脂分子仅存在于气体微泡液界面的浓度。 还公开了制备空气或气体填充的微泡的稳定悬浮液的方法。

    DETECTION OF THE DETACHMENT OF IMMOBILIZED CONTRAST AGENT IN MEDICAL IMAGING APPLICATIONS
    9.
    发明申请
    DETECTION OF THE DETACHMENT OF IMMOBILIZED CONTRAST AGENT IN MEDICAL IMAGING APPLICATIONS 有权
    检测医疗成像应用中静止对比剂的分离

    公开(公告)号：US20090304593A1

    公开(公告)日：2009-12-10

    申请号：US12520839

    申请日：2007-12-21

    申请人： Peter Frinking ,  Tristan Messager ,  Marcel Arditi ,  Nicolas Rognin

    发明人： Peter Frinking ,  Tristan Messager ,  Marcel Arditi ,  Nicolas Rognin

    IPC分类号： A61K49/00 ,  A61P43/00 ,  G06K9/00 ,  A61B8/00

    CPC分类号： G01S7/52041 ,  A61B8/481 ,  G01S7/52026 ,  G01S7/52038 ,  G01S7/52071 ,  G01S7/52074

    摘要： An embodiment of a solution is proposed for imaging a body-part that is perfused with a contrast agent. A corresponding method includes the step of providing a sequence of input images (for example, acquired with an ultrasound scanner); the input images offer a digital representation over time of the body-part. Each input image includes a plurality of input values (i.e., pixel or voxel values); each input value is indicative of a response to an interrogation signal (such as an echo signal for ultrasound waves) of a corresponding location of the body-part, which possibly includes the contrast agent. The method further includes the step of generating at least one filtered image from a plurality of selected ones of the input images (such as all of them or a subset thereof). Each filtered image includes a filtered value for each of a plurality of selected ones of the locations (for example, in a region of interest, or ROI). The filtered value of each selected location is indicative of the contrast agent that leaves the selected location after being substantially stationary at the selected location for a period of time, which is comprised between a first non-zero threshold and a second threshold higher than the first threshold (such as because the contrast agent detaches from the location after having been immobilized thereon, or because it was moving very slowly). The filtered value is obtained by reducing, where present, a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or shorter than the first threshold, and by reducing a contribution of the contrast agent that is substantially stationary at the selected location along the selected input images for a period of time equal to or longer than the second threshold.

    摘要翻译： 提出了一种解决方案的实施例，用于对用造影剂灌注的身体部位进行成像。 相应的方法包括提供输入图像序列（例如，用超声波扫描器获取）的步骤; 输入图像随着身体部位的时间而提供数字表示。 每个输入图像包括多个输入值（即像素或体素值）; 每个输入值表示对可能包括造影剂的身体部位的对应位置的询问信号（例如超声波的回波信号）的响应。 该方法还包括从输入图像中的多个所选择的图像生成至少一个滤波图像（例如它们全部或其子集）的步骤。 每个滤波图像包括针对多个选择的位置（例如，在感兴趣区域或ROI中）中的每一个的滤波值。 每个所选择的位置的经滤波的值指示造影剂，其在被选择的位置基本上静止一段时间之后离开所选择的位置，该时间段包括在高于第一个的第一非零阈值和第二阈值之间 阈值（例如因为造影剂在被固定在其上之后从该位置分离，或者由于其移动非常缓慢）。 通过在现有的情况下，通过在等于或小于第一阈值的时间段内减少在所选择的位置处基本上静止在所选择的位置处的造影剂的贡献，并且通过减少 所述造影剂在所选择的输入图像的选定位置基本上静止等于或长于所述第二阈值的时间段。