公开(公告)号：US20140288085A1

公开(公告)日：2014-09-25

申请号：US14216582

申请日：2014-03-17

申请人： CardioMEMS, Inc.

发明人： Jay Yadav

IPC分类号： A61K31/4985 ,  A61B5/0215 ,  A61B5/00 ,  A61K31/519 ,  A61B5/0205

CPC分类号： A61K31/4985 ,  A61B5/0215 ,  A61B5/4848 ,  A61B5/6876 ,  A61K31/519

摘要： Provided herein are methods and systems for the treatment of cardiovascular conditions, including pulmonary hypertension (PH), in subjects that are being treated with a treatment regimen that includes a phosphodiesterase-5 (PDE-5) inhibitor.

摘要翻译： 本文提供了在用包含磷酸二酯酶-5（PDE-5）抑制剂的治疗方案治疗的受试者中用于治疗心血管疾病（包括肺动脉高压（PH））的方法和系统。

公开(公告)号：US08355777B2

公开(公告)日：2013-01-15

申请号：US13236091

申请日：2011-09-19

申请人： Jason White ,  Kelly Tumlin

发明人： Jason White ,  Kelly Tumlin

IPC分类号： A61B5/02

CPC分类号： A61B5/0215 ,  A61B5/03 ,  A61B5/076

摘要： A delivery system for fixation of an implant assembly having an intracorporeal device at a deployment site using an anchoring structure. This invention provides an implant assembly having an anchor for fixation within a vessel. The anchoring structure adapted to be delivered via a catheter.

摘要翻译： 一种用于使用锚定结构固定具有体内装置的植入物组件的递送系统在部署地点。 本发明提供一种植入物组件，其具有用于固定在容器内的锚固件。 适于通过导管输送的锚定结构。

公开(公告)号：US08118749B2

公开(公告)日：2012-02-21

申请号：US11232668

申请日：2005-09-22

申请人： Jason White ,  Kelly Tumlin

发明人： Jason White ,  Kelly Tumlin

IPC分类号： A61B5/02

CPC分类号： A61B5/0215 ,  A61B5/0031 ,  A61B5/03 ,  A61B5/076 ,  A61B5/6882 ,  A61F2/848 ,  A61F2002/9522 ,  A61F2250/0002

摘要： An implant assembly is implanted in vivo within a vascular system in which a vessel divides at a furcation into two sub-vessels, each sub-vessel having a diameter smaller than the diameter of said vessel. An implant assembly is released into a vessel such as a pulmonary arterial vessel of a patient. The implant assembly has a diameter smaller than or substantially equal to the inner diameter of the vessel and larger than the inner diameter of each of the sub-vessels. The implant assembly is configured so that it moves downstream within the vessel along with the flow of blood. When the implant assembly reaches a furcation where the vessel divides, the implant assembly is too large and not sufficiently compliant to fit through either of the smaller branch vessels. The implant assembly thus lodges at the furcation, prevented from moving downstream by being too large and stiff to fit into the branch vessels, and prevented from moving upstream by the flow of blood through the arteries. Alternatively, the implant assembly has a diameter greater than a vessel and compliance characteristics such that, upon release, the implant assembly travels down a narrowing vessel until an interference fit is created between the anchor structure and the vessel wall, thereby preventing further distal movement.

摘要翻译： 植入物组件植入血管系统内，其中血管分叉成两个子血管，每个子血管的直径小于所述血管的直径。 植入物组件被释放到诸如患者的肺动脉血管的容器中。 植入物组件的直径小于或基本上等于容器的内径并且大于每个子容器的内径。 植入物组件被构造成使得其随着血液流动在血管内向下游移动。 当植入物组件到达血管分开的分叉处时，植入物组件太大并且不足够顺从以适合任何较小的分支血管。 植入组件因此在分叉处悬挂，防止由于太大和僵硬而不适合于分支血管而向下游移动，并且防止血液通过动脉的上游流动。 或者，植入物组件具有大于容器的直径和顺应性特征，使得在释放时，植入物组件沿着狭窄的容器行进，直到在锚结构和血管壁之间产生过盈配合，从而防止进一步的远端运动。

公开(公告)号：US07647836B2

公开(公告)日：2010-01-19

申请号：US11748803

申请日：2007-05-15

申请人： David O'Brien ,  Christophe Courcimault ,  Liang You ,  Mark Allen ,  Michael Fonseca ,  Florent Cros

发明人： David O'Brien ,  Christophe Courcimault ,  Liang You ,  Mark Allen ,  Michael Fonseca ,  Florent Cros

IPC分类号： G01L7/00

CPC分类号： G01L9/0075 ,  G01L9/0042 ,  G01L9/0055 ,  Y10T29/49002

摘要： A pressure cavity is durable, stable, and biocompatible and configured in such a way that it constitutes pico to nanoliter-scale volume. The pressure cavity is hermetically sealed from the exterior environment while maintaining the ability to communicate with other devices. Micromachined, hermetically-sealed sensors are configured to receive power and return information through direct electrical contact with external electronics. The pressure cavity and sensor components disposed therein are hermetically sealed from the ambient in order to reduce drift and instability within the sensor. The sensor is designed for harsh and biological environments, e.g. intracorporeal implantation and in vivo use. Additionally, novel manufacturing methods are employed to construct the sensors.

摘要翻译： 压力腔是耐用的，稳定的和生物相容的并且被配置成使得其构成微微至纳升级体积的量。 压力腔与外部环境密封，同时保持与其他设备通信的能力。 微加工的密封传感器配置为通过与外部电子设备的直接电气接触来接收电力并返回信息。 设置在其中的压力腔和传感器部件与环境密封，以便减少传感器内的漂移和不稳定性。 传感器设计用于苛刻和生物环境，例如 体内植入和体内使用。 另外，采用新的制造方法构造传感器。

公开(公告)号：US07595647B2

公开(公告)日：2009-09-29

申请号：US11668601

申请日：2007-01-30

申请人： Jason Kroh ,  Michael Ellis ,  Donald Miller ,  Robert Refermat

发明人： Jason Kroh ,  Michael Ellis ,  Donald Miller ,  Robert Refermat

IPC分类号： G01R27/28 ,  H01B7/00

CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/064 ,  A61B5/07 ,  A61B2560/0219 ,  H01B11/20 ,  H04B5/0043 ,  Y10S128/903

摘要： A coupling loop or antenna is provided that can be used with a system that determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. A cable attached to the coupling loop provides maximum isolation between the energizing signal and the sensor signal by maximizing the distance between the coaxial cables that carry the signals and maintaining the relative positions of the coaxial cables throughout the cable assembly.

摘要翻译： 提供耦合环路或天线，其可以与通过调节激励信号的相位和频率来确定传感器的谐振频率的系统一起使用，直到通电信号的频率与传感器的谐振频率匹配。 连接到耦合回路的电缆通过使承载信号的同轴电缆之间的距离最大化并且保持同轴电缆在整个电缆组件中的相对位置来提供激励信号和传感器信号之间的最大隔离。

公开(公告)号：US20090115397A1

公开(公告)日：2009-05-07

申请号：US12350173

申请日：2009-01-07

申请人： Richard Powers ,  Michael G. Ellis ,  Jason Kroh ,  Donald J. Miller

发明人： Richard Powers ,  Michael G. Ellis ,  Jason Kroh ,  Donald J. Miller

IPC分类号： G01R23/02

CPC分类号： A61B5/02014 ,  A61B5/0031 ,  A61B5/0215 ,  A61B5/076 ,  A61B5/726 ,  A61B2560/0223 ,  G01D21/00

摘要： The present invention determines the resonant frequency of a wireless sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency. The system receives the ring down response of the sensor and determines the resonant frequency of the sensor, which is used to calculate a physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal. The system identifies false locks by detecting an unwanted beat frequency in the coupled signal, as well as determining whether the coupled signal exhibits pulsatile characteristics that correspond to a periodic physiological characteristic, such as blood pressure.

摘要翻译： 本发明通过调节通电信号的相位和频率直到通电信号的频率与传感器的谐振频率相匹配来确定无线传感器的谐振频率。 该系统以低占空比激励传感器，具有预定频率的RF能量门控突发。 系统接收传感器的响铃响应，并确定用于计算物理参数的传感器的谐振频率。 该系统使用一对锁相环来调节激励信号的相位和频率。 该系统通过检测耦合信号中的不期望的拍频来识别假锁，以及确定耦合的信号是否表现出对应于诸如血压的周期性生理特征的脉动特性。

公开(公告)号：US07498799B2

公开(公告)日：2009-03-03

申请号：US11276571

申请日：2006-03-06

申请人： Mark G. Allen ,  Michael Ellis ,  Jason Kroh ,  Donald J. Miller

发明人： Mark G. Allen ,  Michael Ellis ,  Jason Kroh ,  Donald J. Miller

IPC分类号： G01R23/12 ,  G01R35/00

CPC分类号： G01R23/12 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/05 ,  A61B5/076 ,  A61B2560/0219 ,  A61B2560/0223 ,  G01D21/00 ,  G01F15/066 ,  G01R23/145

摘要： The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal.

摘要翻译： 本发明通过调节激励信号的相位和频率直到激励信号的频率与传感器的谐振频率相匹配来确定传感器的谐振频率。 该系统以低占空比激励传感器，具有预定频率或一组频率和预定幅度的RF能量门控突发。 激励信号通过磁耦合耦合到传感器，并且感应传感器中的电流，其以传感器的谐振频率振荡。 系统通过磁耦合接收传感器的响铃响应，并确定传感器的谐振频率，用于计算测量的物理参数。 该系统使用一对锁相环来调节激励信号的相位和频率。

公开(公告)号：US20070199385A1

公开(公告)日：2007-08-30

申请号：US11601597

申请日：2006-11-17

申请人： David O'Brien ,  Liang You

发明人： David O'Brien ,  Liang You

IPC分类号： G01L9/12

CPC分类号： G01L9/0075

摘要： A sensor has a sensor housing defining a cavity therein. A first wall partially defining the cavity is deflectable under a physiologically relevant range of pressures. An integrated circuit chip bearing electronics is fixedly mounted within the cavity. A capacitor comprises first and second capacitor plates in generally parallel, spaced-apart relation. The first capacitor plate is physically coupled to the deflectable wall so as to move as the wall deflects, and the second capacitor plate is carried by the chip. The second capacitor plate is in electrical communication with the input pad of the chip.

摘要翻译： 传感器具有在其中限定空腔的传感器外壳。 部分地限定空腔的第一壁在生理学上相关的压力范围内是可偏转的。 集成电路芯片轴承电子器件固定地安装在腔内。 电容器包括大致平行且间隔开的关系的第一和第二电容器板。 第一电容器板物理耦合到可偏转壁，以便当壁偏转时移动，并且第二电容器板由芯片承载。 第二电容器板与芯片的输入焊盘电连通。

公开(公告)号：US20070096715A1

公开(公告)日：2007-05-03

申请号：US11613645

申请日：2006-12-20

申请人： James Joy ,  Jason Kroh ,  Michael Ellis ,  Mark Allen ,  Wilton Pyle

发明人： James Joy ,  Jason Kroh ,  Michael Ellis ,  Mark Allen ,  Wilton Pyle

IPC分类号： G01R23/12

CPC分类号： G01R23/12 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/05 ,  A61B5/076 ,  A61B2560/0219 ,  A61B2560/0223 ,  G01D21/00 ,  G01F15/066 ,  G01R23/145

摘要： The present invention determines the resonant frequency of a sensor by adjusting the phase and frequency of an energizing signal until the frequency of the energizing signal matches the resonant frequency of the sensor. The system energizes the sensor with a low duty cycle, gated burst of RF energy having a predetermined frequency or set of frequencies and a predetermined amplitude. The energizing signal is coupled to the sensor via magnetic coupling and induces a current in the sensor which oscillates at the resonant frequency of the sensor. The system receives the ring down response of the sensor via magnetic coupling and determines the resonant frequency of the sensor, which is used to calculate the measured physical parameter. The system uses a pair of phase locked loops to adjust the phase and the frequency of the energizing signal.

公开(公告)号：US20060200030A1

公开(公告)日：2006-09-07

申请号：US11180840

申请日：2005-07-13

申请人： Jason White ,  Kelly Tumlin

发明人： Jason White ,  Kelly Tumlin

IPC分类号： A61B5/02

CPC分类号： A61B5/0215 ,  A61B5/03 ,  A61B5/076

摘要： A delivery system for fixation of an implant assembly having an intracorporeal device at a deployment site using an anchoring structure. This invention provides an implant assembly having a an anchor for fixation within a vessel. The anchoring structure adapted to be delivered via a catheter.

摘要翻译： 一种用于使用锚定结构固定具有体内装置的植入物组件的递送系统在部署地点。 本发明提供一种植入物组件，其具有用于固定在血管内的锚固件。 适于通过导管输送的锚定结构。