Methods of using chimeric receptors to identify autoimmune disease
    5.
    发明申请
    Methods of using chimeric receptors to identify autoimmune disease 有权
    使用嵌合受体鉴定自身免疫疾病的方法

    公开(公告)号:US20080187942A1

    公开(公告)日:2008-08-07

    申请号:US11906189

    申请日:2007-10-01

    申请人: James L. Brown

    发明人: James L. Brown

    IPC分类号: C12Q1/66 C12N15/00 C12N5/06

    摘要: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays.

    摘要翻译: 本发明提供了用于诊断和治疗自身免疫疾病的方法和组合物。 特别地,本发明提供了用于诊断和治疗格雷夫斯病的改进方法和组合物。 本发明的方法不仅避免了对放射性的需要,而且比传统上用于诊断格雷夫斯病的方法简单,经济和快速,而且改进了以前基于荧光素酶的自身抗体检测的灵敏度和检测能力 测定。

    Compositions and methods for human metapneumovirus monoclonal antibodies
    6.
    发明申请
    Compositions and methods for human metapneumovirus monoclonal antibodies 有权
    人类偏肺病毒单克隆抗体的组合物和方法

    公开(公告)号:US20070248962A1

    公开(公告)日:2007-10-25

    申请号:US11409600

    申请日:2006-04-24

    IPC分类号: C12Q1/68 C12P21/06

    摘要: The present invention discloses specific human metapneumovirus monoclonal antibodies. The antibody is at least two-fold less reactive with non-human metapneumoviruses including, but not limited to, respiratory viruses or avian metapneumoviruses. Further, the antibody is at least two-fold more reactive with a human metapneumovirus (i.e., for example, Type A or Type B) than with non-human metapneumoviruses including, but not limited to, respiratory viruses or avian metapneumoviruses. Consequently, these novel antibodies are useful as a clinical diagnostic agent, especially when using fresh nasopharengeal aspirates. The invention also contemplates numerous diagnostic platforms that together with the novel antibodies can support economical, fast, and highly selective detection and identification of clinical inoculum samples.

    摘要翻译: 本发明公开了特异性人偏肺病毒单克隆抗体。 该抗体与非人类偏肺病毒的反应性至少降低2倍,包括但不限于呼吸道病毒或禽类间质肺病毒。 此外,抗体与人类偏肺病毒(例如,A型或B型)相比,比非人类重型肺炎病毒(包括但不限于呼吸道病毒或禽类间质肺病毒)具有至少两倍的活性。 因此,这些新型抗体可用作临床诊断剂,特别是在使用新鲜的鼻咽部吸出物时。 本发明还考虑了许多诊断平台,其与新型抗体一起可以支持临床接种物样品的经济,快速和高选择性检测和鉴定。

    Diagnosis of autoimmune disease
    8.
    发明授权
    Diagnosis of autoimmune disease 有权
    自身免疫性疾病诊断

    公开(公告)号:US06852546B1

    公开(公告)日:2005-02-08

    申请号:US09539735

    申请日:2000-03-30

    申请人: James L. Brown

    发明人: James L. Brown

    IPC分类号: C12Q1/02 C12Q1/66 G01N33/564

    CPC分类号: G01N33/564 G01N2800/24

    摘要: The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention avoid the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease.

    摘要翻译: 本发明提供了用于诊断和治疗自身免疫疾病的方法和组合物。 特别地,本发明提供了用于诊断和治疗格雷夫斯病的改进方法和组合物。 本发明的方法避免了放射性的需要,并且比传统上用于诊断格雷夫斯病的方法要简单得多,经济且快速。