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公开(公告)号：US20150071854A1
公开(公告)日：2015-03-12
申请号：US14490328
申请日：2014-09-18
申请人： The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc. , The Government of the United States of America, as represented by the Secretary, Department of Healt
IPC分类号： C07K16/12 , G01N33/569 , A61K51/10
CPC分类号： C07K16/1203 , A61K51/1009 , A61K2039/505 , C07K16/1027 , C07K2317/21 , C07K2317/51 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N33/6893 , G01N2333/115 , G01N2469/10
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
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公开(公告)号：US20120064000A1
公开(公告)日：2012-03-15
申请号：US13195366
申请日：2011-08-01
IPC分类号： A61K51/10 , C12N15/13 , C12N15/63 , A61P31/14 , C12Q1/70 , A61K39/42 , A61K49/16 , C07K16/10 , C12N5/10
CPC分类号： C07K16/1203 , A61K51/1009 , A61K2039/505 , C07K16/1027 , C07K2317/21 , C07K2317/51 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/56983 , G01N33/6893 , G01N2333/115 , G01N2469/10
摘要： The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus. The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
摘要翻译： 本发明涉及结合或中和亨德拉或尼帕病毒的单克隆抗体。 本发明提供了这样的抗体，这种抗体的片段，其保留了Hendra或Nipah病毒结合能力，完全人类抗体保留Hendra或Nipah病毒结合能力，以及包含这些抗体的药物组合物。 本发明还提供了编码本发明的抗体的分离的核酸和用其转化的宿主细胞。 另外，本发明提供了使用本发明的抗体和核酸的预防，治疗和诊断方法。
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3.发明授权Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents 有权用干扰素拮抗功能鉴定病毒蛋白的筛选方法和潜在的抗病毒剂公开(公告)号：US07833774B2
公开(公告)日：2010-11-16
申请号：US12218280
申请日：2008-07-14
CPC分类号： G01N33/5008 , C12N15/1086 , C12Q1/18 , G01N33/502 , G01N33/6866 , G01N2333/005 , G01N2333/115 , G01N2333/145
摘要： The present invention relates, in general, to a screening method for identifying novel viral proteins with interferon antagonizing function using a transfection-based assay, and the use of such proteins in isolating various types of attenuated viruses for the development of vaccine and pharmaceutical formulations. The invention also relates to the use of viral interferon antagonists in screening assays to identify potential anti-viral agents. The invention further relates to protocols utilizing interferon antagonists, e.g., NS1, to enhance gene therapy or DNA vaccination based on their ability to increase gene expression.
摘要翻译： 本发明一般涉及使用基于转染的测定法鉴定具有干扰素拮抗功能的新型病毒蛋白的筛选方法，以及使用这些蛋白质分离各种类型的减毒病毒以开发疫苗和药物制剂。 本发明还涉及病毒干扰素拮抗剂在筛选测定中鉴定潜在的抗病毒剂的用途。 本发明进一步涉及利用干扰素拮抗剂（例如NS1）基于其增加基因表达能力来增强基因治疗或DNA疫苗接种的方案。
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4.发明申请METAPNEUMOVIRUS STRAINS AND THEIR USE IN VACCINE FORMULATIONS AND AS VECTORS FOR EXPRESSION OF ANTIGENIC SEQUENCES AND METHODS FOR PROPAGATING VIRUS 审中-公开金属蛋白酶菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体和用于传播病毒的方法公开(公告)号：US20100167270A1
公开(公告)日：2010-07-01
申请号：US12640808
申请日：2009-12-17
申请人： Jeanne H. Schickli
发明人： Jeanne H. Schickli
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/525 , C12N7/00 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12Q1/37 , C12Q1/701 , G01N2333/115
摘要： The invention relates to improved strains of mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention further relates to methods for propagating mammalian MPV in the absence of trypsin. The methods and compositions of the invention can be used for the preparation of vaccines against, e.g., MPV infections.
摘要翻译： 本发明涉及副粘病毒科家族肺炎链球菌中哺乳动物负链RNA病毒，偏肺病毒（MPV）的改良菌株。 本发明还涉及在不存在胰蛋白酶的情况下繁殖哺乳动物MPV的方法。 本发明的方法和组合物可用于制备针对例如MPV感染的疫苗。
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公开(公告)号：US07671186B2
公开(公告)日：2010-03-02
申请号：US11808794
申请日：2007-06-13
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
摘要翻译： 编码相应嵌合蛋白质的多聚体杂交基因包含编码与编码来自第二病原体的蛋白质的抗原性区域的基因序列连接的第一病原体的蛋白质的抗原性区的基因序列。 病原体特别是副流感病毒（PIV）和呼吸道合胞病毒（RSV）。 单一的重组免疫原能够保护婴儿和类似的敏感个体免受由PIV和RSV引起的疾病。
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公开(公告)号：US20080311624A1
公开(公告)日：2008-12-18
申请号：US11808794
申请日：2007-06-13
申请人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
发明人： Michel H. Klein , Run-Pan Du , Mary E. Ewasyshyn
CPC分类号： G01N33/56983 , A61K39/00 , C07K14/005 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Multimeric hybrid genes encoding the corresponding chimeric protein comprise a gene sequence coding for an antigenic region of a protein from a first pathogen linked to a gene sequence coding for an antigenic region of a protein from a second pathogen. The pathogens particularly are parainfluenza virus (PIV) and respiratory syncytial virus (RSV). A single recombinant immunogen is capable of protecting infants and similar susceptible individuals against diseases caused by both PIV and RSV.
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7.发明申请Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences and methods for propagating virus 审中-公开肺炎病毒菌株及其在疫苗制剂中的用途以及用于表达抗原序列的载体和用于繁殖病毒的方法公开(公告)号：US20060216700A1
公开(公告)日：2006-09-28
申请号：US11373686
申请日：2006-03-09
申请人： Jeanne Schickli
发明人： Jeanne Schickli
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/525 , C12N7/00 , C12N2760/18321 , C12N2760/18322 , C12N2760/18334 , C12N2760/18343 , C12Q1/37 , C12Q1/701 , G01N2333/115
摘要： The invention relates to improved strains of mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention further related to methods for propagating mammalian MPV in the absence of trypsin. The methods and compositions of the invention can be used for the preparation of vaccines against, e.g., MPV infections.
摘要翻译： 本发明涉及副粘病毒科家族肺炎链球菌中哺乳动物负链RNA病毒，偏肺病毒（MPV）的改良菌株。 本发明还涉及在不存在胰蛋白酶的情况下繁殖哺乳动物MPV的方法。 本发明的方法和组合物可用于制备针对例如MPV感染的疫苗。
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公开(公告)号：US20040116341A1
公开(公告)日：2004-06-17
申请号：US10416938
申请日：2004-01-07
发明人： Michael J. Holtzman
IPC分类号： A61K038/17
CPC分类号： A61K38/195 , G01N2333/115 , G01N2333/715
摘要： Methods to treat paramyxovirus infection are disclosed, which comprise administering RANTES protein or an expression system therefor. Also disclosed are methods to identify individuals susceptible to paramyxovirus infection.
摘要翻译： 公开了治疗副粘病毒感染的方法，其包括给予RANTES蛋白或其表达系统。 还公开了鉴定易患副粘病毒感染的个体的方法。
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公开(公告)号：US20180320146A1
公开(公告)日：2018-11-08
申请号：US16030259
申请日：2018-07-09
发明人： Antonius G.P. Oomens
IPC分类号： C12N7/00 , C07K14/005 , C12Q1/06
CPC分类号： C12N7/00 , A61K2039/5254 , A61K2039/5258 , C07K14/005 , C12N2760/18511 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2760/18562 , C12Q1/06 , G01N2333/115 , G01N2500/00
摘要： Highly antigenic yet safe vaccines against diseases caused by Paramyxoviridae viruses such as respiratory syncytial virus (RSV) are provided. The vaccines comprise attenuated Paramyxoviridae viruses with high antigenicity but which display impaired cell-to-cell transmission as a result of genetic manipulation of the gene encoding the matrix (M) protein. In the viruses, the M protein is absent or mutated to a less active form. Screening or assay systems and methods for evaluating the infectivity of mutant M proteins anf for identifying suitable M candidates for live-attenuated vaccine virus and VLP production, are also provided.
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10.发明授权Methods for identifying inhibitors against viruses that use a class I fusion protein 有权用于鉴定使用I类融合蛋白的病毒抑制剂的方法公开(公告)号：US08898047B2
公开(公告)日：2014-11-25
申请号：US12919383
申请日：2009-02-26
申请人： Dirk André Emmy Roymans , Hendrik Leon Augusta Jozef De Bondt , Eric Pierre Alexandre Arnoult , Herman Van Vlijmen , Jean-François Bonfanti
发明人： Dirk André Emmy Roymans , Hendrik Leon Augusta Jozef De Bondt , Eric Pierre Alexandre Arnoult , Herman Van Vlijmen , Jean-François Bonfanti
IPC分类号： G01N33/566 , G01N33/00 , C07K14/135
CPC分类号： G01N33/56983 , C07K2299/00 , G01N2333/115
摘要： The invention concerns the generation of a three dimensional model of the six helix bundle (6HB) complexed with an inhibitor and the use of that model to identify, screen and/or develop inhibitors against viruses that use a class I fusion protein. Such inhibitors of viruses that use a class I fusion protein may be effective for treating, for example, respiratory infections by Respiratory Syncytial Virus (RSV).
摘要翻译： 本发明涉及与抑制剂复合的六个螺旋束（6HB）的三维模型的生成以及该模型用于鉴定，筛选和/或开发使用I类融合蛋白的病毒的抑制剂的用途。 使用I类融合蛋白的这种病毒抑制剂可有效治疗例如呼吸道合胞病毒（RSV）的呼吸道感染。
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