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    LOW PH COMPOSITION AND METHOD FOR STABILIZING NUCLEIC ACIDS IN BIOLOGICAL SAMPLES
    1.
    发明公开
    LOW PH COMPOSITION AND METHOD FOR STABILIZING NUCLEIC ACIDS IN BIOLOGICAL SAMPLES 审中-公开

    公开(公告)号：US20240271184A1

    公开(公告)日：2024-08-15

    申请号：US18568538

    申请日：2022-06-08

    申请人： DNA Genotek Inc.

    发明人： Brice Georges Le Francois ,  Alaya Mikalauskas ,  Bitapi Ray ,  Rafal Michal Iwasiow

    IPC分类号： C12Q1/6806

    CPC分类号： C12Q1/6806

    摘要： An aqueous composition for stabilizing nucleic acid contained in a biological sample at ambient temperature is provided. The aqueous composition comprises: (i) a denaturing agent selected from sodium dodecyl sulphate (SDS) or a guanidinium salt; (ii) aurintricarboxylic acid (ATA); and (iii) at least one of a chelating agent and a buffering agent; wherein the composition has a pH of 4.9 or less. A method of stabilizing nucleic acid contained in a biological sample at ambient temperature is also provided, wherein the method comprises the steps of: a) obtaining a biological sample; b) contacting the biological sample with the above-noted aqueous composition to form a mixture; c) homogenizing the mixture of (b) to form a homogeneous mixture; and d)storing the homogeneous mixture at ambient temperature.

    BIOLOGICAL COLLECTION SYSTEM
    3.
    发明申请
    BIOLOGICAL COLLECTION SYSTEM 有权

    公开(公告)号：US20220113230A1

    公开(公告)日：2022-04-14

    申请号：US17510003

    申请日：2021-10-25

    申请人： DNA GENOTEK, INC.

    发明人： Youssef BIADILLAH ,  Stephen D. ANDREWS

    IPC分类号： G01N1/30 ,  A61B10/00 ,  B01L3/00 ,  G01N1/10 ,  G01N1/00

    摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.

    METHOD FOR COLLECTING AND PRESERVING A BIOLOGICAL SAMPLE
    9.
    发明公开
    METHOD FOR COLLECTING AND PRESERVING A BIOLOGICAL SAMPLE 审中-公开

    公开(公告)号：US20240019344A1

    公开(公告)日：2024-01-18

    申请号：US18165681

    申请日：2023-02-07

    申请人： DNA GENOTEK, INC.

    发明人： Youssef BIADILLAH ,  Stephen D. ANDREWS

    IPC分类号： G01N1/30 ,  A61B10/00 ,  B01L3/00 ,  G01N1/10

    CPC分类号： G01N1/30 ,  A61B10/0051 ,  A61B10/007 ,  A61B10/0096 ,  B01L3/502 ,  G01N1/10 ,  G01N2001/002

    摘要： The disclosure relates to devices, solutions and methods for collecting and processing samples of bodily fluids containing cells (as well as embodiments for the collection, and processing and/or analysis of other fluids including toxic and/or hazardous substances/fluids). In addition, the disclosure relates generally to function genomic studies and to the isolation and preservation of cells from saliva and other bodily fluids (e.g., urine), for cellular analysis. With respect to devices for collection of bodily fluids, some embodiments include two mating bodies, a cap and a tube (for example), where, in some embodiments, the cap includes a closed interior space for holding a sample preservative solution and mates with the tube to constitute the (closed) sample collection device. Upon mating, the preservation solution flows into the closed interior space to preserve cells in the bodily fluid. The tube is configured to receive a donor sample of bodily fluid (e.g., saliva, urine), which can then be subjected to processing to extract a plurality of cells. The plurality of cells can be further processed to isolate one and/or another cell type therefrom. The plurality of cells, as well as the isolated cell type(s), can be analyzed for functional genomic and epigenetic studies, as well as biomarker discovery.